The main goal of the present case report is to propose a minimally invasive percutaneous approach in managing postoperative complication of severe chyloperitoneum. A 41-year-old female underwent laparoscopic donor left nephrectomy and developed chyloperitoneum after six weeks. Because of no response to medical management, no demonstrable chyle leak site on conventional lymphangiogram, no response to lymphatic maceration and glue injection at left L4/L5 level, and continuing persistent severe chyloperitoneum, we performed direct percutaneous Computed Tomography (CT) guided glue injection at probable leak site based on operative details and nonenhanced CT of the abdomen. Complete resolution of chyloperitoneum was achieved at two weeks. We believe that prompt utilization of these percutaneous techniques can achieve timely resolution and should be considered in managing such patients. To our knowledge, this novel approach hasn’t been described in any of the earlier studies.