Aiming at the problem of system controller performance failure caused by improperly setting the value of each weighting coefficient of the model predictive control (MPC), a fractional-order MPC strategy with Takagi–Sugeno fuzzy optimization (T–SFO MPC) is proposed for a vehicle active suspension system. Firstly, the fractional-order model predictive control framework for active suspension systems is designed based on a 1/4 vehicle model. Then, we analyze the influence of different weighting coefficients on the suspension performance and introduce the Takagi–Sugeno fuzzy optimization theory to adaptively adjust the weighting coefficients of the fractional-order MPC controller. Finally, the system responses of the T–SFO MPC, traditional MPC, linear quadratic regulator (LQR), and passive suspension control are numerically analyzed under various road conditions. Simulation results show that suspension response with the T–SFO MPC is significantly improved compared with passive suspension control, traditional MPC control, and LQR control, and the weight coefficients of the T–SFO MPC can be adaptively adjusted according to the dynamic changes of suspension response. Compared with passive suspension, the root mean square (RMS) value of the vertical acceleration of the T–SFO MPC under various roads decreased by a maximum of 37.97%, and the RMS value of suspension dynamic deflection and tire dynamic load decreased by a maximum of 32.94% and 37.8%, respectively. These results validate that the proposed control method can achieve coordinated optimization of vehicle comfort and handling stability.