Pediatric Sleep Studies Research Articles

Pediatric sleep studies

With the increased awareness of the morbidity associated with snoring, polysomnography (PSG) is becoming more prevalent. Many national organizations have recently published clinical guidelines to facilitate decision-making for children with disrupted breathing patterns. This review will discuss these clinical guidelines and describe the rationale behind them. It will also touch on the limitations of PSG. The common theme for the clinical guidelines is that PSG is being underutilized. Not only is obstructive sleep apnea (OSA) associated with behavioral, cognitive, and cardiovascular morbidity, but primary snoring is also not always benign. The interpretation of the PSG is influenced by multiple variables: filter settings, sensors utilized, and how the respiratory events are tabulated. To diagnose OSA, one requires overnight PSG. Multiple guidelines have been published to facilitate decision-making. Many questions remain unanswered and future research as well as PSG standardization will further clarify the role of PSG in the evaluation and treatment of disrupted breathing patterns in children.

Investigation of Pulse Transit Time Characteristics During Single and Recurrent Obstructive Respiratory Events

Conventional overnight polysomnography (PSG) used to determine the respiratory behaviour during sleep can be a complex and expensive procedure. Pulse transit time analysis (PTT) has shown potential to detect obstructive apnoeic and hypopnoeic events (OE) in adults. Due to abnormalities in central ventilatory control, recurring OE may occur. This study was undertaken to determine the potential of PTT to differentiate responses during upper airway obstruction in the paediatric population. This preliminary study included 11 children (10 male; aged 7.5 +/- 3.8 year) recruited to investigate PTT trend during single and recurrent OE. PTT measurements were evaluated against the corresponding PSG results pre-scored by two blinded observers. A total of 110 valid OE (47 single and 63 recurrent) were observed during these PSG studies. There were distinct PTT responses observed for these two types of OE with respect to those of tidal breathing (P < 0.05). For the tidal breathing events, the mean absolute standard deviation (SD) and maximal percentage (%) decrease (MAX) were 7.71 ms and 3.88% respectively. For the recurrent OE, the absolute SD, SD (%) and MAX were 52.21 ms, 8.52% and 55.08% accordingly while for the single OE, the absolute SD, SD (%) and MAX were 12.23 ms, 5.27% and 13.56% respectively. The findings herein can suggest that PTT can be a valuable clinical tool in the paediatric respiratory sleep studies.

Parental Symptom Report and Periodic Limb Movements of Sleep in Children

To examine the prevalence of raised periodic limb movements of sleep (PLMS) index in children referred for polysomnography (PSG) and whether parental report of symptoms correlates with objective measurement during PSG. Records of children undergoing PSG from January 2006 to July 2006 were retrospectively reviewed. At their initial sleep clinic visit, parents had been asked whether their child was restless or moved their legs excessively during sleep. Their response to these questions was compared to the child's PLMS index (number of periodic limb movements per hour) during a full PSG. PLMS were scored according to internationally accepted criteria. Data were examined for 101 children (60 male) with mean age 6.5 years (range 1.2 to 17.6 years). Excessive leg movements were reported by parents in 50% and restlessness in 73%. A raised PLMS index (defined as > or = 5 per hour) was noted in 10 cases (prevalence 10%). Asking parents about whether their child kicks their legs excessively in sleep had sensitivity 50%, specificity 51%, positive predictive value (PPV) 10%, negative predictive value (NPV) 90% and positive likelihood ratio (LR+) 1.02 when compared to objective analysis. Asking parents about whether their child is restless in sleep had sensitivity 70%, specificity 26%, PPV 9%, NPV 89% and LR+ 0.95. Asking parents about their child's symptoms is not an accurate predictor of raised PLMS index. We recommend that leg electromyography be used in all pediatric sleep studies to record PLMS.

Pulse transit time in paediatric respiratory sleep studies

Pulse transit time (PTT) has emerged over the recent decades as a simple and non-invasive measure to quantify inspiratory effort changes in adults with sleep disordered breathing (SDB). Hence, this shows promise to be an effective screening tool for the paediatrics. However, little is known about its utility and suitability until recent studies has been provided quantitative knowledge about its relevance in clinical investigations. In this review, the origins, normative values, current uses and technical issues in its application to paediatric monitoring, particularly during sleep are discussed. Preliminary findings from these investigations suggest favourably its potential as an important element to screen SDB in the children population.

Use of Pulse Transit Time To Distinguish Respiratory Events From Tidal Breathing in Sleeping Children

Currently, esophageal pressure monitoring is the "gold standard" measure for inspiratory efforts, but its invasive nature necessitates a better tolerated and noninvasive method to be used on children. Pulse transit time (PTT) has demonstrated its potential as a noninvasive surrogate marker for inspiratory efforts. The principle velocity determinant of PTT is the change in stiffness of the arterial wall and is inversely correlated to BP. Moreover, PTT has been shown to identify changes in inspiratory effort via the BP fluctuations induced by negative pleural pressure swings. In this study, the capability of PTT to classify respiratory events during sleep as either central or obstructive in nature was investigated. PTT measure was used in adjunct to routine overnight polysomnographic studies performed on 33 children (26 boys and 7 girls; mean +/- SD age, 6.7 +/- 3.9 years). The accuracy of PTT measurements was then evaluated against scored corresponding respiratory events in the polysomnography recordings. Three hundred thirty-four valid respiratory events occurred and were analyzed. One hundred twelve obstructive events (OEs) showed a decrease in mean PTT over a 10-sample window that had a probability of being correctly ranked below the baseline PTT during tidal breathing of 0.92 (p < 0.005); 222 central events (CEs) showed a decrease in the variance of PTT over a 10-sample window that had a probability of being ranked below the baseline PTT of 0.94 (p < 0.005). This indicates that, at a sensitivity of 0.90, OEs can be detected with a specificity of 0.82 and CEs can be detected with a specificity of 0.80. PTT is able to categorize CEs and OEs accordingly in the absence of motion artifacts, including hypopneas. Hence, PTT shows promise to differentiate respiratory events accordingly and can be an important diagnostic tool in pediatric respiratory sleep studies.