Diverse outcomes from the COVID-19 pandemic from different countries raise questions about how information related factors influence judgements about the risks of the outbreak. Adopting a comparative survey approach, this study investigates whether and how, knowledge, content trust, and content magnitude are associated with COVID-19 risk perception among respondents in Ghana and the United States (n = 736) during the first phase of the pandemic (April -June 2020). Using snowball and convenience sampling strategies, the online comparative cross-sectional survey found that US respondents had higher risk perceptions, but in both countries, risk perceptions were moderate to low. The study found that those who trusted traditional media content (television, radio, and printed materials) and received high volumes of information from these sources had higher risk perceptions. Hierarchical linear regression (stepwise) indicated that income is a positive predictor of risk perceptions in both US and Ghana. However, while all three knowledge variables influenced risk perceptions in the US, only transmission knowledge influenced risk perceptions in Ghana. While trust in content from radio lowered risk perceptions, trust in content from television and printed materials increased risk perceptions in Ghana. For the US, trust in the content of printed materials led to higher risk perception. High volumes of information from printed materials increased risk perceptions in Ghana but lowered risk perceptions in the US. For pandemics that require stay-at-home orders, legacy media such as television and printed materials should be considered and utilized for information dissemination in both countries.