Prior to construction, small or large hydropower plants undergo feasibility studies, which involve technical, economic, financial, social, and environmental aspects. Technical studies, particularly, include various engineering disciplines. This study sought to conduct a component of technical feasibility studies, focused on design optimization of the turbine-plant capacity size for a run-of-river case study called Mabula Kapi, on Kaombe River, Serenje, Zambia. The study method used computational modelling, simulation, and optimization techniques, and used secondary data from previous site. A prefeasibility study conducted earlier had underestimated the turbine-plant capacity owing to underestimated discharge data, owing to lack of site gauging station. A less accurate discharge estimation method involving transposition from a gauged similar catchment had been used. A later feasibility-level site hydrological study found improved discharge data. Riding on the improved discharge data, this study found the following optimised plant design parameters based on plant design discharge of 6.20 m3/s: Installed capacity of 10.20 MW; Annual energy production of 42 GWh; Capacity factor of 47.1%; 3 x Pelton wheel of 272 rpm speed, 2.1 m diameter, 2-nozzles of diameter 0.16 m each, 21 buckets of 0.58m width each; and 3 x 4 MVA generators of 50Hz, 22-poles, and 11kV.