Abstract In this study, the welding of dissimilar aluminum alloys, Al 7075 and Al 6061, was investigated using Al 5356 filler rods reinforced with ZrB2 particles. The welding process was conducted using tungsten inert gas (TIG) welding, with and without ultrasonic vibration, to enhance weld quality and reduce hot cracking. Optimization of process parameters for dissimilar TIG welding was performed through Response Surface Methodology (RSM), which generated a design matrix to analyze the influence of process parameters on response variables. Numerical and graphical optimization was applied to minimize hot cracking sensitivity and maximize microhardness. The RSM-based models suggested an optimal welding current of 93 A, the use of Al 5356/ZrB2 nanocomposite filler, and the application of ultrasonic vibrations. Experimental validation of the identified solution demonstrated improvements in weld quality, including increased yield strength and ductility. The combination of nano-reinforced fillers and ultrasonic vibrations was found to enhance weldability and mitigate hot cracking in dissimilar aluminum joints. The mechanism of hot cracking reduction involved grain refinement, degassing, and homogenization due to ultrasonic vibrations, as well as the modification of weld pool chemistry and control of dilution by the nanocomposite filler, which collectively minimized solidification shrinkage and stress. Under these optimized conditions, no hot cracking was observed experimentally.