Based on a relevant geochronological U-Pb zircon dataset (n = 47) from a sample (PBL-109) of the Cerro Punta Blanca pluton (CPB), which is part of a calc-alkaline suite, we corroborate the development of protracted magmatic activity with three major crystallization events for this Permian magmatism: 278 ± 1, 283 ± 2, and 289 ± 2 Ma, which outcrop in the Cordón del Portillo, Cordillera Frontal (CF) of Argentina. These ages can be assigned to the lower section of the magmatic record of the Choiyoi magmatism (ca., 290-265 Ma), while the age of 289 Ma represents the oldest known age for the Choiyoi, indicating the start of this magmatism during the Artinskiense. Considering these geochronological data, we postulate the presence of a deep mush reservoir where protracted magmatic activity permitted the prolonged crystallization of antecrysts (ca. 283–289 Ma). Migration of the parental magma from the mush reservoir zone occurred near the time of emplacement and culminated in the formation of an ephemeral magma chamber at shallow levels, where zircon autocrysts crystallized (ca. 278 Ma). Age spectra reported within individual samples support the idea of massive magma migration when conditions were favorable (e.g., thermally matured crust). In this view, the studied “older” Choiyoi magmatism represents a continuous magmatic event lasting 11 Ma and corresponds to a single magmatic episode rather than different periods of magmatic activity and subsequent emplacements. A later alkali-calcic magmatic event is recorded at 265 ± 4 Ma from a sample of the Cerro Bayo pluton (MH-0113), which could represent the end of the lower section of the Choiyoi magmatism. Whole-rock Sm-Nd, Rb-Sr, and Lu-Hf data in zircon, along with ages reported for the studied igneous and inherited zircon from the CPB; together with isotopic data and ages from the detrital zircon found in the Carboniferous accretionary complex of Chile, indicate that the source of the Permian parental magma in this region was a heterogeneous continental crust mainly formed by Devonian and Carboniferous rocks, related probably to a magmatic arc. However, some contribution from the Carboniferous accretionary complex of Chile to the parental magma should be consider.