Papulovesicular Rash Research Articles

Vasculitis simulating eczematous dermatitis due to C2 deficiency

In a patient with total C2 deficiency and repeated respiratory infections a papulovesicular rash showed to be due to leukocytoclastic vasculitis. The patient´s brother also had a total deficiency of C2 but no clinical symptoms. HLA-investigation in both him and the proband showed the genotype commonly reported in cases with homozygous C2 deficiency. Their heterozygous mother and sister had slightly decreased C2 levels.

Skin rash as a side effect of I-tetramisole

Tetramisole is a new anthelmintic drug recommended for treatment of ascariasis. Various side effects reported with this drug are headache, anorexia, salivation, malaise, fever, diarrhoea, and generalized convulsions. Skin rashes have not been reported. A patient with a papulovesicular rash, confirmed to be due to 1-tetramisole, is presently reported.

Acrodermatitis enteropathica without diarrhea.

Acrodermatitis enteropathica was first recognized by Danbolt and Closs⁴in 1942, although cases had been previously described in the literature under a variety of titles. Further examples of the condition have been reported by Danbolt,^2,3Bloom and Sobel,¹Hodgson-Jones,⁷and Hare and Schlesinger.⁶The disease is now accepted as a clinical entity comprising a cutaneous eruption, gastrointestinal symptoms, and disturbances of growth and development (Sulzberger and Baer).¹⁰It has been well summarized by Dillaha et al.,⁵who also reported the beneficial effects of diiodohydroxyquin (Diodoquin) by mouth as suggested by Schlomovitz.⁹Vedder¹¹noted the occurrence of the condition in a number of siblings. All authors agree on the presence of recurrent attacks of diarrhea or mucoid stools and an erythematous papulovesicular or pustular rash usually surrounding the orifices and on the hands and feet. Paronychia may also be a feature. Thinning

CONTACT DERMATITIS FROM AMORPHOUS SODIUM PENICILLIN

T. G., a chemist aged 36 years, has during the past two years conducted extensive research on the chemistry of penicillin. He first consulted me in December 1943, because of an itchy rash on the eyelids and on the penis of three months' duration. The eruption appeared approximately one year after he had begun the work on penicillin. He was treated symptomatically with soothing applications, and it was noted that whenever he avoided direct contact with penicillin the rash improved or disappeared entirely. Examination showed red, swollen eyelids. The conjunctiva was red. The skin adjacent to the eyelids showed an ill defined, red, pinhead-sized vesiculopapular scaly eruption. The penis was red and edematous and showed a discrete, papulovesicular rash. There were no lesions on the fingers and hands. A patch test on the right arm with a solution made of the yellow amorphous sodium penicillin which is used