Abstract
Acne is defined as a chronic inflammatory disorder of the pilosebaceous unit, which is characterized by comedones, seborrhea, pustules, nodules, pseudocysts and scarring, in some cases. Benzoyl peroxide (BP) is a time tasted molecule in the management of acne. In current study we have tried to compare efficacy of benzoyl peroxide with hydrogen peroxide (HP) in acne vulgaris (AV).To study efficacy and local tolerability of BP and HP in Acne Vulgaris treatment. To compare the efficacy and local tolerability of BP gel and HP cream in a Acne Vulgaris (GRADE 1 AND 2) treatment.A double blinded, randomised control study for the duration of 18 months was carried out in which a total of 150 patients of acne vulgaris (Grade 1 & 2) between the age of 13-30 years of both genders were recruited, which were divided in two groups, with one group treated with benzoyl peroxide gel 2.5% and second group being treated with hydrogen peroxide cream. All the data analysis was done using IBM SPSS ver. 20 software.Both drugs were found to be equally efficacious in reducing acne lesions. Hydrogen peroxide group experienced less side-effects as compared to benzoyl peroxide group.Hydrogen peroxide and benzoyl peroxide are equally efficacious.: In acne grade one and two benzoyl peroxide and hydrogen peroxide are equally efficacious though hydrogen peroxide has less adverse effect.
Highlights
1 It is estimated that in age group of 25 to 40years 41% of people suffer from acne lesions for at least 3 to 4 months per year.[2]
After ethical approval data collection was started and patients were divided randomly in two groups, with one group treated with benzoyl peroxide gel 2.5% and second group being treated with hydrogen peroxide cream, having 75 patients in each group respectively
Acne is the most common skin disorder of pilosebaceous unit which is characterized by excessive sebum production, redness and scaling of skin along with comedones, papules, pustules, nodules and its sequel scarring in some patients. 15
Summary
Acne is the commonest dermatological disorder affecting 85% of individuals in age group of 12 and years. 1 It is estimated that in age group of to 40years 41% of people suffer from acne lesions for at least 3 to 4 months per year.[2]. Acne is the commonest dermatological disorder affecting 85% of individuals in age group of 12 and 24 years. Current treatments includeoral medicationsand topical that counteract sebum production, P. acne colonization and inflammation. According to the first global alliance therapeutic guidelines of acne (2003), (BP) was considered the first drug of choice for treatment of mild and moderate AV.[10] This statement was substantially confirmed in the second global alliance publication in 2009. A new formulation of Hydrogen peroxide 1%(HP) in stabilised cream became available in Indian market. The study product contained hydrogen peroxide (H2O2), which is an odourless and colourless liquid. 14 In present study we tried to evaluate the safety and efficacy of HP stabilized cream for treatment of mild to moderate AV in comparison with BP gel Agrawal et al / IP Indian Journal of Clinical and Experimental Dermatology 2020;6(3):[217–221] aspecialized packaging. 14 In present study we tried to evaluate the safety and efficacy of HP stabilized cream for treatment of mild to moderate AV in comparison with BP gel
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