There are many types of lentic and lotic freshwater sources on earth, such as puddles, ponds, rivers, springs, dams, lakes, etc. and many of them are found near human settlements. But most of the people are not known and aware of these freshwater sources how safe and dangerous they can be. In fact, these water sources are potentially responsible for spreading various deadly trematodiases (trematode parasitic diseases) to both humans and domestic animals. The most common zoonotic or vector-borne dreaded trematodiases found in humans and domestic animals are fascioliasis, schistosomiasis, paragonimiasis, echinostomiasis, amphistomiasis, etc. These parasitic diseases are endemic in almost every country. But these diseases can occur in any geographical area only when different species of snails (Mollusca: Gastropoda) and crabs or crayfish (Crustaceans) are found in the freshwater bodies there. In fact, these aquatic invertebrates are the intermediate hosts of diverse pathogenic digenetic trematode parasites including Fasciola hepatica, Schistosoma mansoni, Paragonimus westermani, Ceylonocotyle scoliocoelium, etc. and complete their life cycle. These are also known as vectors or carriers and are responsible for the transmission or spread of various trematodiases in different geographical areas. Therefore, these diseases are also called vector- borne diseases. Apart from causing varying levels of morbidity and mortality in humans and animals, these diseases also cause tremendous economic losses to livestock owners. However, it is not necessary that all types of freshwater sources are beneficial, but from the point of view of trematodiases, the water sources in which different types of snail species are found can also be dangerous or unsafe for the health of humans and domestic animals. But most of the people are ignorant and unaware of how these parasitic diseases transmitted or spread to humans and domestic animals through various freshwater bodies located around them. The current review highlights how freshwater sources can be hazardous or dangerous to the health of humans and domestic animals in the context of diverse trematodiases and also focused on their prevention and control.