Syndesmocorono-radicular tooth consist of palatoradicular groove that represents anomalous morphology and is the predisposing factor for developing localized chronic periodontitis and pulpal necrosis. This clinical report discusses diagnosis and endodontic-periodontal treatment of maxillary central incisor with palatoradicular groove that begins in the central fossa, crosses cingulum and extends a variable distance onto the root. Both endodontic and periodontal surgical therapy is required for treatment of pulpal pathosis, correction of osseous defect, pocket elimination and groove correction depending on the extent and depth of the radicular groove.Clinical Relevance to Interdisciplinary DentistryEndodontic failure may occur due to communication of palatal groove with pulp cavity. Such anomaly often predisposes to periodontal defects, severe bone destruction or combined endodontic-periodontal lesions. Interdisciplinary treatment modalities used in the present case reports emphasizes on the team approach management consisting of both endodontist and periodontist.