Past 40 Research Articles

State Observers/Kalman Filters are Generally Unsuitable for Feedback Control While a Far More Rational and Superior Solution is Available

-An observer that estimates system state vector x(t) is a state observer. Although a state observer can generate state feedback control signal Kx(t) where the constant gain K can bese parately designed before its realizing observer, the actual observer feedback system cannot have its loop transfer function equal K(sI – A)-1B, the loop transfer function of the direct state feedback control, for a great majority of plant systems. Because loop transfer function determines the sensitivity function and robust properties of the corresponding feedback system, this implies that the robust properties of the Kx(t)-control are failed to be realized by state observers for a great majority of plant systems.Because robustness against system model uncertainty and terminal disturbance is foremost of feedback control even above performance, state observers are unsuitable for feedback control. Although this problem has initiated a vibrant robust control research in the past 40+ years, the result of that research has been unsatisfactory if parameter K is designed separately and prior to observer design. As a result, control theory remains essentially stagnant and a large amount of works still applied Kalman filters and state observers to feedback control applications. Fortunately, this vital problem has found a fundamentally novel yet decisively satisfactory solution, that is to design parameter K based on the key observer parameters! These new observers are not restricted to be state observers, and can have freely designed and reduced observer order for the first time, and thus can guarantee the full realization of loop transfer function and robust properties of their corresponding Kx(t)-control. Such an observer exits for a great majority of plant systems!In addition, this new design principle is very simple to be learned, and adjusted very easily. Thus, a design methodology that can achieve high performance and robustness for general L-T-I systems is finally developed

Managing Challenging Child Behaviour in Pediatric Dentistry Using Pharmacologic Approaches: A Vanishing Art

Amongst the skills and competency expected of the pediatric dental specialist is an enhanced ability to circumvent and obtund interfering and refractory behaviour of moderately to severely apprehensive and resistive children. Wide variation exists among this specialist with respect to individual talents to accomplish treatment on this population making use of both nonpharmacological as well as pharmacological approaches. While advanced training programs vary greatly in the extent to which their residents are exposed to various modalities, likely explanation to account for such lies in the diversity to which their faculty bring competent and diversified experience. Some bring extensive background to the use of a variety of agents and dosing; others conceivably offer limited exposure to residents by not having had extensive use during their own training programs. Expertise and a propensity to include a broad repertoire of agents and modalities by Program Directors is highly variable. External sources include administrative perspectives, safety records, formulary limitations, and biases of state and regulatory agencies as to what agents and regimens impose restrictions on this teaching experience. This editorial expresses observations of this author over the past 40 plus years concludes that the use of pediatric sedation has diminished to the extent that its safe and successful use is at risk of becoming a vanishing art. The end result is that an increasing number of children by virtue of a lack of skilled clinicians in its safe use will be subjected to excessive if not unnecessary use of unconscious techniques and/or physical restraint.

2022 Cannon lecture: an ode to signal transduction: how the growth hormone pathway revealed insight into height, malignancy, and obesity.

Walter Cannon was a highly regarded American neurologist and physiologist with extremely broad interests. In the tradition of Cannon and his broad interests, we discuss our laboratory's multifaceted work in signal transduction over the past 40+ years. We show how our questioning of how growth hormone (GH) in the blood communicates with cells throughout the body to promote body growth and regulate body metabolism led to insight into not only body height but also important regulators of malignancy and body weight. Highlights include finding that 1) A critical initiating step in GH signal transduction is GH activating the GH receptor-associated tyrosine kinase JAK2; 2) GH activation of JAK2 leads to activation of a number of signaling proteins, including STAT transcription factors; 3) JAK2 is autophosphorylated on multiple tyrosines that regulate the activity of JAK2 and recruit signaling proteins to GH/GH receptor/JAK2 complexes; 4) Constitutively activated STAT proteins are associated with cancer; 5) GH activation of JAK2 recruits the adapter protein SH2B1 to GH/GH receptor/JAK2 complexes where it facilitates GH regulation of the actin cytoskeleton and motility; and 6) SH2B1 is recruited to other receptors in the brain, where it enhances satiety, most likely in part by regulating leptin action and neuronal connections of appetite-regulating neurons. These findings have led to increased understanding of how GH functions, as well as therapeutic interventions for certain cancer and obese individuals, thereby reinforcing the great importance of supporting basic research since one never knows ahead of time what important insight it can provide.

EDITORIAL COMMENT

The authors have taken on a controversial topic in the management of couple infertility that has plagued this area of medical care for many years. Their approach is a new attempt to get at the problem and assess the latest data. It is not surprising that the male partner of an infertile couple is often not referred to a reproductive urologist. This has changed little over the past 40 + years as treatment options for male reproductive medicine and surgery have grown.

(Electronics and Photonics Division Award) Let There be Light; Research at the Intersection of Electronics and Photonics

Electronics and photonics have a long and successful history of combining to provide many devices and products that are at the heart of the modern technological world, ranging form solar cells to lasers to digital displays. In this presentation I will first give a brief historical overview of the interplay and interdependence of electronics and photonics. The properties and effects that are commonly exploited in opto/electronics fall primarily in two areas: (a) the effect of incident light (or more generally radiation) due to optical absorption/transmission/reflection and the conversion of photons to electrical charge that can be collected; (b) the injection of electrons & holes leading to the emission of photons. Then I will review selected examples from my research in optoelectronic materials and devices in more or less chronological order over the past 40+ years. An early example [1] in the light-to-charge was integration of infrared detectors using narrow bandgap semiconductors (such as InSb and HgCdTe) with silicon charge coupled devices that performed data storage and image processing functions on arrays of pixels. A major research topic in my group in the charge-to-light category has for many years been electroluminescence [2] from wide bandgap semiconductors (primarily GaN and AlN) doped with rare earth elements (Er, Eu, Tm, etc.). Narrow linewidth emission can occur at wavelengths from near UV to visible to IR, depending on the electronic transitions of the selected RE element and the bandgap of the host material. In the past 10 years, my materials interest switched from inorganic to organic semiconductors and biomaterials, but with a continuing strong opto/electronic component. Currently, a major research focus is in developing simple, low cost and intuitive diagnostic devices for point-of-care use. These devices analyze the composition of biofluids (e.g. blood, sweat, saliva, etc.) to provide a 1st order indication of specific aspects the individual’s health status, such as blood coagulation, stress, etc. The use of light in PoC and other diagnostic devices is widespread. Most common and simplest approach is colorimetric detection in ambient light, where a change of color in a region of the device indicates the presence of a specific biomolecule associated with a given medical condition. Somewhat more complex diagnostic devices use fluorescence of molecules attached to biomarkers to indicate their presence. In our own research, biofluid samples are typically transported by capillary flow to a location where their key properties are measured by a combination of optical emission [3], transmission and absorption [4]. The presentation will conclude with a look forward to other applications where photonics and electronics could join forces.[1] A.J. Steckl, et al., “Application of Charge Coupled Devices to Infrared Detection and Imaging,” Proc. of IEEE, 63(1), 67, Jan 1975 ( doi.org/10.1109/PROC.1975.9708 ).[2] (a) A.J. Steckl and J.M. Zavada, “Optoelectronic Properties and Applications of Rare-Earth-Doped GaN”, Mat. Res. Soc. Bulletin, 24(9), 33, Sep 1999 doi.org/10.1557/S0883769400053045; (b) A. J. Steckl, et al., Invited Paper, “Rare-earth-doped GaN: Growth, Properties and Fabrication of Electroluminescent Devices”, IEEE J. Selected Topics in Quantum Electronics, 8 (4), 749 Jul 2002 doi.org/10.1109/JSTQE.2002.801690 [3] V. Venkatraman and A. J. Steckl, “Quantitative Detection in Lateral Flow Immunoassay Using Integrated Organic Optoelectronics”, IEEE Sensors, 17 (24), 8343, Dec 2017 (doi.org/10.1109/JSEN.2017.2764178 ).[4] P. Ray and A. J. Steckl, “Label-Free Optical Detection of Multiple Stress Biomarkers in Sweat, Plasma, Urine and Saliva”, ACS Sensors 4, 1346, 2019. (doi.org/10.1021/acssensors.9b00301). Figure 1

Genesis and Evolution of NASA’s Satellite Ocean Color Program

We recount, based on our involvements in NASA ocean color flight projects, the chronology of technical challenges, lessons learned, and key developments over the past 40 + years of NASA satellite ocean color, beginning with the Nimbus-7/Coastal Zone Color Scanner, that have led to the upcoming Plankton, Aerosol, Cloud, ocean Ecosystem (PACE) mission. Topics include the evolution of 1) satellite ocean color and field bio-optical data access, 2) satellite sensor capabilities, i.e., CZCS to PACE’s hyperspectral Ocean Color Imager, OCI, 3) atmospheric corrections, 4) pre- and post-launch sensor characterization and calibration, 5) bio-optical algorithms, 6) in situ-derived radiometry and photosynthetic pigment data measurement quality, and 7) applications of hyperspectral satellite observations.

A Guide to Selecting Participatory Research Methods Based on Project and Partnership Goals.

Participatory research engages community stakeholders in the research process, from problem identification and developing the research question, to dissemination of results. There is increasing recognition in the field of health research that community-engaged methods can be used throughout the research process. The volume of guidance for engaging communities and conducting participatory research has grown steadily in the past 40+ years, in many countries and contexts. Further, some institutions now require stakeholder engagement in research as a condition of funding. Interest in collaborating in the research process is also growing among patients and the public. This article provides an overview for selecting participatory research methods based on project and partnerships goals.

An Updated Assessment of the Changing Arctic Sea Ice Cover

Sea ice is an essential component of the Arctic climate system. The Arctic sea ice cover has undergone substantial changes in the past 40+ years, including decline in areal extent in all months (strongest during summer), thinning, loss of multiyear ice cover, earlier melt onset and ice retreat, and later freeze-up and ice advance. In the past 10 years, these trends have been further reinforced, though the trends (not statistically significant at p <0.05) in some parameters (e.g., extent) over the past decade are more moderate. Since 2011, observing capabilities have improved significantly, including collection of the first basin-wide routine observations of sea ice freeboard and thickness by radar and laser altimeters (except during summer). In addition, data from a year-long field campaign during 2019–2020 promises to yield a bounty of in situ data that will vastly improve understanding of small-scale processes and the interactions between sea ice, the ocean, and the atmosphere, as well as provide valuable validation data for satellite missions. Sea ice impacts within the Arctic are clear and are already affecting humans as well as flora and fauna. Impacts outside of the Arctic, while garnering much attention, remain unclear. The future of Arctic sea ice is dependent on future CO2 emissions, but a seasonally ice-free Arctic Ocean is likely in the coming decades. However, year-to-year variability causes considerable uncertainty on exactly when this will happen. The variability is also a challenge for seasonal prediction.

Tumescent Anesthesia: A Brief History Regarding the Evolution of Tumescent Solution.

Tumescent anesthesia, initially developed as a safer and more effective alternative to general anesthesia in performing liposuction, is used extensively today for a wide array of surgical procedures performed by various specialties. The make-up of the tumescent solution is variable, and it has evolved significantly over the past 40+ years. Even prior to Jefferey Klein’s tumescent solution recorded in his article from 1987, “The Tumescent Technique for Lipo-Suction Surgery,” there were significant contributions paving the way to modern formulations.1 In this article, we attempt to provide the most comprehensive history and timeline documenting the evolution of tumescent solution to date. J Drugs Dermatol. 2021;20(12):1283-1287. doi:10.36849/JDD.6212.

Breaking Out of Consumer Welfare Jail: Addressing the Supreme Court's Failure to Protect the Competitive Process

It is time to free antitrust law from the yoke of Robert Bork’s consumer welfare terminology. Bork’s vision has gained ascendency over the past 40 plus years and, subject to variations, is now widely regarded as the core antitrust paradigm. In a companion article, I examined why a consumer welfare standard cannot sustain this role. I made the case for a symmetric welfare standard anchored to the traditional view that the Sherman Act protects the competitive process. In this article, I expand this analysis. A consumer-labelled paradigm invites a static analysis—one focused on competitive effects at only one end of the distribution chain. In fact, competition is a dynamic and interactive process in which players at all levels of the chain add value and affect each other’s choices. All participants in the distribution chain are disciplined by competition – and all should be protected from power-based abuse of competition. I provide extended analysis of why non-price and non-efficiency preferences of buyers and sellers are a critical part of the competitive process and cannot be comfortably accommodated by consumer welfare standards. I offer examples of preferences, not just of consumers but of all participants in the distribution of goods and services, that are at the heart of the competitive process. I then examine Supreme Court decisions. More than a few recent cases demonstrate a fixation with consumer welfare standards and fail to protect competition. Righting the antitrust ship will require embracing a tradition-based, symmetric welfare standard that equally protects all players in the competitive system.

Advancements in reactor stability analysis methods; personal perspective

Understanding the origins and propagation of flow-induced instabilities is very important for the operation and safety of the current and next generations of boiling water reactors (BWR), as well as for future new reactor types, such as the supercritical-pressure reactors, cooled by either water or CO2. Consequently, substantial (or even extensive) efforts have been made during the past 40+ years to investigate the physical phenomena governing such instabilities, and to develop models and computational tools to simulate the dynamics of marginally-stable/unstable boiling systems. The purpose of this paper is to present an updated perspective on, and discuss new aspects of, selected studies performed by the author and his collaborators, associates and graduate students, aimed at the development of various methods for the analysis of flow-induced instabilities in both boiling and supercritical-pressure systems. The impact of model and method selection on the results of predictions will also be discussed for a large class of systems, including the neutronically-coupled oscillations. Since the current paper is a part of the NED issue commemorating 40 years since the first NURETH–series conference, the list of references includes eleven (11) related papers published before in various NURETH proceedings, as well as other related journal articles and conference papers.

Habitat International Coalition: Networked practices, knowledges and pedagogies for translocal housing activism

How do global coalitions of civil society, non-governmental and community-based organisations, social movements and academics, make visible, defend and produce habitat rights? This conversation with the President of the Habitat International Coalition (HIC), Adriana Allen, examines HIC’s perspectives on the practices, knowledges and pedagogies for translocal housing activism through reflections structured along several themes. These include understanding the horizontal democratic practices of working as a ‘network of networks’, with particular focus on how translocality can go beyond international mobility. The discussion also addresses the struggle for recognition and for pursuing epistemic justice, highlighting caveats and potentials of knowledge co-production and popular pedagogies; and the diversity of understandings of housing (including, radical housing) which the Coalition nurtures and reconciles. The conversation highlights the value of foregrounding an explicitly rights-based housing agenda, which has been continuously nurtured over the past 40+ years of HIC’s work on the social production of habitat.

Canadian Studies

Canadian Studies was launched in Hungary in 1979, when the first course in Canadian literature was offered at the English Department of Eötvös Loránd University, Budapest. This article is intended to explore the history of this discipline in the past 40+ years, focusing on the growing awareness of Canada and its culture in Hungarian academic and intellectual life. As early as the mid-1980s, universities in Hungary offered various courses in Canadian Studies, which were followed by a large number of publications, conferences, and the institutionalization of the field. The article gives a survey of Canadian Studies in Hungary in the international context, showing the ways in which interaction with colleagues in Europe and beyond, and with institutions, such as the Central European Association for Canadian Studies, have promoted the work of Hungarian researchers. The article also discusses the fields of interest and individual achievements of Hungarian scholars, as well as the challenges Canadian Studies has faced.

Status of coral reefs in Antigua & Barbuda: using data to inform management.

The nation of Antigua and Barbuda has experienced major degradation of its coral reef ecosystems over the past 40+ years. The primary drivers of this degradation are multiple and are highly linked to anthropogenic influences, including over-exploitation and poor management of marine resources. The effectiveness of management actions in marine protected areas (MPAs) has often been hampered by a lack of data to inform management recommendations. This was emphasized by The Nature Conservancy’s (TNC) Coral Reef Report Card which highlighted not only the lack of data collection in Antigua and Barbuda and other Caribbean nations, but also illustrated how spatially dispersed available datasets are. The government of Antigua and Barbuda recognized the need for a marine data collection program to better inform the designation and management of MPAs as a tool to improve the health of the marine ecosystems. The Atlantic Gulf Rapid Reef Assessment (AGRRA) protocol has been identified as a means to address planning and management for marine areas. Three AGRRA surveys have been conducted in the years following the TNC 2016 report, in previously established managed areas: North East Marine Management Area (NEMMA) in 2017 and Nelson Dockyard National Park (NDNP) in 2019 as well as areas outlined for future management (Redonda in 2018). Our surveys were conducted to provide updated datasets to inform management for the aforementioned areas. While the results of these surveys mirror the underlying poor coral reef-health conditions, which have been shown to exist within the Caribbean region, they also highlight intra-site variation that exists within each survey location. This knowledge can be crucial in guiding management decisions in these marine areas, through zoning and other management prescriptions. Additionally, the marine surveys conducted around Redonda established useful marine baselines to aid in monitoring the island’s recovery following removal of terrestrial invasive species. This article provides an overview of data collected using the AGRRA methodology in marine zones across Antigua and Barbuda which have current or future management prescriptions and provides recommendations to demonstrate the data’s future utilization for marine conservation and management.

(Electronics and Photonics Division Award Address) Let There be Light... – Research at the Intersection of Electronics and Photonics

Electronics and photonics have a long and successful history of combining to provide many devices and products that are at the heart of the modern technological world, ranging form solar cells to lasers to digital displays. In this presentation I will first give a brief historical overview of the interplay and interdependence of electronics and photonics. The properties and effects that are commonly exploited in opto/electronics fall primarily in two areas: (a) the effect of incident light (or more generally radiation) due to optical absorption/transmission/reflection and the conversion of photons to electrical charge that can be collected; (b) the injection of electrons & holes leading to the emission of photons. Then I will review selected examples from my research in optoelectronic materials and devices in more or less chronological order over the past 40+ years. An early example [1] in the light-to-charge was integration of infrared detectors using narrow bandgap semiconductors (such as InSb and HgCdTe) with silicon charge coupled devices that performed data storage and image processing functions on arrays of pixels. A major research topic in my group in the charge-to-light category has for many years been electroluminescence [2] from wide bandgap semiconductors (primarily GaN and AlN) doped with rare earth elements (Er, Eu, Tm, etc.). Narrow linewidth emission can occur at wavelengths from near UV to visible to IR, depending on the electronic transitions of the selected RE element and the bandgap of the host material. In the past 10 years, my materials interest switched from inorganic to organic semiconductors and biomaterials, but with a continuing strong opto/electronic component. Currently, a major research focus is in developing simple, low cost and intuitive diagnostic devices for point-of-care use. These devices analyze the composition of biofluids (e.g. blood, sweat, saliva, etc.) to provide a 1st order indication of specific aspects the individual’s health status, such as blood coagulation, stress, etc. The use of light in PoC and other diagnostic devices is widespread. Most common and simplest approach is colorimetric detection in ambient light, where a change of color in a region of the device indicates the presence of a specific biomolecule associated with a given medical condition. Somewhat more complex diagnostic devices use fluorescence of molecules attached to biomarkers to indicate their presence. In our own research, biofluid samples are typically transported by capillary flow to a location where their key properties are measured by a combination of optical emission [3], transmission and absorption [4]. The presentation will conclude with a look forward to other applications where photonics and electronics could join forces.[1] A.J. Steckl, et al., “Application of Charge Coupled Devices to Infrared Detection and Imaging,” Proc. of IEEE, 63(1), 67, Jan 1975 ( doi.org/10.1109/PROC.1975.9708 ).[2] (a) A.J. Steckl and J.M. Zavada, “Optoelectronic Properties and Applications of Rare-Earth-Doped GaN”, Mat. Res. Soc. Bulletin, 24(9), 33, Sep 1999 doi.org/10.1557/S0883769400053045; (b) A. J. Steckl, et al., Invited Paper, “Rare-earth-doped GaN: Growth, Properties and Fabrication of Electroluminescent Devices”, IEEE J. Selected Topics in Quantum Electronics, 8 (4), 749 Jul 2002 doi.org/10.1109/JSTQE.2002.801690 [3] V. Venkatraman and A. J. Steckl, “Quantitative Detection in Lateral Flow Immunoassay Using Integrated Organic Optoelectronics”, IEEE Sensors, 17 (24), 8343, Dec 2017 (doi.org/10.1109/JSEN.2017.2764178 ).[4] P. Ray and A. J. Steckl, “Label-Free Optical Detection of Multiple Stress Biomarkers in Sweat, Plasma, Urine and Saliva”, ACS Sensors 4, 1346, 2019. (doi.org/10.1021/acssensors.9b00301). Figure 1

Advances in Our Understanding of Behavioral Intervention: 1980 to 2020 for Individuals Diagnosed with Autism Spectrum Disorder

There are three branches of science of behavior analysis [i.e., experimental analysis of behavior, behavior analysis, and applied behavior analysis (ABA)]. ABA can be defined as a systematic approach to understanding behavior of social interest. For the past 40 plus years, researchers have evaluated ABA and ABA based procedures (e.g., behavioral intervention) as they relate to individuals diagnosed with autism spectrum disorder (ASD) and have implemented behavioral intervention in clinical settings for individuals diagnosed with ASD. In this paper, we discuss some of the pivotal contributions in the field of ABA in research and clinical practice. Additionally, we provide recommendations for the science and clinical practice of behavioral intervention in the next 40years.

Toward deterministic construction of low noise avalanche photodetector materials

Over the past 40+ years, III-V materials have been intensively studied for avalanche photodetectors, driven by applications including optical communications, imaging, quantum information processing, and autonomous vehicle navigation. Unfortunately, impact ionization is a stochastic process that introduces noise, thereby limiting sensitivity and achievable bandwidths, leading to intense effort to mitigate this noise through the identification of different materials and device structures. Exploration of these materials has seen limited success as it has proceeded in a largely ad hoc fashion due to little consensus regarding which fundamental properties are important. Here, we report an exciting step toward deterministic design of low-noise avalanche photodetector materials by alternating the composition at the monolayer scale; this represents a dramatic departure from previous approaches, which have concentrated on either unconventional compounds/alloys or nanoscale band-engineering. In particular, we demonstrate how to substantially improve upon the noise characteristics of the current state-of-the art telecom avalanche multipliers, In0.52Al0.48As grown on InP substrates, by growing the structure as a strain-balanced digital alloy of InAs and AlAs layers, each only a few atomic layers thick. The effective k-factor, which has historically been considered a fundamental material property, was reduced by 6–7× from k = 0.2 for bulk In0.52Al0.48As to k = 0.05 by using the digital alloy technique. We also demonstrate that these “digital alloys” can significantly extend the photodetector cutoff wavelength well beyond those of their random alloy counterparts.

Health Care Regulation Spending Trap

Our health care system has faced many challenges over the past 40 plus years. Now these challenges have forced us into a complicated situation that makes it confusing on how best to proceed. Today third party insurance payers make most health care payments. Our premiums are paid into a risk pool-on medical services for other people. Consumers are disconnected from knowing the cost of goods or services that they are receiving. This commentary reviews the current situation and provides a few common sense approaches for pursuing the best potential policies.

Practical Stereochemistry.

The relationship between fundamental and applied is often uneasy, particularly in modern political climates. A familiar political view, aimed negatively at the scientific community, is that the former is a waste of money whereas the latter gives value for investment. The answer that fundamental is required as the basis for practical suffers from the fact that the timelines between fundamental and practical are often long and the routes contorted and unexpected. This has been my experience. In this Account, examples are given from the research in which I have been involved wherein quite fundamental considerations have led to various applications. The longer the time, the clearer and broader the relationship. Fundamental can and does lead to application. They need and depend on each other. I have seen this both from the side of academia and from small companies. In the course of the past 40 plus years, I have been involved in various aspects of stereochemistry and, in particular, chirality. It has been rewarding to see that several of the developments, most originally grounded in fundamental research considerations, have been used in the chemical community and given new dimensions and often practical applications by others. In this Account, a path-not planned deliberately by me-from orbital symmetry and Woodward-Hoffmann rules through crown ethers to conformational analysis to diastereomeric resolutions to deracemizations powered by Ostwald ripening and the Gibbs-Thomson effect to nucleation to helicenes is described. In order of discussion, the orbital symmetry aspects have via an unusual and unpredicted path has resulted in, among other things, a synthesis of hindered alkenes useful for the production of molecular motors. The crown ether aspects led to discovery of the utility of cesium salts particularly for racemization sensitive nucleophilic substitutions. Work on diastereomeric resolutions has concentrated on the mechanistic as well as practical/commercial aspects of the use of multiple resolving agents (Dutch resolution). During this work the complex relationship between nucleation and chirality in diastereomeric resolutions began to reveal itself. In general, nucleation, especially with involvement of chirality, is a topical challenge that has attracted the attention of many groups. The contribution of this knowledge to the development of attrition driven deracemizations of racemizable conglomerates is described. This remarkable technology allows, without intervention of chiral aids, conversion of certain racemates in quantitative yield and absolute enantiomeric excess to a single enantiomer. From a practical standpoint, this methodology has been used for the production in enantiomerically pure form of commercially interesting compounds like naproxen and clopidogrel (Plavix). Finally an STM investigation of the nucleation behavior of a helicene, prepared via a remarkably short and efficient route, on a metal surface is described.

Dis-Illusioning Psychology: Epistemology and the Contextual Psychology of Ellyn Kaschak

ABSTRACTEllyn Kaschak is a pioneer feminist therapist whose contributions to feminist theory, practice, education, and advocacy have spanned the globe over the past 40 + years. From being a founder of one of the first feminist counseling services in the country in the early 1970s, Kaschak has influenced decades of feminist, family and multi-cultural therapists through her teaching and countless others through her feminist epistemology and theory development and the Mattering Map. This article describes Kaschak’s life and work and the lasting contributions she has made to the field of feminist psychology.