Pathogenesis Of Gastric Carcinoma Research Articles

Investigation for the prevalence of Helicobacter pylori infection in patients with gastric carcinoma in Madras, India.

The most common type of gastric carcinoma, namely the intestinal type, has been proposed to result from a precancerous process in which chronic gastritis, atrophy, intestinal metaplasia and dysplasia develop in a sequential manner. Helicobacter pylori is considered as the main cause of chronic atrophic gastritis and thus may play a role in the gastric carcinogenesis process. The present study was aimed at investigating the prevalence of H. pylori in the gastric carcinoma cases. Urease tests and ELISA developed in our laboratory and culture were used to assess the prevalence of H. pylori in the study group. The positivity of H. pylori by various tests ranged from 56.0 to 62.6% in the gastric carcinoma group and 37.3 to 46.6% in the control subjects, the difference being statistically significant. This suggests that H. pylori infection could be associated with an increased risk for gastric carcinoma, but only a very small percentage of the infected persons develops gastric carcinoma. Therefore, it is suggested that along with other critical risk factors, H. pylori may act as a cofactor in the pathogenesis of gastric carcinoma.

Gastric carcinoma.

Despite a marked decline in the incidence of gastric carcinoma in many industrialized nations, cancer of the stomach remains the second most common cause of cancer-related deaths in the world.1 In 1995, 22,800 Americans will be given a diagnosis of gastric carcinoma, and 14,700 will die of the disease.2 This review discusses recent developments in our understanding of the epidemiology and pathogenesis of gastric carcinoma, methods of diagnosis and staging, and approaches to treatment and palliation.Epidemiology and BiologyIncidenceIn 1930, gastric carcinoma was the leading cause of cancer-related deaths among American men and the third most common cause . . .

Is Helicobacter pylori a causal agent in gastric carcinoma?

The aim of this study is to clarify the relationship between Helicobacter pylori (H. pylori) infection and gastric carcinoma. 94 patients with gastric carcinoma and 111 patients with chronic gastritis were involved in this study. They were classified into 3 age groups: Group A (40 years and under), Group B (41-59), Group C (60 years and over). Serum samples were tested for H. pylori IgG antibodies by ELISA and for pepsinogen (PG) by RIA. The ratio of PG I/PG II was used as a marker for atrophic gastritis. Results were as follows. In the incidence of H. pylori antibodies, there was no significant differences between gastric carcinoma and chronic gastritis in any of the groups. In the quantity of H. pylori antibodies, there was no significant difference between gastric carcinoma and chronic gastritis in any of the groups. The ratio of PG I/PG II was significantly decreased in H. pylori positive cases when compared to H. pylori negative cases in each group with chronic gastritis and group A and B with gastric carcinoma. The ratio of PG I/PG II in gastric carcinoma was significantly lower than that of chronic gastritis. As conclusion, from the point of view of the prevalence of H. pylori, it is suggested that H. pylori is not a direct causal agent in the pathogenesis of gastric carcinoma.

Helicobacter pylori and gastric carcinoma

A retrospective study was performed on gastric carcinomas to establish the prevalence of Helicobacter pylori infection in gastric epithelium adjacent to the tumour. A total of 105 carcinomas were studied. The overall prevalence of Helicobacter pylori infection was 59%. The prevalence in different age cohorts from patients with gastric carcinoma was compared with that in patients suffering from non-ulcer dyspepsia and, based on serological testing, with that in healthy blood donors. The presence of Helicobacter pylori in cancer patients aged 41-50 and 51-60 was significantly higher than in blood donors. No difference was seen in comparison with non-ulcer dyspepsia patients. The presence of Helicobacter pylori showed an inverse correlation with the extent of intestinal metaplasia. The intestinal type of carcinoma was associated with a higher bacterial load than the diffuse type. These data suggest that the presence of Helicobacter pylori in gastric mucosa could play a role in the pathogenesis of gastric carcinoma, especially in the young age group.

The Effect of Secretin on Plasma Concentration of Gastrin in Fasting Patients with Carcinoma of the Stomach

Schrumpf, E. & Myren, J. The effect of secretin on plasma concentration of gastrin in fasting patients with carcinoma of the stomach. Scand. J. Gastroent. 1973, 8, 479-482.The basal gastrin level in patients with gastric carcinoma and achlorhydria has been found to be not significantly different from that in achlorhydric subjects without carcinoma. A significantly smaller decrease (p<0.05) of basal plasma level of gastrin by secretin has, however, been found in 4 achlorhydric patients with gastric carcinoma than in 6 achlorhydric patients without carcinoma of the stomach, suggesting that the gastrin-producing cells in the former patients are autonomous. In 6 patients with gastric carcinoma without achlorhydria secretin caused a significant decrease in the basal gastrin level, whereas no effect of secretin was seen on the gastrin level in 8 fasting normals. In speculating about the pathogenesis of gastric carcinoma in achlorhydria, we suggest that it may be the gastrin-producing cells which turn malignant.