AbstractInside many U.S. oil and gas‐producing regions, the oil and gas sector dominates local anthropogenic emission fluxes of C2‐C5 alkanes. Here, we present a detailed analysis of the impact of these emissions on secondary species production over the continental United States using the GEOS‐Chem model. Oil‐ and gas‐producing areas in the central United States show the highest summertime surface ozone (O3) enhancements due to oil and gas C2‐C5 alkane emissions. The Colorado Front Range is the most impacted 8‐hr O3 non‐attainment area in the United States with 3‐hr daytime instantaneous O3 enhancements >4 ppb. From three selected non‐attainment areas, the Colorado Front Range has (1) the lowest monthly mean VOC reactivity (1.5 s−1); (2) the highest percent contribution of oil and gas sources (52%) to calculated VOC reactivity; and (3) the largest relative increases in PAN (peroxyacetyl nitrate), PPN (peroxypropionyl nitrate), and >C4 alkyl nitrates. Enhanced abundances of PAN, PPN, and >C4 alkyl nitrates have the potential to perturb remote O3 production through increased NOx export to remote regions via PAN chemistry. Globally, simulated C2‐C5 alkane emissions from the U.S. oil and gas sector contribute 0.5 Tg (~0.17%) to the tropospheric O3 burden with a ~0.27% contribution in the Northern Hemisphere.