Aims & Objectives: Drug errors cause considerable harm to patients. A recent spot-check on our Paediatric Critical Care Unit (PCCU) revealed a culture of under-reporting errors. By increasing the reporting of errors and implementing change following analysis of the type of errors that occurred, we aimed to reduce drug errors in the PCCU by 30% by February 2020. Methods: Using Quality Improvement (QI) methodology we created a driver diagram and process map using members of the multidisciplinary team to better understand the main areas where drug errors could occur. “Plan, Do, Study, Act” (PDSA) cycles were used to develop and improve the reporting tool, frequency and timing of use. Data collected on a weekly basis included: number of errors per active drug prescription; staffing acuity and monthly Datixes. Change ideas included: reintroduction of a prescribing zone and “Dual Prescribing” followed by PDSA cycles to evaluate them. Results: An increase in errors was initially noted, with an average of 1.1 errors per active prescription. By December 2019 this had decreased to an average of 0.28 errors per prescription. Feedback revealed that “Dual Prescribing” of all new prescriptions by the nurse in charge was too time consuming, but was tolerated by the bedside nurse for their individual patient. In times of busyness it was felt that this would be difficult. Conclusions: Reducing drug errors through the use of QI methodology is possible. Further testing and refining of the current change ideas should result in an improved system of prescribing within the PCCU.