Abstract
The present investigation is undertaken to evaluate the comparative anti gout activity of the ethanolic (EEPM) and methanolic (MEPM) seed extracts of Pedalium murex. The Invitro anti gout arthritic activity of the plant extracts was evaluated using xanthine oxidase and protease enzyme inhibition as well as membrane stabilization using well established protocols. In silico anti arthritic activity was studied using molecular docking analysis from 10 GCMS derived compounds with that of the immunuo stimulatory proteins TLR2, TLR4, MMP2 and MMP7 to find out the suitable antagonistic ligand for these proteins. In the present investigation the EEPM extract showed better anti gout activity comparable to the MEPM extract in terms of xanthine oxidase and protease enzyme inhibition as well as membrane stabilization. The anti out arthritic activity of EEPM was comparable to the positive control used in the present study. In the In silico studies among the 10 compounds docked for the proteins TLR2, TLR4, MMP2 and MMP7, three compounds namely 11 -Eicosenoic Acid Methyl ester, Docosanoic Acid, Methyl ester and 1,2Benzendicarboxylic Acid, mono (2-ethylhexyl) ester could inhibit the above mentioned immuno stimulatory proteins and there by suppress the reactions observed in the gouty arthritis.
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