Ground-level ozone (O3) pollution in the North China Plain has become a serious environmental problem over the last few decades. The influence of anthropogenic emissions and meteorological conditions on ozone trends have become the focus of widespread research. We studied the long-term ozone trends at urban and suburban sites in a typical city in North China and quantified the contributions of anthropogenic and meteorological factors. The results show that urban O3 increased and suburban O3 decreased from 2010 to 2020. The annual 90th percentile of the maximum daily 8-h average of ozone in urban areas increased by 3.01 μgm−3year−1 and, in suburban areas, it decreased by 3.74 μgm−3year−1. In contrast to the meteorological contributions, anthropogenic impacts are the decisive reason for the different ozone trends in urban and suburban areas. The rapid decline in nitrogen oxides (NOX) in urban and suburban areas has had various effects. In urban areas, this leads to a weaker titration of NOX and enhanced O3 formation, while in suburban areas, this weakens the photochemical production of O3. Sensitivity analysis shows that the O3 formation regime is in a transition state in both the urban and suburban areas. However, this tends to be limited to volatile organic compounds (VOCs) in urban areas and to NOX in suburban areas. One reasonable approach to controlling ozone pollution should be to reduce nitrogen oxide emissions while strengthening the control of VOCs.