Permanent Pressure Research Articles

Tissue Culture Propagation of Afzelia africana Sm. Ex. Pers. – A Potential Candidate for Biofuel

This study, the first of its kind reports an in vitro shoot regeneration protocol in Afzelia africana. A. africana is a medicinal and multipurpose tree that is under permanent pressure from its continuous exploitation for medicine, food and timber products. Adding to its being under threat of extinction, the seeds are dormant and recalcitrant with a low rate of seed germination thus posing a challenge on its propagation through conventional planting. In vitro propagation method is appropriate for propagating A. africana since it can boycott the use of seeds. Leaf, nodal, cotyledonary node, shoot tip, stem and hypocotyl explants were cultured on Murashige and Skoog (MS) medium 1962 diluted with different concentrations and combinations of plant growth regulators and phloroglucinol. Two sets of experiment were done; the first was a preliminary one that tested the responsiveness of explants in vitro while the second tested the effect of thiaduzuron, benzyladenine and phloroglucinol on shoot multiplication and elongation from cotyledonary node explants. Although, both the cotyledonary node and nodal explants induced multiple shoots, the response was better in cotyledonary explants, hence the shoot multiplication protocol was maximized using cotyledonary nodes. This study has paved a path for the rapid regeneration of A. africana through in vitro propagation.

Automated Workflow Uses Pressure, Rate Measurements for Well Monitoring

_ This article, written by JPT Technology Editor Chris Carpenter, contains highlights of paper SPE 218470, “A New Automated Workflow for Well Monitoring Using Permanent Pressure and Rate Measurements,” by Anton Shchipanov, SPE, NORCE; Boyu Cui, SPE, University of Stavanger; and Vitaly Starikov, SPE, Heriot-Watt University, et al. The paper has not been peer reviewed. _ The complete paper describes an integrated workflow for automated well monitoring using pressure and rate measurements obtained with permanent gauges and flowmeters. The workflow is based on time-lapse pressure transient analysis (PTA) and integrates the following components: virtual flowmetering (VFM), transient identification, feature extraction and pattern recognition in transient pressure responses, and assessment of well performance based on PTA metrics. The methodology behind the workflow combines different physics-informed and data-driven methods described in the paper. A New Workflow for Automated Well Monitoring The concept of the automated workflow described in the complete paper has been suggested in the literature. The workflow consists of four main steps (Fig. 1), and integrates the following components: - VFM - Pressure transient identification - PTA feature extraction and time-lapse pattern recognition - PTA metrics to obtain the well-performance profile VFM. The well flow rate is often measured more sparsely than its bottomhole or wellhead pressure for many reasons. However, the permanent downhole or wellhead gauges, when installed in a well, provide high-frequency real-time pressure and temperature measurements. This disparity in the pressure- and rate-measurement sampling rates is a problem for PTA, which requires accurate and synchronized input for flow rates in line with the pressure time series. VFM helps reconstruct missing flow-rate measurements using available pressure measurements. The automated well-monitoring workflow described in this paper would benefit from integration of a relatively simple but robust and scalable VFM model having modest input-data requirements. The steady-state vertical-lift-performance-based VFM model was chosen for use by the authors after testing. The model uses only the bottomhole and wellhead pressure difference, which fits well with the automated workflow requirements. Put simply, the VFM-developed algorithm identifies the suitable pressure and flow-rate samples to train the VFM model; estimates, filters, and verifies the evolution of the model coefficients; and predicts the missing flow-rate values using the pressure measurements where available. This prediction applies only to the time when the well is flowing; as for shut-in periods, the algorithm assigns zero rate values. Transient Identification. Proper transient identification is crucial for PTA because accurate identification of the starting break point of a transient and sequential synchronization with corresponding rate governs the reliability of PTA interpretation results. This is important not only for the transient in question but also for the well history preceding the transient. In the latter case, proper transient identification may help in reliable rate time allocation throughout the well history for common cases of uncertain rates. The workflow of the extended method consists of two main stages. First, the breakpoints indicating start and end of shut-in transients are detected using the topographic prominence max rotation (TPMR) method. This automatically provides detection of flowing transients between the shut-ins identified. Second, the breakpoints of multirate periods (assuming stepwise rate changes) are detected within the long flowing transients using the local minimum in rotation (LMIR) method. As a result, the well pressure history is divided into sequential flowing and shut-in transients, also differentiating flowing transients governed by stepwise rate changes. Neither TPMR nor LMIR methods require denoising, so raw data from permanent gauges may be used without any preprocessing.

Effects of continuous negative pressure suction combined with autologous platelet-rich gel on the levels of CRP, IL-6, wound healing and length of stay in clients with diabetic foot

ObjectiveContinuous passive pressure suction and APG gel therapy effect diabetic foot IL-6, CRP, wound healing, and hospitalization. MethodsClinicopathological data from 102 diabetic foot ulcer patients treated at our institution between March 2018 and May 2022 was examined. Tables generated 51 joint and controlling teams randomly. The observation team received passive pressure suction and APG gel whereas the controlled team received conventional treatment. Teams monitored therapy outcomes, adverse responses, wound healing, hospital stay, and costs. Both teams compared blood uric acid, cystatin C, homocysteine, and serum IL-6, IL-10, and CRP before and after medication. ResultsThe joint team had higher hospitalization costs, shorter stays, and faster wound healing than the controlled team. Diaparity was significant (P < 0.05). The united team worked 100 %, unlike the controlling team. This difference was significant (P < 0.05). Both teams showed significant decreases in CRP, IL-6, and IL-10 levels after therapy (P < 0.05). After therapy, both the combined and controlled teams had substantial differences in blood CRP, IL-6, and IL-10 levels (P < 0.05). Both teams had significantly decreased uric acid, cystatin C, and homocysteine after treatment. The combined team showed significantly decreased uric acid, cystatin C, homocysteine levels following therapy compared to the control team (P < 0.05). ConclusionThe joint team experienced considerably fewer adverse events (3.92 % vs. 17.65 %) than the controls team (P < 0.05). Permanent passive pressure suction and APG gel therapy lower inflammatory response, blood uric acid, cystatin C, and homocysteine, speeding wound healing, reducing side effects.

Degradation effects in FRNC jackets of optical fiber cables

AbstractIn large scale manufacturing, polymeric materials for cable jackets are subjected to high temperature and shear, what can induce degradation processes. In result, changes in structure of polymer materials can occur what is critical for their applications. Permanent market pressure on increase of productivity and product reliability as well as rigorous administrative regulations in telecommunication industry are the driving forces for development and introduction of new advanced Flame Retardant Non-corrosive jacketing materials. Despite many studies, their behavior is still neither well characterized nor understood in large-scale production. The object of studies was characterization of a relationship between processing conditions and effects of degradation of FRNC cable materials. The main goal was to find the processing factors limiting the production speed. Materials taken into consideration were two commercially available thermoplastic FRNC compounds dedicated to fiber optic cables, based on linear low-density polyethylene/ethylene–vinyl acetate composites with high loading of aluminum trihydroxide and magnesium dihydroxide fillers. Thermal degradation of cable materials was studied with use of thermogravimetry and rheometry. The series of jacket samples under different processing conditions were produced. Material processing behavior was characterized, and tensile and heat aging performance of cable jacket were tested. The results showed that the primary limiting factors for line speed increase were the melt pressure and jacket tensile performance, but neither the shrinkage nor extruder motor load. The result and general approach to the FRNC investigation can be successfully used in cable industry or in other industries involving the extrusion of FRNC materials.

ПСИХОЕМОЦІЙНЕ ВИГОРАННЯ ОСОБИСТОСТІ : ТЕОРЕТИЧНІ АСПЕКТИ ПРОБЛЕМИ

Purpose. The objective is to conduct an analytical review of multidirectional studies on psychoemotional burnout of personality as a phenomenon that negatively impacts and significantly complicates its professional activity and interpersonal communication. Methods. To achieve this objective, the following scientific-theoretical methods were applied: analysis, synthesis, generalization, which allowed for the revelation of substantive and functional parameters of psychoemotional burnout. Results. A range of studies explains the cause-and-effect essence of psychoemotional burnout by the specifics of a person's professional activity. Burnout leads to the appearance of psychological and/or psychosomatic changes, adversely affects affective balance, generates increased stress, heightened anxiety, oppressive frustration, and other depressive feelings, experiences, and behavioral modalities. Monotonous and emotionally exhausting as well as physically amortizing professional activity in a specific field, along with permanent pressure from administration, may stimulate feelings of mental discomfort, increase the frequency of intra- and interpersonal conflicts, stimulate social withdrawal, loneliness, and experiences of disappointment in life values. Conclusions. Psychoemotional burnout is regarded as a complex and branching phenomenon that exerts an unfavorable influence on a person's life and complicates their communicative relationships within the family and at work. Manifestations of psychoemotional burnout and psychophysical exhaustion have been studied extensively with diverse samples (students, police officers, medical professionals, firefighters, athletes, deprived children, etc.). A common feature of the analyzed studies is the recognition of the uncomfortable and destructive pressure of psychoemotional burnout on the affective-cognitive behavioral tactics and strategies of the individual.

Scalable protein production by Komagataella phaffii enabled by ARS plasmids and carbon source-based selection

BackgroundMost recombinant Komagataella phaffii (Pichia pastoris) strains for protein production are generated by genomic integration of expression cassettes. The clonal variability in gene copy numbers, integration loci and consequently product titers limit the aptitude for high throughput applications in drug discovery, enzyme engineering or most comparative analyses of genetic elements such as promoters or secretion signals. Circular episomal plasmids with an autonomously replicating sequence (ARS), an alternative which would alleviate some of these limitations, are inherently unstable in K. phaffii. Permanent selection pressure, mostly enabled by antibiotic resistance or auxotrophy markers, is crucial for plasmid maintenance and hardly scalable for production. The establishment and use of extrachromosomal ARS plasmids with key genes of the glycerol metabolism (glycerol kinase 1, GUT1, and triosephosphate isomerase 1, TPI1) as selection markers was investigated to obtain a system with high transformation rates that can be directly used for scalable production processes in lab scale bioreactors.ResultsIn micro-scale deep-well plate experiments, ARS plasmids employing the Ashbya gossypii TEF1 (transcription elongation factor 1) promoter to regulate transcription of the marker gene were found to deliver high transformation efficiencies and the best performances with the reporter protein (CalB, lipase B of Candida antarctica) for both, the GUT1- and TPI1-based, marker systems. The GUT1 marker-bearing strain surpassed the reference strain with integrated expression cassette by 46% upon re-evaluation in shake flask cultures regarding CalB production, while the TPI1 system was slightly less productive compared to the control. In 5 L bioreactor methanol-free fed-batch cultivations, the episomal production system employing the GUT1 marker led to 100% increased CalB activity in the culture supernatant compared to integration construct.ConclusionsFor the first time, a scalable and methanol-independent expression system for recombinant protein production for K. phaffii using episomal expression vectors was demonstrated. Expression of the GUT1 selection marker gene of the new ARS plasmids was refined by employing the TEF1 promoter of A. gossypii. Additionally, the antibiotic-free marker toolbox for K. phaffii was expanded by the TPI1 marker system, which proved to be similarly suited for the use in episomal plasmids as well as integrative expression constructs for the purpose of recombinant protein production.

Design of short Venturi flow meters for incompressible and isothermal flow applications

The Venturi flow meter offers a range of measurement options for liquids, gas, steam, and slurries in piped systems. The main criteria for assessing Venturi performance include permanent pressure loss, discharge coefficient, relative pressure loss coefficient, and measurement accuracy. However, the extended length of Venturis, relative to other flow rate measuring instruments, can present limitations in some applications. Furthermore, the manufacturing of shorter Venturis requires less material and energy. This study addresses the challenge by developing shorter Venturi meters that adhere to established performance standards. Previous studies show that cone angles, the ratio of throat diameter to inlet diameter (β-ratio), and the throat length impact the performance of a Venturi. The scope of this research considers single-phase, incompressible and isothermal flows. The investigation focuses on the effect of cone angles for flows with Reynolds numbers ranging from 5000 to 10,000,000. Two axisymmetric Venturis, with a β-ratio of 0.7, were designed and evaluated against an ISO-5167 classical Venturi with the same β-ratio. Despite the ISO-5167 Venturi outperforming the others across the key criteria, a Venturi designed with a 40-degree convergent cone angle and a 10-degree divergent cone angle was 24.9 % shorter than the classical design and demonstrated similar performance to the ISO-5167 Venturi across Reynolds numbers from 100,000 to 10,000,000.

Fractures overseen: soviet medical experts splitting from the international epistemic community during the interwar period

ABSTRACT Soviet medical science went through a deep and systematic transformation. Initiated in the very early days of the Communist regime, a moment of disrupting and isolating impact uprooted it from its former organizational and epistemic foundations and re-adjusted the expert output and modus operandi to state needs. Professional identities, paradigmatic approaches and everyday practices resulting from these were transformed and forcibly aligned with the expectations of the new powerholders, aligned with the newly formulated party-bound loyalties and secured by the broad array of severe sanctions. This article systematically approaches the dark side of the Soviet interwar transformation in medicine with a special focus on a sample of psychiatric experts. The paper analyses the entanglement between domestic pressures exercised upon scholars by the emerging totalitarianism, forcing them to detach and considerably re-adjust their international ties, while nonetheless trying to remain a part of this cross-border epistemic community. While international contacts did not cease entirely, their expanse, intensity and the very mode of cooperation had to change dramatically so as to fit the new regime´s vision upon medicine. International networks were re-appropriated for the sake of promoting the success of the Communist state, with scholars functioning as involuntary ambassadors of the regime. Though perfectly compatible with the practices and outputs of their fellow experts elsewhere across the globe while exposed to the permanent pressure of political terror at home, Soviet public health and its experts became deeply transformed and detached in manifold ways from their peers and their medical science. Largely overlooked, the early fractures of the interwar period carry on into the Cold War-influenced second half of the twentieth century.

Politische Unterstützung im Dauerstresstest – Einstellungen zur Demokratie in Thüringen seit der Jahrtausendwende

ZusammenfassungVor dem Hintergrund der aktuellen Vielfachkrise und der Langzeitfolgen des Systemumbruchs untersucht der Beitrag die regionale politische Kultur in Thüringen. Auf Basis der Daten des Thüringen-Monitors zeigt die Langzeitanalyse der demokratischen Einstellungen für die Jahre 2000 bis 2022 ein differenziertes Ergebnis. Trotz einer hohen Volatilität von Vertrauens- und Zufriedenheitswerten kann bis zum Jahr 2021 ein tendenziell linearer Anstieg der politischen Unterstützung für die Demokratie in Thüringen festgestellt werden. Der starke Rückgang der Werte für die Demokratiezufriedenheit und das Vertrauen in die parteienstaatlichen Institutionen im Jahr 2022 zeigt jedoch, dass lang aufgebaute Unterstützungswerte in Kürze verschleißen können. Mit Blick auf die Determinanten der politischen Unterstützung bestätigen sich für Thüringen, dass die Performanz- sowie Deprivations- und eingeschränkt auch die Sozialisationshypothese erklärungsstarke Ansätze zur Bestimmung politischer Unterstützung darstellen.

Military-economic confrontation of Russia and the West in the special military operation for demilitarization/denazification of Ukraine

Subject. The article addresses Russia's sovereignty protection in the face of destructive factors. Objectives. The aim is to compare Russia and NATO member countries in terms of military potential, analyze the directions of reorganization of the Russian military economy. Methods. The study employs methods of systems analysis. Results. We established that militarily and economically, Russia turned out to be more developed. It used the sanctions pressure as an opportunity to really increase the efficiency of the entire social production. Conclusions. Only achieving the synchronization of socio-economic and military strategic planning, improving the quality of military and political and macroeconomic forecasting, with extensive use of artificial intelligence, and considering the Soviet experience in mobilization of the economy, will make it possible to ensure social progress and national security under permanent sanctions pressure.

The Effect of Differential Pressure and Permanent Pressure Loss on Multi-Hole Orifice Plate

Abstract The widely used orifice plate falls under restricted type flow devices, has the highest differential pressure and permanent pressure drop in the ensemble. The objective is to curtail the permanent pressure drop and maintain the differential pressure across the orifice plate, and thereby, the power required to pump the liquid is retrenched. So, three-hole, four-hole and five-hole orifice plates with an identical area to that of the single-hole orifice plate were designed and experiments were carried out. It is observed that the experimental results almost matched with the simulation data. In comparing the performance, the four-hole orifice plate yielded a higher differential pressure and higher-pressure loss. In contrast, the five-hole orifice yielded lower differential pressure and higher-pressure loss compared to the single-hole orifice plate. In case of three-hole orifice plate it performed better than the single-hole orifice with reduced pressure loss and higher differential pressure. It was also found that the power consumed by the pump for pumping was lower for three-hole, four-hole and five-hole orifice plates compared to the single-hole orifice plate. Thus, the three-hole orifice plate performs better than a single-hole orifice plate in terms of higher differential pressure, reduced permanent pressure loss and lower power consumption of the pump.

Effects of Bias Voltage and Target Current on Microstructure and Load Measurement Performance of ZnO Piezoelectric Coatings Applied to Bolt in Transformer

Electrical accidents caused by bolt looseness in transformers have been frequently reported in recent years. The monitoring, and warning of, axial force as an indicator of looseness is one of the key issues affecting the operation and maintenance of transformers. Traditional ultrasonic testing and a patch-type ultrasonic method, using piezoelectric probes and coupling agents, showed poor repeatability and accuracy in detecting the bolt pre-tightening force, because of the uncertainty of the contact interface produced via manual operation. A permanent thin-film pressure sensor (PMTS), which provides accurate and in-situ stress detection, is more suitable for bolts, to reveal the pretightening force. The key is depositing a nano-zinc oxide (ZnO) piezoelectric film with an excellent measurement performance, which could be tuned using deposition parameters. This paper investigates the effects of the current and bias voltage on the crystal structure and performance of ZnO piezoelectric films. The results show that the crystallinity degree and resistance decrease with the increase in bias voltage, while the target current could increase the crystallinity. However, a high current also brings large particles in the coating surface, which greatly decrease the resistance. The cause is expected to be related to the ion energy, which could be affected by the bias voltage and current. The PMTS deposited with an optimized bias voltage and current revealed excellent measurement performance, and is expected to be applied to the bolt, to detect the pretightening force.

Vegetative and micropropagation potential of Piper guineense (Schumach and Thonn)

The continuous loss of forest plants due to deforestation, and the increasing demand for Piper guineense because of its medicinal and food value, has put a permanent pressure on its population in the wild where it is collected. A method for conservation and mass propagation is therefore required. This research was undertaken to determine the optimal concentration of auxin needed for vegetative propagation and to investigate the potential of Piper guineense for micropropagation. The auxin optimization study of vegetative propagation was based on the use of two-nodal stem cuttings treated with five different concentrations of indole-butyric acid (IBA). Growth parameters such as the number of sprouted, rooted and survived cuttings among others were determined. To investigate the potential of Piper guineense for micropropagation, nodal explants were subjected to different sterilizing treatments using ethanol, NaOCl, mancozeb, streptomycin and Plant Preservative Mixture (PPM). The effect of plant growth regulators (PGRs) was tested on sterilized nodal explants using full strength Murashige and Skoog (MS) hormone-free media alone as control and MS media supplemented with PGRs (BA, NAA and KIN) at different concentrations and combinations. Significant differences were observed across the treatments for all growth parameters measured. However, 2000 ppm IBA significantly (p&lt;0.05) influenced sprouting and rooting of the stem cuttings. Piper guineense explants have deep tissue contaminants, which cannot be eradicated by surface sterilization alone except double sterilization using PPM. On control media, neither shoot nor root response was observed while the highest percentage of induced roots was obtained from explants cultured on MS +1 mg/L BA + 0.25 mg/L NAA. Shoot induction was only achieved when BA was used alone and when subcultured on media supplemented with NAA, which generated roots.

PTA-metrics for time-lapse analysis of well performance

Monitoring of a well and the surrounding reservoir performances is a crucial component in evaluating on-going and planning future well and field operations. This is carried out at all stages of a well life-span: from exploration to production and, sometimes, after abandonment. Despite tremendous progress in reservoir simulations, simple and fast techniques for well-reservoir performance evaluation are still demanded in the industry, especially in the context of the vast amount of permanent well monitoring data continuously accumulated. Such techniques are of special interest for on-the-fly well monitoring to detect and alarm about deteriorating performance issues. Installation of permanent pressure gauges in many wells motivated development of time-lapse Pressure Transient Analysis (PTA), capable of revealing and monitoring of different factors governing well performance and reservoir production. The paper describes PTA-based metrics introduced in the context of automated interpretation of time-lapse pressure responses and their derivatives. The paper begins with a review of time-lapse PTA applications in the oil and gas industry and examples of patterns formed by the time-lapse pressure transients and their derivatives in the log–log scale. Then, integral-based PTA-metrics for well-reservoir performance analysis are introduced. The metrics enable to distinguish between reservoir and well-reservoir connection contributions to a well’s performance using the Bourdet derivative, while avoiding the need for selecting and matching of a well-reservoir model. The metrics were further tested with synthetic well models and field cases. The testing demonstrated high accuracy of the metrics for the cases of vertical wells with stable transient patterns. Testing for the horizontal well cases has confirmed reliability of the metrics for the stable patterns, while change of the patterns may reduce the metrics reliability. Model independence and using only pressure and rate measurements as input data are the main advantages of the metrics for integration into automated interpretation workflows and on-the-fly analysis intensively developed in the industry.

Housing and choice in Iquique and Alto Hospicio, Chile: Possibilities and limitations regarding the 2030 agenda and SDG 11

Access to housing, more than an enforceable right, has become a multidimensional problem in Chile. Faced with the impossibility of obtaining housing through subsidies, informal settlements—camps and land grabs—have expanded through the country's different cities since 2019. Given the evident collision with the Sustainable Development Goals (in particular Goal 11) commitments to sustainable cities, the Chilean State has increased its housing budget since 2020 to reactivate investment during the COVID-19 pandemic and expand the housing access alternatives for lower-class families with few possibilities chances of obtaining a bank mortgage. But is it possible to choose housing in contexts like the one described? In addition to environmental difficulties, cities in northern Chile, wedged between the sea and the desert, need to produce a socially sustainable environment in accordance with the requirements of complex, dynamic systems under permanent pressure to generate wellbeing. This manuscript seeks to explore and analyze these tensions in the cities of Iquique and Alto Hospicio, in Chile's Tarapacá Region. They form a dynamic conurbation, where daily mobility and the dispute over access to housing clash with the choice offered by the different subsidy programs and the expansion of camps on the edges of the desert. So, how far or how close is SDG 11 in places like these? Is there a viable alternative for urban sustainability in precarious spaces?

Стратегическое планирование развития АПК в обеспечении экономико-продовольственной безопасности России

Abstract. The purpose of the study is to substantiate the directions of improving the system of state strategic planning for the development of the agro-industrial complex of Russia in the conditions of permanent geopolitical pressure on the economy to ensure the economic and food security of our country. Tasks that were solved during the research: the analysis of trends in the development of the agro-industrial complex of Russia, the main indicators characterizing the economic results of its work; the main legal documents defining the priorities of strategic planning for the development of the agro-industrial complex are considered; the main strategic problems and priorities of its development to ensure the economic and food security of the country are identified. The main research methods were economic-statistical, tabular, graphical, predictive, comparative with subsequent data generalization. The information base included materials from the Government of the Russian Federation, the Federal State Statistics Service of the Russian Federation, the Ministry of Agriculture of the Russian Federation, the Food and Agriculture Organization of the United Nations, as well as current regulations. The scientific novelty of the study is to substantiate the expediency and necessity of improving state strategic decisions in the field of agricultural development in the context of new sanctions measures by unfriendly states. The priorities of state support for the development of the industry in the long term have been identified, among which it is necessary to include a change in the structure of the agro-industrial complex, its technological renewal and financial support for agricultural producers in the conditions of the sanctions and post-sanctions period. The results consist in determining the main strategic priorities of the state in the development of the agro-industrial complex, aimed at improving the system of strategic planning for the development of the industry and ensuring the economic and food security of the country in the conditions of the sanctions and post-sanctions period.

Стратегическое планирование развития АПК в обеспечении экономико-продовольственной безопасности России

Abstract. The purpose of the study is to substantiate the directions of improving the system of state strategic planning for the development of the agro-industrial complex of Russia in the conditions of permanent geopolitical pressure on the economy to ensure the economic and food security of our country. Tasks that were solved during the research: the analysis of trends in the development of the agro-industrial complex of Russia, the main indicators characterizing the economic results of its work; the main legal documents defining the priorities of strategic planning for the development of the agro-industrial complex are considered; the main strategic problems and priorities of its development to ensure the economic and food security of the country are identified. The main research methods were economic-statistical, tabular, graphical, predictive, comparative with subsequent data generalization. The information base included materials from the Government of the Russian Federation, the Federal State Statistics Service of the Russian Federation, the Ministry of Agriculture of the Russian Federation, the Food and Agriculture Organization of the United Nations, as well as current regulations. The scientific novelty of the study is to substantiate the expediency and necessity of improving state strategic decisions in the field of agricultural development in the context of new sanctions measures by unfriendly states. The priorities of state support for the development of the industry in the long term have been identified, among which it is necessary to include a change in the structure of the agro-industrial complex, its technological renewal and financial support for agricultural producers in the conditions of the sanctions and post-sanctions period. The results consist in determining the main strategic priorities of the state in the development of the agro-industrial complex, aimed at improving the system of strategic planning for the development of the industry and ensuring the economic and food security of the country in the conditions of the sanctions and post-sanctions period.

TREATMENT OF COMPLICATED DEEP SOFT TISSUE INFECTIONS BY A COMBINATION OF NEGATIVE PRESSURE WOUND THERAPY AND INTRALESIONAL TOPICAL APPLICATION WITH STABLE OZONIDES OZOILE® FIRST CASES IN BULGARIA

Introduction. Severe necrotizing soft tissue infections (SNSTI) are life-threatening conditions that require timely diagnosis and immediate surgical treatment. As part of the comprehensive treatment of severe fasciitis, the application of a new method of treatment, combined permanent negative pressure wound therapy (NPWT) and Ozoile ®, stable ozonides from organic extra- virgin olive oil +OIL®, may be considered. The aim is a retrospective analysis of patients with severe soft tissue infections treated at the First Surgical Clinic of UMHAT "Dr. G. Stranski" LtD - Pleven with NPWT negative pressure and topical applications of Ozoile ®, stable ozonides from organic extra- virgin olive oil +OIL® and to compare the final results and outcome with group patients treated by conventional methods and NPWT alone. Materials and methods. A retrospective, randomized study over 1 year (March 2022- March 2023), including 84 patients with SNSTI treated surgically with NPWT and local ozone therapy; 35 with NPWT and 170 by fasciotomy, wound debridement, and wound lavages. Results. A total of 232 patients with SNSTI were divided into three subgroups according to treatment strategy. NPWT with local ozone therapy has a significantly shorter hospital stay (p&lt;0,05), time to sterilization (p&lt;0,05), and faster epithelization rate (p&lt;0,05), compared with the conventional treatment strategy. Conclusion The NPWT combines with topica application of Ozoile® and stable ozonides is a novel and effective method for the treatment of SNSTI.

Zmiany w zbiorowiskach chwastów segetalnych wybranych roślin uprawnych na przestrzeni ostatnich 50 lat oraz prognozy na przyszłość

Permanent human pressure on agricultural fields is a factor shaping and modifying the composition and structure of segetal commu¬nities. On arable fields, especially large-area ones, the phenomenon of impoverishment of species composition and the formation of fragmentary communities with a small number of species is observed. Communities appropriate for a given type of soil or crops are disappearing. In the communities, the total number of species is decreasing, but the number of troublesome species is increasing, which causes an increase in weed infestation of the stands. Weeds with wide adaptability, including ruderal species, which are starting to ap¬pear more and more often on agricultural fields, are becoming a problem. In recent years, an increase in the intensity of thermophilic species has also been observed. Among them, new taxa appear so far in southern Europe, such as common velvetleaf (Abutilon theo¬phrasti Medik.) or common ragweed (Ambrosia artemisiifolia L.). In the near future, we should expect problems from species that pose a significant threat to our southern neighbors, such as the Aleppo grass [Sorgum halepense (L.) Pers.], hairy cupgrass [Eriochloa villosa (Thunb.) Kunth.] or narrow-leaved ragwort (Senecio inequidens DC).

Book Review – China Revitalized Through Memory in the Novel “Ivory Dragon”, by Fatos Kongoli

The subject of this novel takes shape and begins and elaborates on an event in the 90s, when Genci Skampa, a reporter in a daily newspaper, is invited to a meeting of journalists from the Balkan Peninsula in the capital of France, Paris. The events and destinies of the characters, who sometimes surrender to memory and sometimes return to objective reality, follow a trajectory that is not at all chronological, moving from Tirana, towards Beijing, then towards Paris and vice versa. However, the road remains one and only, and the main theme of this work is about the life of the Albanian student in Beijing during the 60s, of the last century, centred on the university corps of that city, where young people who came almost from prosperous communist countries world, they experience redemption and freedom for the first time, but this freedom remains conditioned under the unspeakable atmosphere for the mentality of these teenagers, that of the Chinese Cultural Revolution. At that time, i.e. in his student years, the young Albanian Genci Skampa met and fell in love with the elegant Chinese student, Sui Lin. In the chapters of this novel, all the deformations of living as well as the occasional contrasts are arranged somewhat carelessly: the permanent pressure exerted by the wild discipline, the silent temptations, but also the spiritual and psychological related disturbances that one experiences during the experience of first love. At the same time, some elements and phenomena make up a somewhat separate world, forged by events and people who leave behind indelible traces, imbued with pronounced notes of lyricism and drama at the same time, gradually transforming into shadows of the past that haunts the protagonist of this novel on his way back from Beijing to Tirana, but also that of his departure years later from Tirana to Paris, to crucify the main character forever in the memory. Keywords: love, Albanian, Chinese, student, memory.