Oxide Nano Research Articles

Energizing the Thermal Conductivity and Optical Performance of Salt Hydrate Phase Change Material Using Copper (II) Oxide Nano Additives for Sustainable Thermal Energy Storage

Due to intermittent nature of solar energy, scientists and researchers are working to develop thermal energy storage (TES) systems for effectively use the solar energy. One promising avenue involves utilizing phase change materials (PCMs), but primary challenge lies in their limited thermal conductivity, which results in slower heat transfer rate and lower thermal energy storage density. The present research work demonstrates, to develop and explore a PCM composite by embedding salt hydrate and coper (II) oxide to enhance the heat transfer mechanism for potential utilization of TES material. The optical behavior, and thermal conductivity were analyzed by using Ultraviolet visible spectrum, and thermal property analyzer. The developed copper oxide dispersed PCM composite displayed the thermal conductivity was energized up to 71.5 % without affecting the other properties. Also, the optical absorptance was remarkably enhanced and the transmittance reduced to 87 %. Increasing the concentration of copper oxide nanoparticles in the salt hydrate PCM improves the optical absorptivity and heat conductivity. With these extraordinary abilities the nanocomposite could play a significant role in progress of sustainable TES with significance to contribute towards sustainable development goal of affordable and clean energy and climate change.

Nano copper in the diet of laying quails: productive performance, metabolism, and tissue concentration.

The study evaluated the use of nano copper in semi-purified diets for laying quails and its effect on performance, metabolic state, and bioavailability. A total of 160 (180-days-old) quails were distributed in a completely randomized design, in a 3x3+1 factorial. The copper sources used were copper sulfate, copper oxide, and nano copper oxide, at levels of 200, 400, and 800 ppm each, totaling nine treatments plus a negative control (with no copper inclusion). The following variables were determined: weight gain, feed intake, egg production, egg weight, hemoglobin, hematocrit, Cu in the tissues and Cu bioavailability. Data were subjected to analysis of variance at 5% probability. The effect of sources and levels, as well as the interaction between the factors were evaluated. When interaction was observed, the effect of sources was evaluated separately by the Tukey's test and the effect of levels by regression, both at 5% probability. Copper nano oxide can be used at up to 800 ppm in the diet of laying quails without altering the productive performance, and with higher bioavailability than conventional copper oxide. Hemoglobin increases with the inclusion of 200 and 400 ppm of nano copper oxide and the hematocrit with 400 ppm.

Investigation on structural, optical and anti-bacterial properties of organic additives iron oxide prepared by chemical route method

Technology and Nanoscience have a remarkable impact on environmental challenges. Scientists are moving away from harmful chemical approach and toward eco-friendly, accessible, efficient, and affordable green chemical methods for synthesizing nanoparticles. This article provides a feasible way to make iron oxide using an Avicennia marina dry fruit, seeds, leaves and green fruit extract. Structural, optical and morphological properties of the manufactured iron oxide nanoparticles have been evaluated using X-ray diffraction spectroscopy (XRD,) Ultra violet visible spectroscopy (UV–Visible), Fourier transform infrared spectroscopy (FT-IR), scanning electron microscope spectroscopy (SEM) and antibacterial activity. The formation of FeO NPs and their crystallinity has been confirmed by XRD, average particle size of FeO NP of dry fruit, seeds, leaves and green fruit are 7.1335 nm, 9.295 nm, 9.680 nm and 10.128 nm respectively. FT-IR spectrum shows the surface functionalization and vibrational phases of the bonds in FeO NPs. Band gap energies decreasing as crystallite size increases, according to UV visible results band gap energies of dry fruit, seeds, leaves and green fruit are 3.16 eV, 2.57 eV, 2.99 eV and 2.52 eV respectively. The antibacterial properties of the produced nanoparticles against Xanthomonas campestris pv vesicatoria, Erwinia spp, Escherichia coli bacteria has been investigated. Iron oxide nano particles has been utilized for antibacterial activity because of their less toxicity, high stability and biocompatibilities. The result shows the produced FeO NPs were minimize on bacterial colony.

PEN-coated superparamagnetic iron-mediated delivery of siSnail2 to inhibit metastasis and promote ferroptosis in the treatment of cancer

Cancer represents a significant global public health challenge, and conventional cancer therapies such as surgery and chemoradiotherapy are not enough due to the increased complexity of cancer. Nanotechnology has the potential to revolutionize tumor treatments by integrating gene therapy, tumor targeting, and drug delivery. In this study, we demonstrated that Snail2 plays a crucial role in the migration and invasion of lung and liver carcinoma. We proposed a novel approach to synergize the aminated crosslinking dextran coat of superparamagnetic iron oxide nano worms (CLIO-NH2, CN) with small interfering Snail2 RNA (siSnail2). The efficiency of siSnail2 delivery was significantly improved by coating CN with N-Isopropylacrylamide-modified polyethylenimine (CNP). In vitro, experiments revealed that CNP@siSnail2 effectively inhibited cancer cell EMT, migration, and invasion. Moreover, CNP@ siSnail2 promoted cancer cell death through various mechanisms, including apoptosis and ferroptosis. The combination of CNP@ siSnail2 and cisplatin significantly improved the anti-tumor effect of the treatment. Animal models demonstrated that the combined treatment of CNP@ siSnail2 and cisplatin resulted in excellent tumor inhibition effects. Our findings provide a potential combined treatment strategy for cancer therapy.

Relative exergy and energy analysis of DI‐CI engine fueled with higher blend of Azadirachta indica biofuel with n‐butanol and NiO as fuel additives

AbstractAlternate fuels are in high demand for current engines and such fuels are studied both property‐wise and tested as fuel in the current engines. In current work, diesel engines are studied for higher blend Neem (Azadirachta indica) biodiesel (NB) as fuel, and fuel additives such as n‐butanol and NiO nano additives are chosen. Experimentation was performed on the experimental stationary engine which is coupled to eddy current dynamometer for four test fuels under varying fuel injection timings. Four test fuels were chosen for experimental studies which are Diesel 90% (vol %) + n‐butanol (10%), pure Neem biodiesel, NB 90% (vol %) + n‐butanol (10%), and Neem Biodiesel 90% + 25 ppm of nickel oxide dissolved in solvent. The synthesis of nickel oxide nano additives was done using a homogenous grinding method and XRD, FESEM, and EDS characterization signifies the presence of NiO. The Neem biodiesel was derived from base catalytic process and was studied using Gas Chromatography and Mass Spectroscopy apparatus for its chemical composition. The experimentation results which were focused were on the energy, exergy derived, and expenditure at varying fuel injection timings. The exergy and energy usage were almost similar in nature and entropy produced during the chemical‐to‐mechanical energy transfer reduced with the advancement in fuel injection timing to 27° bTDC for Diesel 90% + Bt.10%, NB90 + Bt.10% and NB100 + 25 ppm of NiO by 2.2%, 2.9%, and 4.6% respectively. Also, the exergy destruction retarded when with advancement in fuel inlet timing to 27° bTDC by 2.1%, 3%, 6.2%, and 6.8% for the same fuels, respectively.

3D integrated non-noble metal oxides nano arrays for enhanced nitrate electroreduction to ammonia

The electrochemical nitrate reduction reaction (eNO3RR) to ammonia (NH3) is a promising alternative method to the Haber-Bosch process that requires high temperature and pressure. In this contribution, the integrated Co3O4 nanowire arrays on Ni foam (Co3O4/NF) are reported to exhibit the outstanding performance with a high NH3 yield rate of 117.01 mg h−1cm−2, a superior NH3 Faradaic efficiency of 99.28 %, a high effective current density of 1475.71 mA cm−2, and a good operation durability during 40 consecutive recycling tests (40 h) in 1.0 M NaOH (0.1 M NaNO3). The high-valence metal cations as electron-deficient centers can act as Lewis-acid sites, favorably interacting with the Lewis base NO3−, and accordingly boosting the NO3− adsorption and activation. Moreover, the in-situ growth array configuration provides the substantial active sites and constructs a fast electron-transport channel, thus facilitating the conversion of NO3−-to-NH3. Density functional theory (DFT) calculations also reveal that the Co atoms as the active sites are preferred to adsorb NO3−, implying that the NO3− electroreduction dominates the cathodic reaction rather than hydrogen evolution reaction. This study provides a viable method to design integrated electrodes with enhanced eNO3RR activity and selectivity, which might have broad prospects in the application of renewable energy.

Nano-island-like heterojunction of nitrogen-doped carbon quantum dots anchoring on titanium oxide nano sheets@Cu2O for enhancing visible light-driving photocatalytic degradation of methyl orange

Cu2O and TiO2 are promising for photocatalysis owing to their lower cost and excellent performance. Unfortunately, the efficiency of light utilization by Cu2O and TiO2 is still low. Herein, the nano-island-like heterojunction of nitrogen-doped carbon quantum dots anchoring on titanium oxide nano sheets@Cu2O (NCQDs/TNSs@Cu2O) was synthesized through the hydrothermal and chemical precipitation process and its photocatalytic performance was systematically characterized. Benefiting from the unique heterojunction, NCQDs/TNSs@Cu2O exhibited a superior photocatalytic performance. High-resolution transmission electron microscopy showed that NCQDs/TNSs nanoclusters were decorated on Cu2O nanoparticle surface and formed heterojunctions. The UV–Vis-DRS spectra indicated that NCQDs/TNSs@Cu2O exhibited the strong adsorption peaks between 400 and 650 nm. Under simulated sunlight irradiation, NCQDs/TNSs@Cu2O exhibited excellent photocatalytic degradation performance on methyl orange. For example, the degradation was completed within 20 min and the photo-degradation capacity of NCQDs/TNSs@Cu2O remained 90.1 % after four recycling cycles. Furthermore, the potential mechanism for the photo-induced degradation was proposed based on the active substances identified through the electron spin resonance. Conclusively, this study provides a novel perspective on the role of NCQDs and prepares the way for the design of the biomass-based photocatalyst.

Sustainable fabrication of biogenic Fe–Zn nano core-shell and their photocatalytic efficiency against third generation antibiotics

The photocatalysis of third generation antibiotics was deliberated using biogenic iron oxide (FeO NPs) and iron-zinc (Fe–Zn) nano core-shell. Photocatalysts were prepared from aqueous extract of Adiantum incisum (Ai) by reacting with apposite salt solutions. FeO NPs were synthesized by mixing 5 % Ai extract with 5 mM FeSO4.7H2O at alkaline pH (50 °C). While Fe–Zn nano core-shell were synthesized by coating ZnO NPs on FeO NPs using successive reduction method. Synthesis and stabilization of nanoparticles were substantiated by diverse surface plasmonic resonance peak of FeO NPs and Fe–Zn nano core-shell at explicit wavelength ranges. Band gap energy values, Thermogravimetric analysis (TGA), X-Ray Diffraction (XRD), Raman and Scanning Electron Microscope (SEM) analysis validates that coating was done efficaciously. Fourier Transform Infrared Spectroscopy (FTIR) recognized the role of plant phytochemicals in NPs reduction and stabilization. SEM-Energy Dispersive X-Ray analysis (EDX) analysis unveiled that FeO NPs and core-shell aggregates are orbicular in shape. Average crystalline size of FeO NPs and Fe–Zn nano core-shell obtained from XRD was 15.64 nm and 22.94 nm respectively. The photocatalytic degradation of Ampicillin, Levofloxacin and Ceftriaxone under UV and Sunlight displayed that Fe–Zn nano core-shell have high degradation capability than FeO NPs. Degradation potential was higher in UV than in sunlight. Maximum degradation of Ampicillin (74.4 %) was attained under UV light and (60.31 %) in sunlight followed by Levofloxacin. Degradation was further confirmed by conducting FTIR analysis and antimicrobial studies. Gas Chromatography-Mass Spectrometry detected Hexadecenoic acid as the main degradation product in nano treated Ampicillin and Levofloxacin.

Effect of conductive particles embedded phase change material on the productivity of a solar still in a controlled environment

A solar still’s performance using 3 different conductive particles embedded in the phase change material (PCM) has been studied. The conductive particles involved are aluminium scrap (Al), aluminium oxide (Al2O3) nano powder and copper (Cu) nano powder, whereas the PCM is paraffin wax. Four similar solar still models were built with different PCMs, differentiated as Model A, B, C, and D, filled with Al scrap-PCM, Al2O3 nano-PCM, Cu nano-PCM, and Al2O3 + Cu-nano PCM combinations, respectively. The productivity of the solar stills for Models A, B, C, and D are 1.93, 2.15, 1.93, and 2.20 kg/kJ.m2 respectively. It was concluded that Al2O3 + Cu-nano PCM is the most efficient PCM-conductive particle combination and Cu nano powder can be replaced by aluminium scrap as an economical alternative.

A Novel Electrochemical Strategy for the Highly Sensitive Investigation of Tinidazole Using Newly Designed Halloysite Nano Clay and TiO2 Based Sensor

A voltametric technique with high sensitivity has been introduced to perform the electrochemical reduction of Tinidazole (TDZ), a significant antihistamine medication employed to combat infections instigated by various protozoans like Giardia lamblia, Entamoeba histolytica, and Trichomonas vaginalis. This method employs a Titanium oxide and halloysite nano clay modified Glassy Carbon electrode (TiO2-HNC/GCE), which displayed remarkable sensitivity and selectivity in detecting TDZ. The electrode characterization was carried out by XRD and SEM-EDS. The analysis of TDZ explored using cyclic voltammetry (CV) and square wave voltammetry (SWV). The best reduction activity of TDZ was observed in pH of 7.0. The process was determined to be irreversible and controlled by diffusion. Through concentration variance assessments, a linear range of 1.0 μM to 10.0 μM was established. Detection and quantification limits were computed to be 14 nM and 46.9 nM, which is superior to reported works. The practical utility of the modified sensor was verified to detect TDZ concentration in pharmaceutical and biological samples. The investigation of various parameters indicated the sensor’s stability, and sensitivity in yielding valuable outcomes and can be used in pharamaco-kinetics and quality control laboratories.

Formulation and antibacterial properties of lollipops containing of chitosan- zinc oxide nano particles on planktonic and biofilm forms of Streptococcus mutans and Lactobacillus acidophilus

This study aimed to formulate and characterize the experimental lollipops containing chitosan- zinc oxide nanoparticles (CH-ZnO NPs) and investigate their antimicrobial effects against some cariogenic bacteria. The CH-ZnO NPs were synthesized and characterized by X-ray diffraction (XRD), Fourier Transform Infrared Spectroscopy (FTIR) analysis, and Transmission electron microscope (TEM). Then, four groups were made, including lollipops coated with 2 and 4 ml of CH-ZnO NPs, 0.7 ml CH-ZnO NPs incorporated lollipops, and those with no CH-ZnO NPs. Their antibacterial effectiveness against Streptococcus mutans and Lactobacillus acidophilus was evaluated by direct contact test and tissue culture plate method in planktonic and biofilm phases, respectively. Chlorhexidine mouthrinse (CHX) was used as a positive control group. In the planktonic phase, the antibacterial properties of both groups coated with CH-ZnO NPs were comparable and significantly higher than incorporated ones. There was no significant difference between CHX and the lollipops coated with 4 ml of NPs against S. mutans and CHX and two coated groups against L. acidophilus. None of the experimental lollipops in the biofilm phase could reduce both bacteria counts. The experimental lollipops coated with 2 and 4 ml of CH-ZnO NPs could reveal favorable antimicrobial properties against two cariogenic bacteria in the planktonic phase.

Dielectric Properties of Aluminium and Silver Doped Zinc Oxide Nano Powder Prepared by Solution Combustion Synthesis

Aluminium and Silver doped Zinc Oxide nano powder were synthesized by Solution Combustion method using Sucrose (C12H22O11) as fuel at 600o C. X-Ray diffraction pattern analysis confirms synthesized nano powders crystalized in single phase wurtzite structure matched with JCPDS-36-1451. Addition of dopant controls the crystallite size of the synthesized nano powder. The study of dielectric permittivity, dielectric loss, AC conductivity and impedance were investigated in the frequency range of 100Hz to 5MHz at room temperature. It is evident from the analysis that dielectric properties of the samples depends on the nature of the dopant.

Exploring the antibacterial and dermatitis-mitigating properties of chicken egg white-synthesized zinc oxide nano whiskers.

Zinc oxide nanoparticles (ZnO-NPs) have garnered considerable interest in biomedical research primarily owing to their prospective therapeutic implications in combatting pathogenic diseases and microbial infections. The primary objective of this study was to examine the biosynthesis of zinc oxide nanowhiskers (ZnO-NWs) using chicken egg white (albumin) as a bio-template. Furthermore, this study aimed to explore the potential biomedical applications of ZnO NWs in the context of infectious diseases. The NWs synthesized through biological processes were observed using electron microscopy, which allowed for detailed examination of their characteristics. The results of these investigations indicated that the NWs exhibited a size distribution ranging from approximately 10 to 100 nm. Fourier-transform infrared spectroscopy (FTIR) and scanning electron microscopy-energy dispersive X-ray spectroscopy (SEM-EDX) mapping analyses successfully corroborated the size, dimensions, and presence of biological constituents during their formation. In this study, XTT assay and confocal imaging were employed to provide evidence of the efficacy of ZnO-NWs in the eradication of bacterial biofilms. The target bacterial strains were Staphylococcus aureus and Escherichia coli. Furthermore, we sought to address pertinent concerns regarding the biocompatibility of the ZnO-NWs. This was achieved through comprehensive evaluation of the absence of cytotoxicity in normal HEK-293T and erythrocytes. The findings of this investigation unequivocally confirmed the biocompatibility of the ZnO-NWs. The biosynthesized ZnO-NWs demonstrated a noteworthy capacity to mitigate the dermatitis-induced consequences induced by Staphylococcus aureus in murine models after a therapeutic intervention lasting for one week. This study presents a comprehensive examination of the biosynthesis of zinc oxide nanowhiskers (ZnO-NWs) derived from chicken egg whites. These findings highlight the considerable potential of biosynthesized ZnO-NWs as a viable option for the development of therapeutic agents targeting infectious diseases. The antibacterial efficacy of ZnO-NWs against both susceptible and antibiotic-resistant bacterial strains, as well as their ability to eradicate biofilms, suggests their promising role in combating infectious diseases. Furthermore, the confirmed biocompatibility of ZnO-NWs opens avenues for their safe use in biomedical applications. Overall, this research underscores the therapeutic promise of ZnO-NWs and their potential significance in future biomedical advancements.

Modelling and optimization of biodiesel production from waste fish oil using nano immobilized rPichiapastoris whole cell biocatalyst with response surface methodology and hybrid artificial neural network based approach

In this study, zinc oxide (ZnO) nano particle immobilized recombinant whole cell biocatalyst (rWCB) was used for bioconversion of waste fish oil in to biodiesel in a lab scale packed bed reactor (PBR). Central composite design and hybrid artificial neural network (ANN) models were explored to optimize the production of biodiesel. Developed rWCB exhibited maximum lipase activity at 15 % (v/v) of glutaraldehyde concentration and 6 % (w/v) of ZnO nanoparticles at pH of 7. Maximum biodiesel yield reached about 91.54 ± 1.86 % after 43 h in PBR using hybrid ANN model predicted process conditions of 13.2 % (w/v) of nano immobilized rWCB concentration and 4.7:1 of methanol to oil ratio at 33 °C. Importantly, developed nano immobilized rWCB was adequately stable for commercialization. Thus, production of biodiesel from waste fish oil using ZnO nano immobilized rWCB could become potential candidate for commercialization.

A new nanocomposite of copper oxide and magnetite intercalated into Attapulgite clay to enhance the radiation shielding

The effects of Magnetite (Fe3O4) on the radiation shielding properties of different nanocomposites from Attapulgite (ATP) intercalated with different copper oxide (CuO) and magnetite nano (Fe3O4) concentrations were investigated. Different nanocomposites from ATP intercalated with different copper oxide CuO and magnetite nano Fe3O4 concentrations have been synthesized and implemented toward radiation attenuation. The different percent were as the following 40% ATP + X Fe3O4 + (60%–X) CuO that abbreviated to [AT40FeXCu60-x] where X = 15.0%, 30.0%, 45.0%. The ATP and one of the prepared nanocomposites have been characterized using different techniques: FT-IR, TGA, XRD, EDX, and SEM. The density of the synthesized materials was determined. Then their radiation shielding properties were established using GEANT4 and Phy-X software in the selected range of photon energies of 0.015 – 15 MeV. The linear attenuation coefficient (μ), the mass attenuation coefficient (μm), the mean free path (MFP), the half value layer (T1/2), the tenth value layer (T1/10), the effective atomic number (Zeff), and the equivalent atomic number (Zeq) have been calculated to find out the radiation shielding characteristics of the new novel nanocomposites. The μm values were varied from 4.5894 to 0.0204 cm2 g-1 for Base, from 11.9780 to 0.02172 cm2 g-1 for AT40Fe15Cu45, from 12.5030 to 0.02190 cm2 g-1 for AT40Fe45Cu15 and finally from 12.2480 to 0.02181 cm2 g-1 for AT40Fe30Cu30 at photon energy range from 0.015 to 15 MeV. The results showed that the values of the radiation shielding parameters increased with increasing nano Fe3O4 concentration, and the AT40Fe45Cu15 sample has the highest μm and μ and lowest T1/2, T1/10 and MFP. The results of this study have important implications for the development of new radiation-shielding materials. ATP-doped Fe3O4-CuO glasses are a promising new class of radiation shielding materials with improved properties. In conclusion, the study found that the nanocomposite materials with higher nano Fe3O4 concentration have better shielding qualities against γ-rays and neutrons. The AT40Fe45Cu15 sample has the highest shielding qualities for γ-rays, while the AT40Fe30Cu30 sample has the highest fast neutron removal cross-section.

Altering Water Effect and Surface Properties of Heat Cured Poly Methyl Methacrylate by Adding Surface Treated Titanium Di Oxide Nano Particles

Titanium dioxide (TiO2) is extensively used part of our regular life. It can be observed in various commonly utilized goods & customer imports for instance drugs, plastics, cosmetics, food and paper. Universally, the quantity of titanium oxide manufactured in 2009 was 4.68 million tons for that reason the tenacity of the revision is controlling the amount of change on the denture base physical features such as the heat treatment in denture processing (PMMA)through the implementation of modified outer surface titanium di oxide Nano particles. Its properties are comprised of water solubility, surface roughness, water sorption and surface hardness. The contr olled TiO2 powder added to heat cured acrylic material according to the main weight of PMMA in concentration of 3% , 5% and 7%, and then it's mixed regularly by engine of probe ultra-sonication. Titanium oxide Nano fillers were m erged in denture based material with the help of more free radical polymerization in bulk. The nanoparticles were surface treated by a layer of trime thoxysilypropylmethacrylate (TMSPM). 120 specimens were created and separated into 3 sample sets affording to the examination (each sample sets consist of 40 samples) and each sample sets were sectioned in four subsets according to the TiO2 added ratio and ultimately containing 10 samples in each subset. The tests which conducted were indentation hardness (shore D), surface roughness properties as well as water sorption and solubility. For each test four of the sub groups (one control led and three with added Nano TiO2). Important to mention that extremely elevation in surface hardness score and roughness were detected at the ratio of 3%, 5%and7%. Thus escalation of added TiO2 nan-fillers considerably reduced the water solubility and sorption. The accumulation of the powder of TiO2 nanoparticles which have been surface treated to the PMMA acrylic resin thus changing the PMMA properties for example surface rigidity and surface coarseness. In which it’s increased in direct proportional relation with the raise of TiO2 concentration; at the same time addition of surface treated TiO2 Nano particles decrease water sorpt ion and solubility of (PMMA) also in direct proportional relation with the raise of TiO2 concentration.

Viscoelastic and vibrational studies of nano hybrid fibre metal laminates

Employment of distinct fibres (glass/carbon etc.) in Fibre Metal Laminates (FMLs) is one way of enhancing the durable life of an FML and its performance under dynamic loads. In the present work, carbon fibre is employed in GLARE (Glass/Aluminium laminated epoxy) to enhance the vibration (natural frequency) and viscoelastic (storage modulus ( E′), loss modulus ( E″) and Tan δ) properties. Similarly, the influence of 1 wt% of Al2O3 (alumina), ZrO2 (zirconium oxide) and TiO2 (titanium oxide) nano particles are also studied in hybrid (carbon/glass) FML. The mean particle size of Al2O3 (5.1 nm), ZrO2 (25.3 nm) and TiO2 (63.2 nm) were estimated using the Scherer equation with the aid of X-ray diffractometer analysis. Hybridisation resulted in a 22%, 10% and 2% increase of natural frequencies from mode 1 to mode 3 and 36.3%, 15% and 13.2% of E′, E″ and Tanδ, respectively, when compared to GLARE (glass fibre reinforced aluminium laminated epoxy). TiO2-reinforced hybrid FML shows the highest natural frequencies among all nanohybrid FMLs. The results summarise that natural frequencies and viscoelastic properties of nanohybrid FMLs are sensitive to the type of fibre, nano particle reinforcement and its size. A stereo microscope and a scanning electron microscope (SEM) were used to analyse the defects at the interface and the nanoparticle dispersion in the matrix, respectively. Further, a numerical model was developed to perform free vibration analysis, and it was noticed that the results were similar to experimental values.

Hybrid mRNA Nano Vaccine Potentiates Antigenic Peptide Presentation and Dendritic Cell Maturation for Effective Cancer Vaccine Therapy and Enhances Response to Immune Checkpoint Blockade.

Cancer vaccines combined with immune checkpoint blockades (ICB) represent great potential application, yet the insufficient tumor antigen presentation and immature dendritic cells hinder improved efficacy. Here, a hybrid nano vaccine composed by hyper branched poly(beta-amino ester), modified iron oxide nano adjuvant and messenger RNA (mRNA) encoded with model antigen ovalbumin (OVA) is presented. The nano vaccine outperforms three commercialized reagents loaded with the same mRNA, including Lipofectamine MessengerMax, jetPRIME, and in vivo-jetRNA in promoting dendritic cells' transfection, maturation, and peptide presentation. In an OVA-expressing murine model, intratumoral administration of the nano vaccine significantly induced macrophages and dendritic cells' presenting peptides and expressing co-stimulatory CD86. The nano vaccine also elicited strong antigen-specific splenocyte response and promoted CD8+ T cell infiltration. In combination with ICB, the nano vaccine aroused robust tumor suppression in murine models with large tumor burdens (initial volume >300 mm3 ). The hybrid mRNA vaccine represents a versatile and readily transformable platform and augments response to ICB.

Hybrid Nano Supports of Nano Polyaniline, Magnetic Iron Oxide Nanoparticles and Nano Clay as Matrices for The Immobilization of β-Glucosidase, Fructosyltransferase and Carboxymethyl Cellulase

Hybrid Nano Supports of Nano Polyaniline, Magnetic Iron Oxide Nanoparticles and Nano Clay as Matrices for The Immobilization of β-Glucosidase, Fructosyltransferase and Carboxymethyl Cellulase

Multi-Response Optimization of Abrasive Waterjet Cutting on r-GO-Reinforced Fibre Intermetallic Laminates through Moth–Flame Optimization Algorithm

Laminated metal-composite structures, also known as fibre metal laminates (FMLs), have emerged as prominent engineering materials in various industries, particularly in the domains of aircraft and automobile manufacturing. These materials are sought after due to their enhanced impact and fatigue resistance capabilities. The machining of FMLs plays a crucial role in achieving near-net shapes for the purpose of joining and assembling components. Delamination is a prevalent issue encountered during the process of conventional machining, thus rendering FMLs are challenging materials to machine. This study aims to investigate the cutting process of novel fibre intermetallic laminates (FILs) using the abrasive water jet (AWJ) cutting technique. The FILs consists of carbon and aramid fibers that are adhesively bonded with a resin matrix filled with reduced graphene oxide (r-GO) nano fillers. Moreover, these laminates contain embedded Nitinol shape memory alloy sheets as the skin materials. Specifically, the study aims to investigate the impact of different factors, such as the addition of reduced graphene oxide (r-GO) in the laminates (ranging from 0 to 2 wt%), traverse speed (ranging from 400 to 600 mm/min), waterjet pressure (ranging from 200 to 300 MPa), and nozzle height (ranging from 2 to 4 mm), on the material removal rate (MRR), delamination factor (FD), and kerf deviation (KD). ANOVA was used in the statistical analysis to determine the most influential parameters and their effects on the selected responses. The optimal AWJC parameters are determined using a metaheuristic-based moth–flame optimization (MFO) algorithm in order to enhance cut quality. The efficacy of MFO is subsequently compared with similar well-established metaheuristics such as the genetic algorithm, particle swarm algorithm, dragonfly algorithm, and grey-wolf algorithm. MFO was found to outperform in terms of several performance indices, including rapid divergence, diversity, spacing, and hypervolume values, among the algorithms compared.