Permanganate Concentration Research Articles

Permanganometric determination of etamsylate in bulk drug and in tablets

One titrimetric and two spectrophotometric methods which are simple, selective, sensitive, accurate, precise and economical for the determination of etamsylate (ETM) in bulk drug and in tablets employing permanganate as the oxidimetric reagent are described. In titrimetry, ETM is titrated directly with permanganate in sulphuric acid medium. A direct spectrophotometry (method A) involves treating the aqueous solution of the drug with permanganate in alkaline medium and measuring the bluish green product at 610 nm. In indirect spectrophotometry (method B), the drug solution was treated with a fixed concentration of permanganate in H2SO4 medium, and after a specified time, the unreacted permanganate was measured at 545 nm. The molar combining ratio in titrimetry and the optimum assay conditions were studied. Titrimetry is applicable over 1-10 mg range and the calculations are based on a 1:4 (ETM:KMnO4) molar ratio. In spectrophotometry, Beer's law is obeyed over 0.5- 5.0 and 1.5-15 ?g ml-1 for method A and B, respectively. The molar absorptivity values are calculated to be 2.79?104 and 4.17?104 l mol-1 cm-1 for method A and B, respectively and the corresponding sandell sensitivity values are 0.0094 and 0.0063 ?g cm-2. The limits of detection (LOD) and quantification (LOQ) are also reported for spectrophotometric methods. The applicability of the developed methods was demonstrated by the determination of etamsylate in pure drug as well as in commercial dosage forms.

Sequential Injection Titrimetric Analysis of Vitamin C in Drug Formulation Using Potassium Permanganate

Sequential injection analysis technique was utilized for automatic titration of vitamin C in drug formulation. The method is based on the oxidation reaction of vitamin C with potassium permanganate in sulfuric acid media. The titration reaction was monitored by the decrease of absorbance of the permanganate at its maximum wavelength at 525 nm. The super modified simplex computer program was successfully utilized for optimizing the reaction parameters such as sulfuric acid and potassium permanganate concentration as well as determining the stoichiometry of the reaction. The optimized operating conditions were 0.418 μmol/L potassium permanganate and 7.49 μmol/L sulfuric acid with the injection of 0.25 μmol/L vitamin C thus verifying the stoichiometry of 2:5:16 for permanganate, vitamin C and sulfuric acid respectively. In addition a (3 f ) factorial design was employed for studying interaction effects. The method was found to be applicable for the detection of vitamin C in the range between 100 to 350 ppm and it was found to be accurate when statistically compared with the BP standard method. The method exhibited no interferences from excepients added in drug formulation. The method was also found to be faster and more economical compared to the previous reported methods.

Oxidation of microcystin-LR with chlorine and permanganate during drinking water treatment

The oxidation of microcystin-LR (MC-LR) present in natural waters with chlorine and potassium permanganate under real drinking water treatment conditions has been investigated in the present work. The natural waters were spiked with MC-LR, using the typical concentration of 5 μgL -1 found in natural waters. The influence of some operational parameters such as the initial oxidant concentration, pH and temperature and of some drinking water quality parameters such as the NOM and ammonia content has been studied. The initial chlorine concentration and the temperature have a positive effect on MC-LR elimination. However, the pH exerts a negative influence on the MC-LR elimination by chlorine, which indicates that HOCI is the main active oxidant species. High concentrations of NOM and ammonia, which consume chlorine, impede the elimination of MC-LR. During the oxidation with permanganate, the initial permanganate concentration and the temperature have a positive effect on MC-LR removal, while the pH and the ammonia content do not exert any influence on its oxidation. However, high concentrations of NOM reduce the extent of oxidation of MC-LR with permanganate.

Intermediate-scale 2D experimental investigation of in situ chemical oxidation using potassium permanganate for remediation of complex DNAPL source zones

In situ chemical oxidation is a technology that has been applied to speed up remediation of a contaminant source zone by inducing increased mass transfer from DNAPL sources into the aqueous phase for subsequent destruction. The DNAPL source zone can consist of one or more individual sources that may be present as an interconnected pool of high saturation, as a region of disconnected ganglia at residual saturation, or as combinations of these two morphologies. Potassium permanganate (KMnO 4) is a commonly employed oxidant that has been shown to rapidly destroy DNAPL compounds like PCE and TCE following second-order kinetics in an aqueous system. During the oxidation of a target DNAPL compound, or naturally occurring reduced species in the subsurface, manganese oxide (MnO 2) solids are produced. Research has shown that these manganese oxide solids may result in permeability reductions in the porous media thus reducing the ability for oxidant to be transported to individual DNAPL sources. It can also occur at the DNAPL–water interface, decreasing contact of the oxidant with the DNAPL. Additionally, MnO 2 formation at the DNAPL–water interface, and/or flow-bypassing as a result of permeability reductions around the source, may alter the mass transfer from the DNAPL into the aqueous phase, potentially diminishing the magnitude of any DNAPL mass depletion rate increase induced by oxidation. An experiment was performed in a two-dimensional (2D) sand-filled tank that included several discrete DNAPL source zones. Spatial and temporal monitoring of aqueous PCE, chloride, and permanganate concentrations was used to relate changes in mass depletion of, and mass flux, from DNAPL residual and pool source zones to chemical oxidation performance and MnO 2 formation. During the experiment, permeability changes were monitored throughout the 2D tank and these were related to MnO 2 deposition as measured through post-oxidation soil coring. Under the conditions of this experiment, MnO 2 formation was found to reduce permeability in and around DNAPL source zones resulting in changes to the overall flow pattern, with the effects depending on source zone configuration. A pool with little or no residual around it, in a relatively homogeneous flow field, appeared to benefit from resulting MnO 2 pore-blocking that substantially reduced mass transfer from the pool even though there was relatively little PCE mass removed from the pool. In contrast, a pool with residual around it (in a more typical heterogeneous flow field) appeared to undergo increased mass transfer as MnO 2 reduced permeability, altering the water flow and increasing the mixing at the DNAPL–water interface. Further, the magnitude of increased PCE mass depletion during oxidation appeared to depend on the PCE source configuration (pool versus ganglia) and decreased as MnO 2 was formed and deposited at the DNAPL–water interface. Overall, the oxidation of PCE mass appeared to be rate-limited by the mass transfer from the DNAPL to aqueous phase.

Oxidative Desulfurization of Çayirhan Lignites by Permanganate Solution

Unless important developments record new and renewable energy sources, the role of fossil fuels as an energy resource goes on. It is possible to detect sulfur, heavy metals, and tracer elements such as arsenic and selenium by decreasing calorific value of coals. Sulfur oxides, which are the main pollutants in atmosphere, are irritative to humans and plants, and erosion occurs on buildings. Although there are high lignite reservoirs, high sulfur content limits the efficient use of them. In this research, it is aimed to convert combustible sulfur in coal to non-combustible sulfur form in the ash by oxidizing it with permanganate solution. During this research, the effect of two different parameters of potassium permanganate concentration, processing time, and mean particle size were investigated at constant room temperature and shaking rate. The conversion of combustible sulfur to non-combustible sulfur form was achieved optimally with 0.14 M potassium permanganate solution, 0.1 mm mean particle size at 16 h of treatment time, and the combustible sulfur amount was decreased by 46.37% compared to undoped conditions.

Effects of Groundwater Velocity and Permanganate Concentration on DNAPL Mass Depletion Rates during In Situ Oxidation

In situ chemical oxidation (ISCO) using permanganate has been increasingly applied to deplete mass from dense nonaqueous-phase liquid (DNAPL) source zones. However, uncertainty in the performance of ISCO on DNAPL contaminants is partially attributable to a limited understanding of interactions between the oxidant, subsurface hydrology, and DNAPL mass transfer, resulting in failure to optimize ISCO applications. To investigate these interactions, a factorial design experiment was conducted using one-dimensional flow through tube reactors to determine how groundwater velocity, permanganate concentration, and DNAPL type affected DNAPL mass depletion rates. DNAPL mass depletion rates were found to increase with increasing groundwater velocity, or increasing oxidant concentration. An interaction occurred between the two factors, where high oxidant concentrations had little impact on mass depletion rates at high velocities. High oxidant concentration systems experienced gas generation. Mass depletion rates were fastest at high velocities, but required additional oxidant mass and pore volume addition to achieve complete mass depletion. Lower-velocity systems were more efficient with respect to oxidant mass and pore volume requirements, but mass depletion rates were reduced.

Corrosion Compatibility Studies on Carbon Steel and Type 304 Stainless Steel in Acid Permanganate and Organic Acid Mixtures

Type 304 stainless steel and carbon steel are extensively used as structural materials in the reactor coolant systems of nuclear power plants. The corrosion of these structural materials during normal operation and the subsequent neutron activation of their corrosion products leads to the build-up of radiation on the out-of-core surfaces of the coolant systems. The Dilute Chemical Decontamination (DCD) process is one of the methods used to remove the activity that becomes embedded in the oxide layers formed over these structural materials. Permanganate based oxidising reagents are generally used to dissolve chromium from oxide films containing iron, chromium and nickel on the surfaces of Type 304 stainless steel and other chromium-containing alloys. This study has investigated the behaviour of carbon steel in oxidising permanganate based acidic media. The corrosion/decomposition rate varied with temperature. With permanganate concentrations above 1·5 mM for permanganic acid and greater than 6 mM for nitric acid and potassium permanganate (NP), passivation of carbon steel surfaces occurred with negligible loss of weight of the carbon steel and insignificant decomposition of the permanganate. The effects of additions of chromate to permanganate on the passivation of carbon steel have also been evaluated. In the case of permanganic acid, the presence of even 50 ppm of chromate was sufficient to protect the carbon steel surface whereas a minimum of 150 ppm of chromate was required for passivation in the NP medium. Electrochemical polarisation experiments were also carried out to support these observations. When the concentration of permanganic acid was above 200 ppm, the open circuit potential of carbon steel in permanganic acid was +1·0 V (SCE) and it was observed to be passive whereas at lower concentrations the carbon steel was actively corroding at a potential of −0·695 V (SCE).

Effect of pH on the characteristics of potassium permanganate–luminol CL reaction in the presence of trace aluminum(III) and its analytical application

At pHs ≥ 11.45, trace Al was found to enhance the CL from luminol–KMnO 4 system. However, at pHs ≤ 10.42, it was found to inhibit strongly the CL from luminol–KMnO 4 system. The effect of pH, luminol and potassium permanganate concentrations on the kinetic characteristics of CL system was investigated in the presence of trace Al. On this basis, a flow injection inhibition chemiluminescence method was established for the determination of trace Al in this study. Under optimized conditions, the CL decreased linearly with Al(III) concentration in the range of 8–500 μg L −1 and the detection limit (3 σ) of 2 μg L −1. The relative standard deviation (R.S.D.) is 3.6% for 100 μg L −1 Al(III) ( n = 11). The method has been applied to the determination of trace Al in real water samples with satisfactory results without the pretreatment of samples. The results given by the proposed method are in good agreement with those given by ICP-AES detection method.

A microbial fuel cell using permanganate as the cathodic electron acceptor

The microbial fuel cell (MFC) was proved to be a novel bioprocess capable of recovering electrical energy from organic matter. In this study, we report that by using permanganate as the cathodic electron acceptor for a MFC we were actually able to recover much more electrical power than using other existing types of electron acceptors, e.g. using permanganate as the cathodic electron acceptor for a two-chamber MFC generated a maximum power density of 115.60 mW m −2 which was, respectively, 4.5- and 11.3-fold higher than that produced by using hexacynoferrate (25.62 mW m −2) and oxygen (10.2 mW m −2) as the cathodic electron acceptor. This could be attributed to the higher open circuit potential (OCP) provided by permanganate in the MFC. Besides, pH, unlike permanganate concentration, was further found to have a major impact on the OCP and the cathode potential. SEM and XPS analysis demonstrated that manganese dioxide (MnO 2) was in fact the main reduced product of the permanganate at pH 3.6. Moreover, as compared to a two-chamber MFC, a bushing MFC using permanganate as the cathodic electron acceptor achieved an unprecedented maximum power-output of 3986.72 mW m −2. This study for the first time showed that permanganate could be used as an effective cathodic electron acceptor for a MFC.

On-line molecularly imprinted solid phase extraction for the selective spectrophotometric determination of catechol

A molecularly imprinted polymer has been synthesized for a selective on-line catechol extraction, followed by its spectrophotometric determination in guarana powder, mate tea and tap water samples. A clean-up column, containing a methacrylic polymer + C 18 solid phase, was also used in order to enhance selectivity. The imprinted polymer was prepared by bulk polymerization using catechol as template and 4-vinylpyridine as the functional monomer. Permanganate solution was used as spectrophotometric reagent, where Mn(VII) was reduced to Mn(II) by catechol in an acid medium, causing color loss, which was monitored at 528 nm. Physical (extraction flow rate, elution flow rate, coil length) and chemical (nature and concentration of the eluent, potassium permanganate concentration) variables were optimized, and the selectivity was appraised using three molecules (4-chloro-2-methylphenol, 2-cresol, 2-methoxyphenol) similar to catechol. These molecules did not present interference in 1:8, 1:10 and 1:10 (catechol/concomitant) proportions, respectively. The analytical calibration curve ranged from 3.0 up to 100 μmol L − 1 ( r > 0.999; seven concentrations levels, n = 3) and the limits of detection (LOD) and quantification (LOQ) were 0.8 and 2.7 μmol L − 1 , respectively. Precision, expressed as RSD, was of 3.0% (20 μmol L − 1 , n = 10), and the analytical frequency was 15 h − 1 . Accuracy was checked by the HPLC technique and the results did not present significant difference at 95% confidence levels according to the t test.

Determination of Sb(III) and Total Sb in Antileishmanial Drugs by Spectrophotometric Flow‐Injection Hydride Generation

A spectrophotometric procedure based on hydride generation and flow analysis is proposed for determination of antimony (III) [Sb(III)] and total antimony (Sb) in pharmaceutical samples. Firstly, Sb(III) reacts with hydrogen species generated in the system, forming antimony hydride. The reaction leads to a decrease in the permanganate concentration and, hence, in the intensity of the color of this specie, which is spectrophotometrically measured at 528 nm. Total Sb is determined as Sb(III) after Sb(V) reduction using 0.02% (m/v) KI. Some parameters, such as the number of channels of the gas phase separator, injection volume, coil length, and KBH4 concentration, are investigated. The system presents a frequency of ca. 100 h−1 and precision <3.0% [expressed as relative standard deviation (RSD) of 30 measurements using a 3.0 mg L−1 Sb(III) solution]. The analytical curve ranging from 0.5 mg L−1 to 5.0 mg L−1 (r>0.998; n=5) permits limit of detection (LOD) and limit of quantification (LOQ) of 83 and 250 µg L−1. For total Sb, the accuracy is checked by atomic absorption spectrometry applying the t test and the results are in accordance at the 95% confidence level. Recovery tests are used to check the accuracy for Sb(III) determination, and the recoveries are between 95% and 105%.

Spectrophotometric estimation of roxithromycin in tablet dosage forms

A simple and sensitive spectrophotometric method has been developed for determination of roxithromycin in its pharmaceutical dosage forms. In the proposed method, roxithromycin is oxidized with potassium permanganate to liberate formaldehyde, which is determined in situ using acetyl acetone in the presence of ammonium acetate to give a yellow-coloured chromogen with absorption maxima at 412 nm. The method is found to be linear in the concentration range of 10-75 µg/ml with regression coefficient of 0.9987. No significant difference was found between the proposed method and the reported method when two-tailed t-tests are applied. Various reaction parameters, such as concentration of potassium permanganate and reagent, time required for oxidation and maximum colour intensity, were optimized. The method was validated and can be used successfully to assay roxithromycin in its pharmaceutical dosage form, viz, tablets.

Determination of Azithromycin in pharmaceutical dosage forms by Spectrophotometric method

A simple and sensitive spectrophotometric method has been developed for determination of azithromycin in its pharmaceutical dosage forms. In the proposed method, azithromycin is oxidized with potassium permanganate to liberate formaldehyde, which is determined in situ using acetyl acetone, in the presence of ammonium acetate. A yellow coloured chromogen was obtained, having an absorption maxima at 412 nm. The method is found to be linear in the concentration range of 10-75 µg/ml, with regression coefficient of 0.9978. Various reaction parameters such as concentration of potassium permanganate and reagent, time required for oxidation, and maximum colour intensity were optimized. The method was validated, and can be used successfully to assay azithromycin in its pharmaceutical dosage forms viz. tablets, capsules, and injections.

Reaction of Nonaqueous Phase TCE with Permanganate

Oxidative treatment of trichloroethylene (TCE) in the form of dense nonaqueous-phase liquid (DNAPL) by potassium permanganate (KMnO4) was investigated in a series of batch tests. The study focused on understanding the fundamental mechanisms of oxidative removal of DNAPL TCE by permanganate oxidation. Dissolution experiment for DNAPL TCE has been performed as a control experiment in the absence of KMnO4. DNAPL TCE dissolved into the aqueous phase until it reached the saturation concentration of 1200 mg/L (9.16 x 10(-3) M) at 20 degrees C. The rate of dissolution of DNAPL TCE was proportional to the volume of the DNAPL. In the presence of KMnO4, the experimental results showed that the amount of TCE oxidized during the reaction was increased continuously as [MnO4-] decreased even though the rate decreased as [MnO4-] decreased. It was apparent that more DNAPL TCE was removed with a faster rate for higher initial permanganate concentration. At high permanganate concentration, the aqueous concentration of TCE was kept low and practically constant by the chemical reaction between aqueous TCE and MnO4-. However, as MnO4- was consumed in the system, the aqueous concentration started to increase until it reached solubility. From experimental observation, 1.56-1.78 mol of MnO4- was consumed per mole of TCE oxidized. Furthermore, 2.85-2.98 mol of Cl- was released to the solution per mole of TCE oxidized. Since the complete mineralization of TCE requires 2.0 mol of MnO4- and releases 3 mol of Cl- per mol of TCE oxidized, the observed stoichiometric factors indicated incomplete mineralization of TCE, but nearly complete dechlorination. Enhancement factor due to chemical reaction was quantified experimentally. The enhancement factor was shown to be a function of the molar ratio of MnO4- to TCE in the system, and hence varied during the reaction period.

Interphase mass transfer during chemical oxidation of TCE DNAPL in an aqueous system

The chemical oxidation of trichloroethene dense non-aqueous phase liquid by permanganate was studied in an aqueous system using micro-reaction/extraction vessels in a novel approach. Experiments were conducted at ambient temperature (∼20 °C) under static and mixed conditions to evaluate the rate of TCE DNAPL dissolution as a function of permanganate concentration. Chemical oxidation by permanganate was shown to increase the rate of TCE DNAPL dissolution under static conditions and decrease the rate of dissolution under mixed conditions. The apparent inconsistency in results appears to result from the local deposition of a film at the DNAPL interface composed of manganese oxide solids as discovered through visual observation with the aid of a Goniometer. Data from interfacial deposition experiments suggest that the film formed rapidly and reached maturation within approximately 2 h with little or no growth occurring thereafter. A conceptual model of the reaction and mass transfer processes occurring at the DNAPL interface was proposed based on the experimental results.

Níveis de mercúrio total em peixes de água doce de pisciculturas paulistas

Avaliou-se os niveis de mercurio total em amostras de peixes de agua doce, procedentes de pesqueiros e pisciculturas de 39 regioes do estado de Sao Paulo. As especies de peixes estudadas foram: pacu (Piaractus mesopotamicus), tilapia (Oreochromis niloticus), piaucu (Leoporinum sp), matrinxa (Brycon cephalus), tambaqui (Colossoma macropomum) e carpa (Cyprinus carpis). Foram avaliadas tres metodologias de digestao de amostras para a determinacao de mercurio total, variando-se o volume de mistura sulfonitrica utilizada e a concentracao do permanganato de potassio, sendo que o uso de 10mL de mistura sulfonitrica e solucao de permanganato de potassio a 7% (m/v) na digestao da amostra foi a que forneceu as recuperacoes mais altas (96%), precisao de 1% e limite de quantificacao de 0,3µg/kg. Apos a validacao do metodo, foram realizadas as determinacoes de teor de mercurio total em 293 amostras de pescado, usando a tecnica de espectrometria de emissao com fonte de plasma acoplado em gerador de hidretos. Os niveis medios de mercurio encontrados variaram entre: tambaqui (0,0003-0,012mg/kg), carpa (0,063mg/kg), matrinxa (0,0003-0,074mg/kg), pacu (0,0003-0,078mg/kg), piaucu (0,0003-0,183mg/kg) e tilapia (0,0003-0,217mg/kg). Os resultados mostraram que nenhuma das amostras procedentes das diferentes regioes e diferentes pesque-pagues, apresentaram niveis de mercurio total acima do permitido pela legislacao brasileira, que e de 0,5mg/kg para pescado nao-predador.

Sequential Injection Spectrophotometric Kinetic Method for the Determination of Paracetamol in Dosage Forms

A simple, rapid, selective and sensitive kinetic method for the determination of Paracetamol utilizing sequential injection analysis (SIA) technique was explored. The method was based upon comprehensive kinetic investigation of oxidation reaction of paracetamol with potassium permanganate in sulphuric acid media. The absorbance decrease of permanganate was measured at the wavelength 526 nm to monitor the reaction kinetics. The reaction orders with respect to the concentration of sulphuric acid, permanganate and paracetamol were found to be inverse one (-1), positive one (+1), and positive one (+1), respectively. The activation energy was examined and the reaction mechanism was postulated. The fixed time kinetic approach was used for the determination of the drug. The calibration equation "A = 0.0038C + 0.1209", with 0.9931 correlation coefficient (r) was found to be linear for paracetamol concentration ranging between 6.61 × 10 -5 to 1.32 × 10 -3 mol l -1 at the fixed time of 70 s at room temperature. This equation was obtained when injecting 35 µl of 1.0 mol l -1 H2SO4, 30 µl of 2.0 × 10 -3 mol l -1 potassium permanganate, 20 µl of paracetamol and 25 µl water and by adjusting the flow rate at 25 µl s -1 . The newly adopted method was applied for the determination of paracetamol in dosage forms of tablets and capsules containing other drugs. No interference was observed neither from the other drugs of diphenylamine hydrochloride, chloroxazone and pseudophedrine hydrochloride nor from excipients. The proposed SIA kinetic method was found to be accurate and repeatable when the results were statistically compared with the results obtained by the BP standard method.

Decolorization of dyes and textile wastewater by potassium permanganate

Decolorization of 10 types of dye solutions by potassium permanganate was studied. Effects of reaction conditions on the decolorization efficiency were examined in batch experiments. The pH value had a significant effect on the decolorization efficiency. When pH value <1.5, the decolorization efficiency was very high. When pH value >4.0, the dye solutions were almost not decolorized. Concentration of potassium permanganate and temperature also showed significant effects on the decolorization efficiency. The decolorization rate of dye solutions by potassium permanganate was rapid, and most of dye solutions can be decolorized effectively. The results of total organic carbon indicated that dye solutions were degraded incompletely by potassium permanganate. The results of treatment of textile wastewater by potassium permanganate indicated that the oxidation with potassium permanganate might be used as a pre-treatment process before biological treatment.

Kinetic study of permanganate oxidation of tetrachloroethylene at a high pH under acidic conditions

AbstractSince carbon compounds are the main component of dense nonaqueous phase liquids (DNAPLs), the end products of all in situ chemical oxidation (ISCO) will include carbon dioxide. If the production rate of carbon dioxide exceeds the capacity of water to remove the carbon dioxide, degassing will occur. The uncontrolled carbon dioxide gas may change the flow patterns, remobilize the pooled DNAPL, transport DNAPL vapor, and reduce the relative permeability to the aqueous phase. Under high pH buffered conditions, most of the carbon dioxide will be dissolved in water. In this study, potassium permanganate oxidation of tetrachloroethylene (PCE) was conducted using a sodium carbonate buffered solution (1 g/L, pH = 10.6 ± 0.1) at three different temperatures (5, 10, and 20°C) and three potassium permanganate concentrations (0.2, 1, and 5 g/L). Extensive kinetic studies suggest that the overall oxidation is a second‐order reaction and pseudo‐first‐order with respect to PCE and potassium permanganate, respectively. The second‐order rate constant and the activation energy were 0.028 ± 0.001 M−1s−1 at 20°C and 43.9 ± 2.85 kJ/M, respectively. This study provides a base for further experimental and field studies on potassium permanganate oxidation of PCE under natural or artificial high pH buffered conditions. © 2004 Wiley Periodicals, Inc.

Micelles in Physical Chemistry Laboratory. Surfactant Catalyzed Oxidation of Glycine by Acidic Permanganate

미셀 촉매 작용은 이론과 실험 화학 교과내용에서 중요한 부분이다. 산성 용액에서 도데실황산 나트륨(SDS)을 촉매로 한 글리신과 과망가니즈산 칼륨의 반응은 미셀 촉매 작용을 보여주는 반응속도론적 실험으로 적합하며, 고등학교와 대학 학부과정의 물리화학실험에서 사용할 수 있다. 본 연구에서는 이 반응이 계면활성제 존재하에서 반응속도가 빨라지는 것을 관찰하기 위하여 SDS를 넣지 않은 경우와 넣은 경우 모두 실험을 진행하였고, 얻어진 k를 [SDS]에 대하여 도시하였다. SDS의 임계 미셀 농도 이하에서부터 계면활성제에 의한 촉매 효과가 관찰되었는데, 이 선-미셀 촉매 효과는 양의 협동효과에 의한 것임을 알 수 있다. 얻어진 양의 협동지수(n)는 2.37이다. 또한 기질과 산화제의 농도에 따른 반응속도 변화도 논의하였다. 반응은 유사 일차 반응으로 진행되었으며, 글리신과 과망가니즈산 이온의 농도에 각각 일차 반응으로 나타나 전체 반응 차수는 이차 반응이었다. 반응 시간은 3~4시간으로 한 실험 시간에 몇 개의 실험 데이터를 얻을 수 있다. 용액 제조와 실험 과정에 대해서 자세히 기술하였으며, 또한 계면활성제에 의한 촉매 작용의 이론도 논의하였다. Micellar catalysis is an essential part of theoretical and experimental curricular. The sodium dodecylsulfate (SDS) catalyzed reaction between glycine and potassium permanganate in acidic medium is an ideal kinetic experiment for the secondary and undergraduate physical chemistry laboratory, to show the effect of micellar catalysis on rate of the reaction. The reaction is conducted both with and without SDS to observe the rate enhancement in the presence of surfactant. To show surfactant catalysis a plot between k and [SDS] is plotted. As surfactant catalysis is observed even before the critical micelle concentration of SDS, this pre-micellar catalysis can be understood in the light of positive co-operativity. The value of positive cooperative index (n) has been found to be 2.37. Further, dependence of the reaction rate on substrate and oxidant concentrations is also discussed. The reaction follows pseudo-first-order kinetics. The overall reaction is second order, with first-order dependence on both glycine and permanganate concentrations. The theory of surfactant catalysis is also discussed. With the conditions specified in the experiment, total reaction times are in 3~4 hours lab session, thus allowing several data sets to be acquired in a single laboratory period. Preparation of solutions and procedure is also given in detail.