Background Healthscope Pathology offers a warfarin dosing service in Victoria and Queensland with a large number of patients. Very high INR results will inevitably occur and we routinely recommend hospital presentation for patients with INR > 9. Discrepant results compared to the subsequent hospital INR test are sometimes seen. Aims To identify the incidence of INR > 9 in Healthscope Pathology across Victoria and Queensland, the factors contributing to discrepant results, the incidence of bleeding in patients with INR>9 and the incidence of repeat INRs before therapeutic intervention. Methods Retrospective follow-up phone calls to patients and health care providers for all episodes of INR>9 from 01/07/ 2013 to 09/10/2013. Results INR>9 was detected in 130 episodes out of 100,321 INRs done (0.13%). Among 130 episodes, there was a discrepant result in 10 cases, a difficult venepuncture was documented in three cases, five cases were collected in paediatric tubes implying a difficult venepuncture, transfer of underfilled adult citrate tube to paediatric tube occurred in one case and the reason was unknown in one case. Fourteen out of 130 had a bleeding episode. In 41 episodes, vitamin K was given without rechecking INR first, among them only two were actively bleeding. Discussion In a busy dosing service, our rates of very high INR are very low. Even in very high INR, bleeding complications were uncommon. Problems at the point of collection are the major cause for discrepant INR results. Education of phlebotomists, doctors and nurses about the importance of proper collection technique will improve quality of INR result. Repeating INR is also crucial before instituting therapeutic measures. Healthscope Pathology offers a warfarin dosing service in Victoria and Queensland with a large number of patients. Very high INR results will inevitably occur and we routinely recommend hospital presentation for patients with INR > 9. Discrepant results compared to the subsequent hospital INR test are sometimes seen. To identify the incidence of INR > 9 in Healthscope Pathology across Victoria and Queensland, the factors contributing to discrepant results, the incidence of bleeding in patients with INR>9 and the incidence of repeat INRs before therapeutic intervention. Retrospective follow-up phone calls to patients and health care providers for all episodes of INR>9 from 01/07/ 2013 to 09/10/2013. INR>9 was detected in 130 episodes out of 100,321 INRs done (0.13%). Among 130 episodes, there was a discrepant result in 10 cases, a difficult venepuncture was documented in three cases, five cases were collected in paediatric tubes implying a difficult venepuncture, transfer of underfilled adult citrate tube to paediatric tube occurred in one case and the reason was unknown in one case. Fourteen out of 130 had a bleeding episode. In 41 episodes, vitamin K was given without rechecking INR first, among them only two were actively bleeding. In a busy dosing service, our rates of very high INR are very low. Even in very high INR, bleeding complications were uncommon. Problems at the point of collection are the major cause for discrepant INR results. Education of phlebotomists, doctors and nurses about the importance of proper collection technique will improve quality of INR result. Repeating INR is also crucial before instituting therapeutic measures.