Suicidal Ideation In Patients Research Articles

Genetic predisposition toward suicidal ideation in patients with acute coronary syndrome.

The genetic predisposition toward suicidal ideation has been explored to identify subgroups at high risk and to prevent suicide. Acute coronary syndrome (ACS) is associated with an increased risk of suicide, but few studies have explored the genetic predisposition toward suicide in ACS populations. Therefore, this longitudinal study explored the genetic predisposition toward suicidal ideation in ACS patients. In total, of 969 patients within 2 weeks after ACS, 711 were followed at 1 year after ACS. Suicidal ideation was evaluated with the relevant items on the Montgomery–Åsberg Depression Rating Scale. Ten genetic polymorphisms associated with serotonergic systems, neurotrophic factors, carbon metabolism, and inflammatory cytokines were examined. Associations between genetic polymorphisms and suicidal ideation within 2 weeks and 1 year of ACS were investigated using logistic regression models. The 5-HTTLPR s allele was significantly associated with suicidal ideation within 2 weeks of ACS after adjusting for covariates and after the Bonferroni correction. TNF-α –308G/A, IL-1β –511C/T, and IL-1β + 3953C/T were significantly associated with suicidal ideation within 2 weeks after ACS, but these associations did not reach significance after the Bonferroni correction in unadjusted analyses and after adjusting for covariance. However, no significant association between genetic polymorphisms and suicidal ideation was found at 1 year. Genetic predisposition, 5-HTTLPR s allele in particular, may confer susceptibility to suicidal ideation in ACS patients during the acute phase of ACS.

3.55 Assessment of Suicide Risk in Children and Adolescents With Autism Spectrum Disorder Presenting to a Pediatric Emergency Department

Recent research indicates that those with autism spectrum disorder (ASD) are at an elevated risk for suicidal thoughts and behaviors. Given the challenges of identifying suicidality in youth with ASD and the high rates of emergency department (ED) visits in this population, developing methods to assess suicidal ideation in patients with ASD in ED settings is essential to determine the patient’s safest disposition plan. This study compared the efficacy of eliciting the presenting chief concern upon presenting to the ED versus the Ask Suicide-Screening Questions (ASQ), which was administered at triage, in detecting suicidality in children and adolescents with ASD in the ED setting. Additionally, characteristics of children and adolescents with ASD who reported suicidal ideation in the ED were examined.

P.1.a.015 - Genetic association with suicidal ideation in patients with acute coronary syndrome

P.1.a.015 - Genetic association with suicidal ideation in patients with acute coronary syndrome

Association between cognitive deficits and suicidal ideation in patients with major depressive disorder

The role of cognitive function in suicidal ideation in patients with major depressive disorder (MDD) has not been adequately explored. This research sought to measure the relationship between suicidal ideation and cognitive function. Therefore, in this study, the association between cognitive function and suicidal ideation in patients with MDD was assessed. Cognitive function was evaluated in 233 patients with MDD using the Japanese version of the Brief Assessment of Cognition in Schizophrenia (BACS). Suicidal ideation was assessed using item 3 of the Hamilton Depression Rating Scale. Approximately 59.2% of the patients (138/233) expressed suicidal ideation. Among the BACS subtests, only the executive function scores were significantly lower in patients with MDD with than in those without (p < 0.005). In addition, the executive function, motor speed function, and composite scores correlated negatively with the severity of suicidal ideation in these patients. These results suggest that executive function, motor speed function, and global neuropsychological function are associated with suicidal ideation in patients with MDD and that the BACS neuropsychological battery is an efficient instrument for monitoring these characteristics. Moreover, specific BACS scores can potentially serve as cognitive biomarkers of suicide risk in patients with MDD.

Suicidal ideation and its risk factors in borderline personality disorder

Objective To investigate suicidal ideation and its risk factors in patients with borderline personality disorder (BPD), and raise awareness of suicidal risk in BPD. Methods Patients with BPD were selected from in-patient and out-patient departments as case group(n=84), while 84 subjects were selected as control group, 1∶1 matched by gender and age. Barratt impulsiveness scale, Buss-Perry aggression questionnaire, childhood trauma questionnaire, Beck depression inventory, Beck hopelessness scale and Beck scale for suicide ideation were used to measure the two groups. Results (1)In case group, the number of incidence of suicidal occurred was 84 .The scores of suicidal ideation in the recent week(4.94±4.57 vs 0.50±0.51), suicidal ideation in the worst situation(20.43±6.58 vs 1.26±2.60) and the total score(25.37±9.78 vs 1.76±3.65) were statistically higher than those in control group (t=8.499, 24.972, 20.847, all P<0.01). (2) Multiple regression analysis showed that motor impulsivity, physical neglect in childhood, impulsivity, co-morbidity of axis I disorders, physical abuse in childhood, unemployment and unmarried status were risk factors of suicidal ideation in patients with BPD (β=0.876, 0.640, 0.428, 0.350, 0.236, 0.165, -0.205, all P<0.05). Conclusion The suicide ideation of patients with BPD are prevalent and intense. Awareness of risk factors for patients with BPD, thereby reducing the risk of suicide. Key words: Borderline personality disorder; Suicidal ideation; Risk factor

Depression and suicidal ideation in patients with acne, psoriasis, and alopecia areata

Background: Depression is a common yet often underdiagnosed psychiatric comorbidity in patients with chronic skin disorders. Presence of depression can be an aggravating and perpetuating factor for these conditions. Aim: To determine the frequency of depressive disorder and suicidal ideation in adult dermatology outpatients with acne, psoriasis, and alopecia areata and also to determine the correlation between severity and duration of the skin disease with the severity of depressive disorder. Materials and Methods: A total of 174 new patients attending the dermatology outdoor clinic of our hospital diagnosed with acne, psoriasis, and alopecia areata were assessed by the psychiatrist for comorbid depressive disorder and suicidal ideations using Beck Depression Inventory (BDI) and Beck Scale for Suicide Ideation, respectively. Results: Depressive disorder was found in 8.8%, 26.8%, and 13.2% of patients with acne vulgaris, psoriasis, and alopecia areata, respectively, whereas suicidal ideation was found in 1.2%, 5.4%, and 2.6% patients, respectively. Significant correlation of BDI score was found with the severity of psoriasis and alopecia areata and with the duration of alopecia areata. Conclusion: Diagnosing and treating the hidden psychiatric comorbidity in patients with dermatological illnesses can help achieve better control of dermatological disorder and provide holistic care to such patients.

Self-perceived burden, perceived burdensomeness, and suicidal ideation in patients with chronic pain

ABSTRACTBackground: Self-perceived burden and perceived burdensomeness are two apparently related constructs that have arisen independently from research in physical and mental health, respectively. Although both are associated with suicidal ideation in individuals with chronic pain, they have yet to be examined concurrently in the same group of patients.Aims: The aim of this study was to investigate the relationship between the two constructs and their differential prediction of suicidal ideation.Methods: Participants were 260 outpatients of an interdisciplinary chronic pain treatment program. Each participant completed the Self-Perceived Burden Scale (SPBS), the Interpersonal Needs Questionnaire Perceived Burdensomeness Scale (INQPBS), the Beck Scale for Suicide Ideation, and the thoughts of self-harm item of the Patient Health Questionnaire-9.Results: The SPBS and the INQPBS were both unifactorial measures with good internal consistency. They correlated significantly with one another (r = 0.50, P < 0.001), as well as with scores on the two measures of suicidal ideation (rs ranging from 0.29 to 0.62, Ps < 0.001). However, the INQPBS correlated more highly with suicidal ideation than did the SPBS. In regression analyses, the INQPBS predicted unique variance in suicidal ideation after adjusting for the SPBS. Conversely, the SPBS did not contribute uniquely when the INQPBS was entered first.Conclusions: Patients with chronic pain who believe that they have become “a burden to others” are at increased risk for suicidal ideation. The conceptual similarities and differences between the constructs of self-perceived burden and perceived burdensomeness are reviewed to explain why perceived burdensomeness is the stronger predictor of this increased risk.

Reliability, validity and factorial structure of the Arabic version of the international suicide prevention trial (InterSePT) scale for suicidal thinking in schizophrenia patients in Doha, Qatar.

BackgroundPatients with schizophrenia are known to have higher rates of mortality and morbidity when compared to the general population. Suicidality is a major contributor to increased mortality. The International Suicide Prevention Trial (InterSePT) Scale for Suicidal Thinking (ISST) is a validated tool to assess current suicidal ideation in patients with schizophrenia. The aims of the study were to culturally adapt the Arabic translation of ISST and to examine the psychometric characteristics of the Arabic version of the ISST among patients with schizophrenia in Qatar.MethodsISST was translated and adapted into formal Arabic using the back translation method. Patients diagnosed with schizophrenia were randomly recruited from the department of Psychiatry, Rumailah Hospital, Doha, Qatar. Healthy controls were randomly recruited from two primary health care centers in Doha, Qatar. The Arabic version of Module B for suicidality in Mini International Neuropsychiatric Interview was used as the gold standard to which the Arabic ISST was compared.ResultsThe study sample (n = 199) was composed of 100 patients diagnosed with schizophrenia (age 35.30 ± 10.04 years; M/F is 2/1) and 99 controls (age 33.98 ± 8.33 years; M/F is 2/3). The mean score on the ISST was 3.03 ± 4.75 vs. 0.47 ± 1.44 for the schizophrenia and control groups, respectively. Inter-rater reliability coefficient was 0.95, p > 0.001. The overall Cronbach’s alpha was 0.92. Principal Component Analysis produced 3 factors explaining a total of 73.8% of variance.ConclusionsThis is the first study in the Arab countries to validate the Arabic version of the ISST. The psychometric properties indicate that the Arabic ISST is a valid tool to assess the severity of suicidal ideation in Arabic patients with schizophrenia.

P.2.f.008 - Determinants and escitalopram treatment effects on suicidal ideation in patients with acute coronary syndrome: findings from the K-DEPACS and EsDEPACS studies

P.2.f.008 - Determinants and escitalopram treatment effects on suicidal ideation in patients with acute coronary syndrome: findings from the K-DEPACS and EsDEPACS studies

Increased Suicidal Ideation in Patients with Co-Occurring Bipolar Disorder and Post-Traumatic Stress Disorder

Suicide risk increases for those with Bipolar Disorder or PTSD, however little research has focused on risk for co-occurring Bipolar Disorder and PTSD. The aim of this article was to evaluate increased suicide risk in co-occurring disorders, and differences in suicide risk for patients with Bipolar I versus Bipolar II. This study evaluated suicide risk in patients with co-occurring PTSD and Bipolar Disorder (n = 3,158), using the MADRS and Suicide Questionnaire. Those with history of PTSD had significantly higher suicidal ideation than those without (U = 1063375.00, p < .0001). Those with Bipolar I had higher risk than those with Bipolar II. Patients with Bipolar I and PTSD were at higher risk for suicidal ideation, implying the importance of diagnosis and risk assessment.

Determinants and escitalopram treatment effects on suicidal ideation in patients with acute coronary syndrome: Findings from the K-DEPACS and EsDEPACS studies

BackgroundThis study is aimed to investigate the determinants of suicidal ideation as well as to assess escitalopram treatment effects on suicidal ideation in patients with acute coronary syndrome (ACS). MethodsA total of 1152 patients were consecutively recruited at baseline, 2 to 14weeks after a confirmed ACS episode. Of 446 baseline participants with comorbid depressive disorders, 300 were randomized to a 24-week double-blind trial of escitalopram or placebo treatment. Suicidal ideation was determined using the “suicidal thoughts” item of the Montgomery and Asberg Depression Rating Scale. Socio-demographic and clinical characteristics, including depressive and anxiety symptoms, cardiovascular risk factors, and current cardiac status, were assessed. ResultsSuicidal ideation was independently associated with past history of depression, depressive and anxiety disorders, and higher troponin I levels. Escitalopram treatment was significantly more efficacious in reducing and treating suicidal ideation than placebo treatment over a 24-week period. These effects were largely explained by remission status of depressive and anxiety disorders. ConclusionsSuicidal ideation is associated with unfavorable psychiatric and ACS status during the acute phase of ACS. Successful treatment of depression and anxiety with escitalopram had significant beneficial effects on suicidal ideation in these patients.

Factors Associated with Suicidal Ideation in Patients with Chronic Non-Cancer Pain.

This study’s aim was to identify the most important general and pain-related risk factors of suicidal ideation in a large sample of patients with chronic non-cancer pain. A total of 728 patients with chronic non-cancer pain were recruited from the waitlists of eight multidisciplinary pain clinics across Canada. Patients were assessed using self-administered questionnaires to measure demographic, pain-related (intensity, duration, interference, sleep problems), psychological (anxiety, anger, depressive symptoms including suicidal ideation), cognitive (catastrophizing, attitudes/beliefs), and health-related quality of life variables. A hierarchical logistic regression analysis was used to identify the factors that were associated with presence/absence of suicidal ideation while controlling for depressive symptoms. The results showed that being a male, longer pain duration, higher anger levels, feelings of helplessness, greater pain magnification, and being more depressed were significant independent predictor factors of suicidal ideation, while better perceived mental health was related with a lesser likelihood of suicidal ideation. Moreover, being in a relationship and believing in a medical cure for pain might be protective of suicidal ideation while being anxious may be more associated with suicidal ideation. These results indicate that development of suicidal ideation is more closely related to pain chronicity and certain psychosocial factors than how severe or physically incapacitating the pain is. Many of these factors could potentially be modified by early identification of suicidal ideation and developing targeted cognitive interventions for suicidal at-risk patients. Research to examine the efficacy of these interventions for reducing suicidal ideation is warranted.

Ketamine for Treatment of Suicidal Ideation and Reduction of Risk for Suicidal Behavior.

Ketamine, an NMDA receptor antagonist with efficacy as a rapid anti-depressant, has early evidence for action to reduce suicidal ideation. This review will explore several important questions that arise from these studies. First, how do we measure reductions in suicidal ideation that occur over minutes to hours? Second, are the reductions in suicidal ideation after ketamine treatment solely a result of its rapid anti-depressant effect? Third, is ketamine only effective in reducing suicidal ideation in patients with mood disorders? Fourth, could ketamine's action lead us to a greater understanding of the neurobiology of suicidal processes? Last, do the reductions in depression and suicidal ideation after ketamine treatment translate into decreased risk for suicidal behavior? Our review concludes that ketamine treatment can be seen as a double-edged sword, clinically to help provide treatment for acutely suicidal patients and experimentally to explore the neurobiological nature of suicidal ideation and suicidal behavior.

Risk Factors for Suicidal Ideation in Patients Feeling Severely Affected by Multiple Sclerosis.

Being severely affected by multiple sclerosis (MS) brings substantial physical and psychological challenges. Contrary to common thinking that MS is not lethal, there is a higher mortality risk in patients also reflected in alarming rates of assisted suicide, and - where possible - euthanasia. Analyzing independent variables promoting suicidal ideation in severely affected MS patients. A self-report questionnaire with 25 needs categories including one self-assessment item "prone to suicidal ideation" was applied. Included were patients reporting feeling subjectively severely affected by MS. Of 867 patients addressed, 573 (66.1%) completed the questionnaires. 32 items being potential risk factors for suicidal ideation were tested for statistical significance using a multivariate logistic regression model with stepwise, backward elimination procedure. 22.1% of 573 patients (median age 51, range 20-83) had suicidal ideation. 48.4% suffered from secondary progressive, 24.7% from relapsing-remitting and 21.9% from primary progressive MS. A set of six statistically significant criteria for suicidal ideation were found. Three items were risk factors for suicidal ideation: the extent to which MS affects leisure time (p < 0.001), depression (p < 0.000), and feeling socially excluded (p < 0.002). Three items reduced the odds of suicidal ideation: having a purpose in life (p < 0.000), being productive (p < 0.000), and having comfort in faith and spiritual beliefs (p < 0.024). This study identified potentially modifiable factors that may help preventing suicide in people with MS. Integrating palliative care (PC) with its multidisciplinary approach could be beneficial to reduce patient's burden.

Trajectories of suicidal ideation in patients with first-episode psychosis: secondary analysis of data from the OPUS trial

Heterogeneity in suicidal ideation over time in patients with first-episode psychosis is expected, but prototypical trajectories of this have not yet been established. We aimed to identify trajectories of suicidal ideation over a 3-year period and to examine how these trajectories relate to subsequent suicidality. We used longitudinal data from the prospective 10-year follow-up OPUS trial of young Danish patients with first-episode psychosis. Participants were recruited between January, 1998, and December, 2000, from all inpatient and outpatient mental health services in Copenhagen and Aarhus County, were aged between 18 and 45 years, and had a diagnosis in the schizophrenia spectrum. Randomisation was done by a computer-generated randomisation list, stratified in alternating blocks for five centres. In Aarhus, a secretary drew lots when the researcher phoned her. Patients were randomly assigned to a treatment group (modified assertive community treatment) or a control group (standard treatment at community mental health centres) and assessed at treatment initiation, and after 1, 2, 5, and 10 years. We included all patients' data on suicidal ideation from the first three assessments in a latent growth mixture modelling analysis to empirically identify trajectories of suicidal ideation. Multivariable logistic regression analyses were applied to estimate associations between trajectories and subsequent suicidality. This trial is registered with ClinicalTrials.gov, number NCT00157313. Three trajectories for suicidal ideation were identified in 521 patients. 317 of 521 members (61%) of the largest trajectory, low-decreasing, consisted of patients who initially reported suicidal ideation once-to-a-few-times in the past year followed by a decrease in suicidal ideation. 172 of 521 (33%) members of the frequent-stable trajectory reported suicidal ideation sometimes-to-frequently at the first assessment and remained stable over time. Finally, 32 of 521 (6%) members of the frequent-increasing trajectory reported frequent suicidal ideation initially followed by worsening. Compared with the low-decreasing class, the risk of persistent suicidal ideation was higher for patients in the frequent-stable and frequent-increasing classes at 5 years (Odds ratio=4·5, 95% CI 2·50-8·02 and 4·7, 1·55-14·24 respectively) and at 10 years (4·2, 2·42-7·13 and 3·2, 1·20-8·70 respectively). Also the risk of suicide attempt at 5 years was higher for patients in the frequent-stable (2·8, 1·07-7·43) and frequent-increasing classes (6·6, 1·69-25·54) compared with the low-decreasing class. There was no difference in suicide rate at 5 or 10 years between trajectories. Because up to 40% of patients experienced frequent suicidal ideations that persisted or increased during the first years of treatment, our findings warrant special focus on suicidal issues as an integral part of treatment along with treatment to target psychotic symptoms. The Danish Council for Independent Research (Medical Sciences), Trygfonden, The Mental Health Services of the Capital Region of Denmark, The Danish Ministry of Health, The Danish Ministry of Social Affairs, the Psychiatry and Social Service Department in Central Denmark Region, and The Lundbeck Foundation.

Suicidal ideation in patients undergoing brain tumor surgery: prevalence and risk factors.

Suicidal ideation (SI) is an important complication in cancer patients that should be promptly recognized and adequately managed. We investigated the prevalence rate and correlates of pre-operative SI in brain tumor (BT) patients admitted for elective BT surgery. Two hundred and eleven consecutive patients (70% women; mean age 55.9±15.4years) scheduled for BT surgery were evaluated for SI ("suicidal thought" item from the Beck Depression Inventory-II), depressive/anxiety symptom severity (Hospital Anxiety and Depression scale (HADS)), health-related quality of life (SF-36 scale), functional status (Barthel Index), and psychiatric histories and treatments. The majority of patients were diagnosed with meningioma (39%) and high-grade glioma (17%). SI was self-reported by 12 (6%) patients. Patients expressing SI were most commonly diagnosed with meningioma (50%). Patients with SI were more likely to have a past history of psychiatric disorders, scored higher on the HADS anxiety subscale, and reported worse health-related quality of life across physical and mental health domains. In multivariate regression analyses, worse perceived mental health was associated with increased risk for SI independently from clinical, sociodemographic, and other patient-oriented variables considered in the study. SI was self-reported by 6% of BT patients before surgical intervention and was associated with a past history of psychiatric disorders and worse perceived health status. Poor mental health was an independent correlate of SI. The perception of health status by a patient should be considered as an important determinant of poor mental health in BT patients.

Associations of BDNF promoter methylation with the morbidity and suicidal ideation in patients with first-episode major depressive disorder

Objective To explore the role of brain derived neurotrophic factor(BDNF) promoter methylation for the morbidity of depression patients, and to investigate the relevance between BDNF promoter methylation and the suicidal ideation in patients with first-episode major depressive disorder. Methods The peripheral blood samples from 23 cases of depression patients with suicide ideation, 24 cases of depression patients without suicide ideation, and 27 healthy controls were grouped using simple randomization method, and the methylation status of CpG island of BDNF promoter were subsequently evaluated using bisulphite sequencing. Results The methylation rates(median, quartile interval) of depression patients with suicidal ideation, depression patients without suicidal attempt, and the healthy control were detected as follows, CPG-1: 2.60 (0.28), 2.70 (0.60), 6.40 (1.00); CPG-2: 3.35 (1.15), 3.20 (1.00), 14.50 (2.60); CPG-3: 1.50 (0.40), 1.50 (0.60), 4.60 (0.90); CPG-4: 1.75 (0.90), 1.50 (0.50), 3.90 (0.90); CPG-5: 0.80 (0.58), 0.90 (1.00), 5.70 (2.10); CPG-6: 6.05 (1.03), 6.20 (1.70), 14.50 (1.70); CPG-7: 10.55 (1.68), 10.10 (1.50), 14.70 (1.70); CPG-8: 16.35 (0.90), 16.40(1.00), 4.80 (1.20); CPG-9: 4.20 (4.80), 4.70 (1.30), 28.50 (19.30); CPG-10: 10.25 (1.08), 10.30 (1.20), 4.30 (0.90); CPG-11: 62.80 (4.05), 62.30 (4.00), 37.20 (2.60); CPG-12: 5.60 (1.05), 5.60 (1.30), 12.30 (1.80); CPG-13: 4.15 (1.10), 4.10 (1.10), 59.70 (4.90); CPG-14: 5.45 (0.78), 5.70 (0.90), 6.30 (0.60); CPG-15: 3.70 (0.70), 3.90 (1.00), 62.40 (6.50); CPG-16: 8.05 (1.75), 8.10 (1.60), 74.30 (50.90); CPG-17: 3.20 (0.78), 3.20 (0.80), 32.40 (13.20); CPG-18: 1.90 (0.48), 1.80 (0.40), 2.30 (0.30); CPG-19: 35.00 (6.27), 35.20 (3.00), 64.20 (44.70). There was an obvious difference in methylation rate among three groups, which was statistically significant (P<0.01). However, no statistical significance for the methylation rates was observed between the depression patients with suicidal ideation and without suicidal ideation. Interestingly, statistical significance for the methylation rates were observed when compared the depression patients with suicidal ideation with healthy control (P<0.05), and the depression patients without suicidal ideation with healthy control (P<0.05). Conclusion The results show that the association is observed between BDNF promoter methylation and the morbidity of depressive disorder, but not between BDNF promoter methylation and the suicidal ideation of depression patients. Key words: Brain derived neurotrophic factor; Methylation; Depression; Suicide

Two-Part Assessment May Help Predict Suicidal Behavior, Study Finds

A diagnostic that combines a clinical assessment with a blood test predicts future suicidal ideation in patients with a psychiatric disorder with an accuracy of over 90 percent.

Role of depression severity and impulsivity in the relationship between hopelessness and suicidal ideation in patients with major depressive disorder

BackgroundHopelessness, depression and impulsivity all contribute to the development of suicidal ideation in patients with major depressive disorder, but the pathway of these factors to suicidal ideation is not clear. This study examined the meditating effect of depression severity on the relationship between hopelessness and suicidal ideation and explored how this mediating effect was moderated by impulsivity. MethodsA total of 162 patients with major depressive disorder (MDD) completed a structured clinical diagnostic interview and a battery of scales assessing depression severity, hopelessness, suicidal ideation, and impulsivity. Regression analyses with bootstrapping methods were used to examine the mediating and moderating effects of various risk factors. ResultsMediation analysis revealed a significant indirect effect of hopelessness on suicidal ideation, and the effect was fully mediated through depression severity. On moderation analysis, the moderating effects of the relationship between depression severity and suicidal ideation were significant in both the medium and high impulsivity groups. LimitationsThe present study was limited by the assessment of trait impulsivity and observer-rated depression severity, which might not fully reflect momentary impulsivity and feeling of depression when suicidal ideation occurs. ConclusionDepression severity plays a mediator role in the relationship between hopelessness and suicidal ideation and this mechanism is contingent on the levels of impulsivity. MDD patients with higher impulsivity appear to be more likely to have suicidal ideations even when they are less depressed. These findings highlight the importance of impulsivity assessment and alleviation of depressive symptoms to prevent suicidality in patients with MDD.

Changes in intensity of neurotic symptoms associated with reduction of suicidal ideation in patients who underwent psychotherapy in the day hospital for the treatment of neurotic and behavioral disorders.

Analysis of associations between changes in the intensity of neurotic symptoms and reduction of suicidal ideation (SI) or lack of SI reduction, in patients who underwent a course of intensive psychotherapy conducted in integrative approach with predominance of psychodynamic approach in a day hospital. Symptom Checklist KO"O" and Life Inventory completed by 461 women and 219 men treated in the psychotherapeutic day hospital due to neurotic, behavioral or personality disorders between 2005-2013. During the qualification for the therapy 134 women and 80 men reported SI, of whom 84.3% and 77.5% respectively improved. The reduction of neurotic symptoms intensity was greater in patients of both genders who improved in terms of SI than in those who did not. This referred to global intensity of neurotic symptoms (OWK coefficient) in both genders (p<0.001), as well as to the majority of the neurotic symptoms subtypes in both genders (p<0.05): Phobic disorders, Other anxiety disorders, Obsessive-compulsive disorders, Conversions and dissociations, Autonomic disorders, Somatization disorders, Neurasthenia, Avoidance and dependence, Sexual dysfunctions, Dysthymia; and in case of women (p<0.05): Hypochondriasis, Depersonalization and derealization, Impulsiveness and histrionism and Non-organic sleep disorders. The results show effectiveness and comprehensiveness of intensive psychotherapy as a treatment method that leads to improvement in terms of both SI and neurotic symptoms. This suggests that the applied therapy may be effective in preventing suicidality in this group of patients. The observed associations also point in favor of hypothesis on similarities in etiopathogenesis of and partly identical personality-related factors predisposing to SI and neurotic disorders.