Particle Technology Research Articles

Electrolysis Process-Facilitated Engineering of Primary Particles of Cobalt-Free LiNiO2 for Improved Electrochemical Performance.

The particle morphology of LiNiO2 (LNO), the final product of Co-free high-Ni layered oxide cathode materials, must be engineered to prevent the degradation of electrochemical performance caused by the H2-H3 phase transition. Introducing a small amount of dopant oxides (Nb2O5 as an example) during the electrolysis synthesis of the Ni(OH)2 precursor facilitates the engineering of the primary particles of LNO, which is quick, simple, and inexpensive. In addition to the low concentration of Nb that entered the lattice structure, a combination of advanced characterizations indicates that the obtained LNO cathode material contains a high concentration of Nb in the primary particle boundaries in the form of lithium niobium oxide. This electrolysis method facilitated LNO (EMF-LNO) engineering successfully, reducing primary particle size and increasing particle packing density. Therefore, the EMF-LNO cathode material with engineered morphology exhibited increased mechanical strength and electrical contact, blocked electrolyte penetration during cycling, and reduced the H2-H3 phase transition effects.

Fixed-dose dry powder for inhalation of nintedanib, pirfenidone and mycophenolic acid by thin-film freezing (TFF) technology

Nintedanib and pirfenidone have been approved to treat idiopathic pulmonary fibrosis (IPF) by delaying progression of the disease. Recently, mycophenolic acid has also been used as an additive treatment for IPF. This study aims to produce and evaluate fixed-dose combinations (i.e., two-drug and three-drug combinations) of nintedanib, pirfenidone, and mycophenolic acid dry powders for inhalation produced by thin-film freezing (TFF). The TFF process, which is a bottom-up particle engineering technology using a rapid freezing process, allows the formation of a homogeneous powder matrix of the fixed-dose combinations of the two or three drugs. X-ray powder diffraction (XRPD) and modulated differential scanning calorimetry (mDSC) confirmed the presence of amorphous nintedanib and crystalline pirfenidone (NIN-PIR), and amorphous nintedanib and amorphous mycophenolic acid (NIN-MPA) in the two-drug combinations. Two-drug formulations of nintedanib and mycophenolic acid prepared by the TFF process exhibited homogenous porous matrix powders with a high surface area and brittle fracture behavior. The in vitro aerodynamic testing of the two-drug combinations demonstrated that nintedanib and mycophenolic acid have similar particle size distributions and high aerodynamic performance of up to 78–82% fine particle fraction (FPF) of the recovered dose. However, pirfenidone was crystalline in the nintedanib/pirfenidone combinations, resulting in poor aerodynamic performance with FPF (of recovered dose) of 6%–28%. In the three-drug formulations, the TFF process produced a coformer of pirfenidone and mycophenolic acid that prevented pirfenidone crystallization and consequently enhanced aerosolization. Therefore, nintedanib, pirfenidone, and mycophenolic acid exhibited as homogenous brittle matrix powders, resulting in a similar aerodynamic performance with FPF (of recovered dose) of 56%–60%. In conclusion, the fixed-dose combinations produced by the TFF process exhibited drug-excipient miscibility and homogenous brittle matrix powders to enhance aerodynamic performance for inhalation.

Continuous Manufacturing of Cocrystals Using 3D-Printed Microfluidic Chips Coupled with Spray Coating.

Using cocrystals has emerged as a promising strategy to improve the physicochemical properties of active pharmaceutical ingredients (APIs) by forming a new crystalline phase from two or more components. Particle size and morphology control are key quality attributes for cocrystal medicinal products. The needle-shaped morphology is often considered high-risk and complex in the manufacture of solid dosage forms. Cocrystal particle engineering requires advanced methodologies to ensure high-purity cocrystals with improved solubility and bioavailability and with optimal crystal habit for industrial manufacturing. In this study, 3D-printed microfluidic chips were used to control the cocrystal habit and polymorphism of the sulfadimidine (SDM): 4-aminosalicylic acid (4ASA) cocrystal. The addition of PVP in the aqueous phase during mixing resulted in a high-purity cocrystal (with no traces of the individual components), while it also inhibited the growth of needle-shaped crystals. When mixtures were prepared at the macroscale, PVP was not able to control the crystal habit and impurities of individual mixture components remained, indicating that the microfluidic device allowed for a more homogenous and rapid mixing process controlled by the flow rate and the high surface-to-volume ratios of the microchannels. Continuous manufacturing of SDM:4ASA cocrystals coated on beads was successfully implemented when the microfluidic chip was connected in line to a fluidized bed, allowing cocrystal formulation generation by mixing, coating, and drying in a single step.

Controlling Microparticle Morphology in Melt-Jet Printing of Active Pharmaceutical Ingredients through Surface Phenomena.

Achieving homogeneity and reproducibility in the size, shape, and morphology of active pharmaceutical ingredient (API) particles is crucial for their successful manufacturing and performance. Herein, we describe a new method for API particle engineering using melt-jet printing technology as an alternative to the current solvent-based particle engineering methods. Paracetamol, a widely used API, was melted and jetted as droplets onto various surfaces to solidify and form microparticles. The influence of different surfaces (glass, aluminum, polytetrafluoroethylene, and polyethylene) on particle shape was investigated, revealing a correlation between substrate properties (heat conduction, surface energy, and roughness) and particle sphericity. Higher thermal conductivity, surface roughness, and decreased surface energy contributed to larger contact angles and increased sphericity, reaching a near-perfect micro-spherical shape on an aluminum substrate. The integrity and polymorphic form of the printed particles were confirmed through differential scanning calorimetry and X-ray diffraction. Additionally, high-performance liquid chromatography analysis revealed minimal degradation products. The applicability of the printing process to other APIs was demonstrated by printing carbamazepine and indomethacin on aluminum surfaces, resulting in spherical microparticles. This study emphasizes the potential of melt-jet printing as a promising approach for the precise engineering of pharmaceutical particles, enabling effective control over their physiochemical properties.

Lipid-based particle engineering via spray-drying for targeted delivery of antibiotics to the lung

Pulmonary delivery of antibiotics for the treatment of tuberculosis provides several benefits compared to conventional oral and parenteral administration. API-loaded particles delivered directly to alveolar macrophages, where Mycobacterium tuberculosis resides, can reduce the required dose and decrease the severe side effects of conventional treatment. In this work, lipid-microparticles loaded with rifampicin were engineered via spray-drying to be administered as a carrier-free dry powder for inhalation. Although, it is well-known that spray-drying of lipid-based excipients is strongly limited, a completely lipid-based formulation using diglycerol full ester of behenic acid was produced. The solid state of the lipid, providing high melting temperature, absence of polymorphism and monophasic crystallization, led to high yield of spray-dried particles (83%). Inhalable particles of mass median aerodynamic diameter of 2.36 µm, median geometric size of 2.05 µm, and negative surface (-50.03 mV) were engineered. Such attributes were defined for deep lung deposition and targeted delivery of antibiotics to alveolar macrophages. Superior aerodynamic performance as carrier-free DPI was associated to a high fine particle fraction of 79.5 %. No in vitro cytotoxic effects were found after exposing epithelial cell lines and alveolar macrophages. In vitro uptake of particles into alveolar macrophages indicated the efficiency of their targeted delivery. The use of highly processable and safe lipid-based excipients for particle engineering via spray-drying can extend the availability of materials for functionalized applications for pulmonary delivery.

Poly(ethylene glycol) Cross-Linked Antibody Nanoparticles for Tunable Biointeractions

Liver accumulation of nanoparticles is a major challenge in nanoparticle-mediated delivery as it can reduce the delivery of the nanoparticles to their intended site and lead to liver damage and toxicity. Recent studies have shown that particle engineering, e.g., nanoparticle composition, can influence liver uptake and allow homing of nanoparticles to specific organs or tissues. Herein, we investigated the role of nanoparticle cross-linking on liver uptake. We developed a series of antibody nanoparticles (AbNPs) using various poly(ethylene glycol) (PEG) molecule (e.g., different arm numbers and arm lengths) cross-linkers. Specifically, AbNPs based on Herceptin were engineered with PEG cross-linker architectures ranging from 2-arm (at molecular weights of 600 Da, 2.5 kDa, and 5 kDa) to 4-arm and 8-arm via a mesoporous silica templating method. The molecular architecture of PEG modulated not only the targeting ability of the AbNPs in model cell lines but also their interaction with phagocytes in human blood. Increasing the PEG arm length from 600 Da to 5 kDa also reduced the uptake of the nanoparticles in the liver by 85%. Tumor accumulation of Herceptin AbNPs cross-linked with a 5 kDa 2-arm-PEG was 50% higher compared with control AbNPs and displayed similar liver uptake as free Herceptin. This study highlights the role of PEG cross-linking in receptor targeting and liver uptake, which influence tumor targeting, and combined with the versatility and multifunctionality of the antibody nanoparticle platform could lead to the development of organ-selective targeted antibody nanoparticle assemblies.

Experimental investigation of metallic partial-flow particulate filter on a diesel engine's combustion pressure and particle emission

The study aims to present the combustion and exhaust behaviors of a 3 L, four-cylinder common rail diesel engine with three different kinds of conventional B7 diesel fuels with and without a platinum diesel oxidation catalyst (DOC) system and non-catalytic partial flow through a diesel particulate filter (P-DPF). Testing is performed under the three different operating conditions, idle to medium engine loading at 1000, 1500, and 2000 engine revolutions per minute with four different engine torques of 84, 112, 140 and 160 Nm. The surface morphology and agglomerate size of particulate matter (PM), single primary particle analysis as well as the fringe length of the carbon crystallite structure were also examined using scanning electron microscopy (SEM), transmission electron microscopy (TEM) and energy dispersive x-ray spectroscopy (EDS) to achieve a better understanding through image processing. The P-DPF system does not have a significant effect on an engine's in-cylinder combustion characteristics and brake thermal efficiency. The diesel engine's particle emissions are reduced by trapping them on the metallic micro-fibers of a P-DPF. CO2, NO, and O2 levels show that the carbonaceous particle emissions on the micro-structure of the P-DPF passively react with NO2 and O2. Consequently, diesel engine particle emissions can be reduced by around 50% using a P-DPF system under the experimental conditions of the current study.

Design of respirable sprayed microparticles of encapsulated bacteriophages

Antibiotic resistance is exponentially increasing, and the number of deaths caused by bacterial infections is expected to surge. When dealing with the respiratory system, inefficient antibiotics heighten the chance of death from bacterial infection. However, the alternatives to antibiotics are limited. Bacteriophages are a valid option since they can target a specific type of bacterium. Bacteriophages are highly specific and can avoid any side effects when delivered. However, their poor stability makes their use inefficient. Encapsulation is commonly used to protect any bioactive compound for different types of delivery. In the case of respiratory delivery, particle engineering is used to generate stable dry powders to target the nasal or lung areas. This review article provides a guideline for engineering a process of nasal dry powders of encapsulated bacteriophages.

Nanoscale Porosity in Microellipsoids Cloaks Interparticle Capillary Attraction at Fluid Interfaces.

Anisotropic particles pinned at fluid interfaces tend toward disordered multiparticle configurations due to large, orientationally dependent, capillary forces, which is a significant barrier to exploiting these particles to create functional self-assembled materials. Therefore, current interfacial assembly methods typically focus on isotropic spheres, which have minimal capillary attraction and no dependence on orientation in the plane of the interface. In order to create long-range ordered structures with complex configurations via interfacially trapped anisotropic particles, control over the interparticle interaction energy via external fields and/or particle engineering is necessary. Here, we synthesize colloidal ellipsoids with nanoscale porosity and show that their interparticle capillary attraction at a water-air interface is reduced by an order of magnitude compared to their smooth counterparts. This is accomplished by comparing the behavior of smooth, rough, and porous ellipsoids at a water-air interface. By monitoring the dynamics of two particles approaching one another, we show that the porous particles exhibit a much shorter-range capillary interaction potential, with scaling intriguingly different than theory describing the behavior of smooth ellipsoids. Further, interferometry measurements of the fluid deformation surrounding a single particle shows that the interface around porous ellipsoids does not possess the characteristic quadrupolar symmetry of smooth ellipsoids, and quantitatively confirms the decrease in capillary interaction energy. By engineering nanostructured surface features in this fashion, the interfacial capillary interactions between particles may be controlled, informing an approach for the self-assembly of complex two-dimensional microstructures composed of anisotropic particles.

A comprehensive overview of dry powder inhalers for pulmonary drug delivery: Challenges, advances, optimization techniques, and applications

Dry powder inhaler (DPI) is an attractive dosage form for local and systemic pulmonary drug delivery. However, designing DPIs with adequate physicochemical properties is challenging. The development of novel pulmonary drug delivery systems requires the selection of suitable particle engineering techniques, carriers, and excipients. In addition, optimization of physico-chemical properties of such systems is critical for their efficient delivery and drug release. This review highlights the recent advances in the field of inhalable dry powder formulations with a special emphasis on the current particle engineering techniques, challenges in the development of novel pulmonary drug delivery systems, selection of a suitable carrier and excipients, and the evaluation of factors impacting aerosolization. Lastly, the review also discusses the current and emerging applications of DPIs for local and systemic drug delivery.

Combustion characteristics of Al-Li alloy powder and its application in solid propellant

This article is focused on the analysis of Al-Li alloy powder’s thermal oxidation reactivity. The Scanning electron microscope (SEM) analysis results show that the Al-Li particles are uniform and spherical. The phase transformation of the Al-Li alloy powder during the oxidation process was characterized by X-ray Diffraction (XRD), the phase composition of the oxide alloy particles is mainly oxides such as LiAlO2 and LiAl5O8, indicating that the particles are fully burned. Differential scanning calorimetry (DSC) and thermogravimetric analysis (TG) are performed coupled with thermodynamic calculations. The analysis results show that Li can reduce the activation energy required for the powder reaction, promote the combustion of Al powder, reduce the ignition temperature, and make the particles begin to oxidize at low temperature. At the same time, Li can shorter the ignition time of Al-Li alloy particles and improve the particles or propellant combustion characteristics. The results of this work demonstrate that fuel particle engineering for more complete combustion and energy conversion can be achieved by adding other elements and changing the powder formulation.

Enabling direct compression tablet formulation of celecoxib by simultaneously eliminating punch sticking, improving manufacturability, and enhancing dissolution through co-processing with a mesoporous carrier

The development of a high quality tablet of Celecoxib (CEL) is challenged by poor dissolution, poor flowability, and high punch sticking propensity of CEL. In this work, we demonstrate a particle engineering approach, by loading a solution of CEL in an organic solvent into a mesoporous carrier to form a coprocessed composite, to enable the development of tablet formulations up to 40% (w/w) of CEL loading with excellent flowability and tabletability, negligible punch sticking propensity, and a 3-fold increase in in vitro dissolution compared to a standard formulation of crystalline CEL. CEL is amorphous in the drug-carrier composite and remained physically stable after 6 months under accelerated stability conditions when the CEL loading in the composite was ≤ 20% (w/w). However, crystallization of CEL to different extents from the composites was observed under the same stability condition when CEL loading was 30–50% (w/w). The success with CEL encourages broader exploration of this particle engineering approach in enabling direct compression tablet formulations for other challenging active pharmaceutical ingredients.

Microparticulation of Levofloxacin HCl by Crystallo-co-agglomeration Technique

Particle engineering techniques have gained a unique place in the present pharma industry to improve physicochemical properties of the drugs. The aim of this research work was to formulate and evaluate directly compressible agglomerates of Levofloxacin HCl with a view to improve their micromeritic properties and thereby to reduce the cost of production. Fluoroquinolone anti-infective, is used to treat bacterial conjunctivitis, sinusitis, chronic bronchitis, community- acquired pneumonia and pneumonia caused by penicillin resistant strains of Streptococcus pneumonia. Some of the fluoroquinolone high dose’s exhibit poor compressibility and flow properties, hence may not be suitable candidate for direct compression process, but by applying the crystallo-co-agglomeration (CCA) technique, the attempt may be made to change the properties of these molecules to make them suitable candidates for direct compression. This investigation was aimed to utilize CCA process to develop spherical agglomerates of levofloxacin HCl in selected polymers in different ratio. The developed spherical agglomerates of levofloxacin HCl may exhibit improved micrometric and dissolution properties hence may be suitable for direct compression process. Results indicated that micromeritic, mechanical and compressional properties of the agglomerates were greatly influenced by nature and type of polymer incorporated. The mean release time, mean dissolution time, dissolution efficiency, Q30 and Q90 of the tablets prepared from agglomerates showed remarkable increase in CCA compared to tablets prepared by wet granulation. Observations also revealed that by varying the type and concentration of polymer, desired release rate can be obtained.

Insights into the Microstructural Engineering of Cobalt‐Free, High‐Nickel Cathodes Based on Surface Energy for Lithium‐Ion Batteries

AbstractIn order to reduce cost and increase energy density, it is critical to eliminate cobalt and increase nickel content in practical LiNi1−x−yMnxCoyO2 (NMC) and LiNi1−x−yCoxAlyO2 (NCA) cathodes. However, the implementation of cobalt‐free, high‐nickel layered oxide cathodes in lithium‐ion batteries (LIBs) is hindered by the inherent issue of high surface reactivity with the electrolyte and microcrack formation during cycling. Herein, the origin of key parameters for microstructural engineering in cobalt‐free LiNiO2 (LNO) is comprehensively investigated with two representative dopants, B and Al. A notable difference in the segregation energy between B and Al results in different morphologies of LNO particles. The low solubility of B into the host structure leads to a surface‐confined distribution of B, inhibiting the growth of primary particles, whereas the highly soluble Al facilitates primary particle growth. Recognition of this key parameter can help improve the cycle life of cobalt‐free LIBs via microstructural engineering by increasing the aspect ratio inside the cathode particle. It is demonstrated that boron‐doping in LNO (B‐LNO) is the most effective dopant strategy for microstructural engineering of the primary particles. The B‐LNO exhibits an excellent capacity retention of 81% in full cells after 300 cycles compared to both LNO and Al‐doped LNO (Al‐LNO).

Engineering particles for sensing applications via in-situ synthesizing carbon dots@SiO2 photonic crystals

Particle engineering has been one of the hotspots in both stimuli-responsive and smart nanomaterials. However, efficient and facile implementation of robust covalent interaction in particle engineering remains a great challenge. Herein, we firstly propose an easy-to-perform and versatile bottom-up particle engineering strategy for covalent coupling between SiO2 particle and carbon dots (CDs) in situ. Robust covalent interactions enable the nano-micro coupling of CDs and SiO2 particles, and nearly twofold fluorescence enhancement of CDs was obtained. Moreover, hydrogen bond-driven assembly of the carbon dots@SiO2 (CDs@SiO2) particles was demonstrated via molecular dynamics (MD) simulations, which guaranteed the high-quality colloidal photonic crystals (CPCs) without coffee ring effect. In addition, the optical coupling between CPCs and CDs ensures brighter and more saturated structural colors, as well as enhanced fluorescence for microfluidics-derived bi-optical CDs@SiO2 CPC supraballs. Based on this, bi-optical signal detection chip towards veterinary drug is developed. The in-situ covalent coupling strategy developed in this work might open an innovative avenue towards the particle engineering, which will also provide a methodological reference for the design of functional inorganic particles.

Inhalable Nanoparticle-based Dry Powder Formulations for Respiratory Diseases: Challenges and Strategies for TranslationalResearch.

The emergence of novel respiratory infections (e.g., COVID-19) and expeditious development of nanoparticle-based COVID-19 vaccines have recently reignited considerable interest in designing inhalable nanoparticle-based drug delivery systems as next-generation respiratory therapeutics. Among various available devices in aerosol delivery, dry powder inhalers (DPIs) are preferable for delivery of nanoparticles due to their simplicity of use, high portability, and superior long-term stability. Despite research efforts devoted to developing inhaled nanoparticle-based DPI formulations, no such formulations have been approved to date, implying a research gap between bench and bedside. This review aims to address this gap by highlighting important yet often overlooked issues during pre-clinical development. We start with an overview and update on formulation and particle engineering strategies for fabricating inhalable nanoparticle-based dry powder formulations. An important but neglected aspect in in vitro characterization methodologies for linking the powder performance with their bio-fate is then discussed. Finally, the major challenges and strategies in their clinical translation are highlighted. We anticipate that focused research onto the existing knowledge gaps presented in this review would accelerate clinical applications of inhalable nanoparticle-based dry powders from a far-fetched fantasy to a reality.

Graphite-Based Composite Anodes with C-O-Nb Heterointerfaces Enable Fast Lithium Storage.

To better satisfy the increasing demands for electric vehicles, it is crucial to develop fast-charging lithium-ion batteries (LIBs). However, the fast-charging capability of commercial graphite anodes is limited by the sluggish Li+ insertion kinetics. Herein, we report a synergistic engineering of uniform nano-sized T-Nb2 O5 particles on graphite (Gr@Nb2 O5 ) with C-O-Nb heterointerfaces, which prevents the growth and aggregation of T-Nb2 O5 nanoparticles. Through detailed theoretical calculations and pair distribution function analysis, the stable existence of the heterointerfaces is proved, which can accelerate the electron/ion transport. These heterointerfaces endow Gr@Nb2 O5 anodes with high ionic conductivity and excellent structural stability. Consequently, Gr@10-Nb2 O5 anode, where the mass ratio of T-Nb2 O5 /graphite=10/100, exhibits excellent cyclic stability and incredible rate capabilities, with 100.5 mAh g-1 after 10000 stable cycles at an ultrahigh rate of 20 C. In addition, the synergistic Li+ storage mechanism is revealed by systematic electrochemical characterizations and in situ X-ray diffraction. This work offers new insights to the reasonable design of fast-charging graphite-based anodes for the next generation of LIBs.

Nanotherapeutics for pulmonary drug delivery: An emerging approach to overcome respiratory diseases

Pulmonary diseases pose an immense threat to global health. Several nanotherapeutics-based approaches aimed to tackle pulmonary ailments in recent years. The current innovation includes developing nanomedicine for pulmonary delivery of active pharmaceutical ingredients, repurposed drugs, host-directed therapies, or molecules with unconventional mechanisms (such as antimicrobial peptides). But pulmonary delivery of nanomedicines is troublesome due to poor aerodynamic properties for lung deposition and expulsion during inhalation. Nanomedicine can deliver drugs directly into lung tissue via aerosol or dry powder for inhalation to target deep lung deposition and subsequent therapeutic efficacy. Particulate-based drug delivery systems are potentially complementary to conventional inhaled drugs. There are several ways to produce an aerosol or DPI-based therapeutics, and we reviewed some standard methods used to develop nanotherapeutics for inhalation. The developed inhalable formulations can be delivered using inhalation devices, and advanced inhaler device technology has allowed the efficacious delivery of therapeutic compounds via inhalation. In addition, particle engineering is a crucial criterion in developing inhalable formulations to improve drug delivery, enhance therapeutic effects, and perform superior targeting. Technological advancements in inhalation devices have improved the efficiency of lung-based drug delivery mechanisms. This review also enumerated the assessment of pulmonary drug delivery systems, i.e., in vitro, ex vivo, in vivo, or in silico models, which have made significant strides in recent years.

Regulation of Interfacial Lattice Oxygen Activity by Full-Surface Modification Engineering towards Long Cycling Stability for Co-Free Li-Rich Mn-Based Cathode.

The construction of a protective layer for stabilizing anion redox reaction is the key to obtaining long cycling stability for Li-rich Mn-based cathode materials. However, the protection of the exposed surface/interface of the primary particles inside the secondary particles is usually ignored and difficult, let alone the investigation of the impact of the surface engineering of the internal primary particles on the cycling stability. In this work, an efficient method to regulate cycling stability is proposed by simply adjusting the distribution state of the boron nickel complexes coating layer. Theoretical calculation and experimental results display that the full-surface boron nickel complexes coating layer can not only passivate the activity of interface oxygen and improve its stability but also play the role of sharing voltage and protective layer to gradually activate the oxygen redox reaction during cycling. As a result, the elaborately designed cobalt-free Li-rich Mn-based cathode displays the highest discharge-specific capacity retentions of 91.1% after 400 cycles at 1 C and 94.3% even after 800 cycles at 5 C. In particular, the regulation strategy has well universality and is suitable for other high-capacity Li-rich cathode materials.

BIM-based steel reinforcing bar detail construction design and picking optimization

Steel reinforcing bar (SRB) engineering is a very professional, complex, massive, and neglected project, which affects the structural performance and cost of building. Traditional SRB engineering is a labor-intensive project, often accompanied by the quality of SRB construction and the waste of material. At present, information technology is undergoing a revolution. With the rise and optimization of Building Information Modeling (BIM) technology and the continuous improvement of artificial intelligence-based optimization algorithms, new solutions have been put forward to solve these traditional SRB engineering problems. This study combines two different fields of BIM and optimization algorithms to establish a process of BIM-based SRB detail construction design and picking optimization that provides a reference for traditional SRB engineering. It is also an exploration and application of BIM technology to practical engineering.This study classified and analyzed the SRB crash nodes problems classified into four crash nodes classification and proposed a BIM-based SRB designing process. For the problem of the SRB connection position, a general segmental formula for SRB (for example, Longitudinal SRB on columns and beams) was studied, and a set of processes was established to determine the unknowns of the segment formula to locate the connection position of SRB. Besides, this study utilizes BIM’s coherent information transfer and visualization technologies that select Revit software to create new information such as “SRB shape family,“ ”component family,“ ”annotated family,“ and so on. The application of BIM in SRB is carried out through the transfer, transformation, and expression of information in the forms of SRB design drawings, SRB processing schedules, SRB construction schedules, and SRB construction partition charts, and so on. in addition, the problem of one-dimensional blanking of single-size and multiple-size raw materials is discussed with the minimum number of SRB consumed as the objective function. The commonly used classical solution method is analyzed in detail, and Particle Bee Algorithm (PBA) was introduced. Through calculation and comparison of examples, the performance of PBA on the SRB problem was evaluated.The study preliminary proposed a BIM based on SRB detail construction design and picking optimization and secondary development system by a particle engineering project. The results showed that this study had a certain reference contribution for the SRB detail construction design and picking optimization.