AbstractA tetrahydrofuran ring containing oligoethylene glycol ethers has been synthesized from the seed oil of Vernonia anthelmintica. The seed oil was reacted with mono‐, di‐, and triethylene glycols in the presence of boron trifluoride etherate, followed by saponification and esterification (MeOH/H+). The oligoethylene glycol ethers thus obtained were epoxidized with perbenzoic acid. The 9,10‐epoxy oligoethylene glycol ethers so formed were intramolecularly cyclized in dry benzene using boron trifluoride etherate as a catalyst to yield the tetrahydrofuran ring containing oligoethylene glycol ethers; methyl 9,12‐epoxy, 10‐hydroxy‐13‐[2‐hydroxyethyl‐1‐oxy]; methyl 9,12‐epoxy,10‐hydroxy‐13‐[2‐hydroxy‐3‐oxapentyl‐1‐oxy] and methyl 9,12‐epoxy,10‐hydroxy‐13‐[8‐hydroxy‐3,6‐dioxaoctyl‐1‐oxy]octadecanoates, respectively.