Objective: This paper aims to explore the trend, extent and impacting factors of the change in the psychological status of women before and after hysterectomy. Methods: A prospective study was performed to investigate the psychological statuses of 98 female subjects who underwent hysterectomy upon admission and three months after the hysterectomy. Results: The self-rating of the psychological status survey showed significantly lower factor scores including the postoperative BDI and SCL-90 (except paranoid factors) scores than those before the surgery and the same HAMD score as the nurse-administered rating scale. The incidence rate of moderate to severe depression dropped from 48.98% to 13.54% after the surgery. Differently aged patients showed different change extents of SCL-90, and the postoperative BDI and HAMD scores were significantly positively correlated with the preoperative levels. The preoperative HAMD score was negatively correlated with the length of education and positively correlated with the chief complaint. The postoperative HAMD score was positively correlated with the parity and the presence of medical complications and negatively correlated with age. Conclusion: Hysterectomy benefits the psychiatric and somatic health of the patients, and the women who were younger, more prolific, less educated, complain of dysmenorrhea or menorrhagia and have other medical disorders are more prone to perioperative depression.