Meteorological elements can affect the environment and cultures differently and may alter the natural development process contributing significantly to climate change. Meteorological variables of the Brazilian Pantanal were studied and used to determine evapotranspiration with fewer variables. It was found that artificial intelligence can substantially improve environmental modeling when alternative prediction techniques are used, resulting in lower project costs and more reliable results. This work tried to find the best combination by comparing machine learning techniques such as artificial neural networks, random forests, and support vector machines. A new model was created that depends on fewer climatic variables compared to the Penman–Monteith method (the standard method for estimating reference evapotranspiration) and can efficiently describe the reference evapotranspiration. Machine learning techniques are highly efficient for modeling environmental systems since they can process large amounts of data and find the best interactions between the parameters involved. In addition, more than 98% accuracy was obtained using fewer variables compared to the standard method when artificial neural networks are utilized.