Period Of Life Research Articles

Endocrinopathy due to proproteinkovertase 1/3 deficiency: primary enteropathy, diabetes insipidus, secondary hypothyroidism

Proprotein convertase 1/3 (PC1/3) deficiency is an autosomal recessive disease caused by rare mutations in the proprotein convertase subtilisin/kexin type 1 (PCSK 1)gene, associated with severe malabsorptive diarrhea, obesity and some endocrine abnormalities. Proprotein convertase 1/3 is acalcium-dependent serine endoprotease involved in the proteolytic processing of various prohormones (peptide hormones in enteroendocrine cells that are necessary for the absorption of nutrients and is also expressed in the arcuate and paraventricular nuclei of the hypothalamus, in the beta cells of the pancreas) in their bioactive forms. The onset of the disease in the neonatal period of life is characterized by aclinical picture of severe malabsorption diarrhea, accompanied by developmental delays, and requires long-term parenteral nutrition. As the disease progresses, additional endocrine abnormalities develop, including diabetes insipidus, growth hormone deficiency, primary hypogonadism, adrenal insufficiency, hypothyroidism, and obesity. We conducted aprospective observation of apatient with agenetic disease due to proprotein convertase 1/3 deficiency confirmed during follow-up. The patient was examined and treated at the State Novosibirsk Regional Clinical Hospital in Novosibirsk for 11 months, with repeated (3-fold) hospitalizations. Purpose: to demonstrate the features of the onset and course of the disease, as well as the difficulties in verifying the clinical diagnosis of an ultra-rare genetic disease from the category of endocrinopathies, the complexity of medical support and therapy. Apeculiarity of this case is the fact that the identified mutation in the gene was not previously registered in control Russian samples of the genetic mutation of proprotein convertase 1/3 deficiency, as well as apreviously undescribed variant of the nucleotide sequence in exon 4 of the PCSK1 gene in aheterozygous state and was not registered in control samples gnomAD and RUSeq. Proprotein convertase 1/3 deficiency is adisease that is amultidisciplinary problem, since etiopathogenetic therapy has not yet been developed. The disease has achronic course with constant relapses of intestinal syndrome, is difficult to manage with symptomatic treatments and, as it progresses, has ahigh risk of developing additional endocrinopathies and death. All of the above emphasizes the need for early diagnosis and selection of rational replacement and accompanying therapy to save the lives of patients.

Tracing the dynamics of motivational self-constructs across the lifespan: Tales from senior learners of English

In the context of an ageing and increasingly more independent learning population, a narrative inquiry into the life stories of motivated and still active senior language users remains a promising yet unexplored area. This case study forms part of a PhD research (Darnault, 2023) on the motivational dynamics of lifelong foreign language learning (FLL) individuals. We recorded the retrospective stories of 3 exceptionally motivated French senior learners of English, aged 65 to 80, from childhood to their current learning experience. Our triangulated and multimodal approach elicited written, oral and visual data. An inductive thematic analysis first highlighted the emergence of motivational peaks, subsequently followed by the examination of clusters of self-constructs within participants’ individual time frames in light of the L2 Motivational Self System (L2MSS) framework. Results showed that upon retirement all three learners integrated language learning into their daily routine, incorporating it as an integral part of their identity and broader sense of self outside L2 domain-specific motivational constructs. A particularly unyielding hybrid L2 self emerged in later years, drawing from the combination of ought-to, ideal and anti-ought-to selves that prevailed with different degrees of intensity and interaction according to life periods.

Organic fungicides and diphenylamine shift microbiomes of ‘Fuji’ apples during storage

The native microbiome plays an important role in biocontrol efficacy, but less is known about how the microbiome responds to conventional and organic natural product fungicides. This study investigated the effects of the conventional fungicide fludioxonil and the organic fungicide natamycin, with and without the superficial scald inhibitor diphenylamine (DPA) on the microbiomes of ‘Fuji’ apples from 1 to 28 d of storage at 0.5 °C plus 7 d at 20 °C. We hypothesized that fungicide applications would shift the microbiome, with a more pronounced effect from natamycin due to the target specificity of fludioxonil. We also predicted that the antioxidant properties of DPA would shift both bacterial and fungal microbiomes. We found that natamycin resulted in modest fungal shifts and fludioxonil resulted in no observed shifts, while DPA strongly affected the fungal microbiome over time. Chemical treatment was not a predictor of bacterial microbiome variation, but bacterial communities shifted throughout storage. However, many of the trends that occurred during storage were reversed during the 7-d shelf life period at 20 °C after storage. Time in cold storage decreased the relative abundance of Pseudomonas, while DPA application reduced the relative abundance of Aureobasidium, both notable biocontrol genera. These results highlight how chemical applications such as DPA may have unintended effects on beneficial microbes that protect fruit from pathogen infection.

The Psychological and Social Factors That Contribute to The Abuse and Addiction to Drugs Among Adolescents in Jordan

Adolescence represents a pivotal period in an individual's life, marking the transition from childhood to adulthood. During this phase, adolescents are particularly vulnerable to the risks associated with substance abuse. This study, therefore, sought to identify the psychological and social factors contributing to drug abuse and addiction among adolescents in Jordan. To achieve this objective, a qualitative procedural research approach was employed, drawing upon existing literature and prior studies as a foundation for inquiry. The study identified a number of psychological and social factors that contribute to the use and addiction to drugs. These were found to include: a love of tradition; a love of excitement; a lack of maturity in personality; disturbances in the relationship between adolescents and parents; a desire to reduce stress and anxiety; a weak religious conscience; parents' preoccupation with children; excessive cruelty to children; and other factors.

Blood Pressure, Antihypertensive Use, and Late-Life Alzheimer and Non-Alzheimer Dementia Risk: An Individual Participant Data Meta-Analysis.

Previous randomized controlled trials and longitudinal studies have indicated that ongoing antihypertensive use in late life reduces all-cause dementia risk, but the specific impact on Alzheimer dementia (AD) and non-AD risk remains unclear. This study investigates whether previous hypertension or antihypertensive use modifies AD or non-AD risk in late life and the ideal blood pressure (BP) for risk reduction in a diverse consortium of cohort studies. This individual participant data meta-analysis included community-based longitudinal studies of aging from a preexisting consortium. The main outcomes were risk of developing AD and non-AD. The main exposures were hypertension history/antihypertensive use and baseline systolic BP/diastolic BP. Mixed-effects Cox proportional hazards models were used to assess risk and natural splines were applied to model the relationship between BP and the dementia outcomes. The main model controlled for age, age2, sex, education, ethnoracial group, and study cohort. Supplementary analyses included a fully adjusted model, an analysis restricting to those with >5 years of follow-up and models that examined the moderating effect of age, sex, and ethnoracial group. There were 31,250 participants from 14 nations in the analysis (41% male) with a mean baseline age of 72 (SD 7.5, range 60-110) years. Participants with untreated hypertension had a 36% (hazard ratio [HR] 1.36, 95% CI 1.01-1.83, p = 0.0406) and 42% (HR 1.42, 95% CI 1.08-1.87, p = 0.0135) increased risk of AD compared with "healthy controls" and those with treated hypertension, respectively. Compared with "healthy controls" both those with treated (HR 1.29, 95% CI 1.03-1.60, p = 0.0267) and untreated hypertension (HR 1.69, 95% CI 1.19-2.40, p = 0.0032) had greater non-AD risk, but there was no difference between the treated and untreated groups. Baseline diastolic BP had a significant U-shaped relationship (p = 0.0227) with non-AD risk in an analysis restricted to those with 5-year follow-up, but otherwise there was no significant relationship between baseline BP and either AD or non-AD risk. Antihypertensive use was associated with decreased AD but not non-AD risk throughout late life. This suggests that treating hypertension throughout late life continues to be crucial in AD risk mitigation. A single measure of BP was not associated with AD risk, but DBP may have a U-shaped relationship with non-AD risk over longer periods in late life.

Perception Of The Concept Of Death Among Children, Young And Older People And The Comparison Of These Perceptions: A Qualitative Study

Death is one of the most important concepts that make life meaningful and it is the inevitable end. From the moment we are born, we are one step closer to death with every passing second, and this creates the stage of consciousness that enables people to connect and make sense of life more tightly. Death, which means the definitive end of life, has been seen as an important event in all societies and in every period of life. The purpose of the current study is to determine and compare the perceptions of children, young people and older people about death through metaphors. The study is a qualitative research. A total of 192 people, 57 children, 63 young and 72 older people, determined on a voluntary basis constituted the sample of the study. A questionnaire form consisting of open-ended questions was used in the study. Descriptive analysis technique, one of the qualitative research methods, was used in the analysis of the data. It was tried to determine with which metaphors the participants would present their perceptions of death and the common characteristics of the metaphors that would emerge. In the evaluation of the data obtained, content analysis method was used in accordance with the qualitative research design. According to the research findings, 29 metaphors were produced by the children, 37 by the young people and 46 by the older people to express the concept of death. The children compared the concept of death most with old age, sadness, grave, accident, earth, sleep, ending, separation; the young people compared it most with beginning, extinction, exam, loneliness, longing, leaf, fear and the older people compared it most with migration, destiny, happiness, reunion, longing, salvation, bridge. The children predominantly expressed death with negative metaphors, the young people used lively metaphors drawn from life experiences while the older people often portrayed death with positive metaphors. The metaphors created by the children, young and older people were categorized into groups. The metaphors generated by individuals regarding the concept of death and the categories formed from these metaphors reveal how the concept of death is perceived..

A Descriptive Study to Assess the Unhealthy Lifestyle among Perimenopausal Women in a Selected Medical College Hospital, Mangaluru

Abstract Introduction The perimenopausal phase, also known as the menopausal transition, marks a crucial period in a woman's life, characterized by hormonal fluctuations and physiological changes. During this transitory period, lifestyle factors are critical in influencing health outcomes. Lifestyle Appraisal focuses on identifying the lifestyle factors and habits that may affect a woman's health throughout the perimenopausal period. Methods and Materials The objective of the study was to identify perimenopausal women with unhealthy lifestyle practices using a lifestyle appraisal questionnaire. The study used descriptive design to determine the unhealthy lifestyle among perimenopausal women in the age group of 45 to 55 years. A complete enumerative sampling was used to select the 148 participants who fulfilled the inclusion criteria. Every participant completed the self-reported lifestyle assessment questionnaire (LAQ), except for the questions where the researcher measured blood pressure, height, and weight (body mass index [BMI]) with standard protocol. Results Unhealthy lifestyle habits persist in women. The average lifestyle appraisal score was 19.17 ± 6.88, ranging from 8 to 35. The higher the score, the unhealthy their lifestyle. The tool's highest possible score is 73. The majority of the subjects did not engage in regular exercise (43.9%), recreational activities (62.8%), or relaxation exercises (81.1%). A substantial number (54.1%) of women had encountered one to two stressful events in the last 6 months, with friends and family occasionally available for support (64.7%). None of them received love and affection every day, but rather on an occasional basis (69.6%). Most (81.1%) reported consuming meals with fruits and vegetables only two to three times a week, while fatty foods or sweets were ingested daily (60.1%). Furthermore, most (45.3%) participants were classified as overweight, with a BMI falling between 23 and 24.9. Conclusion Simple screening methods can be used to evaluate health and lay the groundwork for understanding a person's lifestyle, which helps preserve and encourage a healthy way of life.

Micronutrient intake inadequacies in Northwest Ethiopian children aged 6–23 months

The early stages of childhood are a crucial period of life for health, with inadequate nutrition impacting physical growth, cognitive development, and the immune system. A considerable proportion of children are affected by micronutrient intake inadequacy and deficiency across the globe. Evidence on micronutrient intake among children aged 6–23 months is limited in Northwest Ethiopia, where there is a divergence between production and dietary consumption practices compared to other regions of the country. This study aimed to determine micronutrient inadequacy and associated factors among children aged 6–23 months. From February 1 to February 18, 2023, 435 children aged 6–23 months participated in a community-based cross-sectional study in the North Mecha District of the Amhara Region, Northwest Ethiopia. The study participants were selected using a multistage sampling technique. A multiphasic interactive 24-h dietary recall was used to collect dietary intake data via an interviewer-administered questionnaire. The interviews were conducted with the mothers of the selected children. Nutrient values for the selected 12 micronutrients were calculated using the NutriSurvey 2007 software and food composition tables from Ethiopia, Tanzania, and Kenya. SPSS version 25 was used for the remaining parts of the analysis. The Nutrient Adequacy Ratio and Mean Adequacy Ratio were calculated to evaluate the nutrient intakes. To identify the factors associated with overall micronutrient intake inadequacy, a binary logistic regression analysis was performed, with statistical significance determined at a p-value < 0.05. The overall prevalence of micronutrient intake inadequacy was 64.7% (95% CI 59.9, 69.2). The odds of inadequacy of micronutrient intake were 2.8 times higher among children aged 6–8 months than children aged 9–23 months (AOR = 2.80, 95% CI 1.71, 4.59). Children with paternal education unable to read and write and primary school incomplete were 3.1 (AOR = 3.12, 95% CI 1.26, 7.70) and 2.4 (AOR = 2.40, 95% CI 1.01, 5.73) times more likely to have micronutrient intake inadequacy, respectively, compared to children with paternal education of primary school completed and above. The likelihood of micronutrient intake inadequacy was 1.8 times higher among children from mothers who had an unfavorable nutrition-related attitude than those from mothers who had a favorable attitude (AOR = 1.76, 95% CI 1.02, 3.05). Inadequate intake of micronutrients was shown to be highly prevalent among children aged 6–23 months. Child age, paternal education, and maternal nutrition-related attitude were significantly associated with micronutrient intake inadequacy. Integrating community-guided nutrition interventions targeting nutrition-related knowledge and attitudes of parents is critical in addressing the inadequate micronutrient intake of children in the study community, where production is not a major problem.

Prevalence of Food Insecurity during Pregnancy in Latin American and the Caribbean Countries: A Systematic Review

In Latin American and Caribbean (LAC) countries, women are particularly affected by food insecurity (FI). This gender gap can be amplified at certain key periods in life, particularly during pregnancy, with negative consequences on maternal and infant health. In the current geopolitical and health context, it is essential to take stock of the prevalence of FI among pregnant women in this region and the associated economic and psychosocial determinants. From 168 publications identified on Pubmed and Scopus, this systematic review selected 13 publications in 7 LAC countries. Although the published data only described the situation before the COVID-19 pandemic (2009–2019), the prevalence of FI in this population was already worrying, ranging from 28.2% to 64.9%. Only 4 of 13 studies investigated socioeconomic and psychosocial determinants among mothers in this region. Thus, the factors most frequently reported concerned mothers’ demographic characteristics (advanced age and ethnic minority), household socioeconomic characteristics (low income, poorest wealth quartile, precarious housing, and welfare recipients), the absence of a stable partner, and a low education level. High prevalences of FI have also been associated with mental distress during pregnancy. In conclusion, few recent studies (notably none since the COVID-19 pandemic) have been published in this region on the issue of FI among women during pregnancy. Yet, this knowledge is essential to the development of a logical framework for the implementation and evaluation of public health programs aimed at women and children. By reducing the FI of mothers in the LAC region, we will contribute to reducing the social inequalities in health that often manifest themselves very early in life.This study was registered at PROSPERO as CRD42024513321 (https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=513321).

Cavitation Characteristics in Ultrasonic Soldering and the Erosion Effect

In this work, the cavitation characteristics of the solder sonocapillary action during ultrasonic soldering were studied by a high-speed camera. The effects of ultrasonic power and time on the acoustic pressure, cavitation characteristics, and erosion effects were also investigated. Results showed that cavitation occurred throughout the entire sonocapillary action. Two kinds of bubble structures were observed. The steady bubbles had large sizes and long life periods. The transient bubbles had small sizes and short life periods. The steady bubbles preferentially appeared at the primary filling stage, while the transient bubbles dominated the entire cavitation field. The sonocapillary action was divided into the primary filling stage, the intermediate filling stage, and the completion filling stage. The primary filling stage had low acoustic pressure but high bubble density because the air content in the solder was high and some additional air entered the solder through the triple interface caused by ultrasonic vibration. Higher ultrasonic power resulted in stronger cavitation and, thus, better erosion effect on the substrate.

Oral tolerance to dietary antigens and Foxp3+ regulatory T cells.

Immune tolerance to foods develops in the intestine upon food ingestion and is essential to prevent IgE-mediated food allergy and gut inflammation. In homeostasis, the intestine is a tolerogenic environment that favors the formation of food-specific Foxp3+ regulatory T cells. A tolerogenic intestinal environment depends on colonization by diverse microbiota and exposure to solid foods at a critical period in early life. These early immune responses lead to the induction of antigen-specific Foxp3+ regulatory T cells in draining mesenteric lymph nodes. These peripherally induced regulatory cells circulate and seed the lamina propria of the gut, exerting suppressive function systemically and locally in the intestine. Successful establishment of a tolerogenic intestinal environment in early life sets the stage for oral tolerance to new antigens in adult life.

Acute Stress Affects the Relaxin/Insulin-Like Family Peptide Receptor 3 mRNA Expression in Brain of Pubertal Male Wistar Rats.

The current literature suggests that relaxin-3/relaxin/insulin-like family peptide receptor 3 (RLN-3/RXFP-3) system is involved in the pathophysiology of affective disorders because the results of anatomical and pharmacological studies have shown that the RLN-3 signaling pathway plays a role in modulating the stress response, anxiety, arousal, depression-like behavior, and neuroendocrine homeostasis. The risk of developing mental illnesses in adulthood is increased by exposure to stress in early periods of life. The available data indicate that puberty is especially characterized by the development of the neural system and emotionality and is a "stress-sensitive" period. The presented study assessed the short-term changes in the expression of RLN-3 and RXFP-3 mRNA in the stress-dependent brain regions in male pubertal Wistar rats that had been subjected to acute stress. Three stressors were applied from 42 to 44 postnatal days (first day: a single forced swim; second day: stress on an elevated platform that was repeated three times; third day: restraint stress three times). Anxiety (open field, elevated plus maze test) and anhedonic-like behavior (sucrose preference test) were estimated during these tests. The corticosterone (CORT) levels and blood morphology were estimated. We found that the RXFP-3 mRNA expression decreased in the brainstem, whereas it increased in the hypothalamus 72h after acute stress. These molecular changes were accompanied by the increased levels of CORT and anxiety-like behavior detected in the open field test that had been conducted earlier, that is, 24h after the stress procedure. These findings shed new light on the neurochemical changes that are involved in the compensatory response to adverse events in pubertal male rats and support other data that suggest a regulatory interplay between the RLN-3 pathway and the hypothalamus-pituitary-adrenal axis activity in the mechanisms of anxiety-like behavior.

Effects of maternal contact and positive human contact during lactation on pork quality: Positive human contact to piglets during lactation improves pork loin muscle pH

Enhancing stress resilience through the early life period in pigs could potentially improve pork quality. It was hypothesised that pigs receiving maternal contact or positive human contact during lactation would have improved carcass and pork quality. Seventy-nine mixed-sex pigs were selected from a 2 × 2 factorial randomised block design for treatments maternal contact (MC+) / reduced maternal contact (MC-); and positive human contact (HC+) / control (HC-). Modified farrowing crates were utilised to reduce maternal contact (MC-). Litters in the HC+ treatment received five minutes of daily positive human interaction (stroking). Treatments ceased at 22 days of age (weaning) and pigs were slaughtered after 21 weeks of age. The m. longissimus thoracis et lumborum pH was higher in HC+ than HC- pigs (P < 0.05) during chilling, from 90 min post slaughter. No HC effects (P > 0.05) were observed for cortisol or haptoglobin concentration, hot carcass weight, P2 backfat, carcass scratches, colour, drip loss, cook loss and shear force. MC+ tended (P < 0.086) to increase carcass weight, P2 and carcass scratch score compared to MC-, but no further impacts were observed. The impact of positive human contact during early life was observed 20+ weeks after treatment with reduced pH decline, potentially indicating a reduction in pre-slaughter stress, however there were no further impacts on pork quality. There is evidence that maternal contact is important for lifetime growth performance of pigs but the impacts on stress resilience are less apparent.

Energy Balance and Dietary Intake in Young Rugby Players during a Pre-Season Micro-Cycle: A Cluster Analysis.

Rugby players must develop excellent levels of conditioning during adolescence. However, this pivotal period of life is also characterized by a surge in biological growth, which further increases the energy and nutritional requirements of this population. This study examined within-individual differences in energy intake (EI) and energy balance (EB) of 46 young rugby players during a pre-season micro-cycle. Two clusters were identified with significantly different characteristics and EB states, suggesting that young rugby players adjust their EI to match their body composition goals. The first cluster is characterized by players with a low body fat% (12.87 ± 2.53). They had a positive EB (330 ± 517 kcal), suggesting a goal of increasing muscle mass. Conversely, the second cluster is characterized by a higher body fat% (23.1 ± 1.6, p < 0.005) and reported a negative, lower EB (-683 ± 425 kcal, p < 0.005), suggesting a goal focused on reducing fat mass. Although our study provides more optimistic results than previous ones regarding the high risk of inadequate EI in young rugby players, we emphasize the importance of rigorous nutritional support, especially for players aiming to lose weight, to avoid severe caloric restriction, as well as the downstream effects of such practices on their nutritional status, given the higher risk of macro- (e.g., CHO < 6 g/kg/d) and micronutrient (e.g., iron < 11 mg/d, calcium < 1300 mg/d, vitamin D < 5 mg/d) deficiencies.

Self-Compassion in Adolescents and Young Adults With Inflammatory Bowel Disease: Relationship of Self-Compassion to Psychosocial and Physical Outcomes.

Adolescents and young adults (AYAs) diagnosed with inflammatory bowel disease (IBD) are at an increased risk for poor physical and mental health due to the complexity of pediatric onset IBD and the unique developmental challenges of this period of life. Self-compassion is increasingly recognized as having an important role in explaining health outcomes and well-being across a range of populations. This study examines the relationship between self-compassion and psychosocial and physical health outcomes in AYAs with IBD. In this cross-sectional study, AYAs with IBD aged 15 to 25 years completed an online survey between February 2020 and October 2021. Questionnaires included the Self-Compassion Scale-Short Form, Patient-Reported Outcomes Measurement Information System (PROMIS) measures for psychosocial, physical and global health outcomes, and IBD disease activity indices. AYAs with higher levels of self-compassion were found to have better psychosocial (ie, anxiety, depressive symptoms, psychological stress, physical stress, peer relationships), physical (ie, fatigue), and global health outcomes. Self-compassion was a significant independent predictor of anxiety (β = -5.80, P = < .001), depressive symptoms (β = -7.09, P = < .001), psychological stress (β = -4.66, P = < .001), physical stress (β = -3.19, P = < .001), peer relationships (β = 3.39, P = .003), fatigue (β = -2.05, P = .019), and improved global health (β = 5.15, P = < .001). This study offers preliminary support for the importance of self-compassion in AYAs with IBD and demonstrates the need for further research in this area.

Empathy and Socio-Emotional Competencies: The Perception of Portuguese Adolescents in Today’s Changing Environment

According to the literature, recent world events seem to play a significant influence in the acquisition and upgrowth of empathy and socio-emotional competencies (SEC), especially in adolescents. In this study we sought to assess the level of socio-emotional competencies and interpersonal reactivity of Portuguese adolescents in today’s context and analyze differences due to sex, relationship status, residence, and educational level on the dimensions of inter-personal reactivity and socio-emotional competencies. Participants were 230 adolescents of both sexes, living in Portugal, with ages between 16 and 18 years old, mostly female, with a secondary educational level, living in an urban area, and not in a relationship. An online questionnaire was applied using the Social and Emotional Competencies (SEC-Q) scale and the Interpersonal Reactivity Index (IRI). The results were that adolescents had an above-average global interpersonal reactivity, with empathic concern and perspective-taking presenting the higher values. Adolescents showed a medium-high average level of SEC, with the highest domains being self-awareness, social awareness, and pro-social behavior. Girls showed significantly more interpersonal reactivity in empathic concern, personal distress, and fantasy, and boys presented more self-awareness. As for the relationship status, adolescents not in a relationship manifested more personal distress, while those in a relationship presented higher values in all dimensions of SEC. Neither residence, nor educational level, presented significant main effects. These results can contribute to thinking about youth protection policies and designing more appropriate interventions to promote well-being in this crucial period of life, especially in times of change.

Síndrome de Burnout em estudantes de enfermagem de uma universidade privada do estado do Rio Grande do Sul

Burnout Syndrome is a state of emotional exhaustion with symptoms of extreme exhaustion, stress, and physical exhaustion resulting from an extreme work situation or a challenge in a period of life. Studies indicate that burnout is present in undergraduate nursing students, and their results have identified high levels of burnout. The objective of this study was to verify the presence of burnout syndrome in undergraduate nursing students at a community institution in the state of Rio Grande do Sul. This is a qualitative-quantitative, exploratory, descriptive and cross-sectional study. Data collection was carried out with 19 students from the ninth and tenth semesters of the nursing course, from September to October 2023, using the instrument called MBI - SS, Maslach Burnout Inventory Student Survey (MBI-SS). The results showed that the majority of students were female, 86.2% (n=16), single 86.2% (n=16), working 78.9% (n=15) and financially responsible for their studies 52.6% (n=10). The scores analyzed revealed the presence of Burnout Syndrome in the sample studied, with high scores of exhaustion and disbelief. We conclude that Burnout Syndrome has affected students in the health area, it is necessary to recognize the situations that lead students to emotional exhaustion, considering the specificity of their training environments.

Neuroimaging of autobiographical memory in dementia with Lewy bodies: a story of insula.

Although deficits in learning and retrieving new information are well characterized in dementia with Lewy bodies, autobiographical memory has never been explored in this disease. Yet, autobiographical memory impairments are a pervasive feature of dementia, well characterized in other neurodegenerative diseases. Moreover, autobiographical memory corresponds to an extension over time of the self, which we hypothesize is altered in dementia with Lewy bodies and impairment of which could be linked to the insular atrophy occurring from an early stage of the disease. In this study, we sought to characterize autobiographical memory impairments and explore their neural correlates in dementia with Lewy bodies, on the assumption that insular damage could impact the self, including its most elaborate components, such as autobiographical memory. Twenty patients with prodromal to mild dementia with Lewy bodies were selected to participate in this exploratory study along with 20 healthy control subjects. The Autobiographical Interview was used to assess autobiographical memory. Performances were compared between patients and control subjects, and an analysis across life periods and recall conditions was performed. 3D magnetic resonance images were acquired for all participants, and correlational analyses were performed in the patient group using voxel-based morphometry. The behavioural results of the Autobiographical Interview showed that autobiographical memory performances were significantly impaired in dementia with Lewy body patients compared to control subjects in a temporally ungraded manner, for both the free recall and the specific probe conditions (P < 0.0001), though with greater improvement after probing in the patient group. Furthermore, autobiographical memory impairments were correlated with grey matter volume within right insular cortex, temporoparietal junction, precuneus, putamen, left temporal cortex, bilateral parahippocampus and cerebellum, using a threshold of P = 0.005 uncorrected. The behavioural results confirm the existence of temporally ungraded autobiographical memory impairments in dementia with Lewy bodies, from the early stage of the disease. As we expected, neuroimaging analysis revealed a role for the insula and the precuneus in autobiographical memory retrieval, two regions associated with elementary aspects of the self, among other brain regions classically associated with autobiographical memory, such as medial temporal lobe and temporoparietal junction. Our findings provide important insights regarding the involvement of the insula in the self and suggest that insular damage could lead to a global collapse of the self, including its more elaborated components, such as autobiographical memory.

Acceptance and commitment coaching for music performance anxiety in adolescent singers.

Most of the anxiety disorders, particularly social anxiety, seem to develop either during childhood or adolescence. Adolescent singers who experience physical, mental and emotional changes along with voice change are particularly prone to the development of MPA. However, adolescence also seems to be an opportune time to instil healthy behaviours in singing students as they are more likely to remember these coping strategies, owing to the release of dopamine and the 'reminiscence bump'. As this period of a singer's life is wrought with inevitable anxiety development, the additional aim of the study was to develop a coaching framework which can be used by singing teachers in their practice. Mindset training for adolescents seems crucial to help them continue singing through puberty so they do not drop out of singing lessons or choir during voice change and identity development. The study aimed to determine if Acceptance and Commitment coaching could be used with adolescent singers with MPA and to record and analyse rich qualitative data in the form of semi-structured participant interviews and questionnaires. When their perception of MPA symptoms and physiological and psychological arousal before a performance changed, their behaviour and reactions changed accordingly. The change took place over a period of time, which was characterised by discoveries about themselves, confusion in understanding new concepts and letting go of old habits. Interestingly, by the end of the coaching sessions, their preoccupation with pleasing the audience and appearing perfect on stage was replaced by a new-found delight in pursuing values and goals related to their singing. Along with this came the acceptance of themselves and others as individuals with the potential for growth and change and the capacity to learn from mistakes. This study marks the first investigation into the effectiveness of using of ACC as an intervention for MPA in adolescent singers undergoing puberty by a singing teacher. The results are promising and suggest that ACC is an effective MPA intervention for adolescent singers to cope with inevitable development-related anxieties and keep them engaged in the activity of singing during their pubertal years.

EDUCATIONAL AND CHARITABLE ACTIVITIES OF IOANN MAXIMOVICH 1697-1711: CHERNIHIV PERIOD

The life and activities of Ioann Maxymovych (1651-1715), a prominent church figure and writer, have repeatedly attracted the attention of researchers. A significant number of investigations are dedicated to his biography and creative works. Almost his entire life was associated with Ukraine. Ioann Maxymovych – educator, church figure, missionary, spiritual writer, Archbishop of Chernihiv and Novgorod-Siversky, Metropolitan of Tobolsk, belongs to the ranks of saints, enlightener of the peoples of Siberia, founder of the first higher education institution on the Left-Bank of Ukraine – Chernihiv Collegium. The article considers the period of life of Ioann Maximovich from 1697-1711, which falls on the time of his active work at the Chernihiv department. The importance of his own efforts in promoting the development of education and enlightenment was emphasized: the establishment of the Chernigov Collegium; literary and translation activities; funding and maintenance of the library and diocesan typography, etc. The article analyzes the rich experience of educational and charitable activities of Ioann Maksimovich in supporting the formation of the Chernihiv diocese, its spiritual and cultural development at the beginning of the 18th century.