Determining the thermal profile of ignition is important because the desired ignition behavior varies with the objective. For example, extended ignition prolongs the time that the engine runs; however, fast ignition offers a higher power gain. The pollution caused by undesirable chemical reactions, as determined by the ignition profile, is another important aspect. Based on a previously developed method, we examined the impact of different theoretical particle size distributions (PSDs) on the thermal ignition profile. We compared different PSDs of polydispersed fuel spray with normal distributions with various means, each corresponding to the same fuel volume. Our results revealed a significant dependence of thermal ignition on the PSD. Systems that comprised only low-radius droplets did not reach ignition, whereas systems with only high-radius droplets required a long time to establish ignition. Moreover, the change in the mean droplet radius unexpectedly resulted in a double hump in the maximum temperature of the combustion process.