Preface After the success of the GIREP Malta Webinar 2020, both GIREP Board members and the organisers/hosts from the University of Malta decided to plan for another meeting for GIREP members, to be organised in 2021. Restrictions due to the COVID-19 pandemic had automatically led the organisers of the first meeting to decide in favour of organising a webinar. There was hope, from both organisers and participants, that the 2nd meeting would be held face-to-face in Malta. But even this idea had to be abandoned in 2021. So a second webinar was organised instead. Seeing that participants of the first webinar indicated the need for further discussion related to physics teacher education, this being such an important topic, the GIREP Board decided that Webinar 2021 would still focus on ‘Physics Teacher Education: What matters?’ This was the title of the GIREP Malta Webinar 2021.During the Webinar, various keynote speeches were presented. Participants were then sub-divided into groups, according to the workgroups of their interest. The workgroups dealt with specific topics for discussion, led by experts in the field. Participants had time at their disposal to present their work and research. They actively interacted with each other and the group leaders, during discussions. A number of papers were submitted, post-webinar. Each paper was independently and anonymously reviewed by two experts.The workgroups dealt specifically with the following topics:• Preparing teachers for TPACK (technological, pedagogical and content knowledge) and Lab work;• Developing and evaluating teacher PCK (Pedagogical Content Knowledge) in Quantum Mechanics (tools and approaches);• In-service Physics teacher education for early childhood and primary levels;• Pre-service Physics teacher education at all levels;• In-service Physics teacher professional learning for second and higher level education.The topic titles shown above have been used as Section Titles for this Journal of Physics: Conference Series publication. Published papers have been sectioned according to the working group in which they were originally presented.Once again, we must admit that organising the GIREP Malta Webinar 2021 and finalising the editing process for the post webinar publications has been quite a challenge. We have worked with passion and enthusiasm. We firmly believe that discussions, interactions and publications of this kind can help improve teaching and learning at all levels, offering creative ideas that can be used personally by teachers to enhance the class environment, both physically and mentally, as well as creating the important link between theory and practice. We would like to thank all those who contributed to the publication of these papers, including the GIREP board, the authors and reviewers. Thank you for your time and effort.List of International Advisory Committee and Scientific Programme Committee, Local Organising Committee, The Editors are available in this Pdf.