Patent Landscape Research Articles

Psychedelics for Medicinal Use: How Will This Alter the Collective Laboratory Consciousness?

The clinical evaluation of hallucinogens and other small molecules, conventionally termed psychedelics, has seen a dramatic increase in the past 5 years. Several key clinical trials recently demonstrated the potential efficacy of these compounds in treating a variety of mental health conditions including depression, anxiety, and substance use disorders. Concurrently, the business and patent landscape of hallucinogen derivatives from both conventional drug companies and emerging commercial entities is rapidly expanding. These 2 developments will require the clinical laboratory to rethink its approach to supporting this evolving area beyond the historic detection of these drugs in an abuse and/or overdose setting. For this Q&A, we invited a group of experts who are associated with psychedelic research, drug discovery, or drug approval to provide insight into this rapidly expanding field. The experts discuss what challenges are ahead for clinical adoption of psychedelic compounds and how this may impact the field of laboratory medicine. The opinions provided are those of the expert authors only and do not reflect opinions or outlooks for their respective institutions.

Patent Landscape Review on Ankle Sprain Prevention Method: Technology Updates

Ankle sprains are among the most prevalent musculoskeletal system injuries. Prevention of ankle sprains is important, given the frequency of occurrence of an ankle sprain, the risk of reinjury, and its long-term effects. A systematic patent review using the World Intellectual Property Organization (WIPO)’s PATENTSCOPE database has been performed to study the current development of ankle sprain prevention methods. Using the PRISMA statement as a basis, a total of 426 patent documents have been selected for review, consisting of 150 granted patents and 276 patent applications. In the past decade, China and the United States of America (43% and 29% of the patent applications, respectively) have shown great interest in developing ankle sprain prevention methods. Approximately 49% (or 74) of the patents from the 150 granted are associated with braces, 46% (or 68) are related to orthosis, 3% (or 5) are related to tape, and the remaining 2% (or 3) are associated with other types of ankle sprain prevention methods. This patent review shows that inventors are leaning towards braces and orthosis as the main prevention methods for ankle sprains, with greater interest in orthosis in recent years. Additionally, patents on smart wearable devices suggest initial commercial interest in the development of smart wearable devices as an ankle sprain prevention method.

Coating of natural fiber composite envisaging through the patent landscape: An overview

AbstractOver many years, the Earth being dug out to take the metals and their associate supplements. Digging the ground leads to the weakening of the soil layers leads to landslides is the direct effect. Indirectly affects many soil‐associated creatures and processes and restricts the water flow. Instead, trying to use an alternative material is the better‐known solution. One such material is natural fibers, which have been improved by many to acquire some characteristics like metal. It is tough to achieve, but it can replace it, at least to a small extent. One such technique adopted is coating the natural fibers to make them a viable material to overcome the hydrophilic nature of the natural fiber material. This article discusses an overview of the coating of natural fibers and envisages the growth of coating over a natural fiber.

Mining tools and patent analytics: new capabilities

The paper discusses feasibility of analyzing promising design solutions using the Patent Landscape analysis even before starting construction of new mining machines in terms of the mining tools. The authors suppose that the purpose-oriented adaptation of the patent analytics tools can help develop methodology of forecasting and substantiation of mining machine performance.

Patent landscape highlighting double-edged scaffold of a WNT5A-agonizing peptide, Foxy5.

Aberrant expression of the WNT signaling pathway has been associated with cancer progression and recurrence. Research over the decades has led to development of WNT-targetable small molecules, but has faced challenges in translating to clinics. Unlike WNT/β-catenin inhibitors, WNT5A-mimicking peptide, Foxy5 has shown encouraging efficacy in impairing metastasis of cancers with low or absent WNT5A expression. Recent patent application US20210008149 advocates the implication of Foxy5 for treatment and prevention of cancer relapse. The inventors have demonstrated the anti-stemness activity of Foxy5 in mice xenograft model via suppressing the expression of colonic cancer stem cell markers. Foxy5 also exhibits non-toxic nature when administered alone or in synergy with standard chemotherapy thus strengthening its candidature in the field of cancer therapeutics.

Examining the Patent Landscape of E-Fuel Technology

Although the end of combustion engine vehicles seems inevitable under a new climate target for 2030, a complete ban on the combustion engine would be counterproductive. E-fuels, which are produced using renewable electricity from hydrogen and carbon dioxide, could act as a possible large-scale solution for achieving climate-neutral mobility, as they allow us to reduce greenhouse gas emissions while leveraging the existing energy infrastructure. Against such a background, it is critical to examine how the related technological landscape is constructed and might affect the subsequent knowledge generation. By adopting a social-network perspective, the aim of this study is to investigate the degree of technological knowledge relatedness of e-fuel technology using patent data. This is accomplished by analyzing the influence of individual knowledge areas and categorizing them into a matrix model, with each quadrant playing a unique role. The main findings show that the patent landscape is dominated by applications from the private sector, and the main knowledge base is centered around chemical engineering and production techniques for liquid hydrocarbon mixture. Furthermore, the analyzed knowledge flows are dominated by intra-technology knowledge flows, thereby being less prone to convergent technology evolution. In particular, the knowledge areas C10L 01 and C10J 03 demonstrated a high influencer role. The findings can also support R&D advisors and decision makers in policy development in reducing their efforts required for conducting technical intelligence activities and determining adequate policies for R&D portfolio management.

Unexploited Potentials of Endophytic Fungi: Patents Review on Endophytic Fungi Related to Secondary Bioactive Compounds

Pharmacognosy Research,2023,15,2,217-225.DOI:10.5530/pres.15.2.023Published:February 2023Type:Review ArticleAuthors:Priyatama V. Powar, and Shilpa Chaudhari Author(s) affiliations:Priyatama V. Powar*, Shilpa Chaudhari Department of Pharmaceutics, Dr. D. Y. Patil College of Pharmacy, Akurdi, Pune, Maharashtra, INDIA. Abstract:Endophytic fungi are various micro-organisms that inhabit intracellular or intercellular plant tissues in symbiotic association [at certain stages of their life cycles], without causing damage or morphological changes. The endophytes from medicinal plants are important resources for discovery of natural products and secondary bioactive metabolites having the potential biotechnological applications in agriculture, medicine, and allied sectors. The endophytic fungi such as Acremonium, Aspergillus, Fusarium, Trichoderma, Penicillium, Phomopsis, Pestalotiopsis, Pseudomassari, Quercina, Trichoderma genera have been reported from different medicinal plants with potential therapeutic activity. On the other hand, the endophytic fungi can also confer profound impacts on their host plants like improvement in growth, activation of systemic tolerances towards abiotic/biotic stresses, enhancement of nutrient solublization, biosynthesis of phytohormones and stimulating accumulation of secondary metabolites. Endophytic fungi have attracted much research interest because they have provided not only novel sources of Cytotoxic compounds, Antimicrobial agents, Bio-stimulants for essential oil biosynthesis, Anticancer agents, antioxidant agents, anti-diabetic agents, immunosuppressant and insecticidal compounds. The present review reveals the importance of endophytic fungi from medicinal plants as a source of bioactive compounds as well as landscape of patents related to the production of secondary metabolites through endophytic fungi and their application in pharmaceutical sectors. Keywords:Biological activity, Endophytic fungi, Patents, Phytohormones., Secondary metabolites, Symbiotic associationView:PDF (564.03 KB)

Using automated patent landscaping and legal geography analysis to spot biopiracy activities in the island of Hispaniola

This paper reports on an automated patent landscaping and legal geography analysis to scrutinize the biopiracy of endemic plants in the island of Hispaniola (Haiti and the Dominican Republic). My analysis relies on shrubs and flowers that may be reaped without a fair and equitable distribution of benefits. My findings highlight that Western pharmaceutical and biotechnology companies' innovations may overlap sovereign states’ intellectual property rights, implying that regulatory gaps must be filled to empower local communities to benefit from biodiversity and ecosystem services. Therefore, I suggest that the island adopt effective and consistent access and benefit-sharing policies, including mechanisms that encourage environmental protection and require prior informed consent and mutually agreed terms for utilizing genetic resources. I also suggest the introduction of disclosure of origin and/or source of genetic resources in their respective patents regime to ensure that Convention on Biological Diversity regulations and other related international frameworks can be followed.

Patent landscape and key technology interaction roadmap using graph convolutional network – Case of mobile communication technologies beyond 5G

Beyond 5G (B5G) in mobile network technologies is the latest communication technology currently under development. B5G is expected to achieve superior capabilities in ultra-high network transmission speed, low latency, low energy consumption, and high coverage, comparing to current 5G network performance. Although B5G is still in the development and implementation stage, there are many patents and non-patent literature depicting B5G innovative technologies and applications. The landscapes of B5G technologies are great references for governments and industries to understand the advances in mobile communication for R&D strategies. Thus, this research focuses on developing a formal tech-mining workflow integrating semantic-based patent and non-patent literature analysis for ontology building, patent technological topic clustering, and graph convolutional network (GCN) modeling for depicting key technology interactions among clusters of sub-domain topics. This research emphasizes the study of B5G patent landscape and key technology interaction roadmap in comprehensive steps as a valuable reference for B5G mobile network R&D, as well as for conducting tech-mining of other technology domains of interests.

Patent landscape analysis-Contributing to the identification of technology trends and informing research and innovation funding policy.

Patents and the systematic analysis thereof provide important decision information for a range of stakeholders pursuing diverse goals. However, in particular academia and small-scale private sector innovators underappreciate the value of patent information for identifying research gaps, ensuring originality of their work and, in turn, maximisation of limited (public) funds. By the same token, pertinent public sector organisations, such as regulators, require overviews of potentially upcoming technologies to adequately adapt regulatory protocols. The latter, in particular if contemporary scientific evidence is not sufficient, can require a substantial amount of time and lead to a delay in the marketing of important innovations. Patent landscape analysis (PLA) is a very useful method to create overviews of technology fields and thereby indicate if, inter alia, a specific line of scientific enquiry and its application have already been pursued or potential regulatory gaps will exist in the near- to mid-term future. The objective of this communication is to increase awareness of the utility of patent information and provide support in retrieval and analysis of pertinent information for those involved in biotech R&D. Based on Espacenet, a patent search engine, we provide basic guidance on search strategy development, piloting and execution, and data preparation and analysis. To highlight the value of PLA, we also summarise selected results of a PLA we performed recently for microbiome targeting interventions, also referred to as live biotherapeutic products.

Role of Liquid Metal in Flexible Electronics and Envisage with the Aid of Patent Landscape: A Conspicuous Review

Role of Liquid Metal in Flexible Electronics and Envisage with the Aid of Patent Landscape: A Conspicuous Review

Abstract A037: PROTACs as emergent treatment modality of metastatic prostate cancer. [R

Abstract Prostate cancer is one of the most commonly diagnosed and fourth leading cause of cancer death in men, with low survival rates for metastatic cancers. Androgen receptor (AR) is one of the most altered Oncogenes in castration-resistant prostate cancer (mCRPC). Suppression of AR signalling is one of the common strategies to treat prostate cancer. Androgen deprivation therapy (ADT) has been the backbone therapy for decades and demonstrated survival benefit when used alongside other therapies including Docetaxel, cabazitaxel or hormone based anti-androgen therapies such as Enzalutamide, abiraterone, darolutamide, and apalutamide. Unfortunately, amplification or mutation in AR gene along with its associated pathway such as alteration of PI3K pathway or upregulation of MYC oncogene drive mCRPC cell proliferation and confers resistance to existing therapies. To overcome such resistance mechanisms, targeted therapy towards Androgen receptor has emerged, where ligand conjugated small molecule inhibitors using proteolysis targeting chimera (PROTAC) strategy, could effectively downregulate the AR expression. Several PROTACs as ‘Androgen Receptor Degraders (ARD)’ are showing promising activity in early-stage clinical studies. Although a promising strategy, challenges exist for its development in future; given that finding the most appropriate protein-protein interaction is essential to find optimal ligand to successfully design PROTAC. Similarly, challenges to optimize safety and efficacy of PROTACs in the clinic, also remain to be addressed. Here we aim to provide comprehensive review, including patent landscape of the therapeutic benefits of using PROTACs and its future development prospect in context to metastatic prostate cancer. Citation Format: Prashant Kashinath Bhavar, Uday Kumar Surampudi, Partha Pratim Sarma, Satish Katike, Adilakshmi Gandham. PROTACs as emergent treatment modality of metastatic prostate cancer. [R [abstract]. In: Proceedings of the AACR Special Conference: Cancer Metastasis; 2022 Nov 14-17; Portland, OR. Philadelphia (PA): AACR; Cancer Res 2022;83(2 Suppl_2):Abstract nr A037.

The patent landscape in the field of stem cell therapy: closing the gap between research and clinic

Stem cell technology is a powerful tool ready to respond to the needs of modern medicine that is experiencing rapid technological development. Given its potential in therapeutic applications, intellectual property rights (IPR) as a protection resource of knowledge are a relevant topic. Patent eligibility of stem cells has been controversial as restrictions to access the fundamental technologies open a gap between research and clinic. Therefore, we depicted the current patent landscape in the field to discuss if this approach moves forward in closing this breach by examining patent activity over the last decade from a transdisciplinary perspective. Stem cell therapeutic applications is an area of continuous growth where patent filing through the PCT is the preferred strategy. Patenting activity is concentrated in the USA, European Union, and Australia; this accumulation in a few key players leads to governance, regulation, and inequality concerns. To boost wealthiness and welfare in society - stem cell therapies' ultimate goal - while at post-pandemic recovery, critical elements in the field of IPR rise to overcome current limitations: to promote bridge builders able to connect the research and business worlds, regulatory updates, novel financing models, new vehicles (startups, spinouts, and spin-offs), and alternative figures of intellectual property.

Smart City Applications: A Patent Landscape Exploration

Smart cities thrive on supporting digital technology innovation of applications and patent protection in the entrepreneurial ecosystem. This research aimed to explore the significant trends in patents related to smart city applications worldwide. The researcher conducted a patent landscape analysis using 22,655 patent materials from the Lens.org database. The study's findings indicate that the number of patents for applications related to smart cities is rising annually. There is an opportunity to use innovations in smart city applications without having to pay royalties by using 1,443 patents that have been discontinued. With seven companies, American corporations have most of the patents for applications in smart cities. The most productive individual investor was Kim Soenghun from Korea, with 946 patents. The electricity (H), physics (G), and new technological developments (Y) patent sections dominate patents related to smart city applications. There were 11,903 simple family patents for smart city applications in seven country jurisdictions; the United States occupied the highest region.

КРУПНЕЙШИЕ ГОРОДА – РЕГИОНАЛЬНЫЕ ЦЕНТРЫ ИННОВАЦИОННОГО РАЗВИТИЯ

The article examines the existing approaches to the definition of the largest cities as regional centers of innovative and scientific development of territories. A study of foreign and domestic experience in the implementation of industrial changes based on spatial agglomeration was conducted, the main models of the implementation of industrial changes were identified, the largest cities – regional innovation centers at various stages of the development of the domestic economy (1989, 2019, 2021) were identified based on the analysis of the patent landscape. The authors formulate a conclusion about the decisive role of the largest cities as points of innovative, scientific and cultural growth in the evolutionary development of territorial production systems.

Impact of Digitalizing Healthcare Business Operations on Cybersecurity Landscape

The technological evolution and digitalization of business operations contributed to healthcare organizations' constantly changing cybersecurity landscape. It is compulsory and mandated by the covered entities to fully comply with the industry regulatory standards, procedures, laws, and guidelines. The compliance officer must pay attention to the change in the business operations and the laws governing the organization's business operation. Developing an automated cybersecurity team that will track the change in the cybersecurity landscape of healthcare businesses as the business operations move toward digitalization and adoption of artificial intelligence-driven solutions. Adopting AI as a defensive measure requires an organization to monitor and assess the patent application landscape before deploying any AI intellectual property for its risk mitigation strategy or infrastructure protection. The security team must ensure that the usage of AI at the organization complies with the US federal and state antitrust laws. The organization's security team will implement control to identify data retention limits and regulate and permit the use of personally identifiable information within the organization. The enforcement will be via an organization's processes, functions, or approved mechanisms. The security team will implement binding techniques to strengthen the information flow enforcement process. This paper will elaborate on the binding technique that will regulate the number of users accessing the organization's resources or information. Keywords: Digitalization, Artificial Intelligence, Controls, Compliance, Rule & Regulation. Journal Reference Format: Yamcharoen P., Folorunsho O.S., Bayewu A. & Ojo T.P. (2022): Impact of Digitalizing Healthcare Business Operations on Cybersecurity Landscape. Journal of Behavioural Informatics, Digital Humanities and Development Research. Vol. 8.No. 4, Pp 27-34. Available online at https://www.isteams.net/behavioralinformaticsjournal. dx.doi.org/10.22624/AIMS/BHI/V8N4P3

Antimalarials: A Patents Landscape Study (2015-Present)

Abstract: Plasmodium falciparum, Plasmodium vivax, Plasmodium ovale, Plasmodium malariae, and P. knowlesi are five Plasmodium species that cause malaria, a life-threatening parasitic disease. In the developing world, the rapid development of Plasmodium falciparum resistance to currently available treatments has become a serious health concern. This work reports a patent landscape analysis of patent documents related to antimalarial. The patent search was conducted using the commercially available CAS SciFinder database and the open-source patent database, The Lens. Seven hundred ninety-seven patents from The Lens and 1172 patent Sci-finder were exported using the antimalarial drug as a keyword. After the initial screening, 58 patent documents were shortlisted for in-depth analysis. After analysis, it was found that most of the top applicants come from the United States and Switzerland, which shows that market protection is more important in these two countries. The top applicants come from private companies, universities, and public-private partnerships. The United States, Europe, China, Canada, and the Republic of Korea lead the patent race in this area. The most-recorded IPC code is A61P33/06, related to the chemical substances or pharmaceutical formulations showing antimalarials activity. Most of the time, antimalarial drugs were made from quinine, artemisinin, trioxolane, naphthoquinones, and isoquinoline derivatives. Quinine and artemisinin are well-established classes of antimalarials with the maximum number of antimalarial drugs in the market. The research and innovations disclosed in most patents were focused on exploring or evaluating the new scaffolds and their mechanism of action against the normal and resistant malarial parasite. In conclusion, it has been found that various scaffolds are needed to be explored further in search of new antimalarial compounds.

PEMT: a patent enrichment tool for drug discovery.

Drug discovery practitioners in industry and academia use semantic tools to extract information from online scientific literature to generate new insights into targets, therapeutics and diseases. However, due to complexities in access and analysis, patent-based literature is often overlooked as a source of information. As drug discovery is a highly competitive field, naturally, tools that tap into patent literature can provide any actor in the field an advantage in terms of better informed decision-making. Hence, we aim to facilitate access to patent literature through the creation of an automatic tool for extracting information from patents described in existing public resources. Here, we present PEMT, a novel patent enrichment tool, that takes advantage of public databases like ChEMBL and SureChEMBL to extract relevant patent information linked to chemical structures and/or gene names described through FAIR principles and metadata annotations. PEMT aims at supporting drug discovery and research by establishing a patent landscape around genes of interest. The pharmaceutical focus of the tool is mainly due to the subselection of International Patent Classification codes, but in principle, it can be used for other patent fields, provided that a link between a concept and chemical structure is investigated. Finally, we demonstrate a use-case in rare diseases by generating a gene-patent list based on the epidemiological prevalence of these diseases and exploring their underlying patent landscapes. PEMT is an open-source Python tool and its source code and PyPi package are available at https://github.com/Fraunhofer-ITMP/PEMT and https://pypi.org/project/PEMT/, respectively. Supplementary data are available at Bioinformatics online.

Hybrid renewable energy resources accuracy, techniques adopted, and the future scope abetted by the patent landscape – a conspicuous review

Abstract Renewables always attract everything than other thrust research areas owing to the global warming issue caused by using the non-renewables therein which should be mitigated at the earliest possible time. The easiest and safest alternative is employing renewable energy resources for the generation of energy that is completely sustainable. Many countries started insisting to seek alternatives trying to terminate to the fullest extent. Even though all these measures are taken, it is very hard to mitigate the utilization of non-renewables, owing to efficacy lag in renewables. The simplest solution for this problem is hybrid usage of renewables to enhance the efficiency. This article took this as a factor, gathered data for hybrid RERs technique with its accuracy range for easy selection of techniques by the stakeholders, trending technology being adopted, and future scope abetted by the patent landscape.

Analyzing technology landscape of carbon capture storage and utilization in Baltic Sea region through patents

Capturing CO2 and preventing it from being released into the atmosphere was first suggested in 1977; using existing technology in new ways. CO2 capture technology has been used since the 1920s for separating CO2 sometimes found in natural gas reservoirs from the saleable methane gas. More recently, investment in CCS is being driven by the oil and gas industries as well as cement, iron and steel, and chemical production industries in the push for decarbonization. Once it is separated from other gases, the carbon dioxide is then compressed, transported, and injected underground for permanent storage. About 90-100 % of produced carbon dioxide can be captured in this manner. Many are betting on CCS as a key to greenhouse gas emission reductions, since leveraging CCS is expected to achieve 14-19 % of the reductions needed by 2050 (1,2,3). In 2020, we sent 40 billion metric tons (t) of carbon dioxide into Earth’s atmosphere. We need to cut that number to 0 by 2050 if we are to avoid the worst consequences of climate change, according to the Intergovernmental Panel on Climate Change (IPCC). The objectives of this paper is to present the patent landscape of Baltic sea region countries (BSR), which includes Lithuania, Latvia, Estonia, Finland, Denmark, Sweden, Russia, Poland and Norway. To perform the analysis searches have been conducted to identify patents related to Carbon capture and sequestration for the BSR. Patent analytics searches have been restricted to dates from 2000-2020. Technologies investigated mainly focuses on CO2 storage, monitoring, utilization and transport.The patent analytics searches have been conducted to identify patents related to CCUS technology. The search resulted in 3299 patent families. A relevancy analysis was done to identify patents which are related to CCUS & resulted in 497 patent families. Identified relevant patents have been categorized in a classification scheme. Results of this patent analytics work shows that in 2009 we have the greatest number of IP activity for CCUS. Exponential growth in patent filing since 2005-2009, showing an increasing trend for CCUS activities, 2010-2015 has an exponential decreasing trend for CCUS activities. In northern and eastern Europe, Russia & Poland are leading the research & patent filing in the CCUS domain. From industry point of view General Electrics (GE)has the highest number of publications followed by Mitsubishi and Siemens. 85 % of 497 relevant Patent families are Alive. GE has around 78 % of its families alive. The top patents are related to capture, storage, sequestration or disposal of greenhouse gases and followed by patents related to separation processes. CO2 capture is the most explored technology/CCUS type along with storage. Unfortunately, there is a decreasing trend in patent filings since 2016. The CCUS technologies are striving to gain traction in the set of options for dealing with climate change, but growth is very slow due to absence or low intervention of government action on climate change, public scepticism, increasing costs, and advances in other options including renewables and shale gas.