Peripheral Vascular Research Articles

Aerobic Versus Resistance Training Effects on Ventricular-Arterial Coupling and Vascular Function in the STRRIDE-AT/RT Trial.

Background: The goal was studying the differential effects of aerobic training (AT) vs. resistance training (RT) on cardiac and peripheral arterial capacity on cardiopulmonary (CP) and peripheral vascular (PV) function in sedentary and obese adults.Methods: In a prospective randomized controlled trial, we studied the effects of 6 months of AT vs. RT in 21 subjects. Testing included cardiac and vascular ultrasoundography and serial CP for ventricular-arterial coupling (Ees/Ea), strain-based variables, brachial artery flow-mediated dilation (BAFMD), and peak VO2 (pVO2; mL/kg/min) and peak O2-pulse (O2p; mL/beat).Results: Within the AT group (n = 11), there were significant increases in rVO2 of 4.2 mL/kg/min (SD 0.93) (p = 0.001); O2p of 1.9 mL/beat (SD 1.3) (p = 0.008) and the brachial artery post-hyperemia peak diameter 0.18 mm (SD 0.08) (p = 0.05). Within the RT group (n = 10) there was a significant increase in left ventricular end diastolic volume 7.0 mL (SD 9.8; p = 0.05) and percent flow-mediated dilation (1.8%) (SD 0.47) (p = 0.004). Comparing the AT and RT groups, post exercise, rVO2 2.97, (SD 1.22), (p = 0.03), O2p 0.01 (SD 1.3), (p = 0.01), peak hyperemic blood flow volume (1.77 mL) (SD 140.69) (p = 0.009), were higher in AT, but LVEDP 115 mL (SD 7.0) (p = 0.05) and Ees/Ea 0.68 mmHg/ml (SD 0.60) p = 0.03 were higher in RT.Discussion: The differential effects of AT and RT in this hypothesis generating study have important implications for exercise modality and clinical endpoints.

Usefulness of Color Doppler Ultrasonography in the Risk Stratification of Thyroid Nodules

Introduction: Thyroid ultrasound (US) is crucial for clinical decision in the management of thyroid nodules. In this cross-sectional study, we aimed to test if the evaluation of thyroid nodules’ vascularization could improve the risk stratification ability of the American College of Radiology (ACR) TI-RADS classification system. Methods: A total of 873 thyroid nodules undergoing fine-needle aspiration were classified according to ACR TI-RADS US classification. Three types of vascularization were identified: type 0, no vascular signals; type 1, peripheral vascular signals; type 2, peripheral and intralesional vascular signals. Cytology specimens were evaluated conforming to the Italian Reporting System for Thyroid Cytology, and TIR3b, TIR4, and TIR5 were defined as high risk for malignancy. Odds ratios (ORs) with 95% confidence intervals (CI) and the areas under the receiver operating characteristic curves (ROC-AUC) for high-risk cytology categories were calculated. Results: The 3 vascular patterns were differently distributed within the cytology categories: 52.4% of TIR1c, 15.9% of TIR2, 5.9% of TIR3a, 6.7% of TIR3b, 12.5% of TIR4, and 28.9% of TIR5 nodules had no vascular signals (p < 0.001). Nodule vascularity alone was not associated with a higher risk of malignant cytology (OR [95% CI] 0.75 [0.43–1.32], p = 0.32), without differences between peripheral (OR [95% CI] 0.65 [0.35–1.20]) and intranodular (OR [95% CI] 0.88 [0.48–1.62]) vascularization (p = 0.22). The ROC-AUC (95% CI) for the diagnosis of malignant cytology was similar when considering TI-RADS classification alone (0.736 [0.684–0.786]) and when considering TI-RADS classification plus the presence/absence of vascular signals (0.736 [0.683–0.789], p value for differences between the ROC-AUCs: 0.91). Among TR1, TR2, and TR3 TI-RADS classes, no nodules without vascular signals showed a malignant cytology, allowing the identification of nodules with benign cytology with 100% specificity within these US classes. Conclusions: Color Doppler study of thyroid nodules does not improve the risk stratification ability of the ACR TI-RADS US classification system.

Option of Using Peripherally Inserted Central Catheters in Elderly Patients With Dementia: An Observational Study.

Background: Peripherally inserted central catheters (PICCs) facilitate the treatment of several diseases. Here, we assessed the clinical course of elderly patients with dementia using PICCs. Methods: This retrospective observational study was conducted at a single dementia treatment center. PICCs were used in elderly inpatients with dementia who required (a) intravenous therapy, supplemental parenteral nutrition, and dysphagia rehabilitation during acute illness; (b) end-of-life care; (c) total parenteral nutrition (TPN); or (d) an alternative to peripheral vascular (PV) access. Results: Fifty-nine patients were enrolled (83.5 ± 6.9 years): 61% were in the acute treatment group, and 17% were in the end-of-life care group. The median catheter lifespan was 42 (23–87.5) days. The incidence of catheter-related bloodstream infection was 0.22 per 1,000 PICC-days, and that of deep venous thrombosis was 0.66 per 1,000 PICC-days. Among the patients in acute treatment group, 19% resumed sufficient oral intake after the treatment using PICC, and 36% resumed oral intake of gelatin-like food. Among the patients in the end-of-life care group, 91% received intravenous fluids continuously until death by initially inserted PICC. Conclusion: In elderly patients with dementia, PICCs might be one of the options during the treatment of acute illness as well as for prolonged support during end-of-life care.

Peripheral Vascular Function in Individuals with Posttraumatic Stress Disorder

THE IMPACT OF POSTTRAUMATIC STRESS DISORDER ON PERIPHERAL VASCULAR FUNCTION J. Weggen, A. Hogwood, B. Imthurn, A. McIntyre, A. Darling, K. Decker and R. Garten. Virginia Commonwealth University, Richmond, VA The physiological manifestations of posttraumatic stress disorder (PTSD) have been associated with an increase in risk of cardiovascular disease (CVD) independent of negative lifestyle factors. Peripheral vascular dysfunction may be a mechanism by which PTSD increases CVD risk via increases in oxidative stress, inflammation, and/or sympathetic nervous system activity. PURPOSE: This study sought to examine peripheral vascular function in those with PTSD compared to age-matched controls. METHODS: Eight individuals with PTSD (5 women, 3 men; age 22 ± 2 years), and sixteen healthy controls (CON; 10 women, 6 men, 23 ± 2 years), participated in the study. Leg vascular function was assessed via passive leg movement (PLM) technique and evaluated with Doppler ultrasonography. PLM-induced increases in leg blood flow were quantified as peak change in blood flow from baseline (ΔPeak LBF) and blood flow area under the curve (LBF AUC). RESULTS: Significant differences in leg vascular function were revealed between groups. The PTSD group reported significantly lower ΔPeak LBF (PTSD: 294.16 ± 54.16; CON: 594.78 ± 73.70 ml∙min-1; p = 0.01) and LBF AUC (PTSD: 57.23 ± 24.37; CON: 169.92 ± 29.84 ml; p = 0.02) when compared to the CON group. CONCLUSION: This study revealed that lower limb vascular function is impaired in individuals with PTSD when compared to healthy counterparts.

IMPACT OF PERIPHERAL VASCULAR DISEASE AND RACE ON OUTCOMES IN PATIENTS WITH CARDIAC ARREST

Peripheral Vascular Disease(PVD) is an independent predictor of elevated risk of myocardial infarction, stroke and death. However, no prior studies have looked into the impact of PVD on outcomes of patients with cardiac arrest. The aim of this study was to assess that if presence of PVD was an

ATHERECTOMY IS ASSOCIATED WITH LOWER RATES OF REPEAT INTERVENTION AFTER BELOW KNEE PERIPHERAL VASCULAR INTERVENTION

Background: There is scarce data to support use of atherectomy devices over other forms of lower extremity peripheral vascular interventions (PVI). Methods: Data from the multicenter Excellence in Peripheral Artery Disease (XLPAD) registry ([NCT01904851][1]) were analyzed to examine predictors of

The influence of peripheral neuropathy and peripheral vascular disease in the outcome of diabetic foot management – a prospective study

Objective: Peripheral neuropathy and Peripheral Vascular Disease are the risk factors for the development of diabetic foot. The aim of this study was to evaluate differences and predictors of outcome parameters in patients with diabetic foot by stratifying these subjects according to the severity of these risk factors. Materials and methods: This is a prospective study conducted in 70 patients in the age group of 30-90 years diagnosed as Type II Diabetes with foot ulcers. After detailed clinical examination the following tests were conducted in all the patients: Complete blood count (CBC), Haemoglobin (Hb), Random Blood Sugar (RBS), Erythrocyte Sedimentation rate (ESR), Chest X-ray(CXR), Electrocardiography (ECG), foot X-ray, pus culture, Neuropathy testing by Semmes Weinstein Monofilament Test and Vibration Perception Threshold and Peripheral vascularity assessment by Duplex Doppler. Then grading of the ulcers was done using Wagner's Grade. The outcome of the patients was assessed by recording the healing time, mode of surgery and amputation rates of the patients. Results: A total of 70 patients with diabetic foot were consecutively included into the study (65.7% male, age (31% in 51-60 years), mean diabetes duration (5.2 years), Ulcer Grade (37% in Grade IV), Foot lesions (45.7% in toe), Blood sugar levels (64% in 300-400 mg/dl), Neuropathy (84%), Peripheral vascular disease (67%), major amputation (7%) and mortality (1.4%). Conclusion: All diabetic patients should undergo testing for neuropathy and peripheral vascular disease apart from doing other tests.

Incidental Total Necrosis of a Successful Flap Due to a Secondary Operation after One Year

Incidental Total Necrosis of a Successful Flap Due to a Secondary Operation after One Year

Prolyl hydroxylase inhibition during hyperoxia prevents oxygen-induced retinopathy in the rat 50/10 model.

To study the effect of systemic hypoxia-inducible factor prolyl hydroxylase inhibition (HIF PHDi) in the rat 50/10 oxygen-induced retinopathy (OIR) model. Oxygen-induced retinopathy was created with the rat 50/10 OIR model. OIR animals received intraperitoneal injections of dimethyloxalylglycine (DMOG, 200 μg/g), an antagonist of α-ketoglutarate cofactor and inhibitor for HIF PHD, on postnatal day (P)3, P5, and P7. Control animals received intraperitoneal injections of PBS. On P14 and P21, animals were humanely killed and the effect on vascular obliteration, tortuosity, and neovascularization quantified. To analyze HIF and erythropoietin, rats at P5 were injected with DMOG (200 μg/g). Western blot or ELISA measured the levels of HIF-1 and Epo protein. Epo mRNA was measured by quantitative PCR. Alternating hyperoxia and hypoxia in untreated rats led to peripheral vascular obliteration on day P14 and P21. Rats that were treated with systemic DMOG by intraperitoneal injections had 3 times less ischemia and greater peripheral vascularity (P = 0.001) than control animals treated with PBS injections. Neovascularization similarly decreased by a factor of 3 (P = 0.0002). Intraperitoneal DMOG administration increased the levels of HIF and Epo in the liver and brain. Serum Epo also increased 6-fold (P = 0.0016). Systemic DMOG had no adverse effect on growth of rats treated with oxygen. One of the many controversies in the study of retinopathy of prematurity is whether hyperoxia or alternating hyperoxia and hypoxia creates the disease phenotype in humans. We have previously demonstrated that PHDi prevents OIR in mice exposed to 5 days of sustained 75% oxygen followed by 5 days of 21% oxygen. The 50/10 rat experiments demonstrate that PHDi is also effective in a 24-hour alternating hyperoxia-hypoxia model. The rat OIR model further validates the therapeutic value of HIF PHDi to prevent retinopathy of prematurity because it reduces oxygen-induced vascular obliteration and retinovascular growth attenuation in prolonged and/or alternating hyperoxia.

8:40 AM Abstract No. 17 - Drug eluting balloons and drug eluting stents in the treatment of peripheral vasculare disease. short and mid-term results

Purpose A prospective study of feasibilty and efficacy of drug eluting balloons (DEB) and drug eluting stents (DES) in the treatment of peripheral vascular disease (PVD) Materials and Methods From September 2009 to July 2012, 191 consecutive patients underwent treatment of PVD using DEB and/or DES. The indications for using DEB/DES were divided into 4 groups: 1) residual stenosis/occlusion after previous therapy (n=116); 2) insufficient result after conventional balloon angioplasty (PTA) and stentimplantation should be avoided (n=19); 3) high risk of residual stenosis in patient suffering from critical limb ischemia (n=53) and 4) miscellaneous (n=3). According to Fontaine classification, 85 patients (45%) had grade 3 or 4 (limb threatening ischemia), and 106 grade 2 (claudicants). All patients were followed-up by physical examination and Doppler sonography and if indicated conventional angiography (DSA). Estimates for the cumulative patency, survival and restenosis rates were calculated by using life table analysis. Results After a mean follow-up of 6 months, residual stenosis (TLR=target lesion region) was seen in 37 patients (20%). Complications were seen in 18 patients (9%), and 4 patients (2%) required surgery. There was no 30-day mortality observed. During follow-up, 13 patients (7%) went to bypass-surgery. The limb salvage rate in patients suffering from limb threatening ischemia was 97% (83/85). Conclusion Using DEB/DES in patients suffering from severe PVD showing complex lesions, gives high immediate and mid-term success rates. Compared to historical data in the literature, the clinical outcome is higher than using conventional methods

2247 KIDNEY STONES ARE ASSOCIATED WITH INCREASED MORTALITY FROM PERIPHERAL VASCULAR DISEASE: AN EXAMINATION OF THE NHANES III DATABASE

You have accessJournal of UrologyStone Disease: Evaluation & Medical Management II1 Apr 20122247 KIDNEY STONES ARE ASSOCIATED WITH INCREASED MORTALITY FROM PERIPHERAL VASCULAR DISEASE: AN EXAMINATION OF THE NHANES III DATABASE Jonathan Shoag, Marshall Stoller, and Brian Eisner Jonathan ShoagJonathan Shoag Boston, MA More articles by this author , Marshall StollerMarshall Stoller San Francisco, CA More articles by this author , and Brian EisnerBrian Eisner Boston, MA More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2012.02.2424AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Epidemiologic evidence suggests a link between kidney stones and risk of vascular disease. Several studies have examined whether patients with kidney stones demonstrate vascular pathology more frequently than those without stones. The current study is an analysis of these relationships in the NHANES III database. METHODS The NHANES III survey was performed by the National Center for Health Statistics (NCHS), Centers for Disease Control and Prevention between 1988 through 1994. The current study focused on the 20,050 adults aged 17 years and older during the six years of NHANES III. Mortality data was obtained from NHANES linked mortality files, which match NHANES III survey participants with NDI death certificate records based on a probabilistic match through December 2006. Multivariate logistic regression was performed to examine the relationship between kidney stone disease and peripheral vascular disease (defined as claudication). Multivariate cox-proportional hazards examined whether kidney stone disease predicts cardiovascular mortality (defined as death from non-cardiac peripheral atherosclerotic disease, aortic aneurysm, aortic dissection, or other peripheral vascular diseases). Multivariate analyses adjusted for known risk factors for stone disease and peripheral vascular disease (age, gender, race, BMI, diabetes mellitus, dyslipidemia, hypertension, gout, tobacco use). RESULTS Of 20,050 participants, 919 (4.6%) reported a history of kidney stone disease, and 128 (0.6%) reported a history of claudication. There were 80 total deaths from peripheral vascular disease. On multivariate cross-sectional analysis, history of kidney stone disease was associated with a significant increase in claudication (OR 2.2, 95% CI 1.2 to 4.0). A history of kidney stone disease was associated with increased risk of death from peripheral vascular disease (HR 2.1, 95% CI 1.0 to 4.2). CONCLUSIONS On multivariate analyses, kidney stone disease appears to be related to prevalent peripheral vascular disease and increased risk of death from peripheral vascular disease. Further studies are necessary to understand the mechanisms underlying these epidemiologic findings. © 2012 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 187Issue 4SApril 2012Page: e906 Advertisement Copyright & Permissions© 2012 by American Urological Association Education and Research, Inc.MetricsAuthor Information Jonathan Shoag Boston, MA More articles by this author Marshall Stoller San Francisco, CA More articles by this author Brian Eisner Boston, MA More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...

Compromised chorionic villous vascularization in idiopathic second trimester fetal loss

Background For normal fetal growth and development a well-developed chorionic villous vascularization is essential. Aim The aim of this study is to investigate whether idiopathic second trimester fetal loss is associated with an underdeveloped chorionic villous vascularization. Methods 38 placentas after late miscarriage, classified as idiopathic fetal loss (IFL, n = 16) or as fetal loss due to intrauterine infection (IUI, n = 22) were collected. After CD34 immunohistochemical staining the villous stromal area, number of villous vessels, vascular area and vascular area density (central, peripheral and total) were measured in randomly selected immature intermediate villi. Results The mean gestational age was 19 + 4 weeks for the IFL group and 20 + 6 weeks for the IUI group. After controlling for gestational age, we found no differences in fetal weight, placental weight, villous stromal area, number of vessels and central vascular features. The mean peripheral vascular area and peripheral vascular area density were, after adjusting for gestational age, reduced in the IFL group. Conclusion Idiopathic second trimester fetal loss is associated with a reduced peripheral chorionic villous vascularization. We hypothesize that in these cases, placentation is already disturbed in first trimester of pregnancy, leading to a reduced materno–fetal interface in second trimester, thus to early postplacental fetal hypoxia and fetal death.

Peripheral moving‐table contrast‐enhanced magnetic resonance angiography (CE‐MRA) using a prototype 18‐channel peripheral vascular coil and scanning parameters optimized to the patient's individual hemodynamics

To demonstrate that with a priori determination of individual patient hemodynamics, peripheral contrast-enhanced magnetic resonance angiography (pCE-MRA) can be customized to maximize signal-to noise ratio (SNR) and avoid venous enhancement. Using a 1.5T MRI scanner and prototype 18-channel peripheral vascular (PV) coil designed for highly accelerated parallel imaging, geometry (g)-factor maps were determined. SNR-maximized protocols considering the two-dimensional sensitivity encoding (2D SENSE) factor, TE, TR, bandwidth (BW), and flip angle (FA) were precalculated and stored. For each exam, a small aortic timing bolus was performed, followed by dynamic three-dimensional (3D)-MRA of the calf. Using this information, the aorta to pedal artery and calf arteriovenous transit times were measured. This enabled estimation of the maximum upper and middle station acquisition duration to allow lower station acquisition to begin prior to venous arrival. The appropriately succinct SNR-optimized protocol for each station was selected and moving-table pCE-MRA was performed using thigh venous compression and high-relaxivity contrast material. The protocol was successfully applied in 15 patients and all imaging demonstrated good SNR without diagnosis-hindering venous enhancement. By knowing each patient's venous enhancement kinetics, scan parameters can be optimized to utilize maximum possible acquisition time. Some time is added for the timing scans, but in return time-resolved calf CE-MRA, maximized SNR, and decreased risk of venous enhancement are gained.

Avaliação do índice de danos permanentes através do SLICC/ACR-DI em pacientes brasileiros com lúpus eritematoso sistêmico

to evaluate the frequency and the different types of organ damage in relation to disease duration in Brazilian patients with SLE followed in a tertiary reference center through the application of the SLICC/ACR-DI. sixty SLE patients were enrolled in this study, and relevant data were obtained through medical history, physical and laboratory examinations reviewing the hospital records. The frequency and different types of organ damage were determined using the SLICC/ACR-DI. Statistics were performed through qui-square and t-tests. Multivariate regression was used to correlate damage with disease duration. forty-one patients (68.3%) presented some cumulative organ damage. Non-caucasoid patients and patients with longer disease duration had a slight tendency to have more damage (p = 0.058). Skin (35.0%), neuropsychiatric (18.3%), ocular (15.0%), peripheral vascularization (16.6%) and cardiovascular (10.0%) systems were more frequently affected. Patients with more than 60 months of disease had a slight tendency to present greater ocular, neuropsychiatric, renal, skin and musculoskeletal damage than patients with shorter disease duration. Patients with more than 120 months of disease had greater pulmonary, cardiovascular and peripheral vascular damage. in this study, 68.3% of permanent damage was observed. Skin, neuropsychiatric, ocular, peripheral vascularization and cardiovascular systems were more frequently affected. Renal and gonadal involvement was not as frequent as previously described. Non-caucasoid patients had a tendency to present higher scores, but more studies are necessary to determinate if ethnic or economic factors are involved.

SYMPTOMATIC PERIPHERAL VASCULAR TREE STENOSIS. Comparison of subtracted and nonsubtracted 3D contrast-enhanced MR angiography with fat suppression

Objective: To determine the clinical feasibility of contrast-enhanced three-dimensional (3D) MR angiography (MRA) with fat suppression spectral inversion at lipids and to compare subtracted and nonsubtracted images. Material and Methods: In 13 patients suspected of having lower extremity ischemia, 3D dynamic contrast-enhanced MRA of the iliac and femoral arteries was performed using the fat suppression technique. The validity of the MRA interpretations of the degree of stenoses was evaluated by comparing with conventional angiography as the gold standard. The contrast-to-noise (C/N) ratios of both subtracted and nonsubtracted maximum-intensity-projection (MIP) images were calculated. Results: In the arteries with stenosis of 50% or greater, the sensitivity and specificity of the subtracted MR angiograms were 100% and 96.5%, respectively, not significantly different from the correponding values in nonsubtracted MRAs (100% and 94.1%, respectively). The C/N ratios of the subtracted images were significantly higher than those of the nonsubtracted images (p<0.001). Conclusion: With this technique, fat suppression can be performed with only a slight increase in the examination time. A lower dose of contrast material can be used in MRA with fat suppression than without it. Subtracted MRA improves the ease of interpretation compared to nonsubtracted MRA.

Output levels and bioeffects indices from diagnostic ultrasound exposure data reported to the FDA

As part of the section 510(k) requirements of the 1976 Medical Device Amendments to the Federal Food, Drug, and Cosmetic Act, manufacturers of diagnostic ultrasound devices submit acoustic output data to the U.S. Food and Drug Administration. Because this information is pertinent to the assessment of any potential bioeffects due to ultrasound exposure, we have summarized the measurement data processed during 1990 and 1991. Exposure data were summarized for real-time B-mode and M-mode, general pulsed Doppler, peripheral vascular (PV) pulsed Doppler, and color flow Doppler. Exposure quantities included peak rarefactional and compressional pressures, spatial-peak pulse-average and spatial-peak temporal-average intensities (both water and derated values), and power. Also, where data permitted, mechanical and thermal indices were calculated. Ranges, means, medians, and standard deviations were categorized for the exposure quantities and indices. In general the temporal-average values (including indices) were higher in Doppler modes than in B/M imaging modes. Differences among the temporal-peak exposure quantities and indices were less distinct, although values tended to be higher in the PV and color flow Doppler categories. These data, along with comparable results collected by others, provide a means to relate the output of current devices to levels of exposure relevant to ultrasound induced biological effects.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>

SMOKING AND PERIPHERAL VASCULAR DISEASE: Podiatric Medical Update

SMOKING AND PERIPHERAL VASCULAR DISEASE: Podiatric Medical Update

BOOK REVIEWS

Australian and New Zealand Journal of SurgeryVolume 59, Issue 12 p. 975-979 BOOK REVIEWS First published: December 1989 https://doi.org/10.1111/j.1445-2197.1989.tb07644.xAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Abstract Book reviewed in this article: BASIC SURGICAL TECHNIQUES: By R. M. Kirk. Edinburgh: Churchill Livingstone, SURGERY OF THE UPPER RESPIRATORY SYSTEM, VOLUME 2: By William Montgomery. NONINVASIVE DIAGNOSIS OF PERIPHERAL VASCULAR DISEASE: Edited by W. R. Felix Jr. CLINICAL ELECTROPHYSIOLOGY OF THE HEART: By D. E. Ward and A. J. Camm. ENDOSCOPIC ULTRASONOGRAPHY IN GASTROENTEROLOGY: Edited by Keiichi Kawai MD. PERSPECTIVES IN COLON AND RECTAL SURGERY, VOLUME 1, NO. 1: Edited by Theodore R. Schrock MD. BAILEY & LOVE'S SHORT PRACTICE OF SURGERY: Revised by A. J. H. Rains and C. V. Mann. COMMON PROBLEMS IN GASTROINTESTINAL SURGERY: Edited by Joshf D. Fischer. Chicago: DIFFICULT PROBLEMS IN GENERAL SURGERY: By John L. Sawyers and Lester F. Williams. CONTROVERSIES IN BREAST DISEASE: DIAGNOSIS AND MANAGEMENT: By Sharon Grundfest-Broniatowski and Caldwell B. Esselstyn Jr. Volume59, Issue12December 1989Pages 975-979 RelatedInformation

Intracapillary oxyhemoglobin saturation in malignant tumours with central or peripheral blood supply

Solid tumours of DS-Carcinosarcoma show two different types of vascular patterns. Central blood supply and drainage are evident in tissue-isolated tumours in the rat kidney, but peripheral vascularization is found within tumours growing sub-cutaneously (s.c.). The oxygenation of both tumour types has been assessed by measurement of the intracapillary oxyhemoglobin saturation using a cryophotometric micromethod. In common with other solid tumours, measurements in tumour capillaries with diameters between 3 and 8 μ m reveal that very low oxyhemoglobin saturation values predominate during normal respiration. However, comparison of tumours at the same stage of growth indicates significantly higher saturation values in s.c. growing tumours than in tissue-isolated ones. It is concluded that the radiosensitivity must be higher in tumours with peripheral blood supply and drainage. In addition, respiration of pure oxygen should increase the radiosensitivity of tumours with peripheral vascular pattern more than that of tumours with central blood supply.

Muscle blood flow measured by XE-133 clearance method and peripheral vascular diseases. Part 2. Normals and patients with peripheral vascular diseases.

Muscle blood flow measured by XE-133 clearance method and peripheral vascular diseases. Part 2. Normals and patients with peripheral vascular diseases.