Percent Of Rats Research Articles

Sulfonamide Therapy of Trichinized White Mice

In an excellent review Van Someren (1939) presented a list of substances tried for the treatment of trichinosis. None of the substances listed were very satisfactory. McCoy (1938) reported that daily doses of 125 mg. of sulfanilamide were ineffective for the treatment of trichonosis in rats. On the other hand a limited study by McNaught, et al (1939) indicated that sulfanilamide administered in the feed at a 1.6 percent concentration affected a larval reduction of 55.0 percent in rats. In view of this observation Riedel and Lunde (1949) undertook an extensive investigation of sulfanilamide and other sulfonamides of medicinal interest to learn their therapeutic possibilities for the treatment of trichinosis in white mice. Rations containing sulfaypridine, sulfathiazole or sulfadiazine at maximum nontoxic levels were ineffective; sulfaguanidine was indefinite; and a 2.0 percent sulfanilamide ration affected a larval reduction of 54.0 percent. The objective of the present study was to compare the effects of sulfanilamide with sulfamerazine and sulfaquinoxaline upon trichinae, and to note if sulfonamide therapy affected a reduction of the mortality among white mice heavily infected with Trichinella spiralis larvae.