Pedalium Research Articles

Green Synthesis, Spectroscopic, Electrochemical and Antifungal Characteristics of Ni-doped CeO2 Nanoparticles

This study intended to synthesize Nickel-doped Cerium oxide (Ni-CeO2 NPs) nanoparticles using Pedalium Murex leaf extract. X-ray diffraction (XRD) was used to investigate the structure of the Ni-CeO2 NPs. The XRD measurements showed that the Ni-CeO2 NPs crystallized into the face-centered cubic system. The Ni(1%)-CeO2 and Ni(3%)-CeO2 NP’s crystallite sizes were between 47[Formula: see text]nm and 59[Formula: see text]nm. FTIR and Raman spectral studies were conducted to investigate the sample’s atomic vibrations and chemical bonding. Energy-dispersive X-ray study and field-emission scanning electron microscopy were performed to examine the surface texture and chemical assembly of the Ni-CeO2 NPs. UV–Vis DRS spectrum study was performed to ascertain the reflectance characteristics and bandgap of Ni-CeO2 NPs. The Ni(1%)-CeO2 and Ni(3%)-CeO2 NPs were found to have bandgaps of 2.73[Formula: see text]eV and 2.82[Formula: see text]eV, respectively. Electrochemical impedance spectroscopy and cyclic voltammetry were employed to explore the electrochemical nature of Ni-CeO2 NPs and their capacitive properties at various scanning rates. Using the agar well-diffusion technique, the antifungal activities of Ni-CeO2 NPs were assessed. The experimental findings illustrate the utility of Ni-CeO2 NPs for supercapacitor electrode material and healthcare applications.

Biosynthesis, Structural, Spectroscopic, Photoluminescence, and Antifungal Activity of Ni-doped CeO2 Nanoparticles.

Pedalium Murex leaf extract was used in this study to create Nickel-doped Cerium oxide (Ni-CeO2) nanoparticles at 3mol% and 5mol% molar concentrations. The biosynthesized process was applied for the fabrication of Ni-CeO2 NPs. The X-ray diffraction method was used to identify their crystal structure. The XRD measurements showed that the Ni-CeO2 NPs crystallized into the face-centred cubic system. Fourier transform infrared spectral study was applied to explore the molecular vibrations and chemical bonding. The surface texture and chemical ingredients of Ni-CeO2 NPs were studied using field-emission scanning electron microscopy and energy-dispersive X-ray analysis. The EDX mapping spectra illustrate the uniform dispersal of Ce, Ni, and O atoms over the sample's surface. X-ray photoelectron spectroscopy (XPS) was conducted to confirm the chemical state of the Ni-CeO2 NPs. UV-Vis spectrum study was performed to ascertain the photon absorption, bandgap, and Urbach edge of Ni-CeO2 NPs. Photoluminescence (PL) research has been used to study the light-emitting characteristic of Ni-CeO2 NPs. The emissive intensity transition corresponding to Ni-CeO2 NPs was found to increase with the dopant level. The CIE 1931 chromaticity map was plotted to find the aptness of the samples for optical uses.The antifungal ability of Ni-CeO2 NPs was evaluated against the fungi candida albicans and candida krusein with the agar well-diffusion process. The fungicidal activity of the 3mol% Ni doped CeO2 nanoparticles has shown a maximum zone of inhibition. The experimental findings illustrate the utility of Ni-CeO2 NPs for optical and antifungal applications.

<I>Pedalium murex L.</I> (Pedaliaceae) - a New Report from Midnapore to the State of West Bengal

<I>Pedalium murex L.</I> (Pedaliaceae) - a New Report from Midnapore to the State of West Bengal

High-voltage aqueous electrolyte–based supercapacitor using biocarbon derived from Pedalium murex waste with commercial-level areal mass loading

High-voltage aqueous electrolyte–based supercapacitor using biocarbon derived from Pedalium murex waste with commercial-level areal mass loading

Formulation and evaluation of paracetamol suspension by using natural suspending agent extracted from Pedalium murex leaves

Formulation and evaluation of paracetamol suspension by using natural suspending agent extracted from Pedalium murex leaves

Ecofriendly bio-synthesis and spectral characterization of copper nanoparticles using fruit extract of Pedalium murex L.: in vitro evaluation of antimicrobial, antioxidant and anticancer activities on human lung cancer A549 cell line

ABSTRACT The usage of copper nanoparticles (CuNPs) is now acknowledged as a promising therapeutic agent in the detection and treatment of cancer. This study aimed to develop a sustainable method for synthesizing CuNPs using Pedalium murex L. and characterization by SEM, FTIR, XRD & UV-Vis methods. The produced CuNPs were primarily spherical and varied in shape, and the average dimension ranged between 20 and 50 nm. The aqueous fruit juice of Pedalium murex L. contained biomolecules that serve as capping and reducing agents for the production of CuNPs, according to the findings of FTIR analysis. Various assays were used to determine the fruit extract’s in vitro antioxidant activity. CuNPs exhibited dose-dependent cytotoxicity and apoptosis promotion in A549 cells. The findings demonstrated that biosynthesized CuNPs using Pedalium murex L. fruit juice have anti-cancer properties and can be used in lung cancer treatment, particularly for early-stage intervention.

Diet-induced animal model anti-obesity, phytochemical profiling, and in silico analysis of culinary plant gokhru (Pedalium murex L.) mucilage

Plant-based diets (PBDs) are renowned for managing and developing bioactive chemical inhibitors to combat obesity, a well-known global public health concern. There are currently no published research studies examining the effects of food plant mucilage dietary supplements on animal models of obesity induced by high-fat diets (HFD). The present research investigated the anti-obesity properties of the culinary plant Pedalium murex L. mucilage (PMM) in obese albino male rats models fed HFD. PMM's HR-LCMS phytochemical profiling and in silico evaluation of anti-obesity and drug-likeness using Schrodinger’s Glide, QikProp, and GROMACS modules were also investigated. In vivo, anti-obesity model animal rat’s daily dietary intake, common blood biochemical parameters, and histological examination of the liver and kidney tissues for the development of macrovesicular and microvesicular steatosis were all performed. Among the 46 Phytochemicals profiled, 7(14)-Bisabolene-2, 3, 10,11tetrol, Moschamine, and N-Feruloyltyramine show prominent anti-obesity activity and drug-like characteristics in silico. Rats given PMM showed significantly lower serum levels of total cholesterol (TC), low-density lipoprotein (LDL), and triglycerides (TGs), increased levels of high-density lipoprotein (HDL), as well as macro-and microvesicular steatosis, lobular inflammation of the liver and kidney tissues. This suggests that PMM is an effective natural anti-obesity therapeutic ingredient or dietary supplement with a high concentration of anti-obesity phytochemicals that mainly satisfies the needs for such natural anti-obesity medicine or a supplement. Communicated by Ramaswamy H. Sarma

Biosynthesis of ZnFe2O4@Ag hybrid nanocomposites for degradation of 2,4-Dichlorophenoxyacetic acid herbicide

This work demonstrates recent advancements in the phytosynthetic and environmentally friendly method of preparing ZnFe2O4 and ZnFe2O4@Ag hybrid nanocomposites using Pedalium murex L leaf extract as a stabilizing and reducing agent. The synthesized nanocomposite was characterized with UV–vis, FTIR, TGA/DSC, XRD, FE-SEM, and EDX to investigate the electronic as well as morphological properties. Moreover, the photocatalytic behaviour of ZnFe2O4 and ZnFe2O4@Ag hybrid nanocomposites was evaluated with a breakdown of 2,4-dichlorophenoxyacetic acid (2,4-DPA) by exposing to UV–Vis light. The results obtained suggest that ZnFe2O4@Ag hybrid nanocomposite exhibited photocatalytic activity for the degradation of 2,4-DPA by approximately 94% in 60 min compared to ZnFe2O4. The hybrid nanostructure of ZnFe2O4@Ag significantly promoted charge transfer and prevented electron and hole recombination resulting in the enhancement of photocatalytic activity. Furthermore, ZnFe2O4@Ag nanocomposite showed the fair recyclable capacity for up to five catalytic cycles with an acceptable degradation percentage of 2,4-DPA. The findings of this study identify efficient charge transfer factor as a major contributor to the catalytic activity, with promising possibilities for the design of environmental remediation nanocomposite for harmful contaminants.

Biofabrication of nickel oxide nanoparticles from Pedalium Murex leaf extract: A promising approach for biomedical and environmental applications

Nanotechnology has become a rapidly progressing field in materials science due to the biosynthesis of nanoparticles (NPs) that has found numerous biomedical applications. The goal of this study was to use the methanolic leaf extract of Pedalium murex (MEPM) as a capping and bio-fabrication agent at room-temperature for the green biosynthesis of nickel metal nanoparticles (NiONPs). Pedalium murex has been widely used in complementary medicine. Characterization of the MEPM stabilized NiONPs was analyzed by UV–Vis, X-ray diffraction spectroscopy (XRD), Fourier-transform infrared spectroscopy (FT-IR), and scanning electron microscopy (SEM). Furthermore, the antioxidant and antibacterial properties of MEPM and NiONPs were studied. Biosynthesized NiONPs showed a lower total flavonoid and phenolic content than MEPM. Compared to MEPM, NiONPs (68%) showed superior antioxidant activity. The antimicrobial activity of the green synthesized NiONPs against Bacillus cereus, Streptococcus pyogenes, Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae and S. typhi was significantly higher than that of MEPM. Congo red (CR) and Rhodamine-B (Rh-B) dye degradation were used to evaluate the catalytic activity of the biosynthesized NPs. Maximum degradation efficiencies of 83% and 85% were observed for the CR and RhB dyes, respectively, both of which followed first-order reaction kinetics. Generally, the biosynthesized NiONPs fabricated by MEPM showed excellent antioxidant and antibacterial efficacy. Therefore, the NiONPs is an eco-friendly, cost-effective, simple, and a promising approach for many biological applications.

Preliminary phytochemical, physico-chemical & HPTLC analysis of aanai nerunjil kudineer

The Siddha system is an Ancient and Indigineous system of medicine followed predominantly by the people of South India. It comprises of various modes of treatment for a number of diseases. Aanai Nerunjil kudineer is a herbal drug which is indicated for many common Genito-Urinary tract disorders in the textbook, Gunapadam Mooligai vaguppu (Siddha Materia Medica). Aanai Nerunjil (Pedalium murex) plants and Seeds of Kothumalli (Coriandrum sativum) were collected from the locality of Tuticorin, Tamilnadu and were dried under sunshade and ground into coarse powder and then mixed in a 4:1 ratio respectively. Aqueous alcoholic Extracts of the powder was made by Hot soxhlet method. Alkaloids, Terpenoids, Glycosides were found to be present in preliminary phytochemical investigation. The Physico-chemical analysis revealed that the LOD at 1050c was 8.4%, Total Ash value as 10.84%, acid insoluble ash as 0.85%, water soluble ash as 3.25%, sulphated ash as 14.56%, pH of 4% aqueous solution as 8.08, volatile oil content of 0.5%.HPTLC was performed in aqueous alcoholic extract at 254nm, 366nm & 575nm and the chromatograms were recorded. The Rf peak values were found to be significant which can further assist in identification of the individual compounds. Keywords: siddha medicine, pedalium murex, coriandrum sativum, preliminary phytochemical, physico chemical, HPTLC Analysis Introduction The World Health Organization has estimated that about 80% of earth's inhabitants rely on traditional medicine for their primary health care needs that primarily involves the use of plant extracts or their active components.1 Over 248, 000 species of higher plants have been identified and from these 12, 000 plants are known to have medicinal properties.2The importance of plants is known to us well. The plant kingdom is a treasure house of potential drugs and in the recent years there has been an increasing awareness about the importance of medicinal plants[3].

Extraction and Physico-Mechanical and Thermal Characterization of a Novel Green Bio-Plasticizer from Pedalium murex Plant Biomass for Biofilm Application

Extraction and Physico-Mechanical and Thermal Characterization of a Novel Green Bio-Plasticizer from Pedalium murex Plant Biomass for Biofilm Application

Effective microwave assisted synthesis of CoFe2O4@TiO2@rGO ternary nanocomposites for the synergic sonophotocatalytic degradation of tetracycline and c antibiotics

A ternary nanocomposite CoFe2O4@TiO2@rGO (CoTG) was prepared by environmentally benign and cost-efficient green microwave and sol-gel methods. The leaf extract of Pedalium murex plant was used as a reducing and stabilising agent during the microwave synthesis. The ternary nanocomposite is effectively investigated for sonophotocatalytic degradation of tetracycline and ciprofloxacin antibiotics in the presence of visible light and ultrasonic irradiation. The XRD, FTIR and EDX results corroborate the pure phase of CoFe2O4/TiO2/rGO nanocomposite. The spherical TiO2 and CoFe2O4 nanoparticles are well impregnated into the sheets of rGO as evidenced by TEM analysis. The CoFe2O4/TiO2/rGO nanocomposite effective visible light active bandgap is elucidated by DRS analysis. The CoTG nanocomposite shows a high efficiency of 92% and 84% degradation of Tetracycline (20 mg/L) and Ciprofloxacin (10 mg/L) within a short duration during the sonophotocatalytic degradation process. As stated by the kinetics analysis, the degrading process complies a pseudo-first order reaction with the following rate constant: Ksonophotocatalytic > Kphotocatalytic > Ksonocatalytic. CIP and TC antibiotics both achieve the high synergic value of 1.375 during degradation. Due to the continuous production of OH and O2 radicals, free electrons actively participate in the degradation process, thereby creating synergistic effects. Using ternary CoTG nanocomposite, this study demonstrates an enhanced approach to antibiotics’ degradation toward environmental remediation and protection.

A Study on Developmental Toxicity and Behavioral Safety Using Ethanolic Extract of Pedalium murex L. on Zebrafish Embryos

Many are returning to nature from synthetics in search of safety and stability. Herbs are the sole way to combat synthetic drugs' side effects. Toxicity testing may reveal herb hazards, allowing for the prevention of potentially hazardous side effects. Due to the short time needed for investigations, transparency of embryos, short life cycle, high fertility, and similarity of genetic data, the zebrafish embryotoxicity model is at the forefront of toxicology research. The zebrafish animal model is utilised to enhance aquaculture output and biomedicine. Pedalium murex L. is a key traditional medicinal herb. Future drug development reference studies must evaluate toxicity factors. In this study, we tested the ethanolic extract of P. murex (EEPM) on zebrafish embryos up to 72 hours post-fertilisation (hpf). This is the first study of EEPM on zebrafish embryos. At 24 hpf, embryos grow and move normally. With more plant extract, the heart rate was normal at 48 hpf. At 72 hpf, no afflicted embryos had a tail, eye, head, or heart development. This is the first study to investigate the visible impact of EEPM on zebrafish embryos. The present research found that the higher dose of EEPM significantly raised the heartbeat in the embryo of zebrafish. It happened due to the small oedema in the heart muscle. Besides these, there is no other damage to the muscle. As a result, the current investigation demonstrated that the prospective use of P. murex is risk-free and has the potential to be used for the development of novel drugs in a clinical trial.

Acute and Repeated Dose 28-Day Oral Toxicity Study of the Aqueous Extracts from the Leafy Stem and Fruit of Pedalium murex D.Royen EX.L in Wistar Rats.

Pedalium murex (P. murex) is used in folk medicine for treatment of male infertility. However, scientific data on its safety are limited. This study was carried out to assess the acute and repeated dose 28-day oral toxicity of the aqueous extracts from P. murex leafy stem and fruit in Wistar rats. The acute toxicity test was performed according to the line 423 of the Organization for Economic Cooperation and Development (OECD) guidelines. The rats were randomly divided into three groups (n = 3). The control group received distilled water, while the experimental groups were given at a single dose, 5000 mg/kg of each extract. The repeated dose 28-day oral toxicity was performed according to the line 407 of the OECD guidelines. 35 rats divided into 7 groups of 5 male rats each were daily treated for 28 days with each extract at 200 mg/kg, 400 mg/kg, and 800 mg/kg, respectively. The in-life parameters were recorded during the follow-up. At the end of this study, organ weights, hematology, biochemistry, and histology parameters were analyzed. In the acute oral toxicity test, there was no morbidity or mortality related to the treatments. Both extracts belong therefore to category 5 of the globally harmonized system (GHS) of classification. In the repeated dose 28-day oral toxicity test, both extracts did not alter animal's behavior. However, both extract administration led to proteinuria and renal damages. P. murex leafy stem and fruit aqueous extracts exhibited potential nephrotoxicity. Therefore, care should be taken when they are used over an extended period.

Neuroprotective Effect of Ethanolic Extract of Pedalium murex Linn Leaf in 3-Nitropropionic acid Induced Neurodegeneration

Neuroprotective Effect of Ethanolic Extract of Pedalium murex Linn Leaf in 3-Nitropropionic acid Induced Neurodegeneration

Neuroprotective Effect of Ethanolic Extract of Pedalium murex Linn Leaf in 3-Nitropropionic acid Induced Neurodegeneration

Neuroprotective Effect of Ethanolic Extract of Pedalium murex Linn Leaf in 3-Nitropropionic acid Induced Neurodegeneration

Bactericidal-like activity of methanolic leaves extract of pedalium murex

Bactericidal-like activity of methanolic leaves extract of pedalium murex

Review Article A Comprehensive Review: Development on Phyto-pharmacological Studies of Pedalium murex Linn

In the present review, the research progress of the plant Pedalium murex Linn. has been rationalized in the diverse aspects of studies like its cytomorphology, traditional uses, pharmacognostic studies, and phytochemical studies, biological studies, etc. In the modern era, the consumption of herbal medicines has amplified greatly due to their effective results. Therefore, it is essential to develop herbal medicine like more effective drugs with fewer side effects and determine their efficacy. Pedalium murex is one of the traditional medicinal plants that belong to the family, Pedaliaceae, a magical source of many bioactive compounds like terpenoids, lipids, phenolic acids, steroids, flavonoids, tannins, saponins, vitamins, carbohydrates, reducing sugars, proteins, etc. with a variety of biological activities viz. antioxidant, antihyperlipidemic, neuroprotective, nephroprotective, anti-nephrolithiasis, aphrodisiac, anti-inflammatory, antipyretic, antimicrobial antiproliferative, insecticidal, hepatoprotective, antidiabetic, etc. It is widely distributed in tropical Africa, Sri Lanka, India, Pakistan, and Mexico. In this review, all the scientific findings of Pedalium murex are explored from Google Scholar, Google web, Science Direct, Pubmed, Medicinal and Aromatic Plants Abstracts (MAPA), etc. This review will be very fruitful for those scientists who are doing or planning to do research work on this plant.

Novel antimicrobial finishing of organic cotton fabrics using nano-emulsions derived from Karanja and Gokhru plants

Plant-based antimicrobial finishing of textiles is comparable in efficacy, can replace synthetic antimicrobial agents, and is environmentally safe and effective. However, developing durable antimicrobial finishes on cotton-based textiles is a challenge. This research reports the development and characterization of nano-emulsions obtained from Karanja [ Milletia pinnata] and Gokhru [ Pedalium murex Linn] plants. The nano-emulsions were produced using Milletia pinnata, coconut oil, and curry leaves (nano-emulsion 1) and Pedalium murex, coconut oil, and curry leaves (nano-emulsion 2). The nano-emulsions were characterized for their thermal stability, particle size, pH, and percentage add-on. Two different oils, with surfactant (polysorbate) ratios [1:1 and 1:2], were finished on organic cotton fabrics using a batch process. Scanning electron microscopy images were evaluated to determine the surface morphology of the finished fabrics, and gas chromatography-mass spectrometry images of nano-emulsions were studied to determine the specific chemical constituents of nano-emulsions 1 and 2. The finished fabrics were evaluated for their antimicrobial resistance using various gram-positive bacteria [ Staphylococcus aureus, Staphylococcus epidermidis], which are found on human skin and cause nosocomial infections, gram-negative bacteria [ Escherichia coli and Klebsiella pneumoniae], which cause urinary tract infections, and fungi [ Aspergillus niger]. The antimicrobial resistance was in the range of 98.62–99.87%, even after 10 washes, indicating that the finishes were effective and durable. The finished and unfinished fabrics were also evaluated for their performance properties, tensile strength, and moisture vapor transmission rate, and the results indicated good durability and comfort characteristics. Our findings highlight the potential of plant-based antimicrobial agents for durable finishing of cotton textiles with antimicrobial properties, thus preventing the spread of infections.

Potential Use of Medicinal Plant Gokhru: A Review

Currently, herbal medicines have attained great preferences over chemical drug based medicines due to more economic, lesser side effects on health and easy availability. Gokhru is an important medicinal plant which is being used in preparation of formulations in pharmaceutical companies. Gokhru is of two types i.e. Chhota gokhru (Tribulus terrestris) and Bada Gokhru (Pedalium murex L.). This review was conducted to study about these two important medicinal plants and their uses in curing various diseases. Further studies can be conducted on these two medicinal plant species by identifying their potential to develop into a new drug or to be used as a medicinal plant in curing various diseases. This review article mainly deals with botanical description, geographical distribution, ecology, environmental conditions required for growth, cultivation, utilization as a source of medicine and future prospect of Tribulus terrestris and Pedalium murex L.