Abstract Study question What is the quality of life of Kazakhstani women with infertility and what additional factors can affect it? Summary answer The FertiQoL questionnaire showed the low quality of life of Kazakhstani women and a significant affect some factors. What is known already Studies showed that infertility problems are among the saddest events in people's lives. It is reported that women undergoing IVF procedures are experiencing various types of psychological burdens like stress, anxiety and depression. Study design, size, duration This cross-sectional study involved women of reproductive age undergoing an IVF cycle at a large IVF center in Kazakhstan in the period from September 1, 2020 to September 31, 2021. Participants/materials, setting, methods The survey was carried out using the Google Form program and was sent to patients of large IVF clinic of Kazakhstan by the attending physician for an online survey. Out of 500 women who were given questionnaires, 453 women completely filled out. Questionnaire results data were entered into SPSS version 26.0 for aggregation and statistical analysis. Two-sample Student's t-test or one-way analysis of variance (ANOVA) was used to test for differences between groups. Main results and the role of chance Total FertiQoL was 59.6±11.3. 292 women with primary infertility and 161 with secondary infertility. According to the main indicators as Total FertiQoL and Core FertiQoL, the results of the scales were significantly higher (p < 0.001). The source of income for infertility treatment affects the level of Treatment FertiQoL. Cronbach's α coefficients of the FertiQoL subscale averaged 0.8. Cronbach's α coefficients of the FertiQoL subscale averaged 0.8. We examined the satisfaction scores by FertiQoL, dividing them into two groups according to the presence of children (Table 3). FertiQoL scores were statistically significantly higher in the group with children than in the group with primary infertility in all areas (p < 0.05), except for Relation, Tolerability (p = 0.65, p = 0.59). Limitations, reasons for caution This study cross-sectional and was conducted in the countries of the Commonwealth of Independent States (CIS) for the first time. We want to continue research in cooperation with other CIS countries. Wider implications of the findings The duration of infertility, age and low economic status negatively affect the quality of life of women. The availability of subsidies from the state for infertility treatment improves the quality of life. The health expenditure percentage of GDP may affect the overall level of satisfaction of women. Trial registration number IRB-A108