Abstract Homogeneous and heterogeneous reactions play a decisive role in biological procedures such as burning, polymer creation, ceramic construction, distillation, and catalysis. The magnetic properties of hemoglobin molecules are organic. Magnetic resonance imaging (MRI) and electronic components with an electromagnetic field are now readily available, allowing for the explanation of fundamental biological processes. These ideas form the foundation of an ongoing study that attempts to look into the impact of both homogeneous and heterogeneous reactivity on the peristaltic transport of magnetohydrodynamics Oldroyd-B fluid. When convective and partial sliding conditions are present, the configuration changes to a non-uniform vertical channel. The fundamental partial differential equations are resolved utilizing the Homotopy Analysis Method. Entropy optimization has been carried out. The primary limits entering the problem are investigated, and then a graph is used to show the influences of temperature, velocity, skin fraction, Nusselt number, and pressure increase against mean circulation, trapping phenomena, homogeneous reactions, and heterogeneous way to respond. When magnetic parameter rises, the velocity of Oldroyd-B fluid and Bejan number decrease, while temperature, entropy generation, and pressure gradient increase. The tables show that the skin friction coefficient rises for accumulative values of the Grashof number and magnetic parameter, while the skin friction coefficient drops for rising values of the velocity slip parameter and Reynolds number. The Nusselt number increases for large values of Eckert, Grashof numbers, and magnetic parameters.
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