We are honored to introduce the Proceedings of the 4th International Conference on Informatics, Engineering, Science, and Technology (INCITEST 2021). With its main theme on “A Future Road Map, Encouraging Optimism and Technology to Face Post Covid-19 Era”, this event is hoped to serve as a platform of gathering for anyone interested in exploring optimism, potential solutions, and answering issues and challenges in the era Covid-19 Pandemic”. Unlike the 1st and 2nd INCITEST, the 3rd and 4th INCITEST was carried out in the virtual conference due to the impact of COVID-19. Universitas Komputer Indonesia (UNIKOM) held this online conference on 10 March 2021 to gather experts and scholars worldwide to continue disseminating the latest advanced research in the field of Informatics, Engineering, Science, and Technology and developing the academic exchange among researchers.Following the success of INCITEST 2018, 2019, and 2020, the enthusiastic responses to the call-for-papers in the fourth INCITEST were increasing. More than 150 papers were submitted to the organizing committee from both local and foreign participants. A peer-review process has been conducted to check paper originality and quality, resulting in 120 accepted papers being presented. The papers have been presented via Zoom in 10 minutes for each paper.It is an honor for us to have four renowned experts as our keynote speakers : Prof. Minoru Terano and Prof. Hiroyuki Iida from Japan Advanced Institute of Science and Technology (JAIST), Dr. Siva Kumar Sivaneshan from Taylor’s University, and Dr. Salmon Priadji Martana from UNIKOM. The keynote speech is presented in the plenary session in online format (via Zoom) and lively broadcasted on UNIKOM Youtube official channel. Each keynote presented their address in 45 minutes duration, including the discussion session. After completing the plenary session, the schedule continued with a parallel session held in an online format. The participants were divided into several classes, which a moderator chaired. Each presenter should present their paper within 5 minutes via Zoom. Five minutes after the presentation will be given to each of them for the discussion session.List of Committees of Incitest 2021 are available in pdf.