BioTechniquesVol. 36, No. 6 WebWatchOpen AccessWebWatchKevin AhernKevin AhernSearch for more papers by this authorPublished Online:6 Jun 2018https://doi.org/10.2144/04366WW01AboutSectionsPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack Citations ShareShare onFacebookTwitterLinkedInRedditEmail Grand PlanWhen it comes to ambitious biology, it's hard to find a project with “bigger britches” than the San Diego Supercomputer Center's Encyclopedia of Life, whose stated goal is to “catalog the complete proteome of every living species.” Inasmuch as all of the species of earth haven't even yet been identified, and the total number is upwards of 50 million, such a plan appears even bolder than the seemingly impossible aims of the human genome project when it was first described. Biologists in recent years, however, have grown accustomed to accomplishing the impossible and that may be partly behind such brash aspirations. Visitors to Encyclopedia of Life will discover a clever book metaphor employed effectively to simplify retrieval of proteome information from the numerous genomes already indexed on the site.http://eol.sdsc.edu/A Sense of CommunityScience can be a cold, cruel world, so a Web site like Developmental Physiologist, which houses a research community-oriented collection of pages is a welcome one indeed. With section topics ranging from “Funding Sources” to “What's New” and “That's My Opinion,” Developmental Physiologist helps researchers stay on top of their field and even allows them a platform from which to vent their spleens. Other features include an extensive listing of jobs available (from graduate opportunities to professorial positions) and complete contact information for all of the physiologists registered at the online database.http://www.biol.unt.edu/developmentalphysiology/ID CardsPoint your browser to the URL below. On the opening page, enter any chemical name or draw any chemical structure. Chances are you'll not only find it in ChemIDPlus's database of over 368,000 compounds, you'll also be able to view it in a 3-D projection, learn its Chemical Abstracts Service (CAS) Registry Number, access safety information about it, and discover any relevant literature links. That's a lot to ask for a simple interface, but that's exactly what ChemIDplus delivers. With an intuitive, Java-based program on board for drawing molecules, ChemIDPlus makes finding information about structures trivial. Better yet, the site's search engine retrieves almost everything you'd want to know about a compound simply by entering its name, CAS Registry Number, or hyphenated formula number.http://chem.sis.nlm.nih.gov/chemidplus/Excellent TypistConsider the myriad causes of disease in humans. Next, consider the percentage of illnesses that can be attributed to genetic differences. Finally, think about the subtlety of mutating single nucleotides, the effects such changes might have on an individual's susceptibility to environmental factors, and how these might manifest themselves in disease. Whew! There's a lot of work ahead for researchers at the National Institute of Environmental Health Sciences (NIEHS)-sponsored Environmental Genome Project at the University of Washington, who are investigating relationships between environmental factors, human gene sequence variation, and disease risk in U.S. populations. A peek at the Gene Targets link on the site reveals the current focus of the program—identifying single nucleotide polymorphisms in genes of DNA repair and cell cycle pathways. A little more snooping reveals the 30 genes for which the analysis is “in progress” and the whopping number of genes (over 200) whose analysis is completed. Double whew!http://egp.gs.washington.edu/welcome.htmlI FlyCross a vast amount of Drosophila melanogaster data with the techno-functionality of the web and what do you get? Probably something akin to the Society for Developmental Biology's Interactive Fly, hosted at Purdue University. With all the razzle-dazzle typical of excellent online sites, Interactive Fly delivers information faster than you can say sonic hedgehog. Click to view a hyperlinked collection of developmental genes (in alphabetical order), genes grouped by function/pathway, or genes involved in organ development. Opt for the for Images section and view electron microscopic pix of Drosophila body parts during development. Top it off with a movie or two in the same section of the site and you're a Drosophila afficionado.http://sdb.bio.purdue.edu/fly/aimain/1aahome.htmFiguresReferencesRelatedDetails Vol. 36, No. 6 Follow us on social media for the latest updates Metrics Downloaded 71 times History Published online 6 June 2018 Published in print June 2004 Information© 2004 Author(s)PDF download
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