Body Parts Research Articles

Plain language review: the safety of relugolix combination therapy for advanced prostate cancer.

Advanced prostate cancer is a cancer that began in the prostate (a part of the male body) and has spread to other parts of the body. This is a review of two clinical research studies of patients with advanced prostate cancer who were treated with relugolix combination therapy. Relugolix is a medicine taken by mouth that lowers a male sex hormone, called testosterone. Relugolix is sometimes combined with other medicines such as novel hormonal therapies (NHTs) or chemotherapy to treat advanced prostate cancer. In one study, patients were treated with relugolix combined with an NHT (abiraterone or apalutamide). In a second study, patients were treated with relugolix combined with an NHT (enzalutamide) or chemotherapy (docetaxel). Researchers wanted to understand what possible side effects may happen due to taking these medicines together as prescribed. They also wanted to see if relugolix combination therapy worked to lower testosterone in the same way as relugolix taken alone. Researchers found that most of the side effects of relugolix combined with an NHT or chemotherapy were mild or moderate. Side effects of relugolix combination therapy were similar to the side effects of the medicines when taken alone. However, patients who received relugolix with enzalutamide or docetaxel were more likely to have a serious side effect compared with patients who received relugolix taken alone. Testosterone stayed below 50 nanograms per deciliter (known as castration levels) for patients who received relugolix with NHT or chemotherapy. Patients who receive relugolix combination therapy generally experience mild or moderate side effects, rather than serious side effects. No new safety issues were found during these studies. Patients maintained low testosterone levels. Patients and their doctors should discuss the benefits and possible harms of relugolix combination therapy to treat advanced prostate cancer.

The body says it all: Non-verbal indicators of choice awareness

Abstract Recent cognitive science research suggests that occasional “blindness” to choice manipulations indicates a lack of awareness in choice making. This claim is based on participants’ tendency not to detect choice manipulations and the similarity between their justifications for choices they made and those they were tricked into believing they made. Using a cognitive-semiotic framework, we argue that such conclusions underestimate the embodied, intersubjective nature of human meaning-making. We support this by investigating choice awareness beyond language to include non-verbal behavior. Forty-one participants were asked to choose from pairs of photographs of human faces the one they found most attractive and then to justify their choices, without knowing that for some of the trials they were asked to justify a choice that they had not made. Verbal responses were categorized as (i) non-manipulated, (ii) detected manipulated, and (iii) undetected manipulated trials. Bodily expressions, assessed using five different Categories of Bodily Expression (CBE): Adaptors, Torso, Head, Face and Hand expressions, revealed differences in: (a) duration, (b) rates of occurrence and (c) variety of the CBEs across trials. Thus, even when manipulations were not verbally detected, participants took longer to assess choices, showed increased bodily expressions, and engaged more body parts in undetected manipulations compared to non-manipulated choice trials. This suggests a degree of awareness to the choice manipulation, even if pre-reflective, manifested in participants’ bodily expressions.

Hyperbranched Thermosensitive Polymer-AuNP Composite Probe for Temperature Colorimetric Detection

Temperature detection is particularly important in the medical and scientific fields. Although there are various temperature detection methods, most of them focus on broad temperature detection, and basic research in specific fields, especially the detection of subtle temperature changes (32–34 °C) during wound infection, is still insufficient. For this purpose, a novel colorimetric temperature sensing probe is designed in this paper, which can quickly and intuitively respond to small temperature changes within a specific range through color changes. In this paper, hyperbranched polyethyleneimine (HPEI) was modified by isobutyrylation to prepare hyperbranched temperature-sensitive polymer (HPEI-IBAm). And it was combined with gold nanoparticles (AuNPs) prepared by a sodium citrate reduction method to construct an HPEI-IBAm-AuNP colorimetric probe. The probe exhibits excellent stability, even at salt concentrations of up to 12 g/L, thanks to the abundant amino functional groups and the large steric hindrance effect unique to HPEI-IBAm. In particular, the temperature detection range of the probe is precisely locked within 32–34 °C, enabling it to respond quickly and accurately to small temperature changes of only 2 °C. This feature is perfectly suited to the practical needs of temperature detection in infected wounds. The linear fitting coefficient of the temperature response is as high as 0.9929, ensuring the accuracy of the test results. The detection performance of the probe remained highly consistent over 10 cycles, fully proving its excellent reusability and durability. In addition, a flexible colorimetric sensor was prepared by combining the probe with polydimethylsiloxane (PDMS) film. This sensor is capable of rapidly detecting human skin temperature in real time, achieving an accuracy of 99.07% to 100.61%. It can provide a possible solution to the challenges of delayed and difficult temperature detection caused by different body parts and uneven surfaces, among others. This demonstrates its extensive practical value and potential, and it is expected to be further applied in the monitoring of wound infections.

Partial colexifications reveal directional tendencies in object naming

Abstract Expressions in which the word for a body part is also used for objects can be found in many languages. Some languages use body part terms to refer to object parts, while others have only a few idiosyncratic examples in their vocabulary. Studying the word forms referring to body and object concepts, i.e., colexifications, across languages, offers insights into cognitive principles facilitating such usage. Previous studies focused on full colexifications in which the same word form expresses two distinct concepts. Here, we utilize a new approach that allows us to analyze partial colexifications in which a concept is built out of the word forms for two separate concepts, like river mouth. Based on a large lexical database, we identified body and object concepts and analyzed 39 colexifications across 329 languages. The results show that word forms for body concepts are used slightly more frequently as a source for object names. However, the detailed examination of directional tendencies and colexifications of word forms between body and object concepts reveals linguistic variation. The study sheds light on meaning extensions between two concrete domains and showcases the synergies that arise through the combination of existing data and methods.

Added value of pre-procedural magnetic resonance angiography in transarterial embolization for refractory musculoskeletal pain

BackgroundTransarterial microembolization (TAME) is a minimally invasive treatment for chronic musculoskeletal disorders. Identifying angiogenesis and the supplying vessels of the target joint is important but challenging. Although magnetic resonance imaging (MRI) is commonly used to diagnose musculoskeletal diseases, it typically excludes vascular imaging. Dynamic contrast-enhanced magnetic resonance angiography (DCE-MRA) has the ability to visualize lesion angiogenesis, identify supplying vessels, and evaluate the vasculature anatomy. We propose that incorporating DCE-MRA into pre-procedural assessments can help identify the culprit vessels, arterial anatomy, and variant assessment of the target joint before TAME.Materials and methodsWe investigated six cases, each presenting pain in different body parts: shoulder adhesive capsulitis, trapezius myalgia, combined tennis and golf elbow, knee osteoarthritis, refractory knee pain after osteotomy, and plantar fasciitis. All patients underwent MRI with DCE-MRA before undergoing TAME. DCE-MRA was performed using either 1.5 T or 3 T MRI scanners, employing 3D-TRICKS or 4D-TRAK XD techniques. The numerical rating scale for pain was evaluated at one, three, and six months after the procedure, and any adverse events were recorded over the entire six-month follow-up period.ResultsPre-procedural DCE-MRA helped to visualize angiogenesis at the lesion site in all patients and identify the supplying vessels, arterial vasculature anatomy, and branching variants. These findings corroborated the subsequent digital subtraction angiography (DSA) findings obtained during TAME. All patients experienced pain reduction and functional improvement after TAME without any complications. The average pain score reduced significantly after TAME treatment (p < 0.05). Two patients underwent a second MRI and DCE-MRA at the six-month follow-up and showed a significant reduction in angiogenesis.ConclusionDCE-MRA offers a valuable pre-procedural assessment tool for TAME procedures by facilitating the visualization of angiogenesis at the lesion site, supplying vessels, and arterial anatomic variants, including the variable orifice of the supplying branches. This information can potentially improve patient selection and pre-procedural planning, leading to better outcomes and reduced risk of complications.

Assessment of early neonatal practices to prevent hypothermia ; A comparative study

Background Globally, neonatal deaths are significantly attributed to hypothermia. This is mostly because of its co-morbidity with asphyxia, premature birth and severe neonatal infections. Worldwide, neonatal hypothermia case fatality rates (CFRs) range from 8.5% to 52%. This study aimed to assess how well a video-based training intervention on mothers’ knowledge and practices in preventing neonatal hypothermia worked. Methods The knowledge and practices of two groups of primi-para mothers—one control group and one intervention group—were compared in order to achieve this. A total of 124 primipara mothers took part in the research. Using a video based tool, the intervention group was educated about preventing hypothermia in newborns. Both control and intervention group mothers were interviewed to compare the knowledge and practices. Results Sixty-one of the sixty-two mothers in the control group were unsure of which body area to cover in order to preserve the baby’s body heat. Following the intervention, 61 out of 62 mothers in the group recognised which body part to cover to protect the baby’s body heat. In the post-intervention group, 98.4% of moms wore a cap over their baby’s head, compared to just 35.5% in the control group. Conclusion The results of this study demonstrate the significant improvement in mothers’ knowledge and actions about the prevention of neonatal hypothermia resulting from the use of a video-based training tool.

Missing pieces and body parts: On bodily integrity and political violence

While much attention is paid to what happens to dead bodies after political violence, disaster, or atrocity, less attention has been paid to body parts, despite the wide-ranging efforts, both material (often forensic) and discursive, to reconstitute or resuscitate the whole dead body. Materializing the whole body is often considered key to truth-telling mechanisms and for closure for family members of the missing and dead, thus the body part is often posited as a problem in need of a solution. We are seeing, largely due to advances in forensic technologies, an increasing belief that all body parts can be identified and distinguished from other materials, and should, therefore, be recovered and repatriated to the whole body in its death. To explore this dynamic, I make two key arguments. First, I suggest that reassembling bodies is framed as a mechanism of re-subjectification that is key to reconciliation and justice after political violence. A body part is an object, but a dead body is in most contexts still considered a subject, even dead, so putting a dead body back together is considered re-humanizing and gives the dead body back its political agency. Second, I suggest that when this cannot be done materially due to the obstacles posed by modern warfare, we often see governance techniques that seek to do so discursively.

Age-Related Influence on Static and Dynamic Balance Abilities: An Inertial Measurement Unit-Based Evaluation

Balance control, a complex sensorimotor skill, declines with age. Assessing balance is crucial for identifying fall risk and implementing interventions in the older population. This study aimed to measure age-dependent changes in static and dynamic balance using inertial measurement units in a clinical setting. This study included 82 healthy participants aged 20–85 years. For the dynamic balance test, participants stood on a horizontally swaying balance board. For the static balance test, they stood on one leg. Inertial measurement units attached to their bodies recorded kinematic data, with average absolute angular velocities assessing balance capabilities. In the dynamic test, the younger participants had smaller average absolute angular velocities in most body parts than those of the middle-aged and older groups, with no significant differences between the middle-aged and older groups. Conversely, in the single-leg stance tests, the young and middle-aged groups outperformed the older group, with no significant differences between the young and middle-aged groups. Thus, dynamic and static balance decline at different stages with age. These results highlight the complementary role of inertial measurement unit-based evaluation in understanding the effect of age on postural control mechanisms, offering valuable insights for tailoring rehabilitation protocols in clinical settings.

Impact of a natural rubber-based scratcher as an environmental enrichment on the scratching behavior, cortisol level, and semen quality of stable male goats

Background and Aim: Goats are valuable livestock because they can generate meat and milk for human consumption. Goat husbandry is becoming more intensive due to the growing demand for goat products, which may impact animal welfare and natural behavior. This study aimed to investigate the impact of natural rubber (para rubber)-based scratchers as an environmental enrichment on scratching behavior, cortisol levels, and semen quality in stable bucks (male goats/goats). Materials and Methods: Nine male goats were used in this study. Scratching behavior and cortisol levels were used as welfare indicators, whereas semen quality was evaluated as an indicator of reproductive potential. These indicators were analyzed before and after scratcher installation. Results: After installing the scratchers, the goats showed a significant increase in scratching behavior and a notable decrease in cortisol levels (p < 0.001). Notably, the goats exhibited a marked preference for scratching against the scratcher (p < 0.001) compared to the stable. They significantly preferred using their heads for scratching (p < 0.001) instead of other body parts. In addition, goats preferred to scratch on the softest rubber scratchers at specific installation locations (p < 0.001). Although there was a slight improvement in semen quality, there was no statistically significant difference (p > 0.05). Conclusion: A natural rubber-based scratcher can increase scratching behavior and reduce cortisol levels, indicating its potential to improve the welfare of farm goats. Selecting an appropriate hardness and preferred location is essential to ensure that the scratcher effectively encourages animals to use it. Keywords: cortisol, goat, para rubber, scratcher, semen quality.

Motion process and failure mode of Pusa landslide, China based on dense optical flow method

ABSTRACT Unmanned aerial vehicle (UAV) is widely applied in geohazard monitoring with its high resolution and feasibility features, where UAV videos can record the whole landslide failure process. Previous studies can only provide the qualitative depiction of the landslide failure process, rather than the quantitative motion process, which makes it difficult to analyse the landslide dynamic characteristics and failure mode. In this letter, we take UAV video of Pusa landslide, China obtained on 28 August 2017 to retrieve the landslide motion process by using the dense optical flow method. Firstly, the landslide boundary can be clearly depicted by the cumulative landslide motion time series maps. Secondly, the maximum cumulative motion distance of the Pusa landslide was located in the middle of the slope body, with the maximum distance as 79 m, while the maximum instantaneous motion rate was around 42 m/s in the middle and lower part of the slope body. Finally, the failure mode of Pusa landslide can be characterized as ‘fissure zone in the middle, fissure extension to the top, rock bulges outward in the middle and landslide failure to high-speed runout debris flow’.

Effect of Telerehabilitation-Based Motor Imagery Training on Pain and Related Factors in People with Multiple Sclerosis: Randomized Controlled Pilot Trial

ObjectivesTo investigate the effect of telerehabilitation-based graded motor imagery (MI,GMI) training on pain and pain-related factors in people with multiple sclerosis (MS). DesignRandomized controlled, assessor-blind pilot trial with repeated measure design. SettingNeurology outpatient clinic. ParticipantsThirty-two people with MS were randomly allocated to intervention (n=16) and control (n=16) groups. InterventionsDuring 8-week GMI training period, the first 2-weeks involved implicit MI training while 6-weeks explicit MI training were conducted. Main OutcomeThe primary outcome was the general pain intensity over the past two days, assessed with Visual Analogue Scale, with a minimum clinically important difference (MCID) of 23 mm. Secondary outcomes included general pain and specific body parts' pain intensity over the past seven days, neuropathic pain intensity, MI ability, fatigue, depression, anxiety, quality of life, sleep quality, daytime sleepiness and cognitive functions scores. Assessments were conducted at baseline, at weeks 8 (post-treatment) and 12 (follow-up). ResultsThe intervention group demonstrated a significant reduction in pain intensity over the past two days compared to control group (p<0.05). Furthermore, at the 8-week assessment, the intervention group surpassed the MCID in pain intensity over the past 2 and 7 days (p<0.05), whereas no significant change was observed in the control group (p>0.05). Significant effects were observed post-treatment on general pain over the past seven days, neuropathic pain, MI ability, fatigue, depression, quality of life, processing speed, and visuospatial memory within intervention group compared to control group (p<0.05). However, the impact on anxiety, sleep quality, daytime sleepiness, and verbal memory between groups were not significant (p>0.05). ConclusionTelerehabilitation-based GMI training stands out as viable for management of chronic pain and pain-related psychosocial symptoms for people with MS.

“Her Prim Answering Smile”

To date, disability readings of J. M. Coetzee’s Life &amp; Times of Michael K have engaged with the implications stemming from the protagonist’s neurodiversity; however, this discourse can be expanded to account for his physical alterity. From birth, K is stigmatized for his cleft lip, a defining corporeal trait that aptly informs his “life and times.” In response, this article argues, K develops a method for negotiating the ableist politics underscoring apartheid South Africa. He studies the body part for which he is stigmatized—mouths. Encountering a series of oral expressions, K gauges each to determine the extent of his participation within his war-torn milieu. Whereas his mother’s smile conjures happiness and prompts engagement, the soldier’s mocking grin is a threatening gesture from which K distances himself. This article suggests Coetzee’s novel questions the state of personhood, asking not who is granted the dignities afforded to the liberal individual in apartheid South Africa, but what that individual must look like in order to experience affections such as compassion and respect.

Between Living and Non-living: Materiality of the Placentain Ming China.

This study explores materiality and material cultures of human placenta in Ming China (1368-1644), for it perfectly displays Chinese ambiguous attitudes towards the human body parts between living and non-living. For a long time, the Chinese had widely applied human body parts in medical treatments and ritual healings. Numerous evidences in relation to their collection, production, efficacy and application are widely recorded in medical works, in particular those found in materia medica. In the sixteenth century, the Bencao gangmu (Systemic Materia Medica, 1596) illustrates thirty-five "human body drugs." Of those, the placenta was believed effective for curing illnesses, nourishing the body and prolonging life. The questions to be answered include: how is the placenta perceived in medical and religious discourses? What is its "materiality" and "efficacy" when it becomes a drug? What ethical issues and moral concerns are involved with eating the placenta? Last but not least, how was the placenta ritually buried after childbirth in premodern China? In so doing, this essay aims to provide a better understanding of the placenta situated in both material and cosmological worlds. It helps us rethink the multiple relations of human body part to part, part to whole, and body to body.

Key Frame Selection for Temporal Graph Optimization of Skeleton-Based Action Recognition

Graph neural networks (GNNs) are extensively utilized to capture the spatial–temporal relationships among human body parts for skeleton-based action recognition. However, due to the inefficient information propagation caused by redundant sampling of video frames in the temporal domain, we focus on refining temporal graphs through key frame selection. To this end, we propose a multi-stage key frame selection (MSKFS) method, aiming to find the most representative frames as the graph nodes to learn compact temporal graph representations of human skeletons for action recognition. The MSKFS progressively selects key frames in two stages: (1) salient posture frame selection based on the global dynamics of body parts and (2) key frame refinement and alignment according to intra-frame correlations. The first stage captures the most salient information and aligns the corresponding information of skeleton sequences within the same category. The second stage enriches the subtle information for the integrity of the information derived by the salient frames. Moreover, variational inference is applied to differentiate the key frame refinement and alignment procedure, allowing the end-to-end optimization of arbitrary graph-based models to represent the obtained compact graph for skeleton-based action recognition. Our MSKFS method achieves state-of-the-art performances on two challenging action recognition datasets.

Effect of Compositionally Different Substrates on Elemental Properties of Bay Bolete Mushrooms: Case Study of 34 Essential and Non-essential Elements from Six Areas Affected Differently by Industrial Pollution.

We studied concentrations of 34 essential and non-essential elements in samples of edible Bay Bolete (Imleria badia) mushrooms added by samples of the growing substrate and bioavailable fraction. The samples were collected from six forested sites affected differently by industrial pollution and underlain by compositionally contrasting bedrock: granite, amphibolite, and peridotite. In all cases, mushrooms behaved as a bioconcentrating system for elements such as Ag, K, P, Rb, S, and Se (BCF > 1) being a bioexcluding system for the rest of the elements analyzed (BCF < 1). Most analyzed elements displayed moderate to high within-mushroom mobility being accumulated preferably in the apical parts of the mushroom's fruiting body (TF > 1). The highest mobility was demonstrated by Cd and Cu. Sodium was the only element with significantly low mobility (TF < 1), and it accumulated preferably in the stipe. Imleria badia seems to be sensitive to the accumulation of elements such as As, Cd, and Pb from the atmospheric deposits. Specific geochemistry of the growing substrate was reflected to different extend in the accumulation of elements such as Ag, Cu, Rb, S, Al, Ca, Fe, Ba, and Na in the mushroom's fruiting bodies.

Hiking Backpack Design Development with Integrated Splint Feature for Fracture Injuries

The background of this design is the risk of fracture injury to climbers when mountaineering. According to the International Alpine Trauma Registry (IATR), there were 306 mountaineering accidents resulting in fractures in 2019. First aid for fractures requires standardized equipment and methods to assist the rescue process. The problem studied is the difficulty of climbers in utilizing climbing equipment as splints when treating fracture victims on the mountain. The purpose of this design is to develop climbing equipment so that it can be converted into a means of bandaging to perform first aid for fracture injuries. The design method used is Quality Function Deployment (QFD), to determine the priority aspects related to the specifications of the means of massaging that users want. The result of the design is a backpack product with an internal frame that applies a collapsible mechanism so that it can be quickly accessed in an emergency and can be adjusted according to the dimensions of the body part that has a fracture injury. The developed splint design successfully meets the criteria for dimensional customization to the user's body and can immobilize the fracture according to standard first aid procedures.

The Effects of War-Related Stress on Human Development: Differences in Body Proportions of Polish Women Born Before and During World War II.

This study aims to explore the lasting effects of stress experienced by pregnant women during World War II (WWII) on body and head measurements of their adult daughters. The research sample consists of 336 female university students born in Poland between 1925 and 1951. The data include body measurements and socioeconomic information (parental occupation and number of siblings) acquired from questionnaires collected between the 1950s and 1970s. Student's t-test, Mann-Whitney test and Analysis of Variance were used to analyze differences in body measurements between groups of women born before and during the war, as well as the possible influences of socioeconomic variables. The mean measurements of body height, symphysion height, and waist circumference were lower in women conceived and born during the war compared to those born in the pre-war period. In contrast, the mean measurements of biacromial (shoulder) width, trunk length, and three head dimensions were higher in women conceived and born during the war. Additionally, the number of siblings appeared to be a significant factor that may have influenced the body measurements of women in both groups. For instance, a higher number of living siblings, particularly sisters, was associated with reduced body dimensions, such as body height and waist circumference, while a greater number of deceased siblings was linked to an increase in certain body dimensions. The results suggest that war-related prenatal conditions may have influenced the postnatal growth and development of women conceived and born during the war. Notably, the direction of these changes varied, which indicates that the growth response to the war-related conditions was a complex adaptation, reflecting both positive and negative changes in different body parts, rather than a uniform pattern of growth suppression.

Few-shot Learning for Sign Language Recognition with Embedding Propagation

Sign language is a primary channel for the deaf and hard-hearing to communicate. Sign language consists of many signs with different variations in hand shapes, motion patterns, and positioning of hands, faces, and body parts. This makes sign language recognition (SLR) a challenging field in computer vision research. This paper tackles the problem of few-shot SLR, where models trained on known sign classes are utilized to recognize instances of unseen signs with only a few examples. In this approach, a transformer encoder is employed to learn the spatial and temporal features of sign gestures, and an embedding propagation technique is used to project these features into the embedding space. Subsequently, a label propagation method is applied to smooth the resulting embeddings. The obtained results demonstrate that combining embedding propagation with label propagation enhances the performance of the SLR system and achieved an accuracy of 76.6%, which surpasses the traditional few-shot prototypical network's accuracy of 72.4%.

Relationship Between Musculoskeletal Disorders on Job Performance

Background: The World Health Organization (WHO) and International Labour Organization (ILO) have identified musculoskeletal disorders (MSDs) as a rising epidemic within the workforce. These injuries account for 33% of all occupational injuries and 40% of medical costs. Objectives: This study aimed to determine the effect of MSDs on the job performance of operating room employees. Methods: This descriptive and analytical study was conducted on 100 participants. Job performance was assessed using the Patterson Job Performance Questionnaire (JPQ), and MSDs were evaluated using the NORDIC Questionnaire. Data were analyzed with SPSS version 16, employing Mann-Whitney, chi-square, and binary logistic regression tests. Results: Among the participants, 43% were women, and 67% were men, with an average age of 27.37 ± 6.45. Sixty-two percent of participants did not have acceptable job performance. Additionally, 83% reported at least one musculoskeletal injury, 64% had at least two injuries, and 62% had three or more injuries across different body parts. The results indicated a significant relationship between job performance and variables such as hip, knee, lower back, upper back injuries, age, gender, literacy level, physical activity, and work experience. However, no significant relationship was found between neck injuries and marital status with job performance (P &lt; 0.05). Conclusions: This study demonstrates that MSDs can negatively impact employee job performance. Given the influence of various occupational factors on performance, it is recommended that future studies simultaneously examine the effects of other occupational hazards.

Cerebral palsy detection from infant using movements of their salient body parts and a feature fusion model

Cerebral palsy detection from infant using movements of their salient body parts and a feature fusion model