The purpose of this study is to estimate the effect of roughness layer thickness on the heat transfer and drag coefficients of ellipsoidal particles. Using an OpenFOAM-based particle-resolved direct numerical simulation (PR-DNS) method, we calculated the drag coefficient and Nusselt number for an isolated axisymmetric nonspherical particle with a rough surface in a uniform flow. The PR-DNS results indicate that the drag coefficient varies linearly with the effective roughness Sef at different angles, which can be expressed as CD=kSef−1+CD0. The changes in k are consistent with the Happel and Brenner equation. Furthermore, the influence of roughness on the heat transfer efficiency factor can be represented by Ef=Sef−65. The models for the drag coefficient and Nusselt number are valid within the ranges 1.25≤Ar≤2.5,1≤Sef≤2, and 10≤Rep≤200, thereby extending the applicability of the equations developed for smooth particles. These newly developed correlations for the drag coefficient and Nusselt number can be utilized for non-isothermal flows of particle mixtures containing materials with various rough-surfaced ellipsoids.