Animals have always been a source of food, materials, protection and wellbeing for humans; however, animal diseases, including zoonoses, have both direct and indirect negative effects on human health, economy and the society. Since its establishment, the veterinary profession has provided crucial input in eradicating disease, increasing animal production and reducing losses due to diseases. Currently, foodborne diseases and zoonoses have raised awareness in developed countries, which have excellent systems for disease surveillance and reporting both in humans and animal populations. Due to lack of modern, integrated surveillance and reporting, the burden of zoonoses and foodborne diseases in developing European countries is much harder to assess. Differences in countries’ animal health status (demonstrated through disease surveillance) have been a main pivot point for international trade of animals and animal products. However, rapid and dramatic evolvement of the health trends in the world changed the principles of animal disease surveillance. Approaches requiring lower cost (i.e. risk-based surveillance) are now proposed, not only due to less available public funding, but also because the costs are harder to justify to policy makers if a disease is exotic and/or rare. Therefore, the veterinary profession has faced insufficient interest of governments and funds for further research into many persistent endemic animal diseases and zoonoses. On the other hand, eradication of selected diseases in some areas while elsewhere they still persist, and the continuous emergence of new diseases, cannot guarantee permanent epidemiological stability. As food safety and security become more important, global trends and events have highlighted the biological, health and economic inseparability of the relationships between humans, animals as pets and/or food sources and wildlife within the social and ecological framework of living space that these species share. Veterinarians are called on and expected to offer strategic and operational solutions for better integration of public health systems (i.e. One Health), animal health, food safety and environmental protection. At the same time, the profession faces challenges in the organisation and implementation of surveillance and disease mitigation measures.