Gill necrosis is a widespread disease of common carp in Europe. Much effort has been concentrated in the investigation of its aetiology during the last 15 years. The results of a three-year research project are presented here and the role of bacteria is demonstrated. This paper shows the development of the disease and the relationship between environmental stress and bacterial invasion. Both healthy and diseased carp populations were monitored for the presence of Flexibacter columnaris. Gill necrosis was reproduced experimentally using Flexibacter columnaris isolates. Based on the bacteriological investigations, artificial infection and field monitoring, three stages of gill necrosis could be distinguished. The first stage is initiated and maintained by environmental stress (probably ammonia, pH, temperature or any toxins). At this stage, Flexibacter columnaris is seldom present on the gills if at all. The gills are pale or dark purple. The second stage starts when Flexibacter columnaris invades the damaged gill (only at water temperatures above 20°C). The infected part of the gill is necrotized and covered with a grey-white coating. The third stage occurs if the fish survives bacterial invasion. Flexibacter columnaris with its grey-white coating disappears and the site of the invasion remains distorted. Different stages of gill necrosis may appear in the same fish population.