Event Abstract Back to Event Contribution of FcγReceptors to Human Respiratory Syncytial Virus Pathogenesis and to the Impairment of T Cell Activation by Dendritic Cells Roberto S. Gómez1*, Bruno A. Ramirez1, Pablo F. Céspedes1, Kelly M. Cautivo1, Sebastián Riquelme1, 2, Carolina Prado1, Pablo Gonzalez1 and Alexis M. Kalergis1, 2, 3 1 Millennium Institute on Immunology and Immunotherapy. Departamento de Genética Molecular y Microbiología, Facultad de Ciencias Biológicas, Chile 2 INSERM U1064, France 3 Departamento de Inmunología Clínica y Reumatología, Facultad de Medicina. Pontificia Universidad Católica de Chile, Chile Human respiratory syncytial virus (hRSV) is the leading cause of infant hospitalization related to respiratory disease. hRSV infection produces abundant infiltration of immune cells into the airways, which combined with an exacerbated pro-inflammatory immune response can lead to significant damage to the lungs. hRSV re-infection is extremely frequent suggesting that hRSV may have evolved molecular mechanisms to interfere with host adaptive immunity. Infection with hRSV can be reduced administrating a humanized neutralizing antibody against the viral fusion protein in high-risk infants. Although neutralizing antibodies against hRSV block the infection of airway cells, here we show that both, BMDCs and lung DCs remain susceptible to infection by antibody-opsonized virus. We observed that such process is mediated by Fcγ receptors expressed on the surface of DCs. Remarkably, we also observed that in the absence of hRSV-specific antibodies FcγRIII knockout mice displayed significantly less cellular infiltration in the lungs after hRSV infection, as compared to wild-type mice suggesting a harmful IgG-independent role for this receptor in hRSV disease. Taken together, our findings suggest a key role for FcγRs on DC infection and subsequent immune responses to both free and IgG opsonized-hRSV, in which FcγRIII plays a relevant part in the development of hRSV pathogenesis. Acknowledgements This work was supported by funding from the Millennium Institute on Immunology and Immunotherapy from Chile (P09/016-F to AMK), La Région Pays de la Loire through the “Chaire d’excellence” program to AMK and Grant “Nouvelles Equipes-nouvelles thématiques” (AK), INSERM CDD grant, the ECOS France-Chile grant, FONDECYT no 1070352, FONDECYT no 1050979, FONDECYT no 1040349, FONDECYT no 1100926, FONDECYT no 1110397, FONDECYT no 1100971, FONDECYT no 1110604 and BMRC CTU06. RG, BR, PC, SR and KC are CON Keywords: Human respiratory syncytial virus, Fcγ receptors, Dendritic Cells, Palivizumab, neutralizing antibodies, immune complexes. Conference: IMMUNOCOLOMBIA2015 - 11th Congress of the Latin American Association of Immunology - 10o. Congreso de la Asociación Colombiana de Alergia, Asma e Inmunología, Medellin, Colombia, 13 Oct - 16 Oct, 2015. Presentation Type: Poster Presentation Topic: Infectious and parasitic diseases Citation: Gómez RS, Ramirez BA, Céspedes PF, Cautivo KM, Riquelme S, Prado C, Gonzalez P and Kalergis AM (2015). Contribution of FcγReceptors to Human Respiratory Syncytial Virus Pathogenesis and to the Impairment of T Cell Activation by Dendritic Cells. Front. Immunol. Conference Abstract: IMMUNOCOLOMBIA2015 - 11th Congress of the Latin American Association of Immunology - 10o. Congreso de la Asociación Colombiana de Alergia, Asma e Inmunología. doi: 10.3389/conf.fimmu.2015.05.00175 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 02 May 2015; Published Online: 14 Sep 2015. * Correspondence: Mr. Roberto S Gómez, Millennium Institute on Immunology and Immunotherapy. Departamento de Genética Molecular y Microbiología, Facultad de Ciencias Biológicas, Santiago, Chile, rsgomezj@gmail.com Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Roberto S Gómez Bruno A Ramirez Pablo F Céspedes Kelly M Cautivo Sebastián Riquelme Carolina Prado Pablo Gonzalez Alexis M Kalergis Google Roberto S Gómez Bruno A Ramirez Pablo F Céspedes Kelly M Cautivo Sebastián Riquelme Carolina Prado Pablo Gonzalez Alexis M Kalergis Google Scholar Roberto S Gómez Bruno A Ramirez Pablo F Céspedes Kelly M Cautivo Sebastián Riquelme Carolina Prado Pablo Gonzalez Alexis M Kalergis PubMed Roberto S Gómez Bruno A Ramirez Pablo F Céspedes Kelly M Cautivo Sebastián Riquelme Carolina Prado Pablo Gonzalez Alexis M Kalergis Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.