Peroxide Cream Research Articles

Efficacy of Microencapsulated Benzoyl Peroxide (E-Bpo) Cream, 5% in Elderly Rosacea Patients

Abstract not available.

Evaluation of safety and efficacy of hydrogen peroxide stabilized cream for treatment of mild to moderate acne vulgaris in comparison with benzoyl peroxide gel - double blinded, randomized control study

Acne is defined as a chronic inflammatory disorder of the pilosebaceous unit, which is characterized by comedones, seborrhea, pustules, nodules, pseudocysts and scarring, in some cases. Benzoyl peroxide (BP) is a time tasted molecule in the management of acne. In current study we have tried to compare efficacy of benzoyl peroxide with hydrogen peroxide (HP) in acne vulgaris (AV).To study efficacy and local tolerability of BP and HP in Acne Vulgaris treatment. To compare the efficacy and local tolerability of BP gel and HP cream in a Acne Vulgaris (GRADE 1 AND 2) treatment.A double blinded, randomised control study for the duration of 18 months was carried out in which a total of 150 patients of acne vulgaris (Grade 1 & 2) between the age of 13-30 years of both genders were recruited, which were divided in two groups, with one group treated with benzoyl peroxide gel 2.5% and second group being treated with hydrogen peroxide cream. All the data analysis was done using IBM SPSS ver. 20 software.Both drugs were found to be equally efficacious in reducing acne lesions. Hydrogen peroxide group experienced less side-effects as compared to benzoyl peroxide group.Hydrogen peroxide and benzoyl peroxide are equally efficacious.: In acne grade one and two benzoyl peroxide and hydrogen peroxide are equally efficacious though hydrogen peroxide has less adverse effect.

330 Characterization of multiple B cell subsets in peripheral blood of psoriasis patients identifies a correlation of regulatory B cells and disease severity

328 Assessment of psoriasis using label-free ultra-broadband optoacoustic mesoscopy J Aguirre, M Schwarz, N Garzorz-Stark, F Lauffer, D Soliman, A Buehler, K Eyerich and V Ntziachristos 1 Institute for Biological and Medical Imaging, Technical University of Munich and Helmholtz Center Munich, Munich, Germany and 2 Department of Dermatology and Allergy, Technical University of Munich, Munich, Germany Psoriasis is one of the most prevalent widespread chronic inflammatory skin disease but modern imaging methods provide only limited view on the disease specific hallmarks. In clinical practice, standard tools to assess disease severity and drug efficacy are based on visual scores that are subjective and inconsistent among different examiners. Here, we introduce paradigm shifting ultra-broadband optoacoustic mesoscopy (OPAM) for visualizing psoriatic skin beyond the reach of current dermatological imaging. Implemented in handheld mode, we show visualization of optical absorption contrast resolving for the first time vascular morphology in the dermis and quantifying inflammatory landmarks such as blood volume, epidermal thickness and characterization of capillary architecture in label free mode. Investigating the mesoscopic appearance of psoriasis in six different patients, we found that OPAM cross sectional images and 3D reconstructions examined for morphological skin alterations, capillary loop elongation, acanthosis and changes in dermal vasculature correlated with the values obtained from histopathological skin samples of the respective patients. Besides, we established a multidimensional computational analysis combining the OPAM parameters of increased dermal blood volume, capillary loop density, acanthosis and vessel structure complexity which significantly correlated with Psoriasis Area Severity Index. Thus, we confirm that obtained imaging data reflected the main clinical signs of psoriatic inflammation namely erythema, scaling and induration of plaques. The method has enormous implications in non-invasive accurate staging, treatment evaluation and assessing a larger spectrum of diseases towards precision medicine. 329 The efficacy of 1% hydrogen peroxide cream for acne vulgaris treatment K Dzilinska, K Kisiel, M Pasikowska, E Jakimiuk, R Debowska and I Eris 1 Dermatology Centre, Miedzyleski Hospital, Warsaw, Poland and 2 Dr Irena Eris Cosmetic Laboratories, Piaseczno, Poland Acne vulgaris most commonly occurs during adolescence, affecting an estimated 80e90% of teenagers. However we observe increasing number of acne vulgaris in adults as well. The purpose of this study was to evaluate the safety and anti-inflammatory, anti-bacterial and soothing effects of topical use of 1% hydrogen peroxide cream. Hydrogen peroxide is a chemical compound that finds use as a strong oxidizer, bleaching agent and disinfectant. Cosmetic industry offers a wide range of products for this condition, however hydrogen peroxide has not been very popular so far. The study was conducted on 19 volunteers with acne vulgaris between ages 16-61 years old. The product was used daily for a week. Skin condition was analyzed using VISIA system as well as by dermatologists according to the Hellgren and Vincent scale and via a questionnaire survey completed by volunteers after one week of product usage. Skin assessment revealed the reduction in the amount of pustules by 63% and reduction of the severity of seborrhea by 32%. Instrumental skin analysis revealed significant decrease of porphyrins, pores and spots. Moreover skin texture was improved by 22%. Results of the presented study demonstrated that systematic application of 1% hydrogen peroxide cream significantly reduces skin inflammation, soothes and accelerates healing process as well as demonstrates great product tolerance. 1% hydrogen peroxide can supplement pharmacological treatment of acne vulgaris with mild to moderate course of disease.

329 The efficacy of 1% hydrogen peroxide cream for acne vulgaris treatment

329 The efficacy of 1% hydrogen peroxide cream for acne vulgaris treatment

Increased cutaneous oxygen availability by topical application of hydrogen peroxide cream enhances the photodynamic reaction to topical 5-aminolevulinic acid-methyl ester

Topical 5-aminolevulinic acid (ALA) and methyl aminolevulinate (MAL) photodynamic therapy (PDT) of skin lesions is an accepted treatment for skin tumours but success rates need improvement. The effectiveness of PDT is influenced by availability of oxygen. The aim of this study was to demonstrate, in normal skin, whether a decrease in skin oxygen tension reduces the photodynamic reaction (PDR); and whether the addition of topical hydrogen peroxide can reverse the effect. Topical MAL and red light were administered to the inner forearms of 40 healthy volunteers. Skin oxygen availability was lowered during the illumination phase of the PDT, by applying blanching pressure with a plastic slide. Topical hydrogen peroxide was applied under the pressure slide, immediately prior to illumination, to reverse the effect. Erythema was assessed by naked eye and laser Doppler perfusion imaging (LDPI), at baseline and at 1, 5, 24 and 48 h following illumination. Decreasing oxygen availability by pressure altered the PDR with a larger number of subjects (17.5%) not demonstrating any visible erythema at any time point after plastic slide pressure compared to a PDR Control site (7.5%). The addition of topical hydrogen peroxide during pressure application, restored the number of subjects showing no visible erythema compared to that of PDR Control. LDPI data showed that there was a decrease in mean perfusion after plastic slide pressure when comparing the change from baseline to 24 h (P < 0.05) with the PDR Control. The addition of hydrogen peroxide not only restored but also increased the mean perfusion compared to that of PDR Control when comparing the change from baseline to 5 h and the change from baseline to 24 h (P < 0.001). Increasing oxygen availability increased the PDR in normal skin. The possibility that addition of topical hydrogen peroxide to PDT protocols for non-melanoma skin cancer may increase reactivity and, thus, be relevant for outcomes warrants further study.

A modern hydrogen peroxide cream for wound healing

A modern hydrogen peroxide cream for wound healing

Improvement of Microcirculation and Healing of Venous Hypertension and Ulcers With Crystacide ®: Evaluation With a Microcirculatory Model, Including Free Radicals, Laser Doppler Flux, and PO2/PCO2Measurements

In 32 patients with chronic venous insufficiency and venous hypertension associated with ulcerations, the effects of the local application of a hydrogen peroxide cream (Crystacide) applied onto the skin was evaluated using a complex, proportional, microcirculatory model to assess and quantify venous microangiopathy after local treatment. A comparative group treated without Crystacide was included. Laser Doppler flowmetry was used to assess skin perfusion (flux and venoarteriolar response) in association with transcutaneous PO2 and PCO2 measurements. Local plasma free radicals were evaluated in the area surrounding the venous ulcer using the D-Roms test. Crystacide was applied around and on the ulcer for 10 days. Crystacide was more effective than the control treatments. PO2 was increased (improved, P < .05), and plasma free radicals, PCO2, and laser Doppler flowmetry were decreased (improving toward normal values, P < .05). Also, the ulcerated area was significantly smaller at 10 days in the Crystacide group in comparison with controls (P < .05). In the proportional microcirculatory model, all parameters indicated an important level of improvement significantly larger than in controls. In conclusion, in chronic venous insufficiency and venous ulcerations, local treatment with Crystacide (10 days) improves the microcirculation and decreases skin free radicals, thus improving healing.

Efficacy and safety of combination therapy of hydrogen peroxide cream and adapalene gel in comparison with benzoyl peroxide cream and adapalene in common acne

Efficacy and safety of combination therapy of hydrogen peroxide cream and adapalene gel in comparison with benzoyl peroxide cream and adapalene in common acne

Efficacy and safety of hydrogen peroxide cream alone or in combination with salicilyc foam in the treatment of mild-to-moderate acne

Background: Common Acne (CA) is a very common skin disease. Topical antiseptics such as benzoyl peroxide and keratolytic agents such as salicilyc acid are widely used as first-line treatment of CA. Recently, a new formulation of hydrogen peroxide 1% in stabilised cream and a new thermophobic foam formulation of salicilyc acid 2% (SAF) became available.

Efficacy and safety of stabilised hydrogen peroxide cream (Crystacide) in mild-to-moderate acne vulgaris: a randomised, controlled trial versus benzoyl peroxide gel

Benzoyl peroxide (BP) is a first-line topical treatment in acne vulgaris (AV). However, its use can cause mild skin irritation and dryness. A new formulation of hydrogen peroxide stabilised (HPS) in monoglycerides cream (Crystacide 1%), indicated in the topical treatment of superficial skin infections, is now available as an alternative treatment. To evaluate efficacy and local tolerability of HPS in mild-to-moderate AV in comparison with BP gel. In a randomised, prospective, investigator-masked parallel-group, 8-week trial, 60 patients (24 men, 36 women, mean age 25 +/- 6 years) with mild-to-moderate AV, affecting mainly the face, were enrolled in the study, after their informed consent. HPS or BP (PanOxyl gel 4%) was applied topically twice daily for 8 weeks. The study endpoints were: (1) Reduction in mean inflammatory (IL), noninflammatory (NIL) and total (TL) acneic lesions in comparison with baseline; (2) Local tolerability assessed evaluating erythema, dryness and burning sensation, using a 0-3 qualitative score (score 0 = poor tolerability; score 3 = very good tolerability). TL, NIL, and IL were assessed by an investigator unaware of treatment allocation at baseline, and week 8. The tolerability score (TS) was assessed at week 4 and 8. At baseline, the two groups were well matched for the main clinical and demographic characteristics. All patients concluded the trial. At week 0, in the HPS group TL, NIL and IL (mean +/- SD) were: 35 +/- 8, 20 +/- 6 and 16 +/- 7. At week 8, HPS reduced TL to 16 +/- 7; NIL to 9 +/- 3 and IL to 7 +/- 3 (p < 0.001). At baseline, TL, NIL and IL, in the BP group, were 32 +/- 9, 24 +/- 8 and 18 +/- 7, respectively. At week 8, BP reduced TL, NIL and IL to 14 +/- 9; 7 +/- 5 and 7 +/- 3 (p < 0.001). In comparison with baseline values, the percentage reductions of IL were 58% and 61% for HPS and BP,respectively (p = n.s.). At the end of the study the TS was 2.9 +/- 0.2 in HPS group and 2.4 +/- 0.8 in BP group (p < 0.025). Two patients in HPS group (6%) and seven patients (23%) in BP group suffered from mild-to-moderate local erythema. HPS has shown to be as effective as BP in reducing both inflammatory and noninflammatory AV lesions in patients with mild-to-moderate disease. In comparison with BP 4% gel, HPS cream shows a better local tolerability profile.

Efficacy and safety of stabilised hydrogen peroxide cream (Crystacide) in mild-to-moderate acne vulgaris: a randomised, controlled trial versus benzoyl peroxide gel

SUMMARYBackground: Benzoyl peroxide (BP) is a first-line topical treatment in acne vulgaris (AV). However, its use can cause mild skin irritation and dryness. A new formulation of hydrogen peroxide stabilised (HPS) in monoglycerides cream (Crystacide 1%), indicated in the topical treatment of superficial skin infections, is now available as an alternative treatment.Study aim: To evaluate efficacy and local tolerability of HPS in mild-to-moderate AV in comparison with BP gel.*Crystacide is a registered trademark licensed to Mipharm Spa, Milan, ItalyMethods and patients: In a randomised, prospective, investigator-masked parallel-group, 8-week trial, 60 patients (24 men, 36 women, mean age 25 ± 6 years) with mild-to-moderate AV, affecting mainly the face, were enrolled in the study, after their informed consent. HPS or BP (PanOxyl gel 4%) was applied topically twice daily for 8 weeks.Study outcomes: The study endpoints were: (1) Reduction in mean inflammatory (IL), non-inflammatory (NIL) and total (TL) acneic lesions in comparison with baseline; (2) Local tolerability assessed evaluating erythema, dryness and burning sensation, using a 0-3 qualitative score (score 0 = poor tolerability; score 3 = very good tolerability).Results: TL, NIL, and IL were assessed by an investigator unaware of treatment allocation at baseline, and week 8. The tolerability score (TS) was assessed at week 4 and 8. At baseline, the two groups were well matched for the main clinical and demographic characteristics. All patients concluded the trial. At week 0, in the HPS group TL, NIL and IL (mean ± SD) were: 35 ± 8, 20 ± 6 and 16 ± 7. At week 8, HPS reduced TL to 16 ± 7; NIL to 9 ± 3 and IL to 7 ± 3 (p < 0.001). At baseline, TL, NIL and IL, in the BP group, were 32 ± 9, 24 ± 8 and 18 ± 7, respectively. At week 8, BP reduced TL, NIL and IL to 14 ± 9; 7 ± 5 and 7 ± 3 (p < 0.001). In comparison with baseline values, the percentage reductions of IL were 58% and 61% for HPS and BP, respectively (p = n.s.). At the end of the study the TS was 2.9 ± 0.2 in HPS group and 2.4 ± 0.8 in BP group (p < 0.025). Two patients in HPS group (6%) and seven patients (23%) in BP group suffered from mild-to-moderate local erythema.Conclusions: HPS has shown to be as effective as BP in reducing both inflammatory and noninflammatory AV lesions in patients with mild-to-moderate disease. In comparison with BP 4% gel, HPS cream shows a better local tolerability profile.PanOxyl is a registered trademark of Stiefel aboratories Inc, Coral Gables, Fl, US

Topical hydrogen peroxide treatment of ischemic ulcers in the guinea pig: Blood recruitment in multiple skin sites

Background: Oxygen deficit is a key factor associated with delayed healing of ischemic wounds in human beings. Topical oxygen-releasing compounds such as hydrogen peroxide or tetrachlorodecaoxide have been suggested as therapy for ischemic tissue. Objective: Our purpose was to monitor the effect of hydrogen peroxide cream on the process of ischemic ulcer healing with a model for ischemic ulcers in the guinea pig. Methods: Measurement of vascular perfusion with a laser Doppler velocimeter and gross observations of percentage of nonnecrotic wound surface were made on ischemic wounds in guinea pigs after treatment with either a hydrogen peroxide cream or a placebo cream. Results: Visual evaluations of the percentage of nonnecrotic wound surface showed no statistically significant differences among the treatments. In contrast, vascular perfusion measurements resulted in statistically significant differences. Blood flow was significantly higher up to day 15 in ulcers treated with 2% hydrogen peroxide cream than in those treated with placebo cream. Vascular perfusion was significantly higher in ulcers treated with 3.5% hydrogen peroxide cream than in ulcers treated with either 1.5% hydrogen peroxide cream or placebo. Adjacent control sites in guinea pigs whose ulcers were treated with hydrogen peroxide cream showed increased vascular perfusion compared with corresponding sites in animals whose ulcers were treated with placebo. Even distant flank control sites of ulcers treated with 3.5% hydrogen peroxide cream showed increased vascular perfusion. Conclusion: Treatment of ischemia-induced ulcers with hydrogen peroxide cream enhanced cutaneous blood recruitment not only to ulcers and adjacent sites, but also to distant sites.

The effect of topical antimicrobial agents on the production of toxic shock syndrome toxin-1.

Three hundred isolates of Staphylococcus aureus from wound swabs were examined for the production of toxic shock syndrome toxin 1 (TSST-1). The isolates were collected from community patients, surgical inpatients and from patients in the Regional Burns Unit, Booth Hall Children's Hospital, Manchester. The overall incidence of toxin production was 17% and there was no significant variation between the sources of the strains. All 55 TSST-1-producing strains were grown in sublethal concentrations of five topical antimicrobial compounds and the level of toxin produced was determined and compared with the amount produced in a control broth after incubation for 24 h. The effects of sublethal concentrations of the compounds on TSST-1 production were strain dependent; some compounds tended to increase production (at least four-fold) and some tended to decrease production (at least four-fold). Some of the strains showed an increase in toxin production in the presence of chlorhexidine gluconate/cetrimide solution and silver sulphadiazine cream whereas 18%, 42% and 47% of the strains showed a decrease in toxin production in the presence of povidone iodine solution, stabilised hydrogen peroxide cream and mupirocin ointment, respectively. Preliminary results suggest that silver sulphadiazine cream induces toxin formation earlier in the growth cycle.

Hydrogen peroxide cream for the prevention of white pressure areas in UVA sunbeds.

A single application of 1% hydrogen peroxide in a stabilized lipid cream during 2 min before UVA exposure prevents white spots in anoxic pressure areas in sunbed use, causing an almost normal pigmentation. During maintenance exposure with UVA once a week this pigmentation will remain unchanged if the pressure areas are pretreated with hydrogen peroxide before each irradiation. White spots will appear 3-4 weeks after finishing hydrogen peroxide pretreatment in the pressure areas thus exposed to UVA alone.