Participants In Test Group Research Articles

EFFECT OF ZANJABĪL (ZINGIBER OFFICINALE) IN NON-ALCOHOLIC FATTY LIVER DISEASE- A RANDOMIZED CONTROLLED TRIAL

Non Alcoholic Fatty Liver Disease (NAFLD) is a reversible condition of the liver, wherein large vacuoles of triglyceride fat accumulates in liver cells via the process of steatosis, despite any evidence of excessive alcohol consumption. In view of present scenario of high prevalence and limited treatment options, this study was conducted to assess the effect of Murabba-i- Zanjabīl in NAFLD. Present study was designed as a randomized placebo controlled trial with 30 patients in test group and 10 patients in control group. Participants in test group were administered with Murabba-i- Zanjabīl, 5 gm twice daily, 30 minutes before food for 45 days and those in control group were given 1 capsule of 500 mg each containing wheat flour twice daily, 30 minutes before food for 45 days. All the participants were asked to follow up at every 15 days for assessment of subjective parameters. Objective parameter was assessed before and after the trial period. On statistical analysis the test formulation showed significant reduction in scores (p<0.05) for most of the parameters on both inter and intra group analysis, while the reduction in control group was not found to be statistically significant (p.0.05). This study lays out that Murabbā-i Zanjabīl in a dose of 5gm twice daily given for 45 days is more effective than placebo in treating NAFLD. There was no adverse effect reported during the trial. It was thus concluded that Murabbā-i Zanjabīl is effective and safe in therapeutic management of NAFLD.

Preliminary Study: Panel Test of Brief Assessment of Cognition in Schizophrenia (BACS) Bahasa Version

Cognitive function in patients with schizophrenia may be affected by multi factors, which will also affect their language ability to understand the instrument’s rules. Panel test was held in June until August 2017, comparing ten patients schizophrenia in remission (test group) with ten controlled psychiatric residents to understand BACS Bahasa version’s rules. Data was presented descriptively. Compared to controlled residents, one participant of test group failed to understand meaning half of words list in verbal memory. Six participants of test group also failed to understand the letter fluency’s rule by keep mentioning word begin with capital letter as example and five participants in test group also asked what kind of word that they can mention. In Tower of London, two participants in controlled group and four from test group need to use the props to understand the rules. Two participants from test group also need longer than 20 second for each item in this test. There is evidence that language ability may be affected in schizophrenia group. This evidence may increase difficulty in conducting the next test and simplifying the rules need to be done especially in Tower of London section.

Safety and immunogenicity of a Vi-DT typhoid conjugate vaccine: Phase I trial in Healthy Filipino adults and children

BackgroundTyphoid fever remains a major public health problem in low- and middle-income countries where children aged 2–14 years bear the greatest burden. Vi polysaccharide is poorly immunogenic in children <2 years of age, and protection in adults is modest. The limitations of Vi polysaccharide vaccines can be overcome by conjugation of the Vi to a carrier protein. A typhoid conjugate vaccine composed of Vi polysaccharide conjugated to diphtheria toxoid (Vi-DT) has been developed. The Phase I study results are presented here. MethodsThis was a randomized, observer-blinded Phase I study to assess the safety and immunogenicity of Vi-DT compared to Vi polysaccharide vaccine, conducted in Manila, Philippines. Participants enrolled in an age de-escalation manner (18–45, 6–17 and 2–5 years) were randomized between Test (Vi-DT, 25 µg) administered at 0 and 4 weeks and Comparator (Vi polysaccharide, Typhim Vi® and Vaxigrip®, Sanofi Pasteur) vaccines. ResultsA total of 144 participants were enrolled (48 by age strata, 24 in Test and Comparator groups each). No serious adverse event was reported in either group. Solicited and unsolicited adverse events were mild or moderate in both groups with the exception of a 4-year old girl in Test group with grade 3 fever which resolved without sequelae. All participants in Test group seroconverted after first and second doses of Vi-DT while the proportions in the Comparator group were 97.1% and 97.2%, after first dose of Typhim Vi® and second dose of Vaxigrip®, respectively. Vi-DT showed 4-fold higher Geometric Mean Titers (GMT) compared to Typhim Vi® (adjusted for age strata, p < 0.001). No further increase of GMT was detected after the second dose of Vi-DT. Anti-DT IgG seroresponse rates were 81.2% and 84.5% post first and second Vi-DT doses, respectively. ConclusionsVi-DT vaccine was safe, well-tolerated and immunogenic in participants aged 2–45 years.ClinicalTrials.gov registration number: NCT02645032.

The effect of nutrition education course on awareness of obese and overweight female 1st-year High School students of Isfahan based on transtheoretical model of behavioral change.

BACKGROUND/AIM:Today, the problem of obesity is a chronic condition that affects all age groups in developed and developing countries. Since adolescence is a transitional period and behavioral patterns formed in this period affect people in their adult years, attention to obesity and extra weight in this age group is more important than other groups. Therefore, this study aims to investigate the effects of nutrition education course on awareness of female 1st-year high school students of Isfahan based on transtheoretical model ( TTM) of behavioral change.MATERIALS AND METHODS:In this semi-empirical study, 64 female 1st-year high school students with weight problem were selected using nonpercent stratified sampling and divided into two control and test groups. Data gathering was carried out using researcher-made nutrition awareness and stages of change questionnaire whose validity and reliability was confirmed. Participants in the test group participated in a 2-month education with sessions every 2 weeks and received one brochure and 3 educational massages each week. Data were analyzed using independent t-test and Mann–Whitney test.RESULTS:The results showed that the average nutrition awareness score of students in test group was significantly higher than control group after intervention. Students in test group were also in higher stages of change compared to control group after intervention.CONCLUSION:The results show that TTM was effective in changing nutritional behavior in students.