Parts Of West Africa Research Articles

A review of the role of the Cucurbitaceae family in food security in West Africa

Background: Food and nutritional security are main development goals in several countries of Africa. In West Africa, the use of African indigenous vegetables caters for the food and nutritional needs of a high proportion of the people, most particularly amongst the poor and rural dwellers. The family Cucurbitaceae is one of the most important and widely grown vegetables in the tropical and subtropical climates.Aim and objective: This review discusses the culinary relevance of several species of Cucurbitaceae and their roles in food security in West Africa.Methods: A literature search was conducted on electronic databases such as Google Books, Google Scholar, Scopus and Web of Science.Discussions: Certain genera such as Telfairia, Cucurbita and Citrullus and other Egusi species are commonly cultivated in different parts of West Africa including Nigeria for their fruits, seeds and leaves because of their crucial nutrient compositions and palatability in local diets. These species and other species of Cucurbitaceae are used as traditional vegetables or African indigenous vegetables and are either sourced from the wild or cultivated in several African countries. Some of these species have played roles beyond food security but have also been crucial tools for nutritional security, especially within the low-income group and rural communities.Conclusions: Several communities in West Africa use almost all parts of the plant (leaves, fruit, seed, flowers) of some species of this family as food or in food preparations. Their use could also lead to innovative pathways towards reducing diseases associated with malnutrition especially those related to protein deficiency.

Sub-acute toxicity studies of the hypocotyl extract of Borassus Aethiopum on hepato-renal functions, and haematological indices in wistar rats

Context: Borassus aethiopum is a tropical plant found in the most parts of West Africa. The fruits, sap, and hypocotyl are used for nutritional purposes and in traditional herbal medicine for the treatment of various diseases and infertility. Despite its widespread use, there is insufficient data on its safety profile. Aim: This study is aimed to evaluate the safety of the plant on the hematological indices, liver, and kidney function. Materials and Methods: Twenty Adult male Wistar rats were divided into 4 groups of 5 rats each and were orally administered with different doses of the extract (250, 500, and 1000 mg/kg) and 1 ml of distilled water, respectively, for 28 days. The median lethal dose (LD50) was determined using Lorke's method. The hematological indices, liver and kidney functions of the animals were assessed using standard procedures with the aid of an autoanalyzer. Result: The oral median lethal dose (LD50) was determined to be greater than 5000 mg/kg. No mortality was recorded in the rats after 28 days of daily treatment. With sub-chronic administration, no adverse toxicological effect was observed. There was also no significant difference observed in the hematological, liver, and kidney function parameters between the control group and extract-treated groups. Conclusion: The present study shows that methanol hypocotyl extract of Borassus aethiopum is pre-clinically safe in Wistar rats at the doses tested and may not likely produce any toxic effect on prolonged administration.

Challenges and Opportunities in Lassa fever Control Efforts in Nigeria

Lassa fever is a viral zoonotic tropical disease endemic in parts of West Africa. It causes substantial mortality, morbidity and economic burdens on affected populations. The year 2019 marked the 50th anniversary of the first diagnosis of Lassa fever in Nigeria. Over the years, a few and sporadic intervention measures have been undertaken to control Lassa fever in Nigeria. However, the disease has remained a burden due to neglect, and apathy from the Government. Here we highlight the Lassa fever control efforts so far undertaken in Nigeria. We also point to some challenges and opportunities for effective Lassa fever control efforts. In addition, we proposed few Lassa fever control measures, which vary from advocacies, training of local communities and health workers in the use of rapid, cheap diagnostic tools. We also propose an integrated genomic surveillance platform that utilizes one health approach, in tracking and tackling Lassa fever, as the key future of Lassa fever control effort. In this review, we present IGOHRAL, an integrated genomic platform that utilizes clinical, genomic and epidemiological data in a one-health approach to tackle Lassa fever problem. Lassa fever (LF) is a serious viral hemorrhagic fever endemic in West Africa. The history of Lassa fever virus (LVS) in Nigeria is that of neglect, wickedness and apathy (Akpede et al., 2018). Lassa virus was first diagnosed in a missionary hospital in Nigeria in 1969 (Carey et al., 1972). There was an outbreak of a febrile illness involving hospital staff and those who visited the hospitals. The aetiology was later confirmed to be LVS. Prior to this outbreak, there have been several descriptions of illness resembling LF (Monath, 1975). However, a genomics study by Anderson et al. later confirmed that the LVS emerged in present day Nigeria over 1060 years ago (Andersen et al., 2015).

Continuous Intake of High Doses of Piper guineense (Ashanti pepper) Aqueous Seed Extract Impairs Renal Function in Wistar Rats

BACKGROUND: Piper guineense seed is a well known spice consumed in many parts of West Africa as a result of its nutritional and medicinal properties. METHODS: Twenty Wistar rats were divided into four groups of five per group. The phytochemical analyses was done; different concentration of aqueous seed extract of Piper guineense was administered for 21 days to three experimental groups, Group 2 (25 mg/kg), Group 3 (50 mg/kg), Group 4 (100 mg/kg), while group 1 were given only rat feed and water. RESULTS: The investigation revealed that in low and medium dose groups, creatinine (62.3±7.3 to 51.1±4.5 and 51.1±8.1 respectively) and urea (6.6±1.3 to 5.2±0.8 and 4.8±1.0) levels decreased significantly while in high dose group, creatinine (62.3±7.3 to 66.9±11.0) and urea (6.6±1.3 to 7.0±0.8) increased significantly. There was a dose dependent increase in the serum electrolyte (sodium, potassium, chlorine and bicarbonate). Only bicarbonate (19.1±0.8 to 24.3±1.3) and chloride (102.4±3.8 to 107.0±1.6) had significant increase in their values. The histological study showed that at a low (25mg/kg) and medium dose (50mg/kg) of aqueous seed extract of Piper guineense the normal cyto-architecture of the kidney was maintained while in high dose group (100mg/kg) normal cyto-architecture of the kidney was distorted. CONCLUSION: The result obtained suggests that Piper guineense seed may not be harmful at a moderate dose; but high doses could be toxic. Caution should be taken on the quantity of Piper guineense seed consumed.

Human immunodeficiency virus type 1 (HIV-1) subtype diversity in Busia, Western Kenya

HIV infection is currently the single biggest epidemic globally. HIV the etiologic agent for AIDS is divided into two types: HIV-1 and HIV-2. HIV-2 is rare and is mainly found in some parts of West Africa. HIV-1 accounts for most cases of AIDS reported globally. HIV-1 strains can be classified into four groups: The major group M, group O, group N and the most recent group P. All of which may represent separate introductions of SIVs into humans. This cross sectional study determined the HIV-1 subtype diversity in Busia, Western Kenya. Briefly, participants were consented into the study based on pre-determined inclusion criteria. Viral RNA quantification was performed to select participants with virologic failure for drug resistance testing. HIV drug resistance testing (DRT) was performed and sequences obtained were used to determine circulating HIV-1 subtypes using the REGA HIV-1 Subtyping Tool Version 3.0. Phylogenetic analysis was performed using MEGA software V7.0 to confirm the circulating HIV subtypes. Out of 915 participants screened, 146 participants had virologic failure although 140 were successfully sequenced. Subtype A1 was the most prevalent subtype present in 52.9% of the participants followed by subtype D (20.7%), CRF A1_D (7.1%) subtype C and subtype B (4.3%) and subtype A2 (3.6%). Sequences within the same subtype and CRF clustered close together on the phylogenetic tree. An increase in CRFs in the population compared to previous studies. Circulating HIV subtypes should be continually monitored in Busia to determine trends in transmission and map the circulating recombinant forms for epidemiological purposes. Key words: HIV-1, Busia county, subtype diversity, reverse transcriptase.

Antimicrobial properties of Vernonia amygdalina on Escherichia coli and Proteus species isolated from urine samples: Potential antimicrobial alternative for urinary tract infection

Vernonia amygdalina is a member of the Asteraceae family and a shrub of 2-3m tall with a petiole leaf of about 6mm wide and naturally distributed in many parts of West Africa. It is reported to have several health benefits including antimicrobial efficacy. The study assessed the antimicrobial effects of aqueous and ethanolic extracts of Vernonia amygdalina on clinical isolates of Escherichia coli and Proteus spp. Of the 41 urine samples collected included in this research, 21 clinical samples (urine) were collected from Kwararafa Hospital Wukari while the remaining 20 samples were taken from students of Federal University Wukari. Standard microbiological techniques were employed in this investigation. Extracts of the leaves were made using Ethanol and aqueous procedures. The antimicrobial activity of the extracts was tested using pathogenic isolates of Proteus species and Escherichia coli. It was observed that Escherichia coli were susceptible to both extracts of the leaf in high concentrations. The aqueous extract of the leaf shows moderate growth on the Proteus species but the ethanolic extract of the leaf presented significant antimicrobial activity on Proteus spp. This study has revealed greatly that extracts of Vernonia amygdalina in high concentration possess strong antimicrobial activities against the tested clinical isolates Proteus species and Escherichia coli with ethanolic extract of the leaves exhibiting greater antimicrobial significance against the tested clinical isolates compared to aqueous extracts of the leaves.

Increased high-temperature extremes and associated population exposure in Africa by the mid-21st century

Previous studies warned that heat extremes are likely to intensify and frequently occur in the future due to climate change. Apart from changing climate, the population's size and distribution contribute to the total changes in the population exposed to heat extremes. The present study uses the ensemble mean of global climate models from the Coupled Model Inter-comparison Project Phase six (CMIP6) and population projection to assess the future changes in high-temperature extremes and exposure to the population by the middle of this century (2041–2060) in Africa compared to the recent climate taken from 1991 to 2010. Two Shared Socioeconomic Pathways (SSPs), namely SSP2-4.5 and SSP5-8.5, are used. Changes in population exposure and its contributors are quantified at continental and for various sub-regions. The intensity of high-temperature extremes is anticipated to escalate between 0.25 to 1.8 °C and 0.6 to 4 °C under SSP2-4.5 and SSP5-8.5, respectively, with Sahara and West Southern Africa projected to warm faster than the rest of the regions. On average, warm days' frequency is also expected to upsurge under SSP2-4.5 (26–59%) and SSP5-8.5 (30–69%) relative to the recent climate. By the mid-21st century, continental population exposure is expected to upsurge by ~25% (28%) of the reference period under SSP2-4.5|SSP2 (SSP5-8.5|SSP5). The highest increase in exposure is expected in most parts of West Africa (WAF), followed by East Africa. The projected changes in continental exposure (~353.6 million person-days under SSP2-4.5|SSP2 and ~401.4 million person-days under SSP5-8.5|SSP5) are mainly due to the interaction effect. However, the climate's influence is more than the population, especially for WAF, South-East Africa and East Southern Africa. The study findings are vital for climate change adaptation.

Liver Function Tests Values in Albino Wistar Rats Administered with Isolated Nigeria Achatina achatina Snail Lectin.

Achatina achatina snail specie are considered by many people in Nigeria, Ghana and other parts of West Africa to be the most prized snail for eating. In general, lectins bind to sugar moieties in cell walls or membrane, thereby change the physiology of the membrane to cause agglutination, mitosis or other biochemical changes in the cell. It has been deduced that lectins could be toxic and can as well be used as potent administrations that could be used or serve as substitutes for routine treatment or management of many disorders. Based on these, the toxicity of the Achatina achatina snail lectin in animals was investigated with a view to determining the nutritional value of the snail as food stuffs by carrying out tests to determine the blood values of Liver Function Tests (LFT) parameters in Albino Wistar Rats administered with the lectin. A total of 120 samples of the Nigeria Achatina achatina snail specie were collected, authenticated at the Zoology Department of the University of Nigeria, Nsukka and 80mls of pooled crude Lectin extract was obtained. Purifications were performed on 20mls of the crude extract in three steps viz, Ammonium sulphate precipitation and Dialysis (Partial purifications), Con A Sepharose 4B affinity Chromatography column (Complete purification). The affinity purified lectin was used for all the tests conducted in this research. The crude, partially and complete/affinity purified Lectin extracts were subjected to Haemagglutination tests. The Lectin was further assessed to determine its effects on Liver Function Tests (LFT) parameters viz, Total bilirubin (TB), Conjugate bilirubin (CB), Alkaline phosphatase (ALP), Aspartate transaminase (AST) and Alanine transaminase (ALT) as follows: A total of Thirty-five (35) male Albino Wistar Rats weighing 101-180g and aged 2-3 months obtained from the Animal house of University of Nigeria, Nsukka, were used in this research. The animals were Grouped into 5 (A-E) and allowed for 2 weeks acclimatization. Graded doses of 0.04ml, 0.05ml and 0.06ml of the Affinity purified Lectin were administered intra-peritoneally to each of the rats in Groups A-D (test groups) according to their body weights at intervals of 2 days for 1 week. Group E served as the control. Two (2) mls of blood was collected from each of the rats before and 24 hours after the last day of lectin administration for the following tests: TB, CB, ALP, AST and ALT (performed by means of Roche Cobas C111 automated chemistry analyser). The results of the research showed as follows: On complete/affinity purification, 15mls of pure sample containing only the high molecular weight lectin was obtained. The respective haemagglutination tests on the crude, partially and affinity purified Lectin showed on standardization preferential agglutinations with Blood group A type. Bar charts statistics show that there was Post lectin administration mean increase in TB, CB and AST when the Post administrations values were compared with the Pre values. The Bar charts statistics show that there was Post lectin administration mean decrease in ALP and ALT. However, the differences in the Pre and Post administration mean values of these parameters were further subjected to one way analysis of variance (ANOVA) test statistics aimed at determining whether the mean increases or decreases in these assessed parameters were statistically significant. The ANOVA statistics show that the effects of the lectin on all the assessed LFT parameters viz, TB, CB, ALP, AST and ALT were statistically insignificant (P > 0.05). The results obtained in this research has succeeded in demonstrating that the A. achatina snail lectin is non-toxic, non-carcinogenic and therefore point to its nutritive value as food stuff, hence supports the snail eating education.

Lassa fever outcomes and prognostic factors in Nigeria (LASCOPE): a prospective cohort study

SummaryBackgroundLassa fever is a viral haemorrhagic fever endemic in parts of west Africa. New treatments are needed to decrease mortality, but pretrial reference data on the disease characteristics are scarce. We aimed to document baseline characteristics and outcomes for patients hospitalised with Lassa fever in Nigeria.MethodsWe did a prospective cohort study (LASCOPE) at the Federal Medical Centre in Owo, Nigeria. All patients admitted with confirmed Lassa fever were invited to participate and asked to give informed consent. Patients of all ages, including newborn infants, were eligible for inclusion, as were pregnant women. All participants received standard supportive care and intravenous ribavirin according to Nigeria Centre for Disease Control guidelines and underwent systematic biological monitoring for 30 days. Patients' characteristics, care received, mortality, and associated factors were recorded using standard WHO forms. We used univariable and multivariable logistic regression models to investigate an association between baseline characteristics and mortality at day 30.FindingsBetween April 5, 2018, and March 15, 2020, 534 patients with confirmed Lassa fever were admitted to hospital, of whom 510 (96%) gave consent and were included in the analysis. The cohort included 258 (51%) male patients, 252 (49%) female patients, 426 (84%) adults, and 84 (16%) children (younger than 18 years). The median time between first symptoms and hospital admission was 8 days (IQR 7–13). At baseline, 176 (38%) of 466 patients had a Lassa fever RT-PCR cycle threshold (Ct) lower than 30. From admission to end of follow-up, 120 (25%) of 484 reached a National Early Warning Score (second version; NEWS2) of 7 or higher, 67 (14%) of 495 reached a Kidney Disease–Improving Global Outcome (KDIGO) stage of 2 or higher, and 41 (8%) of 510 underwent dialysis. All patients received ribavirin for a median of 10 days (IQR 9–13). 62 (12%) patients died (57 [13%] adults and five [6%] children). The median time to death was 3 days (1–6). The baseline factors independently associated with mortality were the following: age 45 years or older (adjusted odds ratio 16·30, 95% CI 5·31–50·30), NEWS2 of 7 or higher (4·79, 1·75–13·10), KDIGO grade 2 or higher (7·52, 2·66–21·20), plasma alanine aminotransferase 3 or more times the upper limit of normal (4·96, 1·69–14·60), and Lassa fever RT-PCR Ct value lower than 30 (4·65, 1·50–14·50).InterpretationOur findings comprehensively document clinical and biological characteristics of patients with Lassa fever and their relationship with mortality, providing prospective estimates that could be useful for designing future therapeutic trials. Such trials comparing new Lassa fever treatments to a standard of care should take no more than 15% as the reference mortality rate and consider adopting a combination of mortality and need for dialysis as the primary endpoint.FundingInstitut National de la Santé et de la Recherche Médicale, University of Oxford, EU, UK Department for International Development, Wellcome Trust, French Ministry of Foreign Affairs, Agence Nationale de Recherches sur le SIDA et les hépatites virales, French National Research Institute for Sustainable Development.

Anti-sickling activities of two isolated compounds from the root of Combretum racemosum P. beauv. (Combretaceae)

Ethnopharmacological relevanceEvaluation of plants such as Combretum racemosum with claimed traditional use in the management of sickle cell anaemia in Nigeria and other parts of West Africa could serve as a useful research strategy in the search for potential anti-sickling drugs and templates.Aim of the study: This study aimed at evaluating the antisickling potential of C. racemosum by activity-guided purification and isolation of its active constituents. Materials and methodsCrude methanol extract of the root of C. racemosum and the fractions obtained by partitioning with chloroform, ethyl acetate, and aqueous were investigated for anti-sickling activity against sodium metabisulphite induced sickling of sickle cell haemoglobin (HbSS). Repeated chromatographic separations were conducted on the most active chloroform fraction to purify and isolate bioactive compounds for further tests for anti-sickling activity. The characterization of the isolated compounds was done by mass spectrometry (FD+MS) and nuclear magnetic resonance (1HNMR) spectroscopy. ResultsThe chloroform fraction (FA) (% sickled erythrocyte ranged from 3.0 to 34.1) exhibited better anti-sickling activity than aqueous (% sickled erythrocyte ranged from 38.9 to 51.5) as well as the crude methanol (% sickled erythrocyte ranged from 19.1 to 30.4). Hence, the phytochemical investigation was focused on the chloroform fraction, which led to the identification of two ellagic acid derivatives (3,3′,4′-tri-O-methyl ellagic acid (A) and 3,3′-di-O- methyl ellagic acid (B). The two isolated compounds possessed good, comparable anti-sickling activities with compound A exhibiting a slightly better in vitro activity. ConclusionThis paper reports for the first time anti-sickling principles from C. racemosum and therefore, provided some justification for the ethnomedicinal use of the plant in the management of sickle cell disease.

Early Kanem-Borno fired brick élite locations in Kanem, Chad: archaeological and historical implications

ABSTRACT One of the most intriguing problems concerning the Kanem-Borno sultanate of the central Sahel between the eighth and nineteenth centuries AD concerns its early intra-African connections. Apart from historically documented linkages with North and parts of West Africa, were there trade and other contacts with eastern regions such as Darfur, the Middle Nile Valley and areas beyond prior to the fifteenth century? Addressing the results of recent archaeological field research conducted in Kanem, Chad, this paper lays the foundations of an answer to that and other pressing questions concerning Kanem-Borno. Because the region concerned is a virtual archaeological blank, the first and foremost goal of fieldwork was securely to identify and describe locations once related to the sultanate. Based on previous studies as well as various new surveys, test-excavations and radiometric dating, archaeological sites undoubtedly associated with early Kanem-Borno were located and preliminarily investigated. Those sites consist of the ruins of fired brick enclosures encompassing fired brick buildings or groups thereof dated to the eleventh to fourteenth centuries. Taking into account the construction materials used and newly available absolute dates, as well as historical data, it is assumed that these sites were élite localities very probably founded and occupied by members of what would become the Sayfuwa aristocracy and related groups.

Laboratory and microcosm experiments reveal contrasted adaptive responses to ammonia and water mineralisation in aquatic stages of the sibling species Anopheles gambiae (sensu stricto) and Anopheles coluzzii

BackgroundThe sibling species of the malaria mosquito, Anopheles gambiae (sensu stricto) and Anopheles coluzzii co-exist in many parts of West Africa and are thought to have recently diverged through a process of ecological speciation with gene flow. Divergent larval ecological adaptations, resulting in Genotype-by-Environment (G × E) interactions, have been proposed as important drivers of speciation in these species. In West Africa, An. coluzzii tends to be associated with permanent man-made larval habitats such as irrigated rice fields, which are typically more eutrophic and mineral and ammonia-rich than the temporary rain pools exploited by An. gambiae (s.s.)MethodsTo highlight G × E interactions at the larval stage and their possible role in ecological speciation of these species, we first investigated the effect of exposure to ammonium hydroxide and water mineralisation on larval developmental success. Mosquito larvae were exposed to two water sources and increasing ammonia concentrations in small containers until adult emergence. In a second experiment, larval developmental success was compared across two contrasted microcosms to highlight G × E interactions under conditions such as those found in the natural environment.ResultsThe first experiment revealed significant G × E interactions in developmental success and phenotypic quality for both species in response to increasing ammonia concentrations and water mineralisation. The An. coluzzii strain outperformed the An. gambiae (s.s.) strain under limited conditions that were closer to more eutrophic habitats. The second experiment revealed divergent crisscrossing reaction norms in the developmental success of the sibling species in the two contrasted larval environments. As expected, An. coluzzii had higher emergence rates in the rice paddy environment with emerging adults of superior phenotypic quality compared to An. gambiae (s.s.), and vice versa, in the rain puddle environment.ConclusionsEvidence for such G × E interactions lends support to the hypothesis that divergent larval adaptations to the environmental conditions found in man-made habitats such as rice fields in An. coluzzii may have been an important driver of its ecological speciation. Graphical

Geology of the Structurally Controlled Quartz Vein Gold Mineralization in the Dikko Area, Part of Zungeru—Minna—Birnin Gwari Schist Belt, NW Nigeria

Dikko area, Niger State, North Central Nigeria falls within the Pan-African thermo-tectonic event which occurred in Nigeria as in other parts of West Africa with widespread effect on the mineralization of rejuvenated basement and geosynclinal trough deposits. The Pan-African Belt in Nigeria forms part of the Benin-Nigeria (Dahomeyan) shield which is regarded as the southern prolongation of the circumcratonic Pan-African belt of the West African Craton. Structurally controlled, gold-bearing quartz veins were measured and studied in the area from an extensive geological ground investigation. Field and petrographical studies indicate that the Neoproterozoic rocks constitute gneisses, amphibolite schist, amphibolites and migmatites. The amphibolites are intruded by pegmatites. The associated quartz veins are generally concordant with the main N-S regional structural trend. The lithological and structural studies carried out in these areas have demonstrated the relationship between structures and mineralization and/or lithology. The main characteristics of the gold mineralization in the area appear to indicate hydrothermal mineralization in connection with shear zones. This study allows us to predict that quartz veins in the amphibolite can be mined at a profit and a detailed geochemical and resource valuation needs to be carried out for the Au and associated Galena and Ag mineralization to fully exploit their economic potential.

Toxicological implications of sequential administration of herbal and conventional medicines: Evidence from an in vivo study on Azadirachta indica and artesunate in male Wistar rats

In most parts of West Africa and other developing countries, herbal medicines are sometimes used by patients concomitantly receiving conventional drugs, which can result in potentially serious adverse effects. This study examined in vivo cytotoxic effects of Azadirachta indica extracts followed by artesunate administration on some markers of liver and kidney toxicity. Serum ALT, GGT, urea, creatinine, interleukin 1β, tumor necrosis factor α, tissue malondialdehyde and glutathione levels and liver and kidney histology in healthy male Wistar rats administered 100 and 200 mg/kg A. indica for 5 days followed by 10 mg/kg Artesunate for 5 days was determined. Results showed significantly ( p < 0.05) higher serum ALT, GGT, urea, creatinine, interleukin 1β and tumor necrosis factor α levels with proportional increase of 16.5, 21.7, 9.2, 6.9, 9.1 and 9.1% respectively when compared to normal control was observed. Malondialdehyde levels were significantly ( p < 0.05) higher with a proportional increase of 57.8%, while glutathione levels were significantly ( p < 0.05) lower with a proportional decrease of 13.4% in liver homogenates of the treated rats relative to normal control. Histological examination of the liver and kidney of the co-treated rats showed vascular congestion and necrosis. Collectively, the results suggest that administration of A. indica followed by artesunate could predispose to liver and kidney associated cytotoxicity. These findings could have implications for people who habitually use herbal preparations and conventional drugs in sequential fashion.

Contesting Visions of Modernity in Ghanaian Salafis’ Islamic Reform

This article re-interrogates the complex conceptions and debates concerning ideas of modernity expressed by Salafi leaders in Ghana between the 1970s and the 1980s. Previous research has suggested that the Salafi movement in Ghana, as in other parts of West Africa, inspired the appropriation of some ideas associated with modernity to help develop Muslim communities, and reinforce the appeal of their arguments against opponents. Arguing that while the Qur’ānic censure of reprehensible innovations (bid’a) is incompatible with material ideas of progress, they insisted that, if carefully analyzed, some modern ideas may in fact be consistent with the Qur’ān. This article presents a case study of two Muslim groups belonging to the broader Salafi movement in Ghana. It analyses the relationship between Salafi clerics trained in traditional and classical Islamic texts (‘ulamā), and the Western-educated scholars, referred to here as modernists, in the Islamic Research and Reformation Centre (IRRC) and their respective attitudes toward modernity. While this study highlights that these two groups of reformers both appropriated modern ideas for administrative efficiency, they differed among themselves on whether the Islamic reform project should engage in opportunities in the secular milieu, or solely focus on eradicating religious unorthodoxy. The study concludes that the ‘ulamā consciously navigated a complex balance between appropriating secular ideals for Islamic reform while asserting the relevance of eradicating what they believed to be unacceptable religious innovations that verged on apostasy.

African Peacekeeping and African Integration: Current Challenges

Peacekeeping and economic union are the two most important dimensions of African integration. The first section of this article aims to analyse some current challenges to African peacekeeping, peacemaking, and African integration. The continuing Libyan civil war epitomizes the diplomatic stalemates and military stalemates which form the limits of current African peacekeeping. It exposes the North African Regional Capability and North African Standby Brigade as paper structures which do not exist operationally, and so limit the capacity of the African Union’s Peace and Security Council. The military intervention of states outside Africa can polarize conflicts and escalate civil wars. Africa’s colonial epoch serves as a warning of the potential dangers of foreign military bases in Africa. In parts of West Africa, states sub-contract peacemaking and anti-terrorist operations to unsupervised local militias, which are lawless at best, and commit ethnic killings at worst. African integration fares better in the economic dimension. The second section analyses African integration, with its focus on the most recent step of the African Continental Free Trade Area (AfCFTA), which starts to lay the cornerstone envisaged four decades ago in the Lagos Plan of Action, and three decades ago in the Abuja Treaty for an African Economic Community. The historic track record of African continental organizations indicates that a decade will be a realistic minimum period for it to be substantially implemented. The Pan-African Payment and Settlement System will help operationalize the AfCFTA by lowering forex currency transaction charges. Severe difficulties can be predicted for future attempts to upgrade the AfCFTA into a continental customs union, and ultimately into a continental common market.

15 Climate Change and the Evolving Fulani Pastoralists Cattle Production System in Nigeria: A Need to Retool Extension and Innovation Services

Abstract The Fulani pastoralists of Nigeria, as in other parts of West Africa, are traditionally semi- sedentary or nomadic herders, and are often described as the largest nomadic group in the world. The combined effects of climate change and instability due to terrorist activities have led to massive displacement of many Nigerian Fulani households to Southwestern Nigeria in search of refuge, pasture and water for their cattle. The objective of this project was to examine the current Fulani cattle production system. In addition to obtaining data via focus groups and direct observation, a survey was administered to members of 600 Fulani pastoralist households to determine cattle production techniques and herding strategies adopted. The observation period occurred over a 24 month period in three Southwestern Nigeria states (Ogun, Kwara and Oyo). Herding activities were mapped by using hand-held Global Positioning System (GPS) to obtain the coordinates of grazing routes and settlements. The results showed that the Fulani operate a system of male social contract and kinship networks in labor utilization and movement of herds. Among semi-sedentary and sedentary groups, the grazing orbit was usually within 5km to 10km radius of the settlement, depending on the season. Of the households observed, very few had access to tap or treated water (0.9% in Oyo, 1.4% in Ogun and 0.2% in Kwara). In Ogun, rivers and streams provided water for the largest number of households, while in Kwara, hand-dug wells were the largest providers. In Oyo, streams and rivers provided water for a large percentage of the Fulani households. In addition to a lack of basic water infrastructure, the results further revealed low productivity of cattle due to poor management and the utilization of cattle breeds with low genetic potential. It is recommended that micro-ranches, enhanced by extension services that provide training on cattle management, be implemented for this population.

Lassa Fever: An Evolving Emergency in West Africa.

Lassa fever remains endemic in parts of West Africa and continues to pose as a quiescent threat globally. We described the background on Lassa fever, factors contributing to its emergence and spread, preventive measures, and potential solutions. This review provides a holistic and comprehensive source for academicians, clinicians, researchers, policymakers, infectious disease epidemiologists, virologists, and other stakeholders.

Egg case concentrate of Mantis religiosa abrogates the accumulation of cadmium in muscular and bone tissues of African catfish via activation of nitric oxide and myeloperoxidase activity.

The study examined the prophylactic effect of praying mantis egg case powder (PMECP) against the accumulation of cadmium (Cd) in key tissues of African catfish (Clarias gariepinus). Thirty African catfish were randomly distributed into six (n=5) groups. Group I was treated with normal fish diet (NFD) only. Group II was exposed to Cd+NFD. Group III was exposed to Cd+NFD +EC50 PMECP. Group IV was exposed to Cd+NFD +EC50 PMECP+10% EC50 PMECP. Group V was exposed to Cd+NFD +EC50 PMECP+20% EC50 PMECP. Group VI was treated with EC50 PMECP+NFD for 14days. Inhibitory concentration (IC50 ) of PMECP significantly scavenged free radicals in vitro with corresponding increase in the activity of myeloperoxidase (MPO) and nitric oxide (NO) level. PMECP also showed highest growth-rate pattern and downregulation of cavitation within the lamellae. Hence, PMECP may be a prophylactic agent against the Cd accumulation in African catfish. PRACTICAL APPLICATIONS: Mantis religiosa egg case is widely used in Asian traditional medicine and some part of West Africa, as prevention against several diseases such as urinary disorders, infertility, impotence, and shingles. Our previous investigation showed that Mantis religiosa egg case flour could prevent hepatotoxicity, inhibit respiratory dysfunction, and interrupt oxidative damage in lungs. It is also commonly utilized for its high protein content and clear airways potential. The results of this study revealed empirical evidence concerning the possible usage of PMECP as natural, alternative, and/or complementary protein supplement with prophylactic potentials. Hence, this study underlines PMECP as prophylactic agent in abrogating the accumulation of cadmium as well as improving the protein content in African catfish.

Blyden’s Philosophy and Its Impact on West African Intellectuals: Case of J.E. Casely Hayford of the Gold Coast (Ghana)

This study examines the impact of Blyden’s philosophy on J.E. Casely Hayford of the Gold Coast (Ghana). It exposes Blyden’s ideas, a philosophy on Africans physical and intellectual emancipation, and points out the similarities in the thought of both men. Blyden toured different parts of West Africa and spoke with great intensity about the African problem and ways of its remedy. His ideas had a lot of influence at the time and precipitated the emergence of nationalist messiah who undertook a mission to redefine the African universe. This study examines the ideas and intellect of J.E.Casely Hayford and revealed that his thoughts were a potency of Edward Wilmot Blyden’s philosophy. An examination of his ideas reveals how Joseph Ephraim Casely Hayford took an uncompromising stand against the derogatory and the glaring abuses of European colonialism. He shaped cultural nationalism that disdained the apparent repulsive and despotic colonial hegemony and fashioned a new outlook for fellow Africans to stand up as humans. This article concludes that Hayford, drawing on Blyden’s philosophy, succeeded in fashioning a culture of protest against all forms of black degradation and thus presented a continuity in black political thought that remained up to present.