University Of Padova Research Articles

GPT models classify free text from emergency department accesses in children with medical complexity

Abstract Background Emergency Department (ED) management software often collects clinical information as free text, but its unstructured nature limits routine use. While Machine Learning (ML) techniques have been employed to classify such information, they demand substantial data and computational resources. GPT-based models, using direct text prompts, offer a solution without requiring retraining, potentially simplifying clinical practice. Aims To assess OpenAI GPT’s performance in automating data extraction from ED medical records of complex pediatric patients. Methods Electronic admission records of children and young adults referring to the pediatric ED of Padova University Hospital (2007-2023) were analyzed. Principal variables of interest were discharge diagnosis, reason for ED access, required medical procedures, color code at triage, color code at discharge/hospitalization, outcome of the access. GPT-4 classification, via OpenAI API, was compared with manual classification by an expert pediatrician on sample of 791 records. Results Preliminary results of this study analyzed 107 records, showing a correct classification of discharge diagnosis in 95% of records. The reason for access to the ED was correctly identified in 97% of cases, while outcome of admission and color code, both at triage and discharge/hospitalization, were correctly classified in all given cases. Misclassification occurred mainly in cases where classification made by the model was incomplete (e.g., in the case of a trauma, abbreviated site of lesion was not identified by the model). Conclusions GPT-based models demonstrate feasibility, accuracy, and efficiency in transforming unstructured data into structured formats. Ultimately, GPT-based models could provide aid to the medical personnel in decision-making processes. Key messages • Emergency departments often collect clinical data in unstructured free text format, resulting in usability limitations. • GPT-powered models efficiently convert unstructured data to structured formats, offering potential support for medical decision-making.

Immersive technologies between technicization and human dimension: general aspects and applications

Aim. The paper offers an overview of the most studied and used immersive tech- nologies to date, considering the main applications and possible related experiments. In recent years, the technological revolution is profoundly changing humanity’s way of life. Immersive Technologies, in particular Augmented Reality (AR) and Virtual Reality (VR), are changing the relationship between humans and technology. Methods. Immersive technologies are introduced starting from a historical point of view, through a possible definition and concepts that describe in particular AR and VR, towards the recent developments. Results. Industry, the entertainment sector, marketing, medicine, education and training are considered as main fields of application. Then the focus goes on the disci- pline of Public Speaking, considering its challenges, techniques and benefits. Conclusions. The potential benefits of AR and VR in the considered application fields are highlighted, and a discussion of a study conducted at the University of Padova (Italy) relating to Public Speaking, are indicated. Negative aspects related to issues such as pri- vacy and control are also highlighted.

Nitroxide Spin Labels for Exploring Relationships Between Molecular Structure, Microenvironment and EPR Parameters: A Mini-review Dedicated to Carlo Corvaja

AbstractThis mini-review is dedicated to Carlo Corvaja (University of Padova) in recognition of his important contributions to the study of biomimetic donor–acceptor model dyads and triads and to the understanding of spin exchange in excited fullerene–nitroxide derivatives. We report on attractive examples of multi-frequency and multi-resonance EPR spectroscopy, highlighting recent work in Padova and Berlin/Mülheim. The examples selected include TR-EPR, ENDOR, and EDNMR experiments on photoexcited spin-labeled macromolecules, such as fullerene–nitroxide complexes or photosynthetic bacterial reaction centers, which were optionally NO spin-labeled. From the spin interaction parameters measured, detailed information about structure and dynamics of macromolecules embedded in liquid-solution or solid-state microenvironments could be extracted.

Consumption of Sylimarin, Pyrroloquinoline Quinone Sodium Salt and Myricetin: Effects on Alcohol Levels and Markers of Oxidative Stress-A Pilot Study.

Alcohol abuse is one of the most common causes of mortality worldwide. This study aimed to investigate the efficacy of a treatment in reducing circulating ethanol and oxidative stress biomarkers. Twenty wine-drinking subjects were investigated in a randomized controlled, single-blind trial (ClinicalTrials.gov. Identifier: NCT06548503; Ethical Committee of the University of Padova (HEC-DSB/12-2023) to evaluate the effect of the intake of a product containing silymarin, pyrroloquinoline quinone sodium salt, and myricetin (referred to as Si.Pi.Mi. for this project) on blood alcohol, ethyl glucuronide (EtG: marker for alcohol consumption) and markers of oxidative stress levels (Reactive Oxygen Species-ROS, Total Antioxidant Capacity-TAC, CoQ10, thiols redox status, 8-isoprostane, NO metabolites, neopterin, and uric acid). The effects of the treatment versus placebo were evaluated acutely and after 1 week of supplementation in blood and/or saliva and urine samples. Si.Pi.Mi intake reduced circulating ethanol after 120 min (-33%). Changes in oxidative stress biomarkers, particularly a TAC (range +9-12%) increase and an 8-isoprostane (marker of lipidic peroxidation) decrease (range -22-27%), were observed too. After the administration of Si.Pi.Mi, the data seemed to suggest a better alcohol metabolism and oxidative balance in response to wine intake. Further verification is requested.

Making a difference.

This is a personal account of one academic scientist who founded two biotechnology companies. Both companies were initially incubated within the walls of the university under a creative student incubator program whereby biology students could pursue their graduate academic degrees while gaining valuable biotechnology experiences. After the companies transitioned out of the university environment, the professor and his students pursued diagnostic and therapeutic drug development resulting in the completion of several clinical trials. The value of international scientific collaborations with colleagues at the University of Padova (Italy) is also described.

Communicating science through films: the case of the International Festival of Scientific and Educational Film (1956–1975)

ABSTRACT The Rassegna Internazionale del film Scientifico-didattico (International Festival of Scientific and Educational Film [IFSEF]) was a pioneering science-based public event held at the University of Padova from 1956 to 1975 in collaboration with the Venice International Film Festival. The IFSEF is treated as a case of a multiform space to question the permeable boundaries between hard scientific content and its aesthetic dimension, educational role, and science communication activity. Through the notions of ‘surplus of meaning’, ‘boundary object’ and ‘boundary space’, which are concepts at the intersection of science and technology studies, film studies and media studies, the IFSEF emerges as a distinctive moment in the construction of science as a multiform object in society, thus providing an opportunity to analyse the management of the evolving boundaries between scientific expertise and science communication at the dawn of modern science communication practice. The main point that emerges from the analysis of the IFSEF is the idea that the identity, meanings, structures and logics that characterise the IFSEF in many ways reflect crucial issues at the heart of the historical evolution of the boundaries between science and society, between the scientific community and other social actors, and between scientific epistemologies and different views of science-related content, thus contributing to a redefinition of the roles and identities of the actors involved in the configuration of the festival.

Children's Literature, Ecocritical Dialogues and Social-Emotional Learning: Developing Integrated Teaching Practices

An innovative primary teacher education course at the University of Padova combines children's literature, ecocritical dialogues, and social-emotional learning (SEL). It aims to enhance educational quality and prepare teachers for global environmental and social challenges. Developed through the Green Dialogues project, it fosters internationalization and interdisciplinarity. This article examines the course's interdisciplinary teamwork, focusing on its design and teaching methods. A case study highlights the benefits of incorporating ecocritical and SEL approaches in climate action teacher education. The course illustrates how children's stories can foster environmental and social consciousness and empathy among students. This approach not only enhances pedagogical practices but also prepares teachers to contribute meaningfully to climate literacy and social equity in European higher education.

Spontaneous ovulation in the cat: incidence among queens presented at a veterinary teaching facility.

The queen is recognised as an induced ovulator. Ovulation without male contact is generally regarded as spontaneous. The aim of this study was to provide an estimate of the incidence of spontaneous ovulation in a population of intact queens presented to a veterinary care facility for both reproductive and non-reproductive reasons. The secondary objective was to determine the roles of age, breed, body weight, presence of tom cats or other cycling queens, and physical contact with humans on triggering spontaneous ovulation, along with its implications. Serum samples from post-pubertal intact queens presented between January 2020 and June 2023 to the Veterinary Teaching Hospital of the University of Padova, Italy, were retrieved and assayed for progesterone (P4) levels. Serum P4 above 2.0 ng/ml without a history of male contact was considered as proof of spontaneous ovulation. In total, 31 serum samples from 29 intact post-pubertal queens were obtained. Of the 31 samples, 14 had a P4 concentration above 2.0 ng/ml and 9/29 (31.0%) queens ovulated spontaneously. The mean age and weight of the nine spontaneously ovulating queens were 4.3 ± 5.7 years and 3.7 ± 0.8 kg, respectively. One queen ovulated spontaneously at her first heat at 6 months of age, which makes it the earliest spontaneous ovulation reported. As both our findings and previous publications indicate that the incidence of spontaneous ovulation in queens is consistently ⩾30%, cats should not be considered strictly induced ovulators, but as a species in which ovulation can be either spontaneous or induced. Since the risk of progesterone-dependent conditions (cystic endometrial hyperplasia - pyometra complex, feline mammary hypertrophy) is increased in these queens, veterinarians should be aware and advise breeders and clients accordingly.

Redevelopment of the Urban Area of the Former Canossian Oratory within the City Walls of Feltre

This paper concerns the redevelopment of an urban space within the historic walls of Feltre, an ancient city located inthe province of Belluno, not far from Venice. It is particularly focused on the disused Oratory of the Canossian Friars,at the top of the medieval city. The site is now abandoned and degraded, devoid of function and unresolved in form.It is located close to the city's main square and is bordered by pre-existing buildings of relevant historical importance,including the Castle, the Napoleonic Stables, the Clock Tower, the Civic Museum and the Church of San Rocco. In another respect, the former Oratory of the Canossian Friars, which was investigated by our research group at the Department of Civil, Environmental and Architectural Engineering of the University of Padova, is proposed as a case study regarding the relationship between new and old.

SPRISS: Scalable and precise resistive impact sensor for smallsats, architecture description and tests

Space debris are a tangible risk for satellites in Earth orbits. Indeed, in the last decades fragmentation events have generated a large number of uncontrolled objects that have made the debris population grow. Modelling the space debris environment is becoming a fundamental task to evaluate the vulnerability of operational satellites, the probability of accidental collisions with uncontrolled objects, and the evolution of the debris population. With this aim, remote and in-situ measurements provide valuable data to tune the space debris population models and improve their reliability. While large satellites can be observed and tracked from ground, the sub-millimeter debris population requires in-situ measurements. In this context, in-orbit impact sensors are a key technology to obtain information about the sub-mm space debris environment. In this framework, a small-scale impact sensor sized to be integrated in a 2U CubeSat is being developed at the University of Padova. The sensor consists of a multitude of thin, conductive stripes arranged on a thin film of non-conductive material. When a debris hits the sensor, one or more stripes are severed, and the impact is detected. Moreover, the sensor design ensures low power consumption, making it feasible for CubeSat space missions. This work presents the latest outcomes obtained from the development of the sensor. Specifically, structural analyses are performed to assess that the sensor can withstand the launch loads, as well as thermal analyses to confirm its endurance capability with in-orbit temperatures. The number of expected impacts during the mission is predicted through orbital propagation, using state-of-the-art debris environment modelling tools. Finally, the paper presents a functional shooting test and vibration tests, executed onto a development model of the sensor, which verify its functionality and validate a Technology Readiness Level (TRL) of 4.

Tumor inflammatory microenvironment contribution to survival in resected upstaged adenocarcinomas

IntroductionTumor Inflammatory microenvironment (TIME) encompasses several immune pathways modulating cancer development and escape that are not entirely uncoded. The results achieved with immunotherapy elicited the scientific debate on TIME also in non-small cell lung cancer (NSCLC). We aimed to investigate whether TIME (in terms of PD-L1 expression and/or Tumor Infiltrating Lymphocytes - TILs) played a separate role in terms of survival (OS) in resected upstaged lung adenocarcinomas (ADCs), excluding other perioperative variables as confounders. Materials and methodsThis retrospective study included 50 patients with a clinically resectable lung ADC, undergoing surgery (lobectomy or segmentectomy) at the Thoracic Unit of Padova University Hospital between 2016 and 2022 and receiving an unexpected pathological upstaging (IIB or higher). ResultsDespite microscopical variables increasing from IIB to IIIB, survival was not significantly related to them. OS was better in TIME-active patients (defined as the presence of positive PD-L1 and/or TILs>10 %) than double negatives (PD-L1-/TILs-) (p = 0.01). In IIB or higher ADCs, TIME-active patients showed an improved survival compared to double negatives, merging the current TIME theories. ConclusionTIME seems to be associated with survival independently from other microscopical parameter, even in case of resected upstaged adenocarcinomas.

The Impact of Antenatal Corticosteroids on the Metabolome of Preterm Newborns: An Untargeted Approach.

We analyzed and compared variations in the urinary metabolome, as well as postnatal clinical outcomes among preterm infants, based on the timing of antenatal corticosteroid (ACS) administration in response to preterm labor onset in their mothers. This was a prospective observational study held in the Neonatal Intensive Care Unit, Department of Woman's and Child's Health, Padova University Hospital (Italy). A urine sample was obtained from each patient within 24 h of birth; Mass Spectrometry-based untargeted metabolomics analysis was then conducted. We searched for any significant disparities in the metabolomic profile of preterm newborns subjected to antenatal corticosteroid (ACS) treatment at varying timings; their correlation with clinical outcomes were also evaluated. The group receiving ACS within the optimal time window (1-7 days before delivery) exhibited elevated levels of cysteine, N-acetylglutamine, propionyl carnitine and 5-hydroxyindolacetic acid, coupled with a decrease in pipecolic acid. Clinically, this group demonstrated a reduced need for invasive ventilation (p = 0.04). In conclusion, metabolomics analysis identified several metabolites that discriminated preterm infants whose mothers received ACS within the recommended time window. Elevated levels of cysteine and 5-Hydroxyindoleacetic acid, metabolites characterized by antioxidant and anti-inflammatory properties, were observed in these infants. This metabolic profile correlated with improved respiratory outcomes, as evidenced by a reduced necessity for invasive ventilation at birth.

From surgery to functional capacity: muscle strength modifications in women post sleeve gastrectomy.

Severe obesity is characterized by excessive accumulation of fat generating a general health decline. Multidisciplinary treatment of obesity leads to significant weight loss in a few patients; therefore, many incur bariatric surgery. The main purpose of the study is to evaluate changes in functional capacity of people with obesity undergoing bariatric surgery and, in parallel, to correlate pre-surgery functional capacity with weight loss to improve exercise prescription during pre-operatory stage. sixty women with diagnosed obesity were included. Maximal oxygen consumption, upper and lower limb strength and level of physical activity were recorded 1 month before and 6 months after sleeve gastrectomy. significant reduction on body weight (-30.1kg) and Body Mass Index (-11.4kg/m2) were highlighted after surgery. Absolute grip strength decreased significantly (-1.1kg), while body weight normalized grip and lower limb strength increased significantly. The level of physical activity increased especially in leisure time (+ 593 METs/week) and active transport (+ 189.3 METs/week). Pre-surgery BMI and age predicted the amount of weight loss after surgery. Sleeve gastrectomy induces a reduction of muscle strength despite the increase of time spent in physical activity. Further research is necessary to integrate these results with data on body composition, and objective evaluation of physical activity level to define useful information for exercise prescription in terms of surgery pre-habilitation. Padova University Hospital Board (protocol n. 2027 dated January 12, 2017).

Combined Covalent and Supramolecular Polymerization To Reinforce Perylenebisimide Photosynthetic "Quantasomes".

Invited for the cover of this issue are the groups of Marcella Bonchio at the University of Padova and Jérôme Canivet at the CNRS-University of Lyon. The image depicts the hierarchical self-organization of bio-inspired quantasomes, crosslinked within a polystyrene network to enchain their lateral and orthogonal proximity for long-lasting oxygen evolution using green photons. Read the full text of the article at 10.1002/chem.202303784.

Concept and Feasibility Analysis of the Alba Cubesat Mission

AbstractAlbaSat is a 2-Unit CubeSat which is being developed by a student team at the University of Padova. The Alba project aims to design, build, test, launch, and operate the first student CubeSat of the University of Padova, featuring four different payloads. The first goal is to collect data regarding the debris environment in Low Earth Orbit, the second goal is the study of the satellite vibrations, the third one is about CubeSat attitude determination through laser ranging technology, and the fourth goal concerns satellite laser and quantum communication. The Alba CubeSat mission has been selected by the European Space Agency to join the Fly Your Satellite! Design Booster program in December 2022. This paper presents the feasibility study of the Alba CubeSat mission reproduced in the framework of the “Space Systems Laboratory” class of Master of Science in Aerospace Engineering at the University of Padova. In the beginning, a mission requirements definition was conducted. After that, the mission feasibility was considered, with preliminary requirements verification to assess the ability of the spacecraft to survive the space environment, including compliance with Debris Mitigation Guidelines, ground station visibility and minimum operative lifetime evaluation. The Alba mission sets a base for a better understanding of the space environment and its interaction with nanosatellites, and an improvement of the accuracy of debris models. Furthermore, this paper, describing the educational experience and the results achieved, will provide a useful example for future students’ studies on CubeSat mission design.

Personalising circadian hygiene educational initiatives aimed at university students-"He who has ears to hear, let him hear".

The aim of the present study was to characterise "early drop-outs" (n = 3185) out of a group of university students (n = 7766) engaged in an ongoing circadian education initiative, to evaluate its efficacy and direct its developments. The initiative is aimed at improving sleep timing/quality through one of two sets of circadian hygiene advice covering the timing of sleep, meals, exercise and light exposure, and it has already been shown to have a positive effect on sleep timing. This second, interim analysis confirmed the high prevalence of disturbed night sleep and social jetlag amongst students at Padova University. Three-thousand, one-hundred and eighty-five (41.0%) students were early drop-outs. These were more commonly males (46.4 versus 37.6%; χ2 = 58, p < 0.0001), had later sleep-wake habits, more daytime sleepiness and worse night sleep quality. Chronotype distribution was also different, with a slight but significantly higher proportion of extremely evening/evening types amongst early drop-outs (χ2 = 10, p < 0.05). These results suggest that the more evening the student, the lower their likelihood of choosing/being able to follow circadian advice.

A call-to-action for energy conservation and sustainability in the clinical laboratory: Experiences from the University of Padova

ObjectivesHealthcare has a considerable environmental impact, yet it has been largely overlooked. Clinical laboratories, in particular, consume significantly more energy and water per unit area compared to standard office buildings. It is crucial to raise awareness among laboratories about the significance of embracing eco-friendly practices. Numerous energy-saving measures do not incur additional costs but necessitate a shift in organizational culture and mindset. Design & MethodsThis paper conducts a cost-benefit analysis of energy consumption at the Laboratory Medicine Unit of University Hospital of Padova, beginning with laboratory refrigerators and freezers. ResultsThe need to rationalize the existing units, especially the combined refrigerators-freezers, and reorganize the contents of the Ultra-Low Temperature freezers with an energy-saving perspective has emerged. ConclusionsBy implementing these practices, this initiative can gradually expand to encompass more green activities in the future.

First person – Samuele Metti

ABSTRACT First Person is a series of interviews with the first authors of a selection of papers published in Journal of Cell Science, helping researchers promote themselves alongside their papers. Samuele Metti is co-first author on ‘ Native collagen VI delays early muscle stem cell differentiation’, published in JCS. Samuele conducted the research described in this article while a PhD student in Prof. Paolo Bonaldo's lab at University of Padova, Italy. He is now a postdoc in the lab of Prof. Gisou van der Goot at School of Life Science, École Polytechnique Fédérale de Lausanne, Switzerland, investigating how extracellular matrix proteins affect muscle stem cell behaviour.

Traffic Tolerance of Perennial Ryegrass (Lolium perenne L.) Cultivars as Affected by Nitrogen Fertilization

Perennial ryegrass (Lolium perenne L.) is one of the most widely used species for sports fields in temperate climates because of its high wear tolerance. However, wear tolerance of cultivars may vary according to local environmental conditions and turfgrass management. In this study, we evaluated the wear tolerance of six perennial ryegrass cultivars (Adagio, Apple SGL, Equate, Firebird, Principal 2, Tetradark) under two fertility treatments (100 or 200 kg N⋅ha−1⋅yr−1) over 2 years. The field trial was performed at the Experimental Agricultural Farm at the University of Padova in northeastern Italy in a silty loam soil. Plots were arranged in a randomized complete block with three replications and subjected to three traffic events per week using a sports field wear simulator. Turfgrass quality (TQ), percent green cover (PGC), and normalized difference vegetation index (NDVI) were recorded every 2 weeks and averaged over each month. Although perennial ryegrass cultivars responded differently to wear stress, the higher nitrogen (N) rate positively affected the TQ of them all. ‘Tetradrak’ and ‘Equate’ had the lowest TQ, especially during the active growing seasons (spring and autumn). However, ‘Tetradark’ was particularly negatively affected during the cool fall months. The impact of a higher N fertilization rate on PGC and NDVI appeared to be more pronounced in spring than in fall. Furthermore, slight differences among cultivars and treatments were observed in summer and winter when temperatures were a limiting growth factor.

Bulk-flow composites in paediatric dentistry: long term survival of posterior restorations. A retrospective study.

Dental decay is a prevalent bacterial disease affecting a significant percentage of children globally. In paediatric dentistry, various materials are available for restoring deciduous teeth, addressing both functional and aesthetic concerns. However, paediatric dentists encounter challenges related to patient compliance, limited working time, and material handling. This study aims to observe the survival rate of bulk-fill composite restorations in paediatric patients over a five-year follow-up. A total of 198 patients aged 0 to 12 years underwent 673 class II restorations on deciduous first molars (1M) and second molars (2M). All restorations were conducted performed by 1 Pediatric DDS resident students from the Paediatric Dentistry Department (Padova University), utilizing using different isolation techniques. Bulk-fill composite restorations were evaluated over a five-year follow-up, and data were collected by a single investigator. After five years, 177 patients and 611 restorations were assessed. The retention rate was higher in primary second molars than in first molars, with fewer marginal dyschromies and less formation of secondary caries. The overall failure rate was higher in primary first molars and primary lower second molars. Bulk-fill composites demonstrated significantly positive performance in terms of retention, maintenance, and marginal dyschromies. Bulk-fill composites are promising materials of choice in paediatric dentistry due to their easy handling and favorable properties. Further research is necessary to compare high and low viscosity bulk-fill composites and assess the impact of different variables on restoration success.