Pain In Oral Cavity Research Articles

A retrospective study of clinical profile of para-phenylenediamene poisoning (hair dye poisoning) in cases admitted in medical college

India has a high suicide rate and a large proportion of these suicides occur through poisoning. Poisoning by Hair dye has been increasing and constitutes a large proportion of the poisoning cases. The principle toxic constituent of Hair dye poisoning is Paraphenylenediamine (PPD).Present study was done by analyzing the demographic profile, clinical presentation, biochemical profile, life saving interventions and mortality in cases of PPD poisoning. This study was conducted on 80 cases. Angioedema, pain in oral cavity, dark coloured urine, oro-facial edema were main clinical features. Raised TLC count, elevated liver enzymes (sgpt, sgot), elevated serum creatinine, hypocalcemia, elevated bilirubin, low haemoglobin.Paraphenylene diamine poisoning is developing now days due to easy obtainability and low cheap price. It is more common in poor, illiterate, married females of younger age group living in rural areas. Aggressive treatment and Tracheostomy can save life of Patients.

Evaluate the clinical efficacy of Amrutadi tablet(Anubhut) as palliative care management in oral squamous cell carcinoma w.s.r to tobacco induced oral cancer -a single case study

Aim: To Evaluate the clinical efficacy of Amrutadi tablet (Anubhuta)as palliative care management in oral squamous cell carcinoma.
 Background: The disease arbuda was prevalent during the Vedic period. In athar-vaveda2 there is reference of arbuda and its management. Arbuda is one of the surgical diseases and was explained in detailed by sushruta the pioneer of in ancient ayurvedic texts that have remarkable similarities with modern interpretation of cancer. Cancer is one of the most dreaded diseases of the 20th century and spreading further with continuance and increasing incidence in 21st century. Cancer is a disease caused by uncontrolled division of abnormal cells in any part of the body.More than 90% of cancer of the tobacco induced oral cancer are squamous cell carcinoma.
 Results and Discussion: A case of pain in oral cavity and mouth ulceration after biopsy and mri diagnosed as oral squamous cell carcinoma was given Amrutadi tablet for a period of 30 days. Symptom of pain in oral cavity mouth ulceration and associated symtoms dysphagia, anorexia has been improved moderately within a month. Assesement of patient has been done based on subjective and objective criteria before and after treatment, which shows improvement in patient condition.

Comparative Study to Evaluate Surgical Outcome and Donor Site Morbidity of Buccal Versus Lingual Mucosa Graft in Anterior Urethroplasty

Background: Stricture urethra is a frequent urological problem and substitution urethroplasty is the standard treatment for longer (>2 cm) urerthral strictures, multiple urethral strictures and recurrent strictures. Currently, buccal mucosa graft (BMG) is the preferred donor site for substitution urethroplasty which is associated with donor site morbidities. The mucosa covering the lateral and undersurface of the tongue is identical to the rest of the lining of oral cavity and seems to be associated with less risk of donor site complications. The aim of the study was to compare the surgical outcome and donor site morbidity of buccal versus lingual mucosa graft in anterior urethroplasty. Methods: A prospective experimental study was done in the department of Urology Dhaka Medical College Hospital during the period of April 2017 to September 2018. Total 54 Patients were included by purposive sampling for the study as per inclusion and exclusion Criteria. Patients were than allocated into two groups. Group A consisted of 27 patients where Lingual mucosa graft (LMG) urethroplasty done and group B also consisted of 27 patients where Buccal mucosa graft (BMG) urethroplasty done. Results: In the present study, the baseline characteristics of the patients in group A and Group B were almost similar having no statistically significant difference. The overall surgical outcome between two groups was in group A 92% and in group B 88%. The inter-group difference was not statistically significant. Donor site complications more frequently occurred in Group B. Pain in oral cavity at 3rd week in Group A was in 1(4%) patient and in group B was in 9(36%) patients, at 6th month follow up, eating and drinking problem (Group A 4% versus group B 32%), peri-numbness (Group A 4% versus Group B 28%), oral tightness (Group A 0% versus Group B 32%), salivary disturbance (Group A 0% versus Group B 28%) were significant statistically (p<0.05). Conclusion: We conclude that that lingual mucosa ....

Evaluation of Pain-Relieving Effect of Menthol and Benzocaine Patches in Orthodontic Patients: A Triple-Blind Randomized Controlled Trial

Purpose: This study aimed to compare the effect of benzocaine and menthol patches on pain alleviation following elastomeric separator placement.Patients and Methods: This triple-blind split-mouth trial was conducted on healthy 14-25 years old patients of orthodontic department. Eligibility criteria included presence of second premolar, first and second molars in both sides of the mandible, no chronic pain in oral cavity, or chronic consumption of analgesic drugs. Elastomeric separators were placed mesial and distal of first mandibular molars and patients were randomized into two groups: 1) menthol/ placebo patches, 2) benzocaine/ placebo patches. The mucosal patches were placed randomly on the buccal area of mandibular first molars on both sides. Main outcome was pain level reported by patients on the Visual Analogue Scale (VAS) in seven-time intervals in three following days. Data were analyzed by linear mixed model. P-value was set to be 0.05. Results: Sixty-four patients were randomized in a 1:1 ratio with no loss to follow-up. Both benzocaine and menthol patches significantly reduced mean pain level compared to placebo patch (P< 0.001). Benzocaine patch had more analgesic effect; however, the difference was not statistically significant (P=0.115). Time interval had a significant effect on recorded pain except the first time interval. Age and gender had no significant effect on pain. No adverse event was reported in patients. Conclusions: Both benzocaine and menthol patches were effective in alleviating pain. Therefore, they can be recommended to be used for reducing pain following orthodontic elastomeric separator placement.

Prospective feasibility study of indigo naturalis ointment for chemotherapy-induced oral mucositis

ObjectivesIndigo naturalis, a herbal medicine effective against ulcerative colitis, exhibits anti-inflammatory effects and induces interleukin-22-mediated antimicrobial peptide production. Anti-inflammatory activity and the prevention of secondary infection are essential for the...

ODONTALGIA IN MAXILLOFACIAL REGION

Odontogenic lesions of the trigeminal nerve branch system (neuritis, neuralgia, odontalgia) that tend to have a long chronic course are more common in middle and old age. They can be caused by defects in the treatment and restoration of teeth, inflammatory and traumatic processes in the maxillofacial region, and others. The dentist should distinguish between the terms: "odontalgia" and "odontogenic trigeminal neuralgia". Odontogenic neuralgias do not disappear after the elimination of the main odontogenic pathological focus. If after the sanitation of the oral cavity pain disappears, then we are talking about odontalgia.&#x0D; Sometimes it is very difficult to find the cause of the disease. Pain in the facial area and occipital region of the head can also occur with osteochondrosis of the cervical ridge and provoke pain in the system of the trigeminal nerve branches. Pain and paresthesias can occur in the occipital region of the head and neck, and then spread to the parietal, zygomatic region or the entire face. More often the pain radiates to the frontal region, orbit, or ear. The reverse development of the syndrome may also occur: pain sensations begin in the face and spread to the cervico-occipital region.&#x0D; The article presents a case of odontalgia of the maxillofacial region that arose after the treatment of complicated caries of the 26th tooth. The pain periodically appeared in the left occipital region, and then passed to the orbit; a feeling of distension in the eyeball appeared, then the pain passed to the left upper jaw and gradually subsided. The patient described pain as acute, appeared in the form of seizures, and was not associated with the action of thermal stimuli. After clinical and laboratory examination, the oral cavity was sanitized, including the course of treatment of generalized periodontitis, restoration of the destroyed crown of tooth 23, and root canal therapy of previously treated tooth 26 for chronic pulpitis complicated by periodontitis. An old filling was removed from the tooth (no R-contrast lining material was found at the bottom of the tooth cavity). After the preparation of the tooth cavity, an attempt was made to carry out high-quality endodontic treatment, but the root canals were completely obliterated. Endodontic retreatment of the tooth 26 was unsuccessful. An antiseptic solution was left at the bottom of the tooth cavity, then a paste and a phosphate cement pad were placed; after that a photocomposite restoration was done. In parallel, a course of the treatment for osteochondrosis of the cervical spine was carried out by a neurologist. The performed oral sanitation and the treatment of cervical osteochondrosis failed to be effective. Pain in the back of the head and maxillofacial area practically did not change, continued with the same frequency and intensity. Additional clinical, laboratory and X-ray examination did not allow us to establish an obvious cause of the disease. Therefore, after the medical consultation with doctors of related specialties (oral surgeons, neurologists), we decided to perform therapija ex juvantibus, i.e. to remove the "causal" tooth. After the 26 tooth was removed, the pain completely disappeared.&#x0D; The above case testifies that sometimes it can be very difficult to establish the cause of neurological pain, and thus, to make correct diagnosis and to prescribe proper treatment. It is possible to presume that recurrent pain attacks in the left occipital region that move to the orbit of the eye, a feeling of distension of the eyeball, pain in the left upper jaw, slowly subsiding and not associated with the action of thermal stimuli were provoked by the painful condition of the pulp-periodontal complex of tooth 26, which did not respond to endodontic treatment. The extraction of the tooth led to the complete disappearance of neurological pain, which is characteristic of odontalgia of the maxillofacial region.

Quality of Life in Patients with Recurrent Oral Squamous Cell Carcinoma: A Study from India.

Locoregional recurrence of oral cancer causes significant morbidity. This study aims at assessing the functional outcomes of patients undergoing treatment for recurrent oral squamous cell carcinoma. This study was done in a tertiary care center in North India and includes prospective cohort of 179 recurrent oral carcinoma patients, from September 2017 to September 2018. Patients undergoing treatment of recurrent oral carcinoma were assessed for quality-of-life score at baseline before starting treatment and two months after the completion of the treatment. For the assessment, EORTC QLQH&N35 questionnaire was used. Of 179 patients included, 71 (39.66%) patients underwent salvage surgery and 104 patients (58.10%) received palliative chemotherapy. One hundred and thirty patients could complete the "EORTC-QOL-H&N-35" questionnaire on required two occasions. Forty-nine patients died before completing second questionnaire. More than half (55.6%) of patients who underwent salvage surgery had improved quality of life after the procedures. They have little or no pain in oral cavity, improved swallowing, less odynophagia, improvement in neck and shoulder pain, less problems with the external appearance and socialization, and enjoyed better sexual life. In patients receiving palliative chemotherapy, the quality of life declined in majority (88.1%) of the patients. Although salvage surgery is the best modality of treatment for recurrent oral carcinoma, only about one-third of patients qualify for surgery and enjoy improved quality of life following surgery. On the other hand, in majority of the patients receiving palliative chemotherapy, the quality of life worsened with time and treatment.

Dent-O-Myths Amid Young Community: A Cross-Sectional Study

INTRODUCTION: The word ‘Myth’ is derived from the Greek word “Mythos”, meaning the stories passed by a group of certain population having a strong impact on seeking general and dental treatment even during illness. AIM: The aim of this study was to access the prevalence of dental myths among the young population and to interpret their level of knowledge, awareness and perception. MATERIALS AND METHOD: A cross-sectional questionnaire survey was conducted amongst 500 young population of age between 18-28 years between May to August 2020, COVID-19 pandemic period. A pretested validated questionnaire was formatted on Google forms and circulated in various social media platforms. The collected data was subjected to statistical analysis. RESULTS: The mean age of the study population was 22.66±2.38 years, and 59% were females and 41% were males. About 65% (325) and 56% (280) of the study subjects believed correctly that mouthwash alone will not maintain oral health and chewing gum will not clean their teeth, respectively. When asked about their responses in case of pain in oral cavity, most people 46% (230) reported they would visit a dentist and major segment of study subjects 56% (281) believed that there can be more methods for treating oral pain other than the extraction of the tooth itself.CONCLUSION: The result of this study revealed that the younger population are more aware and didn’t believe much regarding various dental myths.

Evaluation of Oral Health Status and Oral Care of Patients with Rheumatoid Arthritis.

Objective Rheumatoid arthritis (RA) and periodontal disease (PD) are common chronic, immunoinflammatory, destructive, and progressive diseases; however, the correlations between those two are not yet widely discussed. The purpose of this study was to evaluate the relationship between the selected demographic and clinical parameters of RA patients and oral health status parameters, on the basis of self-assessment. Materials and Methods Three hundred patients under treatment were included in the study. Questionnaires were completed by 164 out of 300 patients. Results A total of 100 females and 64 males took part in the study, with a mean age of 65 ± 11.1 years. In younger patients, the disease activity score (DAS28) was higher, and it was associated with pain or discomfort in the oral cavity and with difficulties in toothbrushing. Discomfort or pain in the oral cavity was to a significant extent associated with the poor gingival state, gingival bleeding, and difficulties in biting or chewing. Conclusions In RA patients, difficulties in biting or chewing, discomfort or pain in oral cavity, feeling of the presence of movable teeth, and gingival bleeding are indications of periodontal infection. Maintaining awareness of oral health and RA is a key issue in the simultaneous management of proper oral care and RA due to the mutual influence of those two factors.

Gambaran Kualitas Hidup Terkait Kesehatan Gigi Dan Mulut Pecandu Narkoba (Penelitian)

Background: In the medical world, drugs are often used as medicine in medication and science development. There is a connection between drug abuse and oral health problems. Oral health status significantly affects one’s life quality. Research results in several countries have shown a poor life quality among drug abusers. In Indonesia, there has never been any research conducted on life quality overview in connection with dental and oral health among drug abusers, by using OHRQoL instrument, especially the ‘Oral Impact on Daily Performance’. Objective: The purpose of this research is to create an overview of the quality of life in relation to drug abusers dental and oral health. Methods:This research is descriptive observational type, which uses the Cross sectional approach and total sampling method. Respondents are recipients of metadon therapy in Grogol Petamburan Municipality Health Center. Data gathering was conducted by obtaining questionnaires which were immediately completed by respondents. Results: There were 49 respondents in this research. Drug addicts often experience difficulty in chewing (32.7%), speech disorders (26.5%), absence of pain in oral cavity (36.7%), sleep disorders as a result of dental and oral health issues (32.7%), infrequent pain prior to sleep (36.7%), embarrassment due to dental and oral issues (30.6%), dental and oral problems-induced irritability (36.7%). Conclusions: As an overall conclusion, drug abusers experience poor life quality in relation to dental and oral heatlh

Autologous buccal mucosa harvest under local anesthesia: Feasibility, safety, and acceptance for substitution urethroplasty.

Objective:The objective of the study is to report our experience with buccal mucosa harvest under local anesthetic agent infiltration for urethroplasty.Materials and Methods:All patients who had buccal mucosa graft harvest under local anesthesia (1% Xylocaine) for repair of their urethral stricture, from January 2007 to December 2016, were retrospectively studied from two public urologic service centers. The demographic data of the patient, length of graft harvested, complications recorded, among other things, were entered into a pro forma and the data were analyzed using IBM SPSS Statistics version 16.Results:A total of 102 patients underwent urethroplasty with buccal mucosa harvested under local anesthesia; however, only 88 patients had complete data for analysis. The mean age was 55.03 years (±12.30). The mean harvested graft length was 5.41 cm (±2.62 cm). There was no need for conversion to general anesthesia. The majority of them (94.3%) reported that it was “easy” or “very easy” to maintain the mouth opened during the procedure. Over 91% do not have difficulty opening their mouth after the harvest. Only a patient had bothersome primary hemorrhage that required gauze packing. No significant oral cavity pain was experience in 69.3% of patients; among those with pain, the perineal pain was more. Over 90% of the patients will be willing to undergo the procedure again under local anesthetic infiltration again.Conclusion:Buccal mucosa harvest under local anesthesia infiltration is feasible, safe, and acceptable among our patients who had urethroplasty for urethral stricture disease.

Plasma N-acylethanolamine and endocannabinoid levels in burning mouth syndrome: Potential role in disease pathogenesis.

The objective was to measure endocannabinoid (eCB) ligands and non-cannabinoid N-acylethanolamine (NAE) molecules in plasma from individuals with burning mouth syndrome (BMS) and to determine whether plasma eCB/NAE levels correlated with pain, inflammation and depressive symptomatology in this cohort. Plasma content of the eCBs, anandamide (AEA) and 2-arachidonoyl-glycerol (2-AG), and the NAE molecules, palmitoylethanolamide (PEA) and oleoylethanolamide (OEA) were assessed in healthy subjects (n = 8) and in a cohort of newly diagnosed BMS patients (n = 9) using liquid chromatography-tandem mass spectrometry. Plasma eCBs and NAE profiles were correlated with self-rated oral cavity pain intensities, depressive symptomatology and plasma IL-8 levels. Plasma levels of PEA, but not OEA, AEA or 2-AG, were significantly elevated in patients with BMS, when compared to plasma from healthy individuals. Plasma PEA, OEA and AEA levels correlated with depressive symptomatology. This is the first evidence to indicate that circulating eCB/NAE levels are altered in BMS.

Plasma IL-8 signature correlates with pain and depressive symptomatology in patients with burning mouth syndrome: Results from a pilot study.

Burning mouth syndrome (BMS) is a neuropathic orofacial pain condition of unknown aetiology that encompasses intra-oral burning pain without abnormal clinical findings. Psychological, neural and inflammatory processes are associated with BMS pathogenesis. Currently, studies characterising plasma cytokine/chemokine profiles with pain and depression in patients with BMS are lacking. Considering that inflammation is associated with the pathophysiology of BMS, and that inflammation is closely associated with pain and depression, we aimed to correlate depressive symptomatology and oral cavity pain with plasma cytokine/chemokine signatures in a cohort of patients with BMS. In this study, plasma protein levels of Th1 cytokines (IFN-γ, IL-2, IL-12p70, TNF-α), Th2 cytokines (IL-4, IL-10, IL-6, IL-13) and the chemokine IL-8 were assessed in patients with BMS (n = 10) and healthy volunteers (n = 10), using pro-inflammatory-10-plex assays. Clinical histories, alongside self-rated oral cavity pain intensities and depressive symptomatology were assessed using a visual analogue scale and the 16-item Quick Inventory of Depressive Symptomatology questionnaires, respectively. We present evidence that BMS is associated with increased depressive symptomatology and enhanced oral cavity pain. Plasma isolated from BMS patients display enhanced expression of the pro-inflammatory chemokine IL-8, when compared to plasma from healthy individuals. Plasma IL-8 signature correlates with pain and depressive symptomatology in the study cohort. Overall, these findings indicate that plasma IL-8 profiles are dysregulated in BMS and that modulation of IL-8 production in the disorder may be a tool in the management of BMS symptomatology.

R11 - Mucositis pain: treatment pptions for the patient

Background: Oral mucositis (OM) is the most frequent complication deriving from oncology treatment, causing pain of the oral cavity and dysphagia that greatly compromise the patient's quality of life. Under-treated pain of OM, can lead to malnutrition, weight-loss, astenia and emotional stress. Therefore, swift, effective symptom-management of OM is of vital importance. Analgesic therapy is often inappropriate or ineffective, whereas opiates such as Morphine are available only to a limited number of patients. Moreover, the difficulty in executing multicentric studies on narcotic drugs makes for a very grim scenario indeed. Morphine is still considered the number one drug of choice for moderate to severe oncological pain, according to EAPC (European Association for Palliative Care). However, Morphine is not generally administered for the treatment of OM pain. The objective of this article is to assess the efficacy of analgesic therapy administered during cancer treatment with specific regard to OM. Materials (patients) and methods: Assessment of pain intensity of OM during oncology treatment in patients of the National Tumor Institute of Milan. Results: Of the 150 subjects with OM in relation to various regimes of oncology treatment, 138 referred oral cavity pain of differing intensity. Data analysis revealed that 58% (88 subjects) referred oral-pharyngeal pain (NRS 5 or more) that was uncontrolled, and 27% of the same group (41 patients) received no pain mediction. Of the 52 patients that referred severe pain (NRS 7-10), 42%, (22 subjects) used no pain medication while only 19%, (10 subjects) received strong, IV opiates. Conclusions: OM pain receives little consideration, hence inadequate treatment, negtively influencing the patient's quality of life. The WHO Assessment Scale most utilized for confirming OM is not specific for identifying pain intensity of the oral cavity. Despite the fact that Morphine is considered one of the drugs of choice for oncological pain, it is not generally administered as treatment for moderate/severe OM. Proper use of specific assessment tools, identification of the most appropriate treatment for pain relief for OM as well as reference to common guidelines would greatly assist in resolving the issue so that patients may continue oncology treatment, unhindered by complications deriving from OM.

A prospective study of incidence, clinical and quality of life consequences of oral mucositis post palifermin prophylaxis in patients undergoing high-dose chemotherapy and autologous hematopoietic cell transplantation.

Autologous hematopoietic cell transplantation (AHCT) has presented a revolutionary advance in the management of hematologic malignancies with low toxicity. However, oral mucositis (OM) remains a distressing toxic effect of AHCT and one of the major side effects of the conditioning. This prospective, observational study aimed to evaluate the severity of oral cavity pain and quality of life (QOL) and explore incidence, duration, and potential risk factors of moderate/severe OM. Thirty-nine patients receiving prophylactic palifermin post-AHCT were enrolled. QOL and severity of pain were assessed using validated questionnaires (Functional Assessment of Cancer Therapy-General (FACT-G) and mouth and throat soreness (MTS), respectively). The incidence of moderate/severe OM was 28.2% with a median duration of 5days and was associated with younger age and female gender. Severity of pain related to OM was generally low or moderate with only 25% of patients reporting a score >6 on the MTS scale of 0-10 on day +7. Health-related QOL was worse on day +7 in the transplant unit compared to day 1, while on discharge day, all scores recovered and the total FACT-G score was not different from that on day 1. In our population, the incidence and duration of OM and the severity of pain related to OM appeared to be lower compared to that reported in previous studies. The impact of OM on QOL assessments seemed to be reversible with optimal supportive care despite the major transient disabilities mainly attributable to OM.

A prospective study of evaluation of methods to decrease the morbidity in oral submucous fibrosis

Aim: To evaluate the effect of antioxidants, intralesional steroids and laser in decreasing morbidity in patients of oral submucous fibrosisIntroduction: Oral submucous fibrosis (OSMF) is a chronic disorder characterized by progressive fibrosis of the lining mucosa of the upper digestive tract involving the oral cavity, oropharynx, and rarely the upper third of the esophagus, resulting in intolerance to spicy foods, burning sensation in the mouth, limitation of mouth opening and tongue mobility, xerostomia, dysphagia and hoarseness. OSMF has been reported to occur commonly in conjunction with premalignant diseases such as leukoplakia and lichen planus and therefore aprecursor to oral cavity cancer in many cases.Materials and Methods: This prospective study included 60 patients with OSMF attending the Ear Nose &amp; Throat Clinic of Dhiraj Hospital, Piparia. Patients of OSMF were evaluated as per Performa and for proper treatment planning were broadly classified into 4 groups based on classification suggested by Sinha et al.Conclusion: Lycopene, an antioxidant has significant response in early cases of OSMF in decreasing the burning pain in oral cavity in OSMF. Inj. triamcinolone and Inj. hyaluronidase, given submucosally havesignificant response in early cases of OSMF to improve cheek flexibility.CO2 laser have significant results in achieving satisfactory mouth opening in OSMF but notcheek flexibility.

Lamiaceae Peppermint Oil with Surfactant Showing Equal Antifungal Activity against &amp;lt;i&amp;gt;Candida albicans&amp;lt;/i&amp;gt; to Rosemary Chemotype CINEOL

Oral candidiasis causes pain in oral cavity or tongue. Antifungal drugs are commonly used for the treatment of candidiasis, however, there could be several problems such as side effects, drug resistance, or contraindication to concomitant use with drugs already taken. The development of substituting antimicrobial agents, which could be used internally or as gargling agents, is expected. Some essential oils have been known for the activities against microbes. We focused on the three chemotype essential oils from rosemary and five essential oils from Lamiaceae plants including rosemary, and examined their antifungal activity against Candida albicans by broth microdilution method. The activity with or without addition of Tween 80 or Tween 20 was statistically analyzed. Minimal inhibitory concentration (MIC) values of the essential oils were significantly decreased when either of the two surfactants was added. Among the tested oils, only CAMPHOR, a rosemary chemotype, showed a significantly lower MIC with addition of Tween 20 than Tween 80. It is inferred that the antifungal activity of essential oils is influenced by the type of surfactants. Some of the essential oils showed the same values of MIC and the minimal fungicidal concentration (MFC) when surfactant was added. Peppermint showed the same MICs and MFCs in most cases, and its low MFC indicated potent fungicidal activity against C. albicans, as observed in CINEOL. We will discuss peppermint oil as one of the potential candidates for antifungal agents against C. albicans.

Suicidal behavior in a patient with burning mouth syndrome.

Introduction. Chronic pain of the oral cavity is a long-term condition and like all other types of chronic pain is associated with numerous comorbidities such as depression or anxiety. Case Presentation. This is a case of a 93-year-old patient suffering from chronic oral cavity pain who repeatedly stabbed his palate due to ongoing local pain, over the last few months, which he could not further tolerate. The patient was suffering from depression and also a diagnosis of “burning mouth syndrome” (BMS) was made. Discussion. Burning mouth syndrome (BMS) is characterized by a burning sensation in the tongue or other oral sites. BMS has high psychiatric comorbidity but can occur in the absence of psychiatric diagnosis. Patients with multiple forms of pain must be considered as potential candidates for underdiagnosed depression (major) and suicidal thoughts.

Diagnosis klinis infeksi herpes zoster (laporan kasus)Clinic diagnosis of herpes zoster (case report)

Varicella is the fastest spreading infection. This virus classified as DNA virus with primer infection that causedchicken pox mainly seen in children. Reactivation of this infection causes herpes zoster or shingle. Painfull of areainvolved proceed the unilateral and segmental nature of disease. If facial involved segmentally, it occurs painespecially at the facial and dentition that sometimes suspect as pulpitis. This case report is aimed to discussdiagnosis and management of herpes zoster with headache. Patient, male, 66 years old came with chief complaint ofheadache and ulcers on right facial with eat disturbance due to oral cavity pain. The diagnosis was herpes zoster.Patient was prescribed with acyclovir 1600 mg 4 times per day, analgesic, antibiotic mouth wash, and vitamins.Oral pain disappeared in 3 days, dan after 3 weeks healed completely. Diagnosis of herpes zoster could be get fromdetail anamnesis and examination.

The influence of dental care associated with laser therapy on oral mucositis during allogeneic hematopoietic cell transplant: retrospective study.

To verify decrease in frequency and severity of oral mucositis in patients submitted to dental care and laser therapy during allogeneic hematopoietic cell transplant. Medical records of patients submitted or not to dental care associated with laser therapy during allogeneic transplant were reviewed. The following data were collected: sex, age, underlying disease, myeloablative conditioning regimens, prophylaxis for graft versus host disease, extension and severity of oral mucositis, pain in the oral cavity and when swallowing, diarrhea, need of peripheral parenteral nutrition and presence of acute graft versus host disease. Significant reduction in extension and severity of oral mucositis, as well as in frequency of oral cavity pain, was observed in patients with dental care/laser therapy (p < 0.01). There were no statistically significant differences regarding frequency of diarrhea, pain when swallowing, and need of parenteral nutrition among the groups. Significant association was found between acute graft versus host disease and pain when swallowing (p < 0.01). Acute graft versus host disease was not associated with oral mucositis severity, oral cavity pain, and diarrhea. Dental care associated with laser therapy reduces the extension and severity of oral mucositis in patients with allogeneic hematopoietic transplant. Further studies are necessary to clarify the isolate efficacy of laser therapy in these conditions, mainly regarding the influence of reduced oral mucositis on the graft versus host disease.