Abstract
The genetic predisposition toward suicidal ideation has been explored to identify subgroups at high risk and to prevent suicide. Acute coronary syndrome (ACS) is associated with an increased risk of suicide, but few studies have explored the genetic predisposition toward suicide in ACS populations. Therefore, this longitudinal study explored the genetic predisposition toward suicidal ideation in ACS patients. In total, of 969 patients within 2 weeks after ACS, 711 were followed at 1 year after ACS. Suicidal ideation was evaluated with the relevant items on the Montgomery–Åsberg Depression Rating Scale. Ten genetic polymorphisms associated with serotonergic systems, neurotrophic factors, carbon metabolism, and inflammatory cytokines were examined. Associations between genetic polymorphisms and suicidal ideation within 2 weeks and 1 year of ACS were investigated using logistic regression models. The 5-HTTLPR s allele was significantly associated with suicidal ideation within 2 weeks of ACS after adjusting for covariates and after the Bonferroni correction. TNF-α –308G/A, IL-1β –511C/T, and IL-1β + 3953C/T were significantly associated with suicidal ideation within 2 weeks after ACS, but these associations did not reach significance after the Bonferroni correction in unadjusted analyses and after adjusting for covariance. However, no significant association between genetic polymorphisms and suicidal ideation was found at 1 year. Genetic predisposition, 5-HTTLPR s allele in particular, may confer susceptibility to suicidal ideation in ACS patients during the acute phase of ACS.
Highlights
Suicide, the most devastating outcome of mental health disorders, constitutes a major public health problem
Our results confirmed that genetic predisposition played a significant role in suicidal ideation (SI) in Acute coronary syndrome (ACS) patients during the acute phase, whereas the significance of the genetic association was lost during the chronic phase
5-HTTLPR was significantly associated with SI in ACS during the acute phase, including after adjusting for covariates as well as after Bonferroni correction
Summary
The most devastating outcome of mental health disorders, constitutes a major public health problem. Many studies have explored the etiology of suicide to identify subgroups at high risk. Physical illnesses are known risk factors, as severe and chronic illnesses are stressful events that may contribute to suicide [2]. Acute coronary syndrome (ACS) is a severe physical illness that is associated with the leading cause of death worldwide; it is associated with an increased risk of depression, which may increase suicide risk [3]. Previous population-based case–control studies found that ACS was strongly associated with an increased risk of suicide per se, and this risk was highest shortly after discharge [4]. Few studies have explored the genetic predisposition for suicide in ACS populations
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