Preparation Of Pellets Research Articles

One-step synthesis of porous Li4SiO4 pellets by polyvinyl alcohol (PVA) method for CO2 capture

Li4SiO4 has shown great prospects for cyclic high-temperature CO2 capture due to its excellent stability, high capacity and low regeneration temperature. However, dense morphology and attrition problem are the main obstacles that lie in its way to the practical applications. This work, for the first time, proposed a simple polyvinyl alcohol (PVA) technique for the one-step preparation of porous spherical Li4SiO4 pellets. The produced pellets exhibited a uniform diameter distribution of 2.5–3.5 mm and high capacity of 0.320 g CO2/g sorbent. Besides, the PVA method-derived Li4SiO4 pellets also presented excellent cyclic stability in the extended sorption/desorption operations of 30 cycles. It has been indicated that the enhancement of CO2 sorption capacity is ascribed to the formation of abundant pore channels and cavities resulted from the burning out of the well-dispersed polyvinyl alcohol. Moreover, the influence of CO2 presence at desorption stage on the sorbent performance was also investigated. It was indicated that the existence of CO2 at desorption stage caused sintering, which in turn resulted in the reduction of CO2 sorption capacity. In addition, the mechanical property of the pellets was tested. The weight loss was lower than 9 wt% over 2400 rotations in the anti-attrition ability test. In general, the high CO2 sorption capacity and satisfying mechanical property of the Li4SiO4 pellets via PVA route endows this method with promising prospects for the granulation of Li4SiO4 sorbents for realistic CO2 removal.

Different trends for preparation of budesonide pellets with enhanced dissolution rate

The current research attempts different approaches to overcome the poor dissolution of budesonide (a poorly water-soluble drug) from pellet formulations. Various methods such as liqui-pellet (LP) and pellets made of solid dispersion (SDP) were employed and compared to conventional pellets (CP). In SDP method, budesonide:PVP solid dispersion was prepared followed by extrusion-pelletization. Solid dispersion of budesonide-PVP was also layered to the surface of placebo pellets (LSDP). In LP technique, budesonide dispersed in PEG 400 was mixed with Avicel or Avicel:lactose and was extruded-spheronized. Pellets were evaluated for their shape, size, mechanical properties and dissolution rate. The pellets made by LSDP method were significantly harder than CP or PSDP. LP with a loading factor greater than 0.34 was very soft compared to CP and SDP. Pelletization of budesonide SD (PSDP) did not have a tremendous effect on the dissolution enhancement of budesonide compared to CP whilst LSDP showed faster drug release. In conclusion, the layering of budesonide solid dispersion on placebo pellets (LSDP) was the most promising approach for the production of pellets with the highest dissolution rate so that more than 80% of the drug was released within the first 5 min. Also this formulation had proper mechanical properties. This method has the capability to overcome the poor dissolution of budesonide associated with the pellet containing Avicel, and could be employed for the dissolution enhancement of other poorly water-soluble drugs in pellet form.

Optimal Composition of Li Argyrodite with Harmonious Conductivity and Chemical/Electrochemical Stability: Fine-Tuned Via Tandem Particle Swarm Optimization.

A tandem (two‐step) particle swarm optimization (PSO) algorithm is implemented in the argyrodite‐based multidimensional composition space for the discovery of an optimal argyrodite composition, i.e., with the highest ionic conductivity (7.78 mS cm−1). To enhance the industrial adaptability, an elaborate pellet preparation procedure is not used. The optimal composition (Li5.5PS4.5Cl0.89Br0.61) is fine‐tuned to enhance its practical viability by incorporating oxygen in a stepwise manner. The final composition (Li5.5PS4.23O0.27Cl0.89Br0.61), which exhibits an ionic conductivity (σ ion) of 6.70 mS cm−1 and an activation barrier of 0.27 eV, is further characterized by analyzing both its moisture and electrochemical stability. Relative to the other compositions, the exposure of Li5.5PS4.23O0.27Cl0.89Br0.61 to a humid atmosphere results in the least amount of H2S released and a negligible change in structure. The improvement in the interfacial stability between the Li(Ni0.9Co0.05Mn0.05)O2 cathode and Li5.5PS4.23O0.27Cl0.89Br0.61 also results in greater specific capacity during fast charge/discharge. The structural and chemical features of Li5.5PS4.5Cl0.89Br0.61 and Li5.5PS4.23O0.27Cl0.89Br0.61 argyrodites are characterized using synchrotron X‐ray diffraction, Raman spectroscopy, and X‐ray photoelectron spectroscopy. This work presents a novel argyrodite composition with favorably balanced properties while providing broad insights into material discovery methodologies with applications for battery development.

Development and Validation of Chemometric Assisted Fourier Transform Infrared Spectroscopic Method for Simultaneous Determination of Montelukast Sodium and Fexofenadine Hydrochloride in Pharmaceutical Dosage Forms

A new analytical method has been developed for the simultaneous estimation of Montelukast sodium and Fexofenadine hydrochloride in pharmaceutical dosage forms using chemometrically assisted Fourier Transform Infrared (FTIR) Spectroscopy. This method involves preparation of solid pellets of Montelukast sodium and Fexofenadine hydrochloride using Potassium bromide (KBr) with the aid of geometric mixing. The spectra were measured by direct measurement technique using reduced path length in absorbance mode and the equipment was configured to collect spectra at 8cm-1 resolution. The spectra were collected between the ranges of 4000cm-1 to 450cm-1. Infrared spectra of the two drugs showed different functional group peaks with base line correction; from which intense, clear and proportionate peaks at 1704cm-1 and 3421cm-1 corresponding to C=O stretching and O- H group were selected for Montelukast and Fexofenadine respectively for quantitative estimation using chemometrics. Beer-Lambert’s law was obeyed over the concentration range of 5-25 μg/mg for Montelukast and Fexofenadine. The developed method was validated according to International Conference on Harmonisation (ICH) guidelines. The validation parameters - precision, accuracy, limit of quantitation, limit of detection were determined and found to be within the limits. This method was successfully applied for analysis of marketed formulations of Montelukast sodium and Fexofenadine hydrochloride.

Effect of hydrothermal and hydrothermal oxidation pretreatment on the physicochemical properties of biofuel pellet

The effects of hydrothermal pretreatment with and without H2O2 addition on the properties of the resulted biofuel pellets prepared from cotton stalk (CS) and Chinese fir wood sawdust (WS) were mainly studied in the paper. Based on the changes of three main components (hemicellulose, cellulose and lignin) of biomass during the pretreatment process, the relaxation density, compressive strength, heating values (HVs), and combustion characteristics of the resulted pellets were analyzed to evaluate the feasibility of the utilization as biofuel pellets. The results indicate that the hydrothermal pretreatments with and without H2O2 addition are beneficial to the quality of the resulted biofuel pellets. Particularly, the hydrothermal pretreatment with H2O2 addition, namely the hydrothermal oxidation pretreatment can significantly alleviate the pretreatment severity of the high-strength biofuel pellet preparation. H2O2 addition promotes the decomposition of hemicellulose and cellulose during the pretreatment. Compared with CS, WS is more sensitive to the pretreatment, especially hydrothermal oxidation pretreatment. The crystallinity index and the cellulose content of the biomass sample both increase firstly and then decrease with the increasing pretreatment temperature. In the study, the pretreatment temperature for the biofuel pellets with the best mechanical properties is 230 °C for the hydrothermal process and 200 °C for the hydrothermal oxidation process, respectively. The HVs of the resulted biofuel pellet increases with the increasing pretreatment intensity and the suitable pretreatment can improve the combustion characteristics of the resulted biomass. The mechanical properties of the pretreated biofuel pellets were positively correlated with the crystallinity and the content of the cellulose. HVs of WS pellets is higher than CS pellets, with the better mechanical properties. The cellulose is more favorable for the improvement of the combustion properties of the biomass sample than the hemicellulose and lignin. In addition, HVs and the compressive strength of all the biofuel pellets prepared from the pretreated biomasses meet the Sweden Standard (SS18 7120) and the Ministry of Agriculture of China standard (NY/T1878–2010), respectively.

Development of an innovative external (in air) Particle Induced Gamma-ray Emission method for rapid non-destructive determination of isotopic composition of boron in “As received” boron based ceramic neutron absorbers

Boron is an important element in nuclear reactor technology due to its high neutron absorption cross section of 10B isotope. Isotopic composition of B (IC, 10B/11B atom ratio) determination in finished neutron absorbers is a necessity under chemical quality control (CQC). We report an innovative greener method for rapid and non-destructive approach of isotopic composition determination of B in “as received” boron based ceramic neutron absorbers including boron carbides and hexa-borides by external (in air) Particle Induced Gamma-ray Emission (PIGE) using 3.5 MeV proton beam. It involves irradiation of “as received” powder samples wrapped in a thin Mylar film and measurement of prompt gamma rays at 429, 718 and 2125 keV from 10B(p,αγ)7Be, 10B(p,p’γ)10B and 11B(p,p’γ)11B, respectively, using a HPGe detector system. The method was standardized with natural and enriched B4C powders. For validation, the results of isotopic composition obtained from “as received” samples were compared with that obtained from pellet samples using both external and vacuum chamber PIGE methods. IC values obtained for natural to 10B enriched samples (19.8–67 atom % of 10B) are very encouraging with 1–2% and 0.3–0.7% uncertainties from single and replicate sample experiments. The method is truly non-destructive as the samples can be returned back as such after the experiment as they are not radioactive. Compared to existing PIGE method for isotopic composition of B, the developed method keeps promise for wide applications as it is simple, sensitive and rapid and it does not require vacuum, pellet preparation with a binder, exact mass of the sample and beam current measurement.

Preparation, Optimization, and Evaluation of Pellets Containing Mesalamine With Natural Gums For Colon Drug Delivery System

The purpose of the present work was to formulate colon-targeted mesalamine pellets containing gums of Moringa oleifera Lam. (MOG) and Cyamopsis tetragonolobus Taub. (CTG). Formulation of single stimuli mediated release is also difficult to target colon due to variation in the physiological condition, so in present work, pH dependent and enzyme degradation mechanisms are being used to release of drug at the colonic site. Extrusion and spheronization techniques were used for the preparation of pellets. For formulation optimization, factorial design study 32 was used for the selection of the optimized batch. It was found that high ratio of solvent 80:20 and 10% and 7.5% concentration of MOG and CTG respectively produce optimized pellets showed good physical properties and release for F8M and F8C and after coating it showed in vitro release at the colonic condition and in vivo roentgenographic images for targeting. As to say as advantages, spheronization and extrusion method was proved to have economized, whereas natural gums used to control release which added advantage as being as inert and biocompatible. This further formulation scope at industrial scales to reduce side effects of synthetic polymer and make it more biocompatible with the body.

Physicochemical Aspects of Oxidative Consolidation Behavior of Manganese Ore Powders with Various Mn/Fe Mass Ratios for Pellet Preparation.

With the depletion of rich manganese ore resources, plentiful manganese ore powders with various Mn/Fe mass ratios are produced. The physicochemical aspects of oxidative consolidation behavior of manganese ores with various Mn/Fe mass ratios were investigated in this work to determine whether manganese ore powders with high iron content (Fe-Mn ore) can be prepared as high-quality pellets. Physicochemical properties of the pellets were investigated, including cold compression strength (CCS), phase transformation, microstructural evolution, Vickers hardness (HV), porosity, and lattice parameter. CCS testing indicated that the strength of roasted Fe-Mn ore pellets was observably lower than that of pure hematite or manganese ore pellets. Phase and morphology results showed that in Fe-Mn ore pellets, an Mn ferrite phase was generated between hematite and pyrolusite particles. However, newborn Mn ferrites and hematite had an obvious crystal boundary in the crystallographic particles. Moreover, poorly crystallized Mn ferrite particles were evident, along with Mn and Fe element concentration gradients, due to the inadequate diffusion of metal ions. This resulted in poor mechanical properties of the Fe-Mn ore pellets. A temperature over 1275 °C and a roasting time of 15 min is required for the oxidative consolidation of Fe-Mn ores. In such optimized cases, Mn, Fe, O, and Al elements were uniformly distributed in the well-crystallized Mn ferrite grains, which provided favorable mineralogy for the consolidation of Fe-Mn ore powders.

Modulation of Antioxidant Defense in Farmed Rainbow Trout (Oncorhynchus mykiss) Fed with a Diet Supplemented by the Waste Derived from the Supercritical Fluid Extraction of Basil (Ocimum basilicum).

Phytotherapy is based on the use of plants to prevent or treat human and animal diseases. Recently, the use of essential oils and polyphenol-enriched extracts is also rapidly increasing in the aquaculture sector as a means of greater industrial and environmental sustainability. Previous studies assessed the antibacterial and antiparasitic effects of these bioactive compounds on fish. However, studies on the modulation of oxidative stress biomarkers are still scant to date. Thus, in this study, the modulation of antioxidant defense against oxidative stress exerted by fish diets supplemented with a basil supercritical extract (F1-BEO) was assessed in rainbow trout Oncorhynchus mykiss. The F1-BEO extracted with supercritical fluid extraction was added to the commercial feed flour (0.5, 1, 2, 3% w/w) and mixed with fish oil to obtain a suitable compound for pellet preparation. Fish were fed for 30 days. The levels of stress biomarkers such as superoxide dismutase, catalase, glutathione peroxidase, glutathione S-transferase, glutathione reductase, glyoxalase I, glyoxalase II, lactate dehydrogenase, glutathione and malondialdehyde showed a boost in the antioxidant pathway in fish fed with a 0.5% F1-BEO-supplemented diet. Higher F1-BEO supplementation led to a failure of activity of several enzymes and the depletion of glutathione levels. Malondialdehyde concentration suggests a sufficient oxidative stress defense against lipid peroxidation in all experimental groups, except for a 3% F1-BEO-supplemented diet (liver 168.87 ± 38.79 nmol/mg prot; kidney 146.86 ± 23.28 nmol/mg prot), compared to control (liver 127.76 ± 18.15 nmol/mg prot; kidney 98.68 ± 15.65 nmol/mg prot). Our results suggest supplementing F1-BEO in fish diets up to 0.5% to avoid potential oxidative pressure in farmed trout.

Shaping of ZIF-8 upon EPR control for efficient uptake of guest molecules

Shaping of metal-organic frameworks (MOFs) is one of the crucial steps toward their industrial applications. A number of methods for preparation of pellets containing MOF-micro/nanoparticles have been developed up to date; however, the uptake rates of guest molecules by such shaped MOFs and their dependence on preparation procedure were not analyzed in detail. Since optimization of the uptake rates is vital for practical use, in this work we employ spin-probe Electron Paramagnetic Resonance (EPR) to study solvent diffusion into ZIF-8 based pellets. This dedicated approach allows one to selectively monitor the impregnation of ZIF-8 particles embedded in the pellet, and corresponding diffusion coefficients can be obtained for the molecules of interest. Optimization of shaping procedure upon EPR control yields robust pellets with pore filling rates comparable to those for powdered ZIF-8. The proposed methodology yielded highly permeable ZIF-8-based pellets and is promising for future application in shaping of various MOFs. • Quantitative study of guest diffusion from liquid to shaped MOF nanocomposites. • Advanced ‘EPR control’ methodology for optimization of MOF shaping. • Composites with exceptional diffusion properties for separation applications obtained.

Study on the Pyrolysis Behaviors of Urea-Formaldehyde Resin and Rice Straw Mixed Pellets

In order to study the effect of biomass on the pyrolysis characteristics of urea-formaldehyde resin, the thermogravimetric experiments were carried out respectively using urea-formaldehyde resin (UF), rice straw (RS), and their mixed pellets with different proportions. The pyrolysis kinetics analysis was conducted. The results showed that the pyrolysis process of UF resin and mixed pellets could be divided into three stages: the drying and dehydration of the material, the rapid decomposition of volatile matter, and residue decomposition. The reaction order of UF resin and mixed pellets was discussed using the Coats–Redfern method, the activation energy of UF resin was 54.27 kJ/mol, and this value decreased with the addition of rice straw. As the mass ratio of UF resin to rice straw was 3:1, the activation energy achieved the lowest value, which means that the addition of rice straw was beneficial to the pyrolysis process of UF. In the process of pellet preparation, the falling strength and compressive strength of UF resin pellets can be improved by adding an appropriate proportion of rice straw. In this test, the yield of pyrolytic carbon reached the highest value of 23.93%, as the mass ratio of UF resin to rice straw was 3:2. When the mass ratio was 4:1, the highest liquid product yield of 43.21% was achieved.

Study on Using High Temperature Steam Preparation of Ultra Light Foam TPU Pellets Based Supercritical CO2

This paper mainly introduces the technology of supercritical CO2 pretreatment and high temperature steam preparation of super mild foaming TPU pellets. Mainly discusses the supercritical CO2 pretreatment preparation ultra mild foaming TPU pellets process in high temperature steam condition change of TPU micro foaming granule structure and properties of impact. Experimental results show that the high temperature steam temperature, processing time will influence TPU granules of microporous quantity, structure, resulting in pellets of different physical properties.

Critical spectroscopic considerations towards reliable detection of material using terahertz time-domain spectroscopy

Terahertz (THz) time-domain spectroscopic (TDS) and imaging techniques have been recognized as important tools in recent times for non-contact and non-destructive evaluation of materials, such as, food, pharmaceuticals, and other composite materials of interest. The application of the THz-TDS technique in both material identification and quantification, however, involves the analyses of extremely complex response of the constituents of these composite materials. For a spectroscopist, therefore, it is essential to consider certain critical spectroscopic parameters while acquiring the spectroscopic data using THz-TDS. In this work, using sorbic acid, a widely used preservative in processed food as the typical sample for the spectroscopic measurements, we have systematically investigated the impact of all these critical factors on the spectroscopic identification, quantification, and repeatability of the same. We observed that any sample inhomogeneity or clusters formed inside the composite pellet of the sorbic acid mixed with Teflon during pellet preparation can lead to false spectral responses, depending on the choice of spectroscopic probing point on the sample and number of spectroscopic averages. Furthermore, we analyzed the THz-TDS acquisition in frequency-domain and noted the effect of pellet thickness and sample concentration on the resultant frequency bandwidth and absorption features. Besides THz spectroscopists, a clear understanding of these aspects addressed in this present work, will also assist material engineers in selecting optimum concentration and weight towards formulating advanced composites.

The Potential Migrated Mechanism of Water-Soluble Components in Pellets Prepared by Wet Extrusion/Spheronization: Effect of Drying Rate.

At present, there are numerous researches on the migration of components in tablets and granules, however, the investigation in the pharmaceutical literatures concerning the effect of drying rate on the migration of water-soluble components of pellets is limited. Temperature and Relative Humidity (RH) are crucial parameters during the drying process, which is an essential step in the preparation of pellets via wet extrusion/spheronization. To quantify these variables, the water loss percentage of pellets per minute is defined as the drying rate. The study aimed to investigate the influence of drying rate on the migration of water-soluble components in wet pellets and the potential migrated mechanism. The pellets containing tartrazine as a water-soluble model drug and microcrystalline cellulose as a matrix former were prepared by extrusion/spheronization and dried at four different drying temperatures and relative humidity. Afterwards, the extent of migrated tartrazine was assessed regarding appearance, in-vitro dissolution test, Differential Scanning Calorimetry, X-Ray Powder Diffraction, Attenuated total reflectance Fourier transform infrared spectroscopy and Confocal Raman Mapping. Results demonstrated that red spots of tartrazine appeared on the surface of pellets and more than 40% tartrazine were burst released within 5 minutes when pellets were dried at 60°C/RH 10%. When pellets were dried at 40°C/RH 80%, none of these aforementioned phenomena were observed. In conclusion, the faster the drying rate was, the more tartrazine migrated to the exterior of pellets. Adjusting drying temperature and relative humidity appropriately could inhibit the migration of water-soluble components within wet extrusion/spheronization pellets.

Pre-analytical Evaluation on the Preparation of Cell Pellets for Immunohistochemistry Optimization and Validation of Biomarkers

Pre-analytical Evaluation on the Preparation of Cell Pellets for Immunohistochemistry Optimization and Validation of Biomarkers

Preparation, Characterization and Decolorization Performance of Magnetic Adsorbent Pellets Formed by the Utilization of Electric Flocculation Sludge

AbstractA new magnetic adsorbent pellets(MP) was prepared with electric flocculation sludge as raw material by technologies of alkaline impregnation, heat activation and composition with vermiculite. Its decolorization performance for treating methylene blue (MB) dye wastewater is studied, and its structure was analyzed by FTIR, XRD, SEM, XPS, BET and magnetic hysteresis curve. The results showed that the best prepare condition of MP is that impregnation time of 15 % KOH solution is 48 h and a subsequent calcination at 600 °C for 60 min, m(vermiculite)/m(sludge)=1.0. Characterization analysis illustrates that the activated sludge and vermiculite has been successfully composited. And the organic waste in sludge is converted into activated carbon and the iron species are transformed into Fe3O4. It has mesoporous structure and magnetic property and can be separated from the solution by an external magnetic field. In addition, MP was effective on treating MB wastewater, the decoloration is 85 % at the dosage of 10 g L−1 when the contact time is 84 h and the initial concentration of dye is 10 mg L−1 and 20 mg L−1. The sludge utilization technology investigated in this work is a new process which could reduce the emission, protect the environment and yield the useful by‐product.

FORMULATION AND EVALUATION OF BUDESONIDE PELLETS CONTAINING NATURAL GUMS FOR COLON TARGETING

Pellets formulation with natural gums. The formulation of an enzyme as well as pH dependant pellets containing natural gums such as Mornings oleifera gum Lam. (MOG) and Cyamopsis tetragonolobus gum Taub. (CTG) were used for enzyme dependant release and further coating is provided to shows colon-specific delivery. Extrusion and spheronization techniques were used for the preparation of pellets. Pellets of budesonide evaluated for various properties such as flow behavior, physical properties such as sphericity, roundness, aspect ratio, hardness, and friability also investigated in vitro and in vivo targeting in rabbit. Preparation of pellets was done by using extrusion and spheronization method with the use of optimized concentration of gums those were 7.5% and 10% for CTG and MOG respectively and proportion of solvent mixture of water and Isopropyl alcohol in the ratio of 80:20. Pellets of budesonide evaluated for various properties includes flow behavior, physical properties such as sphericity, roundness, aspect ratio, hardness, and friability and found that all properties as per official limit also in vitro release study found that release of uncoated pellets in a sustained manner in 0.1N HCl for 2h due to swelling of natural gum, therefore further step of the coating was done in fluidized bed coater to prevent the release of drug in the upper part of GIT and after coating found that In vitro release of drug at the colonic environment and it confirmed with in vivo investigation in rabbit with X-ray examination of targeting and found that pellets reach at colonic part without disintegration. The use of natural gums for preparation of pellets in optimized concentration and wetting agent produce a formulation with all required chemical and physical properties and it gives effective in vitro release and also shows In vivo targeting in rabbit and due to use of natural gum for preparation of pellets also reduce some problems of metabolism of synthetic excipients.

Preparation of CaO-containing carbon pellets from coking coal and calcium oxide: Effects of temperature, pore distribution and carbon structure on compressive strength in pyrolysis furnace

Preparation of CaO-containing carbon pellets from coking coal and calcium oxide: Effects of temperature, pore distribution and carbon structure on compressive strength in pyrolysis furnace

Investigation into liquisolid system processability based on the SeDeM Expert System approach

Liquisolid systems are emerging formulation approach for poorly soluble drugs, based on adsorption/absorption of drug dispersion and obtaining free-flowing powder with good compressibility. SeDeM Expert System represents a powder processability evaluation method. It may provide additional insight into liquisolid systems critical quality attributes, but the contribution of this approach remains to be explored. The aims of this study were: pellet preparation by combination of liquisolid technology and water granulation/extrusion, evaluation of liquisolid based systems (pellets/admixtures) and investigation into the applicability of SeDeM Expert System in liquisolid systems characterization. Pellets/admixtures were prepared with microcrystalline cellulose as carrier and crospovidone/silicon dioxide as coating agent. Ibuprofen solution in polyethylene glycol 400 was used as liquid phase. After comprehensive sample characterization, experimentally obtained parameters were mathematically transformed and evaluated in the SeDeM Expert System framework.Pellets exhibited low aspect ratio and excellent flowability, despite liquid load up to 52.2%. The investigated liquisolid admixtures exhibited good flowability and faster drug dissolution than pellets. Single pellet crushing test results exhibited strong correlation with compact indentation hardness and may be used as indentation hardness predictor. SeDeM Expert System provides useful insight into liquisolid system processability and comparative evaluation and it may facilitate final solid dosage form development.

Micronization and coating of bioflavonoids extracted from Citrus sinensis L. peels to preparation of sustained release pellets using supercritical technique

Bioflavonoids such as hesperidin and hesperetin as anticancer and antioxidant agents are widely used in the formulation of many herbal drugs. Recently, promising evidence for the prevention and treatment of COVID 19 using these compounds has been reported. Unfortunately, these compounds are often insoluble in aqueous media and have low stability in gastric acid environment. These factors reduced the bioavailability of related oral dosage forms in digestive system. Reduction of particle size and controlled release delivery system can decline the mentioned problems. In the presented research, extraction of bioflavonoids from Citrus sinensis L. (sweet orange) peels was performed using supercritical carbon dioxide. Experimental central composite design was employed for determination of optimal conditions. Qualification analysis was performed using LC–MS, and hesperidin and hesperetin were identified in herbal extract. Micronization and coating of the flavonoids nanoparticles on sugar spheres have been performed using an inhouse developed supercritical technique. Characterization of coated nanoparticles was done using FESEM and ImageJ software. The in vitro antioxidant activity of coated samples was investigated by ferrous ion chelating activity. According to the extraction results, concentration of ethanol as organic co-solvent has the greatest effect on the extraction yield. Analysis of FESEM images illustrated that nanoparticles of extract components with particle size distribution of 5–100 nm were coated successfully. The solubility and antioxidant activity of nanoparticles in aqueous media have increased significantly compared to original form. This process led to increasing dissolution rate and improving the oral bioavailability of flavonoids.Graphical abstract