Aminosidine Research Articles

Malabsorption Due to Paromomycin

Administration of paromomycin sulfate (2 gm/ day) to seven healthy Thai volunteers resulted in malabsorption of xylose and sucrose. Abnormal fat metabolism was demonstrated histologically, although steatorrhea did not occur. Structures with tinctorial and light microscope features consistent with bacteria were observed in macrophages which accumulated in the lamina propria mucosae near the villus tip of the jejunum. All effects were transient and disappeared when therapy was discontinued. It is suggested that aminoglycoside antibiotic-induced malabsorption may result from an effect of the drug upon protein synthesis in the small intestine.

USE OF EXOGENOUS AND ENDOGENOUS UREA FOR PROTEIN SYNTHESIS IN NORMAL AND UREMIC SUBJECTS.

Abstract If urea, under certain conditions, were used for protein synthesis, the possibility would exist that patients with azotemia could utilize their own urea for anabolic purposes. To investigate this hypothesis, nitrogen balance was studied in a volunteer and in a group of 8 patients with renal disease, 6 of whom were uremic. With the use of a synthetic diet containing essential amino acids in low quantity, it is shown that urea, either if given exogenously or if taken endogenously from waste nitrogen retained in uremia, is utilized for synthesis of nonessential amino acids. Treatment with Humatin, ∗ ∗Parke, Davis & Co., Detroit, Mich. an agent which is effective in suppressing intestinal flora, did not influence the use of urea for protein synthesis.

Effects of paromomycin sulfate in man against Entamoeba histolytica and other intestinal protozoa.

SummaryThirty-two patients infected with Entamoeba histolytica and a variety of other intestinal protozoa were treated with paromomycin sulfate. Average doses of 15 mg/kg/day were given for 5 days and the patients were followed closely by stool examination for 10 weeks. The patients were part of a population in which intestinal protozoa were unusually prevalent.E. histolytica, E. hartmanni, E. coli, Endolimax nana, Iodamoeba bütschlii, Giardia lamblia, Chilomastix mesnili and Trichomonas hominis, all disappeared during treatment. E. histolytica recurred in 2 (of 32), I. bütschlii did not recur in any (of 15), but recurrences of the other protozoa were roughly proportional to their initial prevalence. Five-day mass treatment of cottage mates did not greatly influence recurrences.